Palladium-Catalyzed Cross-Coupling of Gem-Bromofluoroalkenes with Alkylboronic Acids for the Synthesis of Alkylated Monofluoroalkenes

Monofluoroalkenes are versatile fluorinated synthons in organic synthesis, medicinal chemistry and materials science. In light of the importance of alkyl-substituted monofluoroalkenes efficient synthesis of these moieties still represents a synthetic challenge. Herein, we described a mild and efficient methodology to obtain monofluoroalkenes through a stereospecific palladium-catalyzed alkylation of gem-bromofluoroalkenes with primary and strained secondary alkylboronic acids under mild conditions. This novel strategy gives access to a wide range of functionalized tri- and tetrasubstituted monofluoroalkenes in high yield, with good functional group tolerance, independently from the gem-bromofluoroalkenes geometry

Electrolyte-free electrochemical C–H trifluoromethylation of 2-pyridones under batch and flow conditions

International audienceAn environmentally friendly electrochemical process for the direct trifluoromethylation of 2-pyridones with a broad substrate scope has been developed

Copper-catalyzed direct arylation of cyclic enamides using diaryliodonium salts.

International audienceA convenient method for the copper(II)-catalyzed direct arylation of cyclic and nonaromatic enamides using diaryliodonium salts has been developed. The reaction demonstrates large functional group tolerance, good yields, and total regioselectivity with a C(3)-functionalization. The synthetic potential of this coupling was explored by using a range of readily accessible diaryliodonium salts and enamides

Azobenzene: a Visible‐Light Chemical Actinometer for the Characterization of Fluidic Photosystems

International audience(E)-Azobenzene is introduced as a suitable chemical actinometer in the visible spectral range (440–540 nm) for photon flux determination of fluidic microphotoreactors or for assessing efficiency of visible light photo-induced reactions, its evaluation is straightforward without tedious analytics. Photoisomerization quantum yields (ΦE→Z) of (E)-azobenzene were accurately determined upon irradiation at several wavelengths and in different solvents based on well-known diarylethene

Sensitized [2 + 2] intramolecular photocycloaddition of unsaturated enones using UV LEDs in a continuous flow reactor: kinetic and preparative aspects

International audienc