Transcriptional regulation of DC fate specification

Dendritic cells function in the immune system to instruct adaptive immune cells to respond accordingly to different threats. While conventional dendritic cells can be subdivided into two main subtypes, termed cDC1s and cDC2s, it is clear that further heterogeneity exists within these subtypes, particularly for cDC2s. Understanding the signals involved in specifying each of these lineages and subtypes thereof is crucial to (i) enable us to determine their specific functions and (ii) put us in a position to be able to target these cells to promote or prevent a specific function in any given disease setting. Although we still have much to learn regarding the specification of these cells, here we review the most recent advances in our understanding of this and highlight some of the next questions for the future

A fault injection experiment using the AIRLAB Diagnostic Emulation Facility

The preparation for, conduct of, and results of a simulation based fault injection experiment conducted using the AIRLAB Diagnostic Emulation facilities is described. An objective of this experiment was to determine the effectiveness of the diagnostic self-test sequences used to uncover latent faults in a logic network providing the key fault tolerance features for a flight control computer. Another objective was to develop methods, tools, and techniques for conducting the experiment. More than 1600 faults were injected into a logic gate level model of the Data Communicator/Interstage (C/I). For each fault injected, diagnostic self-test sequences consisting of over 300 test vectors were supplied to the C/I model as inputs. For each test vector within a test sequence, the outputs from the C/I model were compared to the outputs of a fault free C/I. If the outputs differed, the fault was considered detectable for the given test vector. These results were then analyzed to determine the effectiveness of some test sequences. The results established coverage of selt-test diagnostics, identified areas in the C/I logic where the tests did not locate faults, and suggest fault latency reduction opportunities

Stakeholder Engagement and Conflicting Discourses in Urban Policy in the Two Rivers Urban Park, Cape Town: An Argumentative Discourse Analysis

Public participation has the potential to either enhance urban development outcomes or entrench disagreement and frustration. A major challenge for policy-makers is how to understand and then respond to the narratives, metaphors and arguments contributed by stakeholders. In analysing the public participation process for the Two Rivers Urban Park (TRUP) in Cape Town, this research applies argumentative discourse analysis to capture and analyse multiple dimensions of stakeholder contributions. Arguments, and other linguistic features, were linked to themes distilled from the data. Associating and matching these themes to stakeholder groups identified discourse coalitions. The analysis supports the claim that the development of TRUP involves more than merely a technical discussion. The metaphors, stories and arguments used by participants to discuss the development of TRUP refer to it as an emblematic issue for the development of the city, its history, the history of South Africa and globalisation across the world. The discourse coalitions identified illuminate diverging ideas of how cities ought to respond to the environment, the private sector and residents. Without this knowledge government cannot hope to respond to stakeholders in a manner they will find satisfactory

The opposite of white: apollo's crow and learning to be silent in King Lear’

This article seeks to re-address the problem of Cordelia – not as a vessel of male prejudice, fantasy or repression but as an image of truth and the social life of that truth as it moves across the play world. Focusing on King Lear, I will examine the complex value of silence, not as negation or nothing, but as an ethical value through which the play explores the contested space of the unsayable. Considering Lear’s investment in power, monstrosity and self-knowledge, I investigate the story of Apollo’s crow, Aesop and Ovid, and what happened to the bird who told the truth and became ‘the opposite of white’. Re-imagining the unspeakable, as well as the unknowable, this essay argues that King Lear rehabilitates the power of nothing through a sceptical analysis of the value of acceptance and restraint, unhinged from their stoic or Christian contexts

A study of problems presented to the social worker by poliomyelitis patients at the Children's Medical Center; September, 1949

Thesis (M.S.)--Boston Universit

Shakespeare and the idea of the book

Shakespeare and the Idea of the Book is about the book in Shakespeare's plays; the book as an object, wherein the article may disclose narratives, corroborate stories, expose versions of reality and perspectives of presence; and the semiotic of the book, wherein the language of the book, of holding, touching, turning leaves, opening pages, reading, revealing and closing may simulate an idea of the body or mind in motion. This thesis is about how the metaphorical and material book appears on Shakespeare's stage, and how the physical and figurative presence of the book challenges the imaginative and representational conditions of theatre. Having chosen seven plays for their particularly significant relationship to the book, I explore each play and its books for the demands they make of each other and what such demands reveal. The Introduction outlines the argument of the project and, drawing on a broad range of Shakespeare's plays, sets out the prevalence of the 'book' and an awareness of the potential discourses through which the object is beginning to move in the Elizabethan period. The thesis is then split into five chapters, the first two dealing with two plays each, Titus Andronicus and Cymbeline, and The Taming of The Shrew and Love's Labour's Lost. The following three chapters deal with individual plays, Richard II, Hamlet, and The Tempest. Although the thesis follows, with the exception of Cymbeline, a chronology of the drama, I make no attempt to suggest that Shakespeare forged a linear narrative in his evolving relationship with the book. Rather, my conclusion demonstrates how the book's extraordinary semantics cope resists a continuum or progressive evolution. The ever-changing capacity of the book, its materiality and language, supports the stage in a quest to define and expand the representational relationship between seeing and thinking, moving and being. Shakespeare's books are, I will argue, like Hamlet's players, 'the abstracts and brief chronicles of the time', and, to that end, 'let them be well used)