CLINICAL EVALUATION OF EFFICACY OF KUSTHADI CHURNA WITH UDUMBARADI TAILA IN THE MANAGEMENT OF KARNINI YONIVYAPAD W.S.R. TO CERVICAL EROSION

Karnini yonivyapad is one of the gynaecological disorders described in Ayurveda under the umbrella of the Yonivyapad. According to the signs and symptoms, it is more nearer to the benign lesion cervical erosion, which occurs due to the replacement of the stratified squamous epithelium of the portio-vaginalis by the columnar epithelium of endocervix. The treatment is designed to destruct the columnar epithelium by any method and to promote the re-epithelization of the squamous tissues. Keeping this point in view, the present clinical trial is taken up with the aim of clinical evaluation of efficacy of Kusthadi churna with Udumbaradi taila in the management of Karnini yonivyapad (cervical erosion). Kusthadi churna along with Yonipichu with Udumbaradi taila group-A, and group-B only Udumbaradi taila yonipichu, and results were assessed on the basis of the epithelization of erosion and improvement in the symptoms. The study reveals that the mixed therapy group showed better results than the group of single drug

TEXTBOOK OF FORENSIC PHARMACY: PHARMACEUTICAL JURISPRUDENCE

This book provides a systematic and comprehensive coverage of the theory as well as the application there of in the field of forensic pharmacy. Every chapter gives the definitions, objectives, and offences under the respective Act. The systematic structure of the book is assigned to cover the major syllabi of forensic pharmacy in 25 chapters and includes all topics of syllabus proposed by AICTE. Largely, it covers the syllabi of diploma, undergraduate and postgraduate courses in pharmacy under various universities. Pharmaceutical Legislation in India and Pharmaceutical Industry The Pharmacy Act, 1948 The Drugs and Cosmetics Act, 1940 and Rules, 1945 The Medicinal and Toilet Preparations (Excise Duties) Act, 1955 and Rules, 1956 The Narcotic Drugs and Psychotropic Substances Act, 1985 and Rules The Essential Commodities Act, 1955 The Drug Price Control Order (DPCO), 1995 New Drug Policy The Drugs and Magic Remedies (Objectionable Advertisements) Act, 1954 The Poisons Act, 1919 The Medical Termination of Pregnancy Act, 1971 The Prevention of Cruelty to Animals Act, 1960 The Shops and Establishment Act, 1954 The All India Council for Technical Education Act, 1987 The Factories Act, 1948 The Minimum Wages Act, 1948 Intellectual Property Rights The Consumer Protection Act, 1986 The Standard of Weights and Measures Act, 1976 Code of Pharmaceutical Ethics Medical and Health Accessories Prescription and Non-prescription Drugs and Diagnostic Aids New Drug Approval and Export Registration Pharmacy, Pharmaceutical Education, Regulation and Career Option

Relapsing severe Crohn’s colitis and perianal fistula on Infliximab maintenance therapy

Perianal fistula occurs in up to 43% of patients with Crohn’s disease. In Crohn’s disease it is important to identify the site of inflammation, area involved and based on that the treatment regimen is decided. Perianal abscesses must be drained and perianal fistulas must be treated with surgical and medical management. In this case report we would discuss about a patient who underwent failure with first line treatment and developed fistula. His symptoms decreased with due course of management and was advised for surgical procedure along with medical management

Multiple brain abscesses of odontogenic origin. May oral microbiota affect their development? a review of the current literature

In the last few years, the role of oral microbiota in the setting of oral diseases such as caries, periodontal disease, oral cancer and systemic infections, including rheumatoid arthritis, car-diovascular disease and brain abscess (BA), has attracted the attention of physicians and researchers. Approximately 5–7% of all BAs have an odontogenic origin, representing an important pathological systemic condition with a high morbidity and mortality. A systematic search of two databases (Pubmed and Ovid EMBASE) was performed for studies published up to 5 January 2021, reporting multiple BAs attributed to an odontogenic origin. According to PRISMA guidelines, we included a total of 16 papers reporting multiple BAs due to odontogenic infections. The aim of this review is to investigate the treatment modality and the clinical outcome of patients with multiple BAs due to odontogenic infections, as well as to identify the most common pathogens involved in this pathological status and their role, in the oral microbiota, in the onset of oral infections. A multidisciplinary approach is essential in the management of multiple BAs. Further studies are required to understand better the role of microbiota in the development of multiple BAs

Gravitational waves and mass ejecta from binary neutron star mergers: Effect of large eccentricities

As current gravitational wave (GW) detectors increase in sensitivity, and particularly as new instruments are being planned, there is the possibility that ground-based GW detectors will observe GWs from highly eccentric neutron star binaries. We present the first detailed study of highly eccentric BNS systems with full (3+1)D numerical relativity simulations using consistent initial conditions, i.e., setups which are in agreement with the Einstein equations and with the equations of general relativistic hydrodynamics in equilibrium. Overall, our simulations cover two different equations of state (EOSs), two different spin configurations, and three to four different initial eccentricities for each pairing of EOS and spin. We extract from the simulated waveforms the frequency of the f-mode oscillations induced during close encounters before the merger of the two stars. The extracted frequency is in good agreement with f-mode oscillations of individual stars for the irrotational cases, which allows an independent measure of the supranuclear equation of state not accessible for binaries on quasicircular orbits. The energy stored in these f-mode oscillations can be as large as 10−3  M⊙∼1051  erg, even with a soft EOS. In order to estimate the stored energy, we also examine the effects of mode mixing due to the stars’ offset from the origin on the f-mode contribution to the GW signal. While in general (eccentric) neutron star mergers produce bright electromagnetic counterparts, we find that for the considered cases with fixed initial separation the luminosity decreases when the eccentricity becomes too large, due to a decrease of the ejecta mass. Finally, the use of consistent initial configurations also allows us to produce high-quality waveforms for different eccentricities which can be used as a test bed for waveform model development of highly eccentric binary neutron star systems.S. V. C. was supported by the DFG Research Training Group 1523/2 “Quantum and Gravitational Fields.” T. D. acknowledges support by the European Union’s Horizon 2020 research and innovation program under Grant Agreement No. 749145, BNSmergers. N. K. J.-M. acknowledges support from STFC Consolidator Grant No. ST/L000636/1. B. B. was supported by DFG Grant No. BR 2176/5-1. W. T. was supported by the National Science Foundation under Grant No. PHY-1707227. Also, this work has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 690904. This research was supported in part by Perimeter Institute for Theoretical Physics. Research at Perimeter Institute is supported by the Government of Canada through Industry Canada and by the Province of Ontario through the Ministry of Economic Development & Innovation. Computations were performed on the supercomputer SuperMUC at the LRZ (Munich) under the project number pr48pu and on the ARA cluster of the University of Jena

Preparation of a New Oxotetracyano- (pyridine)chromate(IV) Anion

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TEXTBOOK of PHARMACEUTICAL PACKAGING TECHNOLOGY

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