Comparison of clinical outcomes following CuT-380A insertion in postplacental period with interval insertion

Background: Postplacental intra-uterine device has many benefits like providing contraception immediately after childbirth, non-interference with lactation and high efficacy. However, concerns about its safety have led to decreased use of this method of contraception. Hence, this study aims to compare the complication rates following insertion of immediate postplacental IUCD (PPIUCD) with interval insertion.Methods: This is a prospective study conducted under the Department of Obstetrics and Gynaecology in PGIMER, Chandigarh. 196 women were included in the study. Women were divided in two groups, those who were inserted with immediate postplacental IUCD versus those who had IUCD insertion in interval period. The two groups were followed up for a period of 6 months and complications were recorded. The PPIUCD group was further subdivided into 2 subgroups based on mode of delivery, vaginal delivery and caesarean section. These PPIUCD subgroups were also compared.Results: There was no statistically significant difference in the incidence of pelvic pain, infection, abnormal uterine bleeding and expulsion between the PPIUCD and interval group. However, when the PPIUCD subgroups were compared, it was seen that no woman in caesarean section subgroup had expulsion of IUCD whereas 9.8% women had expulsion in the vaginal delivery PPIUCD subgroup.Conclusions: Postplacental and interval IUCD seem to be comparable for the incidence of various complications. However, intra-caesarean PPIUCD insertion seems to have a much lower expulsion rate as compared to vaginal delivery PPIUCD insertion

Broad ligament term pregnancy in an unscarred uterus: misdiagnosis and the challenges

A broad ligament pregnancy is a rare condition, but full term broad ligamnet pregnancy especially in an unscarred uterus is extremely rare. It is often misdiagnosed and usually finally diagnosed during surgery. Here is case of full term broad ligament pregnancy, which remained undiagnosed throughout her pregnancy, unfortunately had IUFD. Patient was referred to our hospital in view of failure of induction with increased BP records. No ultrasound was available on admission. On clinical assessment it appeared as transverse lie with IUFD. So cesarean was decided as a mode of delivery. Emergency ultrasound could just confirm IUFD with pelvic mass? Fibroid (actually deviated uterus). On laparotomy the broad ligament pseudosac had occupied entire abdomen. After delivery of baby, anatomy was found completely distorted. Highly vascular omental adhesions on fundus with difficulty in placental removal. Placenta could be traced reaching abdomen posteriorly. The first clinical impression was suspicion of placenta percreta. Uterus appeared non salvageable and hysterectomy was decided. Placenta was found lying in abdomen, adhered to bowel, omentum and fundus of uterus. The final diagnosis of broad ligament pregnancy could be made after the cut section of the uterus and anatomic evaluation. Patient required blood transfusions preoperatively .She remained stable and discharged on postoperative day nine. This case holds importance because may be outcome was different if it was a booked and investigated pregnancy. May be baby and uterus were salvageable with better outcome

“Free radical induced oxidative stress” (frios) parameters: key to reduce feto-maternal mortality in high risk pregnancies

Background: ROS plays role during pregnancy and normal parturition and in recurrent pregnancy loss, initiation of preterm labor, anaemia, preeclampsia, eclampsia, Intrauterine growth retardation. Elevated oxidative stress is found in term infants with fetal distress and in preterm infants. With this background this study was conducted to evaluate the role of FRIOS (free radical induced oxidative stress) in reducing feto -maternal mortality in high risk pregnancies in District Kanpur.Methods: This prospective study was conducted on pregnant women at high risk attending department of Obstetrics and Gynaecology, GSVM Medical College, Kanpur after taking permission from the institutional ethical committee. Informed consent was obtained from all patients. Investigations were carried out to measure oxidant level of Malonaldialdehyde (MDA) enzyme & to measure anti oxidant Super Oxide Dismutase (SOD) enzyme. Levels of these enzymes were compared between normal & each high risk sub groups separately. SPSS software was used for statistical analysis and suitable tests were applied.Results: The mean value in study group was highest in severely anaemic patients (8.53±1.398 Nmoles/ml of plasma) followed by pre eclamptic & eclamptic patients (8.33±1.355 Nmoles/ml of plasma). The mean levels of in study group was lowest in pre eclamptic & eclamptic patients (0.394±.191 u/mg of protein) followed by pre term patients (0.413±0.141 u/mg of protein). Significant difference between MDA enzyme levels in control group and all sub groups of study group was found.Conclusions: Measurement of Malonaldialdehyde (MDA) & Super Oxide Dismutase (SOD) enzymes at an earlier stage can be a valuable tool for early diagnosis, so that we can timely intervene & improve the maternal outcome

Fruit based synthesis of silver nanoparticles-an effect of temperature on the size of particles

The cost effective and eco-friendly technique for synthesis of silver nanoparticles from the extract of seed of P.granatum. The reduction process was simple and convient to handle and was monitored by UV-vis spectroscopy. So the green synthesis of silver nanoparticles from 1mM AgNO3 solution was prepared through the extract of P. granatum seed which act as a capping and reducing agent. The morphology and uniformity of silver nanoparticles were invastigated by TEM and EDX. The functional group of protein molecule was using identified by FTIR. Increase in temperature leads increase  in size of silver nanoparticles

A Simplified Guide for Forensic Analysis of Paper as Evidence

Paper is a versatile material with many uses such as writing, printing, packaging, painting, cleaning etc. Physical evidence from paper based material have great forensic value and forensic analysis of their physical properties, optical properties, electrical properties, strength properties and microscopic structure of fiber reflect the intrinsic chemistry, morphology and structure of individual fiber which assist the investigator to detect the document fraud, link particular suspect material with original document and other samples of the paper associated with the crime. The goal of this research is to examine the properties of paper by nondestructive and destructive technique under forensically sound condition

Assessment of bio-medical waste management in three apex Government hospitals of Agra,

Abstract: Waste management practices in three apex government hospitals of Agra viz., Sarojini Naidu Medical College, Lady Lyall Maternity Hospital and District Hospital were studied during January, 2004 -January, 2005. Data were collected with the help of (i) personal observations of the waste treatment and disposal practices and (ii) assessment of knowledge, attitude and practices of working personnel with the help of questionnaires. The results obtained indicated lack of knowledge and awareness regarding legislations on bio-medical waste management even among qualified hospital personnel. None of these hospitals were equipped with higher technological options e.g. incinerator, autoclave, microwave and had no facilities to treat the liquid waste generated inside the hospital. It is concluded that generation and implementation of a waste management policy, institutional/organizational set up, training and motivation must be given paramount importance to meet the current needs and standards of bio-medical waste management in these hospitals

Phytochemical investigations, in-vitro antioxidant, antimicrobial potential, and in-silico computational docking analysis of Euphorbia milii Des Moul

Euphorbia milii Des Moul is a deciduous bush indigenous to Madagascar. The present study aims to investigate the presence of the phytochemical, in-vitro antioxidant and antimicrobial potency, and in-silico computational analysis of ethanolic and aqueous preparations of E. milii leaves and flowers. The ethanolic and aqueous extracts were tested for in-vitro antioxidant activity by DPPH, H2O2, TAC, and FRAP assay. In addition, antimicrobial potentials were assayed by agar well diffusion technique against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and Candida albicans for various clinical isolates. The qualitative phytochemical analysis results confirmed the existence of alkaloids, flavonoids, phenolics, and tannins. The quantitative analysis elicits the availability of a magnificent number of alkaloids, flavonoids, phenolics, flavonols, and tannins. Among all the extracts, aqueous extracts of leaves exhibited potent antioxidant activity in DPPH, FRAP, and H2O2 assay with the IC50 value of 30.70, 60.05, and 82.92µg/mL, respectively. In agar well diffusion assay, all extracts displayed zone of inhibition varies from 2-24mm at different concentrations ranging from 10-320 mg/mL, whereas no activity was observed against Candida albicans. Furthermore, docking-based computational analysis has revealed that beta-sitosterol and taraxerol are the plant's active constituents responsible for their antimicrobial and antioxidant activities. Research findings suggest that the E. milii plant has an excellent prospect for further study for its extended antioxidative and antimicrobial potential. It could be a natural source of various ailments and can be utilized to develop new drugs

Preterm birth among pregnancies conceived by assisted reproduction techniques in Mumbai, Maharashtra, India

Background: Preterm births are an enormous global problem on families, medical system and economy. The rates of preterm birth are increasing and one of the contributors is growing use of Assisted Reproduction Techniques (ART) leading to multifetal gestations. Some risk factors for preterm birth are specific to women who conceive by ART. Since there is limited data from India, this pilot study was undertaken to assess the magnitude of preterm birth among pregnancies conceived by ART and to study the contributing factors.Methods: Clinic based descriptive cohort study through eight ART clinics in Mumbai for one year. Data was collected using an in-depth questionnaire on socio-demographic characteristics, medical history, ART details, course and complications during pregnancy, mode of delivery, pregnancy outcome, risk factors related to preterm birth and neonatal outcome. Complete details of 113 participants who completed the study were analyzed.Results: Study showed high incidence of preterm birth (76.23%) among women conceived with ART. Multiple gestations were observed in 45.1%. Pregnancy related complications like heterotrophic pregnancy (3%), pre eclampsia (15%) and gestational diabetes (11%) were high. Incidence of caesarean section was very high (98%). Neonatal outcome was good with 98% live births and only 2 still births.Conclusions: Present study highlights that preterm birth, multiple pregnancies, pregnancy related complications like preeclampsia, gestational diabetes and caesarean sections are very high among women conceived by ART. With growing use of ART there is an urgent need to develop a National ART Surveillance system in India like the one in Centre for Disease Control Atlanta to get complete data on the pregnancy course and outcomes of ART conceptions. Efforts to limit the number of embryos transferred should be strengthened to prevent multiple births

In situ detection of dopamine using nitrogen incorporated diamond nanowire electrode

[[abstract]]Significant difference was observed for the simultaneous detection of dopamine (DA), ascorbic acid (AA), and uric acid (UA) mixture using nitrogen incorporated diamond nanowire (DNW) film electrodes grown by microwave plasma enhanced chemical vapor deposition. For the simultaneous sensing of ternary mixtures of DA, AA, and UA, well-separated voltammetric peaks are obtained using DNW film electrodes in differential pulse voltammetry (DPV) measurements. Remarkable signals in cyclic voltammetry responses to DA, AA and UA (three well defined voltammetric peaks at potentials around 235, 30, 367 mV for DA, AA and UA respectively) and prominent enhancement of the voltammetric sensitivity are observed at the DNW electrodes. In comparison to the DPV results of graphite, glassy carbon and boron doped diamond electrodes, the high electrochemical potential difference is achieved via the use of the DNW film electrodes which is essential for distinguishing the aforementioned analytes. The enhancement in EC properties is accounted for by increase in sp2 content, new C–N bonds at the diamond grains, and increase in the electrical conductivity at the grain boundary, as revealed by X-ray photoelectron spectroscopy and near edge X-ray absorption fine structure measurements. Consequently, the DNW film electrodes provide a clear and efficient way for the selective detection of DA in the presence of AA and UA.[[booktype]]紙