5 research outputs found
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Mask Projection Microstereolithography of Novel Biocompatible Polymers
Mask Projection Microstereolithography (MPμSL) selectively cures entire layers of
photopolymer to create three-dimensional parts with features on the micron scale. The resolution
and scale of MPμSL are ideal for fabricating tissue engineering scaffolds with designed
mesostructure. While MPμSL have excellent resolution, there are few biocompatible materials
that are compatible with the vat photopolymerization processes. A novel diacrylate
functionalized Pluronic L-31 block-copolymer and poly(propylene glycol diacrylate) were
synthesized and processed with MPμSL. The resulting structures were analyzed for
biocompatibility, as well as accuracy and mechanical strength to assess feasibility for use in
tissue engineering scaffold fabrication. Preliminary fabricated scaffold geometries are presented
to validate experimental results.Mechanical Engineerin
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Microstereolithography of Tissue Scaffolds Using a Biodegradable Photocurable Polyester
Due to its ability to create complex cellular geometries with extremely fine resolution, mask
projection microstereolithography (MPμSL) can be useful for fabricating designed tissue
scaffolds and other biological constructs for use in Tissue Engineering and Regenerative
Medicine. However, few photocurable materials with low cytotoxicity, adequate cell adhesion,
and degradability can be processed with MPμSL. In this work, we present the fabrication of
biocompatible and biodegradable tissue scaffolds with 50 μm feature sizes from a novel
polyester using MPμSL. Poly(tri(ethylene glycol)adipate) dimethacrylate (PTEGA-DMA) was
synthesized and evaluated for its printability. The curing parameters for printing were identified
and scaffolds were fabricated. Optical and electron microscopy were used to determine the
achievable feature sizes and accuracy of printed parts using the polymer in the MPμSL system.
MC3T3-E1 mouse preosteoblasts were seeded on PTEGA-DMA films to assess adhesion and
biocompatibility.Mechanical Engineerin