10 research outputs found
The impact of statins on health services utilization and mortality in older adults discharged from hospital with ischemic heart disease: a cohort study
- Author
- A Majeed
- A Sgadari
- A Tonkin
- AG Olsson
- AR Levy
- BM Psaty
- C Cooke
- CA Allen-Maycock
- CA Beck
- CA Jackevicius
- CB Eaton
- CC Yang
- CG Fonarow
- CG Isles
- Charmaine A Cooke
- CP Cannon
- D Hunt
- D Williams
- DA Alter
- DB Rubin
- DM Wilson
- DT Ko
- E Simpson
- EM Ohman
- FA McAlister
- FL Paradiso-Hardy
- FM Sacks
- GC Fonarow
- GG Schwartz
- HD Aronow
- Ingrid S Sketris
- J Afilalo
- J Concato
- J Shepherd
- JA de Lomos
- Jafna Cox
- JC LaRosa
- JL Cox
- JL Cox
- JM Foody
- JM Spin
- K Martin
- K Rockwood
- KA Dombrook-Lavender
- KK Teo
- L Pilote
- L Pilote
- L Pilote
- L Wei
- LB Signorello
- LR Harrold
- M Acevedo
- M Miller
- MG Hunink
- MM Joffe
- N Kagansky
- National Cholesterol Education Program (NCEP) Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult treatment Panel III)
- NF Wieringa
- NP Roos
- NP Stocks
- P Rothwell
- PR Rosenbaum
- RB D'Agostino
- RJ Glynn
- S DeWilde
- S Dunlop
- S Schneeweiss
- S Schneeweiss
- S Schneeweiss
- S Schneeweiss
- Scandinavian Simvastatin Survival Study Group
- SJ Lewis
- SM Grundy
- Susan A Kirkland
- TA Miettinen
- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
- TJ Wilt
- World Health Organization Collaborating Centre for Drug Statistics Methodology
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>Cardiovascular disease (CVD) carries a high burden of morbidity and mortality and is associated with significant utilization of health care resources, especially in the elderly. Numerous randomized trials have established the efficacy of cholesterol reduction with statin medications in decreasing mortality in high-risk populations. However, it is not known what the effect of the utilization of these medications in complex older adults has had on mortality and on the utilization of health services, such as physician visits, hospitalizations or cardiovascular procedures.</p> <p>Methods</p> <p>This project linked clinical and hospital data from the Improving Cardiovascular Outcomes in Nova Scotia (ICONS) database with administrative data from the Population Health Research Unit to identify all older adults hospitalized with ischemic heart disease between October 15, 1997 and March 31, 2001. All patients were followed for at least one year or until death. Multiple regression techniques, including Cox proportional hazards models and generalized linear models were employed to compare health services utilization and mortality for statin users and non-statin users.</p> <p>Results</p> <p>Of 4232 older adults discharged alive from the hospital, 1629 (38%) received a statin after discharge. In multivariate models after adjustment for demographic and clinical characteristics, and propensity score, statins were associated with a 26% reduction in all- cause mortality (hazard ratio (HR) 0.74, 95% confidence interval (CI) 0.63-0.88). However, statin use was not associated with subsequent reductions in health service utilization, including re-hospitalizations (HR, 0.98, 95% CI 0.91-1.06), physician visits (relative risk (RR) 0.97, 95% CI 0.92-1.02) or coronary revascularization procedures (HR 1.15, 95% CI 0.97-1.36).</p> <p>Conclusion</p> <p>As the utilization of statins continues to grow, their impact on the health care system will continue to be important. Future studies are needed to continue to ensure that those who would realize significant benefit from the medication receive it.</p
The relationship between type of drug therapy and blood glucose self-monitoring test strips claimed by beneficiaries of the Seniors' Pharmacare Program in Nova Scotia, Canada
- Author
- A Faas
- A Farmer
- A Tengblad
- AJ Karter
- AJ Karter
- AJ Karter
- Arto Ohinmaa
- BW Bode
- C Mensing
- Canadian Diabetes Association Clinical Practice Guidelines Expert Committee
- CD Saudek
- CG Mitchell
- Charmaine Cooke
- Chiranjeev Sanyal
- D Stewart
- Dawn M Frail
- DE Goldstein
- E Ipp
- E Peel
- E Peel
- Gordon Flowerdew
- Ingrid Sketris
- JA Johnson
- JA Johnson
- JM Evans
- K Neeser
- Katarina Hjelm
- KL Tieszen
- MB Davidson
- MI Harris
- MI Harris
- P Gaede
- P Goede
- S Coster
- S Coster
- SB Soumerai
- Stephen D Graham
- V Holmes
- WA Davis
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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- Trask Kara
- Triulzi Darrell
- Trodd Dawn
- Tsang Jennifer
- Tully Redmond
- Turgeon Alexis
- Turki Salah
- Turner Anne
- Turner Anne
- Turner-Bone Ian
- Turns Margaret
- Uddin Ruzena
- Udy Andrew
- Uyeki Tim
- Vaara Suvi
- Vahtera Annukka
- Vamplew Luke
- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- vanât Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
- Venz Ellen
- Verlander Mark
- Verrier Nathalie
- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
- Vowell Emma
- Vujaklija BrajkoviÄ Ana
- Vuylsteke Alain
- Wagh Atul
- Walden Andrew
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Äimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (nâ=â143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (nâ=â152), or no hydrocortisone (nâ=â108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (nâ=â137), shock-dependent (nâ=â146), and no (nâ=â101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
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- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
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- Bensen Nicole
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- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
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- Bevan Emily
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- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
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- Biddie Simon
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- Bojunga Jörg
- Bomken Charlotte
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- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
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- Bothma Pieter
- Boudineau Michel
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- Bradbury Charlotte A.
- Bradley Paul
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- Brugman Curt
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- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
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- Buhr Heidi
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- Cabreros Leilani
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- Catorze Nuno José Teodoro Amaro dos Santos
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- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
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- Cook Tim
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- Cremer Olaf
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- Currie Andrew
- Cusack Rebecca
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- Cutler Sean
- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
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- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
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- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
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- Doble Patricia
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- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
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- McAdams David
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- McCarthy Aine
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- Parke Rachael L.
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- Parker Lorraine
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- Ramakrishnan N
- Ramali Mohamed
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- van de Veerdonk Frank L.
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- Van Der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Haren Frank
- Van Hecke Jolien
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Zanten Arthur
- van Zuylen Tamara
- Van?t Hoff William
- Vandewoestyne Sophie
- Vanjak Christian
- Vanmali Piyush
- van Opdorp Marjolein
- van Vonderen Marit
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
- Vazquez-Grande Gloria
- Veenith Tonny
- Veillard Marion
- Venkatesh Bala
- Verlander Mark
- Vermassen Joris
- Vermeiren Daisy
- Vermont - van der Staaij Janine
- Verrier Nathalie
- Vertue Mark
- Verula Jerik
- Victor Saji
- Viehman Alex
- Vieillard-Baron Antoine
- Vignesh C
- Villot Solenne
- VilĂĄ Clara
- Vincent Rachel
- Virdee Satwinder
- Visentin Elisa
- Visser Yorik
- Vita Tina
- Vivier Dominique
- Vodovar Dominique
- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Volkov Lev
- Voza Gennaro
- Vuylsteke Alain
- Wada Asako
- Waddington Natalia
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
- Walker Susan
- Walsh Joanne
- Walsh Tim
- Walsham James
- Walton Catherine
- Wang Shu
- Ward Geraldine
- Ward Kathryn
- Ward Luke
- Warnapura Loku
- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Watts Angela
- Waugh Victoria
- Webb Steve A.
- Weber Lisa
- Webster Denise
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Alan
- Wells Colin
- Wells Karen
- Welters Ingeborg
- West Lauren
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
- Wijewardena Gayathri
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
- Williams Karen
- Williams Marie
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
System struggles and substitutes: a qualitative study of general practitioner and psychiatrist experiences of prescribing antipsychotics to children and adolescents
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/10/2016
- Field of study
There are significant controversies regarding rising antipsychotic prescription trends in children and adolescents. Many pharmacoepidemiology trend studies have been published, and interpretations of these data are helpful in explaining what is happening in prescribing practices, but not why these patterns exist. There is a lack of qualitative data in this area, and the experience of prescribing antipsychotics to children and adolescents has not been adequately researched. We conducted a qualitative study using an interpretive phenomenological analysis of physicians' experiences of antipsychotic prescribing to children and adolescents. Prescribers participated in individual interviews and a focus group. We used a staged approach for data analysis of transcriptions. In all, 11 physicians including psychiatrists and general practitioners participated in our study. We identified themes related to context, role and identity, and decision-making and filtering. Struggles with health system gaps were significant leading to the use of antipsychotics as substitutes for other treatments. Physicians prescribed antipsychotics to youth for a range of indications and had significant concerns regarding adverse effects. Our results provide knowledge regarding the prescribers' experience of antipsychotics for children and adolescents. Important gaps exist within the health system that are creating opportunities for the initiation and continued use of these agents
COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP): a multicentre, prospective, case-control study
- Author
- Ahmad Tariq
- Alexander James L
- Altmann Daniel M
- Anand Nikhil
- Anandabaskaran Sulak
- Baden Manisha
- Balarajah Sharmili
- Barnes Anna
- Bee Louise
- Bewshea Claire
- Bhatti Suhaylah
- Boyton Rosemary J
- Castro seoane Rocio
- Chukwurah Ijeoma
- Cipriano Bessie
- Constable Laura
- Cooke Graham
- Covil Kate
- D'mello Andrea
- Derikx Lauranne
- Domingo Jason
- Estember Charmaine
- Fiorentino Francesca
- Gardner-Thorpe Helen
- Goodhand James R
- Gros alcalde Beatriz
- Haq Sulaimaan
- Hart Ailsa L
- Hicks Lucy C
- Ibraheim Hajir
- Irving Peter M
- Jones Gareth R
- Kennedy Nicholas A
- Kent Alexandra J
- King Rebecca
- Kirkwood John
- Knight Bridget
- Kok Klaartje
- Kourampa Evgenia
- Lee Irish
- Lees Charlie W
- Linger Rachel
- Liu Zhigang
- Mendoza Vivien
- Muñoz sandoval Diana
- Nice Rachel
- Parkes Miles
- Parkinson Marian
- Pasquale Ciro
- Patel Kamal V
- Patel Mikin
- Pollock Katrina
- Powell Nick
- Ramanathan Anitha
- Reynolds Catherine
- Robisco-Diaz Elena
- Romanczuk Lidia
- Ruocco Giuseppe
- Saifuddin Aamir
- Sanchez Joanne
- Sebastian Shaji
- Shah Parita
- Shamtally Djamila
- Stark Hannah
- Stone Sam
- Teare Julian P
- Watkins Darcy
- Wilken-Smith Stephanie
- Williams Horace R T
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/11/2022
- Field of study
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
- Author
- Abrams Paul H
- Adamson Andrew
- Adeyoju A
- Afzal N
- Ahiaku Ernest K. N
- Ahmed Munir
- Aitken Joanne
- Al Olama Ali Amin
- Al-Samerraie Dr
- Alcock Christopher
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Apakama Ike
- Aparcia F
- Archbold J. A. A
- Ardern-Jones Audrey T
- Arrand John
- Ash D
- Ashford Richard F. U
- Auvinen Anssi
- Badenoch David
- Bagnato Melisa
- Bahl Amit
- Bailey Karen
- Bailey M. J
- Ball Andrew J
- Bancroft E
- Banerjee G
- Banks Annette
- Barber Jim
- Barber N
- Baria Dr
- Barnes Douglas G
- Barrett Sandra
- Barwell Julian
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N. A
- Baxter-Smith D
- Beacock Christopher
- Beaney Ronald P
- Beard Ralph
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Belcheva Olga
- Bellringer James
- Benson Richard
- Bhatt R. I
- Biedermann CĂ©dric
- Bieri Sabine
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C. Shekhar
- Blacklock A. R. E
- Blades Rosemary
- Blizzard Leigh
- Bloomfield David J
- Bollina Prasad
- Bonnington Sue
- Booth C. M
- Bose Pradeep
- Bottomley David
- Boucher Nigel R
- Bower Mark
- Bowsher W. G
- Boyd P. J. R
- Bradley Sita Ann
- Bramble F. James
- Bremer Michael
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Brough Richard
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Brugger Margot
- Butorac Kate
- Butterworth Paul C
- Cahill D
- Callaghan P. S
- Calman Frances
- Campbell Alister
- Cannon-Albright Lisa
- Cao Guangwen
- Carnell Dawn M
- Carr T. W
- Carter Adam C
- Carter Charles J. M
- Carter Simon
- Castle Bruce M
- Chadwick David
- Chakraborti P
- Challis David
- Chambers Suzanne
- Chang Wen-Jun
- Chappuis Pierre O
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F. I
- Chong Irene
- Chow Wai-Man
- Christmas Tim
- Christova Svetlana
- Churn Mark J
- Clarke Noel W
- Clements Judith
- Coe M
- Cohen N. P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Cooke Peter
- Coombs L
- Coomes Margerie
- Cooney Kathleen A
- Cooper Colin S
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P. A
- Corolis Mr
- Corr John
- Corral Roman
- Costello C. B
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crisp John C
- Cruger Dorthe
- Crundwell Malcolm
- Cummings Mr
- Cunningham Julie
- Dahar Nazeer
- Daruwala Pallon
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David P
- Defabiani Nicolas
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickinson Joanne L
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H. Jane
- Doble Andrew
- Dodds David
- Dodova Rumjana
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dork Thilo
- Douglas S. Fiona
- Drake Mr
- Dubrowinskaja Natalia
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W. D
- Durkan Garrett
- Easton Douglas F
- Eccles Diana
- Eden C. D
- Edwards Stephen M
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Ellis B. W
- Ellis R
- Elves Andrew W. S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- English Dallas R
- Errington R. D
- Evans D. Gareth
- Falconer Alison
- Farnham Jim
- Fawcett Derek
- Featherston C
- Feggetter Jeremy
- Ferguson C
- Ferguson Megan
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel M
- Flanagan Louise
- Fletcher Matthew
- Folkes A
- Foote Simon
- Ford Trevor F
- Foulkes William D
- Frim Olivera
- Gallagher Stephen
- Gallegos Christopher
- Gardiner R. A. (Frank)
- Gelister James S
- George Anne
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Girardet Christophe
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E. M
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R. L
- Gurun Riza Murat
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Hall Amanda L
- Hamdy Freddie C
- Hamel Nancy
- Hamilton C
- Hammonds John
- Hampson S. J
- Hanbury Damien C
- Hardman P. D. John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harrison G. S. M
- Harriss D. R
- Harvey-Hills N
- Hawkyard Simon
- Heath Catherine M
- Hehir Michael
- Henderson Brian E
- Hendry David
- Henley Mike
- Herbert Pippa
- Herkommer Kathleen
- Hickish Tamas
- Hillemanns Peter
- Hindmarsh John R
- Hinze Kimberly
- Ho Edwin T. S
- Hodgson Shirley
- Holden David
- Holding Peter
- Hollins Graham W
- Holmes Simon A. V
- Hopper John L
- Horwich Alan
- Hoskin Peter
- Hou Jian-Guo
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert A
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Hutter Pierre
- Iacovou John W
- Ibrahim A
- Ingles Sue A
- Inglis John A
- Irving Stuart
- Irwin C
- Isotalo Jarkko
- Izatt Louise
- Izegbu Victor
- James Michael J
- James N
- James R. Lester
- Jameson Charles
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- John Esther M
- Johnson Emilie K
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joshi Amit D
- Joss Shelagh
- Kachakova Darina
- Kaisary Amir
- Kaneva Radka
- Karim O
- Karp Stephen J
- Karstens Johann H
- Karyadi Danielle M
- Kedda Mary Anne
- Keeley F. X
- Kelham Penelope
- Kelkar Anand R
- Kelleher J. P
- Kenwrick Sue
- Khan F
- Khan Humera
- Khoo Vincent S
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Kockelbergh Roger
- Kolonel Laurence N
- Konzelmann Isabelle
- Koopmeiners Joseph S
- Koreich O
- Kotar Kimberley
- Kote-Jarai Zsofia
- Kourah Mohamed
- Kuczyk Markus
- Kuefer Rainer
- Kulkarni Ravi
- Kumar M
- Kunkler Ian H
- Kwon Erika M
- Kynaston Howard
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lange Ethan M
- Langley Stephen E. M
- Laniado Marc
- Larner T. R
- Lau Maurice W
- Lawrence W. T
- Lawson Anne
- Le Marchand Loic
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J. O
- Lee L
- Lemburger R .John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel A
- Lester Jason
- Leung Hing
- Lewis D. Christopher
- Lewis J
- Lewis Sarah J
- Liston Thomas
- Liu Jo-Fen
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lose Felicity
- Lu Yong-Jie
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C. J
- Lydon Anna
- Lynch Michael
- Lyons Norma
- MacDermott James P. A
- Macdonagh Ruaraidh P
- Machtens Stefan
- Maher E. R
- Mahmood Rana
- Maier Christiane
- Mair Graeme H. M
- Malone Peter R
- Mark I
- Marsden Gemma
- Mason M. D
- Mason Robert
- Matenhelia Shyam
- Matikainen Mika
- Matthews Philip N
- Mattila Henna
- McArdle John
- McBride Donna
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath John
- McInerney Paul
- McIntosh Gregor
- McKay James
- McKinna F
- McLaren Duncan
- McMenemin Rhona
- McNicholas T. A
- McWhirter Rebekah
- Meddings Robert N
- Mee A. David
- Meier Marie-Mathilde
- Memon Mr
- Menzes Pravin
- Meyer Andreas
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E. F
- Mokete Moeketsi
- Money-Kyrle Julian
- Montgomery Bruce
- Montie James E
- Moody Hilary
- Morley Roland
- Morris Sean B
- Morrison Jonathan
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki Jan
- Neal David E
- Neilson Donald
- Nelson Colleen
- Nethersell A
- Newman Beth
- Newman Hugh
- Newton R
- Nicol David
- Nikolov Momchil
- O'Boyle P. J
- O'Brien J
- O'Brien Lynne T
- O'Brien Tim S
- O'Donoghue E
- O'Donoghue Neil
- O'Mara Tracy
- O'Reilly P
- O'Rourke J. S
- O'Sullivan Joe
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Osborn David
- Ostler Peter
- Ostrander Elaine A
- Page Elizabeth C
- Paiss Thomas
- Pakkanen Sanna
- Palfrey Edward
- Panades Miguel
- Pancharatnam M
- Pantelides Michalakis L
- Parikh Omi
- Park Hyun Y
- Park Jong Y
- Parker Christopher C
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Patel Anup
- Patterson Briony
- Patterson Helen
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha A. M
- Perry Matthew
- Persad Raj
- Peter Hans-Ulrich
- Philp N. H
- Philp T
- Pigott Katharine
- Plail R
- Plowman P. Nicholas
- Pocock Richard D
- Polanowski Andrea
- Pope A. J
- Popert Rick
- Popov Elenko
- Porter Tim
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Prasad Krishna
- Prejbisz J. W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Radein Selina
- Ragavan Narasimhan
- Rankin Julia
- Rao Y
- Ravi Ramachandran
- Ray Anna M
- Read Graham
- Rebbeck Timothy R
- Reddy Paul J
- Rimington Peter R
- Rincon Maria
- Roberts J. Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rogers P. B
- Rowbotham Carl
- Rowe Edward
- Rowley Kathryn
- Rundle John
- Russell John M
- Ryan P. G
- Saggar Anand K
- Samanci Ali
- Saunders Edward J
- Sawyer Emma J
- Saxby M. F
- Schaid Daniel
- Schleutker Johanna
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Sellers Thomas A
- Sells Henry
- Serth JĂŒrgen
- Sethia Krishna K
- Severi Gianluca
- Shah Nihil
- Shahabi Ahva
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum L
- Siltanen Sanna
- Simcock R
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smark Heidi
- Smith Charmaine
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Spangler Elaine
- Speakman Mark J
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan Mr
- Sriram Rajagopalan
- Stalder MichĂšle
- Stanford Janet L
- Stankovich James
- Stefflova Klara
- Stenman Ulf-HĂ„kan
- Stern Mariana C
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M. J
- Strachan John R
- Subramonian K
- Sugden Elaine
- Sundar Santhanam
- Sundaram S. K
- Suresh Gokarakonda
- Surowy Harald
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Syndikus Isabel
- Tahir Saad
- Tammela Teuvo L
- Taylor John W
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thomson Russell
- Thurston A
- Tilsley Owen
- Tindall Stuart F
- Tong Dr
- Trembath Richard C
- Tulloch David N
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C. J
- Urwin Graeme H
- Van As Nicholas
- VandenBergh Patrica
- Vesey Sean
- Violet John
- Virdi Jaspal
- Vlahova Aleksandrina
- Vogel Walther
- von Klot Christoph
- Wahlfors Tiina
- Waite Katherine
- Walker Amy
- Walker E. M
- Walker Roger
- Wallace David M. A
- Wang Liang
- Watkin Nicholas A
- Watson M. E
- Waxman J. H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Weber BĂ€rbel
- Wedderburn Andrew
- Wells Paula
- Wemyss-Holden G. D
- Weston P. M. T
- Wheatley Duncan
- Whelan P
- Whillis D
- Wiest Irina
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary A
- Williams John H
- Williams Simon
- Willis Michael
- Wilson J. R
- Wilson Richard
- Wise Marcus
- Woodhams Simon
- Woodhouse Christopher J
- Woolfenden K. A
- Worlding Jane
- Wright Mark
- Wylie James P
- Wynne Chris
- Xu Dan-Feng
- Xu Xing-Xing
- Yaxley John
- Zachariah Babu
- Zakariah Babu
- Zang Angelika
- Zeegers Maurice
- Zeigler-Johnson Charnita
- Zhang Hong-Wei
- Zuhlke Kimberly A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. To identify common PrCa susceptibility alleles, we have previously conducted a genome-wide association study in which 541, 129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and 1,894 controls. We have now evaluated promising associations in a second stage, in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls, and a third stage, involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to previously identified loci, we identified a further seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11, and 22 (P=1.6Ă10â8 to P=2.7Ă10â33)
[The effect of low-dose hydrocortisone on requirement of norepinephrine and lactate clearance in patients with refractory septic shock].
- Author
- Abbey Ianthe
- Abdel Rehim Marwa
- Abdel Rehim Marwa
- Abdul Rahman A
- Abduljawwad Emad
- Abduljawwad Emad
- Abe Emuri
- Abe Ryuzo
- Aboab Jerome
- Aboab Jerome
- Acevedo Juan
- Acharya Anand
- Acquarolo Annamaria
- Acquarolo Annamaria
- Adamzik Michael
- Adamzik Michael
- Adembri Chiara
- Adrie Christophe
- Adrie Christophe
- Afessa Bekele
- Ainoda Yusuke
- Aiyar S
- Al Dabbagh Tarek
- Al Dabbagh Tarek
- Al Knawy Bandar A
- Al Knawy Bandar A
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Abdulkareem Abdulmajeed
- Al-Arabi Rida
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- Alaniz Cesar
- Alevizaki Maria
- Alevizaki Maria
- Alinejad Faranak
- AlJumah Abdulrahman
- AlJumah Abdulrahman
- AlJumah Abdulrahman
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- Ambriz-Plascencia Ana Rosa
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- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
- Annane Djillali
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- Annane Djillali
- Annane Djillali
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- Aronowitz Paul
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- Arroyo Vicente
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- Asehnoune Karim
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- Asfar Pierre
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- Germani Giacomo
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- Gessner Sophia
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- Groeneveld Arie Bastiaan Johan
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- Hsiao Fone-Ching
- Hsieh Chang-Hsun
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- Ioakeimidou Aikaterini
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- Ipaktchi K
- Ipser Jonathan C
- Irazuzta Jose
- Ismail A
- Ito Shunichiro
- Iwaki Noriko
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- Jaalam K
- Jaber Samir
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- Jaeschke Roman
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- Jager Marcus
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- Janes Jonathan M
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- Jantunen Esa
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- Jap Tjin-Shing
- Jayashree M
- Jeanneret S
- Jeffries Howard
- Jelastopoulou Eleni
- Jeon Kyeongman
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- Jessie Elliot M
- Jochberger Stefan
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- Johan Groeneveld A B
- Johnen Daniel
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- Jones Andrew
- Jones D
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- Joyce Christopher J
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- Kache Saraswati
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- Kalafateli Maria
- Kalenka Armin
- Kalpakou Georgia Th
- Kalpakou Georgia Th
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- Kaneko Tadashi
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- Kasaoka Shunji
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- Katagiri Satosi
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- Katsenos Chrysostomos S
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- Kaufmann Ines
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- Kufera Joseph A
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- Kuittinen Taru
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- Smeets R
- Smielewski Peter
- Smith Dominic
- Smith Melissa Lassig
- Smith Melissa Lassig
- Smitz Johan
- Smitz Johan
- Smotherman Carmen
- Smotherman Carmen
- Sneyd James
- Soares Marcio
- Soavi Laura
- Soavi Laura
- Soderberg Ewa
- Soderberg Ewa
- Sogawa Kazuyuki
- Sollevi Alf
- Sollevi Alf
- Solomkin Joseph S
- Solomon Steven B
- Solomon Steven B
- Soop Anne L
- Soop Anne L
- Sotiropoulou Ch
- Souweine Bertrand
- Souweine Bertrand
- Souweine Bertrand
- Souweine Bertrand
- Spadaro Luisa
- Spadaro Luisa
- Spadaro Luisa
- Spies Claudia D
- Spijkstra Jan-Jaap
- Spijkstra Jan-Jaap
- Spranger Joachim
- Spreitzer Ingo
- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
- Sprung Charles L
- Spuler Simone
- Srivijitkamol Apiradee
- Srivijitkamol Apiradee
- Stanciu Carol
- Stein Deborah M Dan J
- Stein Deborah M Dan J
- Steinau H-U
- Steiner Luzius A
- Steingrub Jay S
- Steingrub Jay S
- Steinmann Jorg
- Steinmann Jorg
- Steinstrasser L
- Stellini Roberto
- Stellini Roberto
- Sterk Ethan
- Sterk Ethan
- Stern Naftali
- Stevens N E
- Stevens N E
- Stewart Paul M
- Stiefelhagen Peter
- Stockwell Jana A
- Stockwell Jana A
- Stoffels Monique
- Stojadinovic Bonnie
- Stolz Daiana
- Stolz Daiana
- Stone Angela
- Storms Michelle M
- Stotz Martin
- Stotz Martin
- Stowe R P
- Strack van Schijndel Rob J M
- Strauss Julian
- Strebel Stephan P
- Stromeyer Hans G
- Sturgess David J
- Sturgess David J
- Su Deng-Huang
- Suh Gee Young
- Suh Gee Young
- Suh Gee Young
- Suh Gee Young
- Sun Jiaxiao Junfeng
- Sun Jiaxiao Junfeng
- Sun Jiaxiao Junfeng
- Sun Jiaxiao Junfeng
- Suter Fredy
- Suter Fredy
- Sweeney Daniel A
- Sweeney Daniel A
- Sweeney Lori B
- Sweep Fred C G J
- Tabah Alexis
- Tabah Alexis
- Taccone F S
- Tajiri Takashi
- Takahashi O
- Takano Kazue
- Takano Kazue
- Takata Katsuyoshi
- Takata Katsuyoshi
- Takeda Shinhiro
- Tamim Hani M
- Tamim Hani M
- Tamim Hani M
- Tamim Hani M
- Tamim Hani M
- Tamim Hani M
- Tamimi Waleed
- Tamimi Waleed
- Tamimi Waleed
- Tamimi Waleed
- Tamm Michael
- Tamm Michael
- Tan Terrence
- Tan Terrence
- Tan Terrence
- Tang Benjamin M
- Tang Yee-Loong
- Tanimoto Mitsune
- Tanimoto Mitsune
- Tappy Luc
- Tassin C
- Tassin C
- Taylor Edwin
- Teng Lihua
- Tenhunen Jyrki
- Terblanche Marius
- Terblanche Marius
- Tesniere Antoine
- Tesniere Antoine
- Textoris Julien
- Thalassinos N C
- Theodorakopoulou Maria
- Theodorakopoulou Maria
- Theodorakopoulou Maria
- Thiel Manfred
- Thierry S
- Thirunavukkarasu Neeraja
- Thirunavukkarasu Neeraja
- Thomas Michael
- Thomas Michael
- Thomas Peter
- Thomas Zachariah
- Thomasy Sara M
- Thomopoulos Konstantinos
- Timmons Tracy
- Timsit Jean-Francois Francois
- Timsit Jean-Francois Francois
- Timsit Jean-Francois Francois
- Timsit Jean-Francois Francois
- Tissot Sylvie
- Tol Maneesha M
- Tol Maneesha M
- Toma Alina
- Tomaselli Tania
- Tomaselli Tania
- Tomaselli Tania
- Tomonaga Takeshi
- Tongyoo Surat
- Tongyoo Surat
- Tonietto Tiago
- Tonietto Tiago
- Torgersen Christian
- Torgersen Christian
- Torgersen Christian
- Torggler Filho Francisco
- Tormo Carolina
- Torpy David J
- Torpy David J
- Torpy David J
- Torpy David J
- Torpy David J
- Torpy David J
- Torpy David J
- Torpy David J
- Torpy David J
- Torres Adalberto
- Townsend Sean R
- Townsend Sean R
- Triantos Christos K
- Trifan Anca
- Trips Evelyn
- Trips Evelyn
- Troster Eduardo J
- Trouve-Buisson Thibaut
- Trummler Michael
- Tsagarakis Stylianos
- Tsagarakis Stylianos
- Tsagarakis Stylianos
- Tsagarakis Stylianos
- Tsagarakis Stylianos
- Tsagarakis Stylianos
- Tsagarakis Stylianos
- Tsagarakis Stylianos
- Tsagarakis Stylianos
- Tsagarakis Stylianos
- Tsagarakis Stylianos
- Tsai Ming-Hung
- Tsai Wen-Hui
- Tsekouras A
- Tseng Jo-Chi
- Tseng Jo-Chi
- Tsirantonaki M
- Tsochatzis Emmanuel
- Tsochatzis Emmanuel
- Tsochatzis Emmanuel
- Tsuruta Ryoske
- Tsuruta Ryoske
- Tucci Marisa
- Tuckermann Jan
- Tung Kelly
- Tung Kelly
- Tung Kelly
- Tung Kelly
- Tung Kelly
- Tung Kelly
- Twisk Jos W R
- Tzanela Marinella
- Tzanela Marinella
- Tzanela Marinella
- Tzanela Marinella
- Tzanela Marinella
- Tzanela Marinella
- Uchida Koji
- Uchida Koji
- Uchiyama N
- Udompanturak Suthipol
- Udompanturak Suthipol
- Ulmer Hanno
- Ulmer Hanno
- Um Sang-Won
- Um Sang-Won
- Umberger Reba
- Ungerer Jacobus P J
- Ungerer Jacobus P J
- Ungerer Jacobus P J
- Ungerer Jacobus P J
- Urban Frank K 3rd
- Urban Frank K 3rd
- Urban Frank K 3rd
- Uusaro Ari
- Uusaro Ari
- Uusaro Ari
- Vagenakis A G
- Vallet Benoit
- Vallet Benoit
- Valleur Patrice
- Valoor Harsha T
- van Alfen Nens
- van Alfen Nens
- Van de Louw A
- Van den Berghe Greet
- Van den Berghe Greet
- van den Boogaard Mark
- van der Hoeven Johannes G
- van der Hoeven Johannes G
- van der Horst I C C
- van der Sluijs Veer Gertjan
- van der Voort Peter H J
- van der Voort Peter H J
- van der Werf Sieberen P
- van Raalte Rutger
- van Raalte Rutger
- van Schijndel Rob Joris Maria Strack
- van Stijn Ilse
- van Stijn Ilse
- van Zanten Mark
- van Zanten Mark
- Vander Perre Sarah
- Vanska Matti
- Vardas K
- Vardas K
- Varpula Marjut
- Vassiliadi Dimitra Argyro
- Vassiliadi Dimitra Argyro
- Vassiliadi Dimitra Argyro
- Vassiliadi Dimitra Argyro
- Vassiliadi Dimitra Argyro
- Vassiliadi Dimitra Argyro
- Vassiliagkou Spyridoula D
- Vassiliagkou Spyridoula D
- Vattanavanit Veerapong
- Vattanavanit Veerapong
- Velasco Irineu Tadeu
- Venet Christophe
- Venet Fabienne
- Venkataraman Shekhar
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Venkatesh Balasubramanian
- Verbeek Marcel M
- Verdeal Juan C
- Verdier M-C
- Vermes Istvan
- Viana Marina Vercoza
- Viana Marina Vercoza
- Vicaut Eric
- Villa F
- Villagran Maria J
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vincent Jean Louis J-L Jean-Louis L
- Vinclair Marc
- Vinclair Marc
- Vogeser Michael
- Vogeser Michael
- Vogeser Michael
- Vogt P M
- Volbeda M
- Voll K
- Vollmar Brigitte
- von Dessauer Bettina
- Wagner Nana-Maria
- Walker Mark L
- Walley Keith R
- Wang Chun-Hua Changsong
- Wang Chun-Hua Changsong
- Wang Chun-Hua Changsong
- Wang Ling
- Wang Ling
- Wang Miaomiao
- Wang Miaomiao
- Wang Ti-Hao
- Ward Gregory
- Ward Gregory
- Watson Dale
- Webb Ian
- Webb Steven A R
- Webb Steven A R
- Webb Steven A R
- Webb Steven A R
- Webb Steven A R
- Weber-Carstens Steffen
- Wegner Alexander
- Wegner Alexander
- Wegner Alexander
- Weiler Norbert
- Weiler Norbert
- Weingarten Jacki
- Weireter L J
- Weis Florian
- Weis Florian
- Weiss Manfred
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Weiss Yoram G
- Wensley David
- Wenzel Volker
- Werdan K
- Wernecke Klaus D
- Westendorf Astrid M
- Westendorf Astrid M
- Wester Jos P J
- Wester Jos P J
- Westermeyer Hans D
- Westphal Martin
- Wetterslev J
- Weyland Andreas
- Weyland Andreas
- Whitley Elizabeth M
- Whitley Elizabeth M
- Wiaterek Gregory K
- Williams Mark D
- Williams Mark D
- Winkler Margaret
- Wirtz Stefan P
- Wirtz Stefan P
- Witchel Selma F
- Wolf Anna M
- Wolf Irene M
- Wolf Michel
- Wolf Michel
- Wolf Oliver T
- Wolter Timm
- Won Justin Ging-Shing
- Wong Chieh-Lee
- Wong Hector R
- Wong Hector R
- Wong Hector R
- Wood John C
- Wouters Pieter J
- Woyciechowsky Tiago G
- Wright Robert
- Wu Cheng-Shyong
- Wu Huang-Pin
- Wu Huang-Pin
- Wu Ling-Yi
- Wu Ta-Wei
- Wynn James L
- Xirouchakis Elias
- Xu Jun
- Xu Mujuan
- Xu Mujuan
- Yamamoto Masakazu
- Yamamoto Masakazu
- Yamashita Kiyohiko
- Yang Chunli
- Yang Chunli
- Yee Kristen S
- Yee Kristen S
- Yeh Timothy
- Yu Chung-Chieh
- Yu Chung-Chieh
- Yu Jihion
- Yu Teng-Jen
- Yu Teng-Jen
- Yu Xuezhong
- Yu Yuan-Bin
- Yu Zhui
- Yu Zhui
- Yuan Ying
- Zabalza Michel
- Zakynthinos Spyros
- Zakynthinos Spyros
- Zaloga Gary
- Zaman Muhammad
- Zampieri Fernando Godinho
- Zamri-Saad M
- Zandstra Durk F
- Zandstra Durk F
- Zaritsky Arno
- Zeni Fabrice
- Zervou Maria
- Zhang Fengmin
- Zhang Fengmin
- Zhang Haibo
- Zhang Haibo
- Zhang Qian
- Zhang Qian
- Zhang Yang
- Zhang Yang
- Zhang Zhong
- Zhang Zhong
- Zhao Xin
- Zhao Xin
- Zheng Juanjuan
- Zheng Juanjuan
- Zheng Liangliang
- Zhou Qing
- Zhou Qing
- Zhu Huadong
- Ziegenfuss Marc
- Ziegenfuss Marc
- Zijlstra J G
- Zimmerman Jerry J
- Zimmerman Jerry J
- Zuckerberg Aaron
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2007
- Field of study
Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry
- Author
- A'Court Christine
- Abdel-Qader Muwafeg
- Abe Masahiko
- Abe Masatake
- Abe Mitsunori
- Abe Sumihisa
- Abe Yukihiko
- Abhayaratna Walter
- Accogli Michele
- Adachi Susumu
- Adachi Toru
- Adak Dhriti
- Adam Matthew
- Adriaansen Henk
- Aegerter Emanuel
- Ageta Masato
- Aggarwala Anil
- Agnelli Giancarlo
- AgnieszkaMetzgier-Gumiela AgnieszkaMetzgier-Gumiela
- Ahlmark Hakan
- Ahmad Kamran
- Ahmad Shahid
- Ahmed Fayzal
- Ahn Jung Joo
- Akers Lori
- Akiyama Masahiro
- Al Mahmeed Wael
- Al-Khalili Faris
- Alberts Mark
- Alborough Elizabeth
- Aldegather Jehad
- Aleksandrova Elena
- Alexandre Almeida Carlos
- Ali Amar
- Ali Gholam
- Alia Pilar Montero
- Allasia Bartolomeo
- Alonso Carmela
- Alonso Concepcion
- Altun Armagan
- Alunni Massimo
- Alvarez Garcia Pere
- Alvarez Douglas
- Alvarez Miguel
- Alzogaray Maria Fernanda
- Amarenco Pierre
- Amaro Marisol
- Ambicka Monika
- Ambrosino Pasquale
- Ambrosio Giuseppe
- Amin Joseph
- Amrhein Diana
- Amstutz Daniela
- An Hae Jung
- Andere Natalia
- Andersson Agneta
- Andersson Lisbeth
- Ando Hiroshi
- Ando Shinichi
- Andrzejewski Dariusz
- Angaran Paul
- Ansoult Nadege
- Antonova Petra
- Antonsen Hege
- Aoki Kenji
- Aoyama Takuma
- Appleby Nigel
- Appleby Nigel
- Aracil Villar Joaquin
- Arai Hidekazu
- Araminowicz Joanna
- Aras Funda
- Arcocha Torres Maria Fe
- Argena Antonio
- Arima Shinichi
- Armangau Pauline
- Arstall Margaret
- Asafu-Adjaye Nana
- Asano Hiroshi
- Asano Taku
- Ashraf M. Javed
- Assagay Maharajh S.
- Assouline Serge
- Astridge Penny
- Atar Dan
- Atar Dan
- Ausen Karin
- Austria Aileen
- Aves Theresa
- Avinc Gamze
- Avinc Gamze
- Avinc Gamze
- Axthelm Christoph
- Ayar Ozge
- Aydinlar Ali
- Ayres Bronte
- Azakami Shiro
- Aziz Michael
- Azuma Junya
- Baba Takao
- Babjakova Zuzana
- Babyesiza Adyeri
- Bae Sang Cheol
- Baek Ae Lee
- Baglioni Gregorio
- Bai Chunlin
- Baksh Farisha
- Balaraju Swathi
- Ball Kelly
- Bamungpong Panthipa
- Banfi Elena
- Barbarash Olga
- Barbeira Pablo Saleta
- Barkowski Timothy
- Barnes Dylan
- Barnes Dylan
- Baron Esquivias Gonzalo
- Barraquer Feu Edelmira
- Barreau Angeline
- Barreda Maria
- Barretto Antonio Carlos Pereira
- Barrow Susan
- Barry Lisa
- Bartkowiak Radoslaw
- Bartlett Melialoha
- Bartnik Jerzy
- Basiak Marcin
- Basily Wagdy
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bastani Lisa
- Baszak Jacek
- Batalov Roman
- Batlle Javier
- Batta Claire
- Batta Claire
- Baumbach Sylvia
- Baumgartner Philipp
- Baweja Paramdeep
- Bayat Junaid
- Beattie Andre
- Becerra Munoz Victor
- Begum Haseena
- Bekieszczuk Ewa
- Belenkova Yulia
- Belenky Dmitry
- Bengtsberg Daniel
- Bennett James
- Berardi Mario
- Berg-Johansen Berg-Johansen
- Berge Eivind
- Berge Trude
- Berit Anne
- Berman Sofia Graciela
- Bernat Lukasz
- Berneau Jean-Baptiste
- Best Peggy
- Beton Osman
- Betsuyaku Tetsuo
- Beveridge Rosemary
- Bezrodna Larysa
- Bhargava Kartikeya
- Biagioli Viviana
- Bianchi Alfredo
- Biedrzycka Malgorzata
- Biedrzycka Malgorzata
- Biedrzycki Lukasz
- Biernacka Anita
- Bigcanoe Julie
- Bignell Nanci
- Bilas Roman
- Bilecen Sinan
- Billger Annelie
- Bindig Hans-Walter
- Binnekamp Maurits
- Bird Nigel
- Bireciklioglu Mustafa Fehmi
- Birhan MEHMET BÄ°RHAN
- Bitakova Fatima
- Black Andrew
- Blenkhorn Adam
- Blinkova Marina
- Blombery Peter
- Blumberg Edwin
- Bockova Lucie
- Boda Zoltan
- Boehme Stefanie
- Boen Rigmor
- Boersma Misannia
- Boggian Giulio
- Bonet Jorge
- Bongaerts Maarten
- Bongiorni Maria Grazia
- Bonin Kerstin
- Bonkowski Grzegorz
- Bonner Michelle
- Bonnetain Anne
- Boon Jannie
- Boonyapisit Warangkana
- Boos Laura
- Booysen Maria
- Borjesson Ulf
- Borras Ana Domenech
- Boshoff Cecilia
- Bosman Femmy
- Bosschaert Mike
- Bossolasco Pierdomenico
- Botha Margo
- Bottarelli Maria Luisa
- Bouzamayor Maria Belen Lage
- Bowen-Simpkins Emma
- Bowers Suzanne
- Boys Janice
- Bradshaw Colin
- Braham Simon
- Brauer Gunter
- Bray Bryan
- Breakwell Lynn
- Bremmelgaard Arne
- Breschi Marco
- Breukel Laura
- Briceno Hinojo Ana
- Brimley Jennifer
- Broad Oulton
- Brodmann Marianne
- Bronisz Marek
- Broton Elzbieta
- Brotons Cuixart Carles
- Browne Debbie
- Bruegger Jasmine
- Brugnaux Jean Philippe
- Bruin Sandra
- Brusorio Stefania
- Bruun Michael
- Bruun Michael
- Brzustowska Malgorzata
- Buckley Elizabeth
- Buiks Paul
- Bulla Claudio
- Bultas Jan
- Bunyapipat Thanita
- Burdeina Liudmyla
- Burke Elizabeth
- Burns Stephen
- Busch Florian
- Butter Keith
- Cabrera Ramos Mercedes
- Cabrini Romina
- Caimi Teresa Maria
- Calcagnoli Francesca
- Cameron Alex
- Camm A. John
- Camm A. John
- Camm A. John
- Camm A. John
- Campagna Giuseppe
- Campo Moreno Mariela
- Campo Monica
- Cancho Corchado Gema
- Cannon Claire
- Canosa Roddy
- Canova Michaela
- Cao Shiping
- Cap Austl
- Cappelli Roberto
- Capucci Alessandro
- Carlton Lesley
- Carpenedo Monica
- Carroll Lisa
- Carroll Patrick
- Cartasegna Luis Rodolfo
- Cartwright Simon
- Casanova Gil Miguel
- Casassus Frederic
- Caspar Andreas
- Cassidy Doran
- Cassimjee Soraya
- Castillo Orive Miguel
- Castro Fernandez Daniel
- Catanchin Andrei
- Cebron Jean-Pierre
- Cervellione Kelly
- Cha James
- Cha Tae-Joon
- Chabanna Olena
- Chaiyapong Thanawan
- Chami Charmaine
- Chandwani Prakash
- Chattranukulchai Pairoj
- Chauhan Kuldeep
- Chauhan Naresh
- Cheewatanakornkul Sirichai
- Chemin Frederic
- Chen Jiyan
- Chen Kangning
- Chen Xiao
- Cheryl Laurie Ferleyko
- Cheung Stephen
- Chi Andwoo Jin
- Chiba Kei
- Chibana Hidetoshi
- Ching Chi Keong
- Chizhov Petr
- Chlumsky Jaromir
- Chmielowski Artur
- Cho Amie
- Cho Jeong-Gwan
- Cho Myeong-Chan
- Choi Dong Ju
- Choi Eun A.
- Choi Eun Hee
- Choi Hee Kyung
- Choi Hee Suk
- Chojnowski Przemyslaw
- Choudhary Fiaz
- Choudhary Ulka
- Chowan Hasan
- Christie Heather
- Christoph Marian
- Chugunnaya Svetlana
- Ciabatta Carlo
- Cichomski Rafal
- Cieslak Karol
- Cieszynska Alina
- Ciliberti Giuseppe
- Cimmino Giovanni
- Citykliniken Capio
- Clark M.
- Clarke Bonnie
- Claussen Hege
- Cleveland Tracy
- Cloak Cloak
- Coates Richard
- Coates Steven
- Coates Steven
- Colomes Anne
- Colquhoun David
- Colquhoun David
- Conn Paul
- Connolly Stuart J.
- Conway Gladys
- Cooke Philip
- Cools Frank
- Cooper Krystine
- Corbalan Ramon
- Corbalan Ramon
- Cordoba Mateo
- Corrihons Estelle
- Costa Pinto Joana
- Costello Ben
- Couleru Josette
- Coulshed David
- Coulson DrWarwick
- Coutu Benoit
- Cresp Damien
- Crisby Milita
- Cristina Leone Maria
- Croucher Alexandra
- Curyllo Bartosz
- Cymerman Krzysztof
- Czamara Marcin
- D'Agostini Erika
- D'Avino Maria
- Danielsen Mark
- Danilowicz-Szymanowicz Ludmila
- Daniuk Inna
- Danse Ingrid
- DArienzo Carmela
- Darius Harald
- Darius Harald
- Dastychova Lenka
- Date Haruhiko
- Davids Aziza
- Davies Divin
- Davies Emyr
- Davies Richard
- Davis Kent
- Dawood Dawood
- De Blasio Angelo
- De Cristofaro Raimondo
- De Graaf Judith
- de Meyer Lorinda
- Deacon Melanie
- Debordes Mirjam
- Debrunner Johann
- Debruxelles Sabrina
- Decarsin Nathalie
- Dedek Vratislav
- Dehghani Payam
- Delafontaine Patrice
- Delarche Nicolas
- Demir Mesut
- Denis Isabelle
- DePauw Jill
- Deshpande Bhakti
- Dhakrao Priyanka
- Dhillon Ripple
- Di Ancona Torrette
- Di Minno Giovanni
- Diaz Lopez Carlos Maria
- Dichristin Uta
- Diederichs Roelof
- Diercks Deborah
- Dimitri Hany
- Dixon Sue
- Dobson Simon
- Dohovits Emese
- Doiuchi Junji
- Dolman Marilyn
- Domanska Ewa
- Dominguez Helena
- Dominguez Helena
- Dominguez Ingrid
- Dooldeniya Chaminda
- Dorottya Kanizsai
- Dorsch Wilfried
- Douglas Kevin
- Douglass Shannen
- Drapkina Oksana
- Drasnar Tomas
- Dresser George
- Drexel Heinz
- Drown Jane
- Dshabrailov Janna
- du Preez Miranda
- Duff-Coots Margie
- Dumikyan Anait
- Dwivedi Pratik
- Dwyer Nathan
- Dybala Tomasz
- Dzeletovic Susanna
- Earath Manoj
- Ebert Hans-Holger
- Ebner Karl-Martin
- Eccleston David
- Eden Jane
- Eder Wolfgang
- Edin Anton
- Efe Jana
- Egilsson Arnor
- Egorova Liudmila
- Egyutt Mihaly
- Eikelboom John
- Eikelboom John
- Eisleben Lutherstadt
- Eissing Volker
- Ekstrand Ann-Britt
- El-Aziz Ahmed Abd
- El-Etreby Adel
- Elise Guillermet
- Elkhadem Magdi
- Ellervik Christina
- Ellis Tania
- Elmersson Micael
- Elorriaga Madariaga Ane
- Emelife Samuel
- Emura Yoko
- Endo Masato
- Engdahl Johan
- Engelbrecht Johannes
- Engelthaler Gabriella
- Epelde Gonzalo Francisco
- Erdle Werner
- Erga Knut
- Ericsson Marianne
- Ersanli Murat
- Eskandari Mehdi
- Eslick Renee
- Espallargas Anna
- Estifanos Salah
- Eto Takuma
- Evans Lorlie
- Evans Paul
- Evans Phil
- Ewald Gregory
- Ewert Alayna
- Fairhead Sue
- Fanelli Raffaele
- Faron Andwojciech
- Farquhar Donald
- Fattore Luciano
- Fearon Ann
- Fedele Marta
- Fedorowsky Alain
- Feil Jusztina
- Felekoglu Mehmet Ali
- Felpel Susan
- Femiano Claudio
- Feng Shuai
- Feola Mauro
- Ferdinand Keith
- Ferenczi Judit
- Ferkl Richard
- Fernandez Escobar Esther
- Ferreira-Jardim Antonio
- Ferreira-Jardim Antonio
- Ferrer Ana
- Ferrini Piera Maria
- Fetahovic Taufik
- Fielder Debbie
- Figura-Chmielewska Monika
- Figura-Chmielewska Monika
- Fikry Sameh
- Fikry Sameh
- Finlaison Judy Anne
- Fitzmaurice David
- Fitzmaurice David A.
- Fitzmaurice David A.
- Fitzpatrick Michael
- Fleck Anja
- Fleury Julie
- Flint Kerstin
- Floegel Hildegard
- Floren Karin
- Flynn Ann
- Foechterle Johannes
- Foechterle Johannes
- Fontanillas Maria Teixido
- Foo David
- Fooks Tim
- Foppa Luciano
- Forcignano Fulvio
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- Fox Robin
- Frankiewicz Anna
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- Gladbach Bergisch
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- Goldhaber Samuel Z.
- Goldhaber Samuel Z.
- Goldhaber Samuel Z.
- Goldhaber Samuel Z.
- Goldhaber Samuel Z.
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- Jaremczuk-Kaczmarczyk Adriana
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- Kakkar Ajay K.
- Kakkar Ajay K.
- Kakuda Hirokazu
- Kamath R.
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- Mantovani Lorenzo G.
- Mantovani Lorenzo G.
- Mantovani Lorenzo G.
- Manzanal Rey Aranza
- Mara Guerra Jose
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- Mariankowski Rafal
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- Matthews Rosemary
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- Misselwitz Frank
- Misumi Ikuo
- Mita Teruaki
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- Miyamoto Yasufumi
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- Mntla Pindile
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- Modi Mayank H.
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- More Helse
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- Mori Etsuo
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- Mostovoy Yuriy
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- Nagai Sho
- Nagai Shunichi
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- Nakamura Ryosai
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- Nakazato Ryo
- Nam Gi-Byoung
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- Nanke Toshihiko
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- Panse Shankar G.
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- Patel Jayesh
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- Pieper Karen S.
- Pieper Karen S.
- Pieterse Mathijs
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- Potuznik Petr
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- Primeau Karine
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- Rama Pamela
- Ramachenderan Joanna
- Ramdass Andrew
- Ramesh C.
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- Randfield Simon
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- Raynor Janaya
- Rayoo Rinku
- Reda Ashraf
- Reda Mohamed
- Reed Rory
- Rehling Guenter
- Reichelt Christoph
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- Zaatout Eman
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- Zakutynska-Kowalczyk Karolina
- Zaluska Roman
- Zaman Kashif
- Zateyshchikov Dmitry
- Zauzig Heinz-Dieter
- Zdrowotnej Zespol Opieki
- Zecca Cinzia
- Zemlianskaia Oksana
- Zhai Hong
- Zhan Qiong
- Zhang Guoshan
- Zhang Huaiqin
- Zhang Ran
- Zhang Yi
- Zhao Yusheng
- Zhuravleva Evgeniya
- Zidek Milan
- Zidkova Eva
- Zika Jiri
- Zillo Mariana
- Zimmett Leon
- Zimny Hans-Hermann
- Zincke Stephanie
- Zinka Elzbieta
- Zinka Elzbieta
- Zotova Irina
- Zubeeva Galina
- Zuber Mathieu
- Zutz Stefan
- Zwenkau Schwarz
- Zyczynska Malgorzata
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/06/2019
- Field of study
IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia GonzĂĄlez
- Aleem Muhammad
- Alegre InĂȘs
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz AmorĂłs
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-DĂez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado FabĂola
- Amador Cristina GarcĂa
- Amanullah Nazli
- Amaral HĂ©lida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- AndrĂ©s Beatriz DĂaz San
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- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
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- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
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- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
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- Cholewa Hanna
- Chornet Marta RosellĂł
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
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- Yew Chor Kuan
- Yılmaz GĂŒlseren
- Yilmazlar Tuncay
- YiÄit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)