85 research outputs found

    Grid Scheduling for Interactive Analysis

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    Grids are facing the challenge of moving from batch systems to interactive computing. In the 70s, standalone computer systems have met this challenge, and this was the starting point of pervasive computing. Meeting this challenge will allow grids to be the infrastructure for ambient intelligence and ubiquitous computing. This paper shows that EGEE, the largest world grid, does not yet provide the services required for interactive computing, but that it is amenable to this evolution through relatively modest middleware evolution. A case study on medical image analysis exemplifies the particular needs of ultra-short jobs

    A Secure Grid Medical Data Manager Interfaced to the gLite Middleware

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    International audienceThe medical community is producing and manipulating a tremendous volume of digital data for which computerized archiving, processing and analysis is needed. Grid infrastructures are promising for dealing with challenges arising in computerized medicine but the manipulation of medical data on such infrastructures faces both the problem of interconnecting medical information systems to Grid middlewares and of preserving patients' privacy in a wide and distributed multi-user system. These constraints are often limiting the use of Grids for manipulating sensitive medical data. This paper describes our design of a medical data management system taking advantage of the advanced gLite data management services, developed in the context of the EGEE project, to fulfill the stringent needs of the medical community. It ensures medical data protection through strict data access control, anonymization and encryption. The multi-level access control provides the flexibility needed for imple! menting complex medical use-cases. Data anonymization prevents the exposure of most sensitive data to unauthorized users, and data encryption guarantees data protection even when it is stored at remote sites. Moreover, the developed prototype provides a Grid storage resource manager (SRM) interface to standard medical DICOM servers thereby enabling transparent access to medical data without interfering with medical practice

    Non-Lytic, Actin-Based Exit of Intracellular Parasites from C. elegans Intestinal Cells

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    The intestine is a common site for invasion by intracellular pathogens, but little is known about how pathogens restructure and exit intestinal cells in vivo. The natural microsporidian parasite N. parisii invades intestinal cells of the nematode C. elegans, progresses through its life cycle, and then exits cells in a transmissible spore form. Here we show that N. parisii causes rearrangements of host actin inside intestinal cells as part of a novel parasite exit strategy. First, we show that N. parisii infection causes ectopic localization of the normally apical-restricted actin to the basolateral side of intestinal cells, where it often forms network-like structures. Soon after this actin relocalization, we find that gaps appear in the terminal web, a conserved cytoskeletal structure that could present a barrier to exit. Reducing actin expression creates terminal web gaps in the absence of infection, suggesting that infection-induced actin relocalization triggers gap formation. We show that terminal web gaps form at a distinct stage of infection, precisely timed to precede spore exit, and that all contagious animals exhibit gaps. Interestingly, we find that while perturbations in actin can create these gaps, actin is not required for infection progression or spore formation, but actin is required for spore exit. Finally, we show that despite large numbers of spores exiting intestinal cells, this exit does not cause cell lysis. These results provide insight into parasite manipulation of the host cytoskeleton and non-lytic escape from intestinal cells in vivo

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    Telif Ve Tercüme Heyeti'nce Tedkik Ve Kabul Edilmişdir. Eserin Sonundaki İlave Sayfalarda Eserin "Fihrist"İ Vardır. Eserde "İstanbul Eğitim Enstitüsü Kitaplığı" Ve "Konya Erkek Muallim Mektebi Müdürlüğü [Kütübhanesi]" Mühürleri Vardır

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    Telif Ve Tercüme Heyeti'nce Tedkik Ve Kabul Edilmişdir. Eserin Sonundaki İlave 5 Sayfa Ebced İle Numaralanmış Olup Eserin "Fihrist"İ Vardır. Diğer İlave 1 Sayfada İse Eserin İçerisindeki "Resimler"İn Listesi Vardır. Bezemelidir. Eserde "İstanbul Y. Öğretmen Okulu Kitaplığı", "İzmir Lisesi Kütüphanesi, 1922" Ve "İzmir Erkek Lisesi Talebe Kütübhanesi" Mühürleri Vardır

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    Telif Ve Tercüme Heyeti'nce Tedkik Ve Kabul Edilmişdir. Eserin "Fihrist"İ (285-89 S.) Vardır. Eserin Sonundaki İlave 31 Sayfada "Huruf-I Heca Tertibiyle Fihrist" Vardır. Diğer İlave 2 Sayfada İse "Hata - Sevab Cedveli" Vardır. Eserde "İstanbul Eğitim Enstitüsü Kitaplığı" Mührü Vardır

    La Pamphylie. Géographie et topographie de cette province

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    Texier Charles. La Pamphylie. Géographie et topographie de cette province. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 4ᵉ année, 1860. pp. 164-165
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