Polarized Positron Source with a Compton Multiple Interaction Point Line

ISBN 978-3-95450-115-1International audiencePositron sources are critical components of the future lepton colliders projects. This is essentially due to the high luminosity required, orders of magnitude higher than existing ones. In addition,polarization of the positron beam rather expands the physics research potential of the machine by increasing the precision of the measurements and enhancing certain types of interactions. In this framework, the Compton sources for polarized positron production are taken into account where the high energy gamma rays are produced by the Compton scattering and subsequently converted in the polarized electron-positron pairs in a target. The Compton multiple IPs line is proposed as one of the solutions to increase the number of captured positrons. This allows a significant increase in the emitted gamma ray flux impinging on the target. The gamma ray production with the Compton multiple IPs line is simulated and used for polarized positron generation. Later, a capture section based on an adiabatic matching device followed by a pre-injector linac is simulated to capture and accelerate the positron beam. The results obtained are presented and discussed

Growth hormone secretory in healthy aged women and men of Tunisian population

With aging, men and women experience multiple hormonal changes, and in particular the activity of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis. This perturbation may be involved inaggravations of numerous abnormalities. In 64 healthy elderly, we determined the concentrations of GH in both sexes and its correlation with thyroid-stimulating hormone (TSH), the descriptive data, BMI,electrolytic assessment and some biochemical parameters. Collected data suggest that there was an age-dependent decrease in GH secretion. For TSH, there was a slight increase. The simple regressionanalysis revealed non-significant direct relation between these two hormones. We also found that BMI values were inversely related to the serum concentrations of these hormones. For the lipid metabolism,the positively correlated relation only exists between GH and total-cholesterol, on one hand, and between GH and LDL-cholesterol, on the other. For the other parameters such as glucose and triglycerides as well as HDL-cholesterol, this relation does not exist. For the BMI, this index shows a positively correlated relation with glucose and triglycerides. The electrolytic assessment shows that inmen, phosphorus was positively related to GH. In women, calcium and sodium were positively related to GH. Aging was found to be associated with decreased morning serum GH levels and slightly increased TSH levels in healthy elderly Tunisian population. Reduction of the GH-IGF-I axis in the elderly has important clinical implications. Indeed, this deficiency in GH could contribute to the decline of various functions associated with normal aging

Development of an intense positron source using a crystal--amorphous hybrid target for linear colliders

In a conventional positron source driven by a few GeV electron beam, a high amount of heat is loaded into a positron converter target to generate intense positrons required by linear colliders, and which would eventually damage the converter target. A hybrid target, composed of a single crystal target as a radiator of intense gamma--rays, and an amorphous converter target placed downstream of the crystal, was proposed as a scheme which could overcome the problem.This paper describes the development of an intense positron source with the hybrid target. A series of experiments on positron generation with the hybrid target has been carried out with a 8--GeV electron beam at the KEKB linac. We observed that positron yield from the hybrid target increased when the incident electron beam was aligned to the crystal axis and exceeded the one from the conventional target with the converter target of the same thickness, when its thickness is less than about 2 radiation length. The measurements in the temperature rise of the amorphous converter target was successfully carried out by use of thermocouples. These results lead to establishment to the evaluation of the hybrid target as an intense positron source.Comment: 17pages, 10figure

A positron source using an axially oriented crystal associated to a granular amorphous converter

Submitted to Chinese Physics CA non conventional positron source using the intense γ radiation from an axially oriented monocrystal which materialize into e+e- pairs in a granular amorphous converter is described. The enhancement of photon radiation by multi-GeV electrons crossing a tungsten crystal along its axis is reported. The resulting enhancement of pair production in an amorphous converter placed 2 meters downstream, is also reported. Sweeping off the charged particles from the crystal by a bending magnet upstream of the converter allows a significant reduction of the deposited energy density. Substituting a granular target made of small spheres to the usual compact one, makes easier the energy dissipation. The deposited energy and corresponding heating are analyzed and solutions for cooling are proposed. The configurations studied here for this kind of positron source allow its consideration for unpolarized positrons for the ILC

ERL Scheme for Compton Polarised Positron Sources

International audienceOne of the main challenges for the future linear colliders projects (ILC and CLIC) is to design an efficient positron source taking into account the constraints imposed by the target heating. At present, different schemes have been analysed to produce high energy gammas and to convert them in an amorphous target. One of them considers the possibility to boost the energy of the backscattered photons of a laser pulse by Compton effect. This method is very attractive since the source is independent from the main Linac and since the photon helicity is conserved in Compton scattering and subsequently transferred to the produced pairs. This allows the physics experiments disposing of both positron and electron polarised sources. Different schemes have been proposed to provide the electron beam for the Compton collisions. taking into account the constraint imposed by the low value of the Thomson cross section. One of the explored possibilities is to design an ERL with relatively low repetition frequency, high charge per pulse and then to stack the produced positrons in an accumulation ring. Different considerations on this scheme will be illustrated and the main constraints discussed. MO6RFP06

Positron Production and Capture based on Low Energy Electrons for SuperB

TUPEB057International audienceProviding a high quality and sufficient high current positron beam for the ultra high luminosity B-factory SuperB is a major goal. In this paper a proposition for positrons production and capture scheme based on low energy electrons up to1 GeV is presented. For this technique, several types of flux concentrator used to capture the positrons are being studied. The following accelerating section bringing the positrons up to 280 MeV and the total yield for L-band and S-band type accelerators are given. Also the result of the benchmark between ASTRA and a LAL code based on Geant4 toolkit simulation is discussed

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation.

BACKGROUND: The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks (DSBs), mediators including ATM are recruited to the site of DNA-damage. Subsequent phosphorylation of p53 by ATM and ATM-induced CHK2 results in p53 stabilization, ultimately intensifying transcription of p53-responsive genes involved in DNA repair, cell-cycle checkpoint control and apoptosis. METHODS: In the current study, we investigated the stabilization and activation of p53 and associated DDR proteins in response to treatment of human colorectal cancer cells (HCT116p53+/+) with the MDM2 antagonist, Nutlin-3. RESULTS: Using immunoblotting, Nutlin-3 was observed to stabilize p53, and activate p53 target proteins. Unexpectedly, Nutlin-3 also mediated phosphorylation of p53 at key DNA-damage-specific serine residues (Ser15, 20 and 37). Furthermore, Nutlin-3 induced activation of CHK2 and ATM - proteins required for DNA-damage-dependent phosphorylation and activation of p53, and the phosphorylation of BRCA1 and H2AX - proteins known to be activated specifically in response to DNA damage. Indeed, using immunofluorescent labeling, Nutlin-3 was seen to induce formation of γH2AX foci, an early hallmark of the DDR. Moreover, Nutlin-3 induced phosphorylation of key DDR proteins, initiated cell cycle arrest and led to formation of γH2AX foci in cells lacking p53, whilst γH2AX foci were also noted in MDM2-deficient cells. CONCLUSION: To our knowledge, this is the first solid evidence showing a secondary role for Nutlin-3 as a DDR triggering agent, independent of p53 status, and unrelated to its role as an MDM2 antagonist

Proceedings of the third French-Ukrainian workshop on the instrumentation developments for HEP

The reports collected in these proceedings have been presented in the third French-Ukrainian workshop on the instrumentation developments for high-energy physics held at LAL, Orsay on October 15-16. The workshop was conducted in the scope of the IDEATE International Associated Laboratory (LIA). Joint developments between French and Ukrainian laboratories and universities as well as new proposals have been discussed. The main topics of the papers presented in the Proceedings are developments for accelerator and beam monitoring, detector developments, joint developments for large-scale high-energy and astroparticle physics projects, medical applications.Comment: 3rd French-Ukrainian workshop on the instrumentation developments for High Energy Physics, October 15-16, 2015, LAL, Orsay, France, 94 page

Assessment of Multivessel Coronary Artery Disease Using Cardiovascular Magnetic Resonance Pixelwise Quantitative Perfusion Mapping

OBJECTIVES: The authors sought to compare the diagnostic accuracy of quantitative perfusion maps to visual assessment (VA) of first-pass perfusion images for the detection of multivessel coronary artery disease (MVCAD). BACKGROUND: VA of first-pass stress perfusion cardiac magnetic resonance (CMR) may underestimate ischemia in MVCAD. Pixelwise perfusion mapping allows quantitative measurement of regional myocardial blood flow, which may improve ischemia detection in MVCAD. METHODS: One hundred fifty-one subjects recruited at 2 centers underwent stress perfusion CMR with myocardial perfusion mapping, and invasive coronary angiography with coronary physiology assessment. Ischemic burden was assessed by VA of first-pass images and by quantitative measurement of stress myocardial blood flow using perfusion maps. RESULTS: In patients with MVCAD (2-vessel [2VD] or 3-vessel disease [3VD]; n = 95), perfusion mapping identified significantly more segments with perfusion defects (median segments per patient 12 [interquartile range (IQR): 9 to 16] by mapping vs. 8 [IQR: 5 to 9.5] by VA; p < 0.001). Ischemic burden (IB) measured using mapping was higher in MVCAD compared with IB measured using VA (3VD mapping 100 % (75% to 100%) vs. first-pass 56% (38% to 81%) ; 2VD mapping 63% (50% to 75%) vs. first-pass 41% (31% to 50%); both p < 0.001), but there was no difference in single-vessel disease (mapping 25% (13% to 44%) vs. 25% (13% to 31%). Perfusion mapping was superior to VA for the correct identification of extent of coronary disease (78% vs. 58%; p < 0.001) due to better identification of 3VD (87% vs. 40%) and 2VD (71% vs. 48%). CONCLUSIONS: VA of first-pass stress perfusion underestimates ischemic burden in MVCAD. Pixelwise quantitative perfusion mapping increases the accuracy of CMR in correctly identifying extent of coronary disease. This has important implications for assessment of ischemia and therapeutic decision-making