Parasites Recovered From Overwintering Mimosa Webworm, \u3ci\u3eHomadaula Anisocentra\u3c/i\u3e (Lepidoptera: Plutellidae)

The mimosa webworm, Homadaula anisocentra, overwinters in the pupal stage. Two parasites, Parania geniculata and Elasmus albizziae, are associated with overwintering pupae or the immediate prepupal larvae. Combined parasitism during the winters of 1981-82,1982-83, and 1983-84 was 2.1,3.9, and 2.9%, respectively

Nanofiller-tuned microporous polymer molecular sieves for energy and environmental processes

10.1039/c5ta09060aJournal of Materials Chemistry A41270-27

Community and the voluntary hospitals in Derbyshire and Nottinghamshire, 1900-1946: economy, society, culture.

This thesis spans the first half of the 20th Century, charting the progress and challenges of the voluntary hospital system in Derbyshire and Nottinghamshire. The voluntary hospitals were the key sites of acute medical care for the working-classes from their foundations in the late 18th Century to their demise after the Second World War. Funded by a mixture of charitable donations, mutualist mass-contribution schemes, and occasional state aid in times of crisis, the voluntary hospitals were otherwise independent from any overarching authority, subject only to the demands of their community. This thesis looks at how the voluntary hospitals operated in the mixed socioeconomic background of two Midland counties with drastic regional variation: geographically, socially, and economically. Home to many voluntary hospitals, ranging from the larger Derbyshire Infirmary and Nottingham General in the county capitals, down to tiny cottage hospitals ensconced in the industrial towns and rolling dales. Fundamentally, the thesis asks the question: to what extent are voluntary hospitals reflections of their community? To answer this, myriad sources from over a dozen different hospitals are drawn upon, addressing matters of finance, civil society, recreation and leisure, charity and philanthropy, leadership, mutualism and self-help, war and crisis. It looks at the large-scale fundraising events organised in the towns, the carnivals and parades, as well as the financial schemes masterminded by the hospitals to cultivate a sense of medical security for the populace, as well as financial security for the hospitals. It looks at each ‘era’ within its own context, using context at both a national and - more importantly - local level

A compariso of mebendazole and albendazole in treating children with Trichuris trichiura infection in Durban, South Africa

Objective. To compare the efficacy of mebendazole 500 mg and aIbendazole 400 mg single-close treatments of Trichuris trichiura infection in children in the Durban area of KwaZuluatal, South Africa.Design. A single-blind randomised trial in children with a documented moderate infection of T. mchiura. Ova were counted in stool specimens before and 10 days after treatment by the formal-ether concentration method.Setting. Two shelters for abandoned and orphaned children in Durban.Participants. inety-six children aged between 2 and 12 years.Outcome measures. The number of children who showed reduced T. trichiura ova counts after the treatments, and reductions in ova counts, both expressed as percentages. Statistical analysis using the Wilcoxon 2-sample test and thechi-square test.Results. Eighty-two children completed the trial; 42 received mebendazole and 40 albendazole. Of the mebendazole group 85% showed a reduction in T. trichiura ova count, compared with 75% of children who received albendazole. Mebendazole treatment was associated with a median percentage reduction in ova count of 72.2%, which significantly exceeded the 44.1% reduction after albendazole (P  =0.024).Conclusion. The mebendazole 500 mg single-close therapy was more efficacious than the albendazole 400 mg singledose therapy in treating T. trichiura infection in these children

Urea-Mediated Anomalous Diffusion in Supported Lipid Bilayers

Diffusion in biological membranes is seldom simply Brownian motion; instead, the rate of diffusion is dependent on the timescale of observation and so is often described as anomalous. In order to help better understand this phenomenon, model systems are needed where the anomalous subdiffusion of the lipid bilayer can be tuned and quantified. We recently demonstrated one such model by controlling the excluded area fraction in supported lipid bilayers (SLBs) through the incorporation of lipids derivatised with polyethylene glycol. Here we extend this work, using urea to induce anomalous subdiffusion in SLBs. By tuning incubation time and urea concentration, we produce DCPC bilayers that exhibit anomalous behaviour on the same scale observed in biological membranes

Event driven executive

Tasks may be planned for execution on a single processor or are split up by the designer for execution among a plurality of signal processors. The tasks are modeled using a design aid called a precedence graph, from which a dependency table and a prerequisite table are established for reference within each processor. During execution, at the completion of a given task, an end of task interrupt is provided from any processor which has completed a task to any and all other processors including itself in which completion of that task is a prerequisite for commencement of any dependent tasks. The relevant updated data may be transferred by the processor either before or after signalling task completion to the processors needing the updated data prior to commencing execution of the dependent tasks. Coherency may be ensured, however, by sending the data before the interrupt. When the end of task interrupt is received in a processor, its dependency table is consulted to determine those tasks dependent upon completion of the task which has just been signalled as completed, and task dependency signals indicative thereof are provided and stored in a current status list of a prerequisite table. The current status of all current prerequisites are compared to the complete prerequisites listed for all affected tasks and those tasks for which the comparison indicates that all prerequisites have been met are queued for execution in a selected order

Eye on a Dish Models to Evaluate Splicing Modulation

Inherited retinal dystrophies, such as Leber congenital amaurosis, Stargardt disease, and retinitis pigmentosa, are characterized by photoreceptor dysfunction and death and currently have few treatment options. Recent technological advances in induced pluripotent stem cell (iPSC) technology and differentiation methods mean that human photoreceptors can now be studied in vitro. For example, retinal organoids provide a platform to study the development of the human retina and mechanisms of diseases in the dish, as well as being a potential source for cell transplantation. Here, we describe differentiation protocols for 3D cultures that produce retinal organoids containing photoreceptors with rudimentary outer segments. These protocols can be used as a model to understand retinal disease mechanisms and test potential therapies, including antisense oligonucleotides (AONs) to alter gene expression or RNA processing. This "retina in a dish" model is well suited for use with AONs, as the organoids recapitulate patient mutations in the correct genomic and cellular context, to test potential efficacy and examine off-target effects on the translational path to the clinic