Evaluation of the main achievements of cohesion policy programmes and projects over the longer term in 15 selected regions: case study North East England

This report presents the Pilot Case Study for North East England as part of the study ‘Evaluation of the Main Achievements of Cohesion Policy Programmes over the Longer Term in 15 Selected Regions (from 1989-1993 Programming Period to the Present)’ which is being managed by the European Policies Research Centre and London School of Economics

Repatriation and innovation in and out of the field: the impact of legacy recordings on endangered dance-song traditions and ethnomusicological research

Over the last decade, ethnomusicologists have increasingly become preoccupied with the repatriation of records of songs and dances to communities of origin for a range of reasons that have been summarised elsewhere (see Treloyn and Emberly 2013; Treloyn, Charles and Nulgit 2013). In Australia, the return and dissemination of audio and video recordings from archival and personal collections to cultural heritage communities has emerged as a primary, and almost ubiquitous, fieldwork method

Making Junba good in the Kimberley: Applied (ethnomusicological) research and its discontents

In 2007 the Junba Project was conceived of by elder Ngarinyin practitioners of the Junba dance-song genre in the northcentral Kimberley in conversation with ethnomusicologist Sally Treloyn, in response to a decline in youth participation and concerns for youth social and emotional wellbeing. Elder song man and composer Scotty Nyalgodi Martin declaimed “Without culture we will all be lost”, referring not just to members of his own community but to all Australians and indeed humanity in general. Since that time the Junba Project, in partnership with elder and youth leaders, the Kimberley Aboriginal Law and Culture Centre, Kimberley Language Resource Centre, Mowanjum Art and Culture Centre, and various other community organisations, has sought to identify and develop community-led approaches to sustainability and musico-cultural resilience. Guided by a participatory research model, the project has emphasised an approach to collaboration marked by participation across generations of practitioners, and reiteration and collaborative reflection, with an aim to identify strategies to sustain endangered Junba dance-song practices in changing twentieth and twenty-first century environments

Wanjina oden barnja mirndi: recording cultural stories and places on the road to Jilariba (Munja)

Since 2015, Traditional Owners of the Wanjina Wunggurr Wilinggin Native Title area and the Wilinggin Aboriginal Corporation have been working in collaboration with researchers from Nulungu Research Institute (UNDA), the University of Western Australia and the Australian National University to record cultural stories and places on the road to Jilariba (otherwise known as ‘Munja’ in the remote centre of the Kimberley). Together the group have undertaken field trips along the Munja Track in 2017 and 2018, visiting rock art sites and cultural places to share stories and cultural knowledges with future generations. Focusing initially on the eastern end on Mt Elizabeth Station, the group then travelled the length of the track last year and created a series of videos at places along the way. As part of this seminar, we want to share our experiences from this project, some of the videos we made, as well as discuss our future plans for developing this small LotteryWest-funded Community History Project into a larger Australian Research Council research project. Working together, side by side, step by step, we’re committed to doing this the right way as part of a community-initiated/owned/driven project

Recent Progress in the Management of Retroperitoneal Sarcoma

Retroperitoneal sarcomas (RPS) are rare tumours that typically present late and carry a poor prognosis even following grossly complete resection. In an attempt to improve the outlook for patients with RPS, sarcoma specialists have employed various adjuvant therapies, including extermal beam radiation, intraoperative radiation, brachyradiation and systemic chemotherapy. This article reviews the presentation and prognosis of RPS, and focuses on the results of new treatment strategies compared with conventional management

Repatriation of Song Materials to Support Intergenerational Transmission of Knowledge about Language in the Kimberley Region of Northwest Australia

Increasing interest in the repatriation of song recordings to cultural heritage communities has opened up new possibilities for archives, researchers and local individual, community and organizational stakeholders in recent years. In Australia, repatriation has emerged as a core activity of many, if not all, current ethnomusicological research on Aboriginal song traditions and, as song is a register of language, is an interest of many linguists and community-based language centres. There are numerous published reports that describe the use of repatriated recordings in cultural heritage communities to articulate identity, to demonstrate continuity of tradition, and to recover and revive repertories of song and language. To date, however, there has been very little attention to the precise ways in which this happens, or to the ambiguities that permeate the use of historical recordings to sustain flexible and context-driven musical systems (and the language material that they carry). This paper will examine the repatriation and dissemination of ethnomusicological records (audio, video recordings and associated metadata) in a collaborative song maintenance project based in the Kimberley region of northwest Australia. In doing so, we seek to better understand how repatriation activities can contribute to sustaining endangered practices and knowledges by supporting intergenerational cooperation ---- L’intérêt croissant pour le rapatriement des enregistrements de chansons vers les communautés culturelles a ouvert récemment de nouvelles possibilités pour les archives, les chercheurs, les individus et autres parties prenantes au niveau local. En Australie, le rapatriement est devenu l’activité principale de presque toute la recherche ethnomusicologique sur les traditions de chansons autochtones et, puisqu’une chanson est un registre de langue, a suscité l’intérêt d’un grand nombre de linguistes et des centres de langues communautaires. Il existe de nombreux rapports publiés qui décrivent l’utilisation d’enregistrements rapatriés dans les communautés de patrimoine culturel pour en articuler l’identité, démontrer la continuité de la tradition, et récupérer et relancer les répertoires de la chanson et de la langue. À ce jour, cependant, on a porté peu d’attention à la manière dont cela se produit, ou aux ambiguïtés qui imprègnent l’utilisation d’historique des enregistrements pour soutenir des systèmes musicaux flexibles dirigés par le contexte (et la matière linguistique qu’ils véhiculent). Cet article examine le rapatriement et la diffusion d’enregistrements ethnomusicologiques (enregistrements audio, vidéo et métadonnées associées) dans un projet collaboratif de maintien des chansons situé dans la région de Kimberley au nord-ouest de l’Australie. Ce faisant, nous cherchons à mieux comprendre comment les activités de rapatriement peuvent contribuer à soutenir, via la coopération intergénérationnelle, des pratiques et des connaissances en voie de disparition

A comprehensive review of reviews of school-based interventions to improve sexual-health

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Objective: To systematically review systematic reviews of school-based sexual-health and relationship Education (SHRE) programmes and, thereby, identify interventions and intervention components that promote reductions in risky sexual behaviour among young people. Methods: Electronic bibliographies were searched systematically to identify systematic reviews of school-based interventions targeting sexual-health. Results were summarised using a narrative synthesis. Results: Thirty seven systematic reviews (summarizing 224 primary RCTs) met our inclusion and quality assessment criteria. In general, these reviews analysed distinct sets of primary studies, and no comprehensive review of available primary studies was identified. Interventions were categorized into 5 types that segment this review literature. Unfortunately, many reviews reported weak and inconsistent evidence of behaviour change. Nonetheless, integration of review findings generated a list of 32 design, content, and implementation characteristics that may enhance effectiveness of school-based, sexual-health interventions. Abstinence-only interventions were found to be ineffective in promoting positive changes in sexual behaviour. By contrast, comprehensive interventions, those specifically targeting HIV prevention, and school-based clinics were found to be effective in improving knowledge and changing attitudes, behaviours and health-relevant outcomes. Conclusions: School-based interventions targeting risky sexual behaviour can be effective. Particular design, content and implementation characteristics appear to be associated with greater effectiveness. We recommend consideration of these characteristics by designers of school-based sexual-health interventions.This study was funded as part of National Institute of Health Research’s School for Public Health Research (NIHR SPHR) project with additional support from the NIHR Collaboration for Leadership in Applied Health Research and Care of the South West Peninsula (PenCLAHRC). The views expressed are those of the author(s) and not necessarily those of 2 the NHS, the NIHR or the Department of Health. Author order represents extent of contribution. Funding statement The School for Public Health Research and the Collaboration for Leadership in Applied Health Research and Care of the South West Peninsula is funded by the National Institute for Health Research (NIHR). SPHR is a partnership between the Universities of Sheffield, Bristol, Cambridge, Exeter, UCL; The London School for Hygiene and Tropical Medicine; the LiLaC collaboration between the Universities of Liverpool and Lancaster and Fuse; The Centre for Translational Research in Public Health, a collaboration between Newcastle, Durham, Northumbria, Sunderland and Teesside Universities

Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus

Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder that is characterized by enlarged cerebral ventricles, gait difficulty, incontinence, and dementia. iNPH usually develops after the sixth decade of life in previously asymptomatic individuals. We recently reported that loss-of-function deletions in CWH43 lead to the development of iNPH in a subgroup of patients, but how this occurs is poorly understood. Here, we show that deletions in CWH43 decrease expression of the cell adhesion molecule, L1CAM, in the brains of CWH43 mutant mice and in human HeLa cells harboring a CWH43 deletion. Loss-of-function mutations in L1CAM are a common cause of severe neurodevelopmental defects that include congenital X-linked hydrocephalus. Mechanistically, we find that CWH43 deletion leads to decreased N-glycosylation of L1CAM, decreased association of L1CAM with cell membrane lipid microdomains, increased L1CAM cleavage by plasmin, and increased shedding of cleaved L1CAM in the cerebrospinal fluid. CWH43 deletion also decreased L1CAM nuclear translocation, suggesting decreased L1CAM intracellular signaling. Importantly, the increase in L1CAM cleavage occurred primarily in the ventricular and subventricular zones where brain CWH43 is most highly expressed. Thus, CWH43 deletions may contribute to adult-onset iNPH by selectively downregulating L1CAM in the ventricular and subventricular zone

What is best practice in sex and relationship education? A synthesis of evidence, including stakeholders' views.

OBJECTIVES: Sex and relationship education (SRE) is regarded as vital to improving young people's sexual health, but a third of schools in England lacks good SRE and government guidance is outdated. We aimed to identify what makes SRE programmes effective, acceptable, sustainable and capable of faithful implementation. DESIGN: This is a synthesis of findings from five research packages that we conducted (practitioner interviews, case study investigation, National Survey of Sexual Attitudes and Lifestyles, review of reviews and qualitative synthesis). We also gained feedback on our research from stakeholder consultations. SETTINGS: Primary research and stakeholder consultations were conducted in the UK. Secondary research draws on studies worldwide. RESULTS: Our findings indicate that school-based SRE and school-linked sexual health services can be effective at improving sexual health. We found professional consensus that good programmes start in primary school. Professionals and young people agreed that good programmes are age-appropriate, interactive and take place in a safe environment. Some young women reported preferring single-sex classes, but young men appeared to want mixed classes. Young people and professionals agreed that SRE should take a 'life skills' approach and not focus on abstinence. Young people advocated a 'sex-positive' approach but reported this was lacking. Young people and professionals agreed that SRE should discuss risks, but young people indicated that approaches to risk need revising. Professionals felt teachers should be involved in SRE delivery, but many young people reported disliking having their teachers deliver SRE and we found that key messages could become lost when interpreted by teachers. The divergence between young people and professionals was echoed by stakeholders. We developed criteria for best practice based on the evidence. CONCLUSIONS: We identified key features of effective and acceptable SRE. Our best practice criteria can be used to evaluate existing programmes, contribute to the development of new programmes and inform consultations around statutory SRE

Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients.

Funder: Kidney Research U