La fièvre aphteuse

La fièvre aphteuse, l’une des maladies les plus contagieuses et qui frappe surtout les bovins, mais aussi les porcins, les ovins et les caprins, peut avoir des conséquences dévastatrices sur les agriculteurs et l’économie agricole. Par l’adoption d’une approche novatrice, cet ouvrage explore cette maladie, en apportant des faits concrets et exhaustifs. Chaque chapitre se penche sur une perspective différente, en faisant part des témoignages réfléchis d’agriculteurs et de vétérinaires, d’économistes et de journalistes, tant dans les pays en développement que dans les pays industrialisés

Benthic oxygen exchange over a heterogeneous Zostera noltei meadow in a temperate coastal ecosystem

Seagrass meadows support intense but highly variable benthic metabolic rates that still need to be better evaluated to determine an accurate trophic status. The present study assessed how seagrasses and associated benthic macrofauna control spatiotemporal changes in benthic oxygen exchanges within a temperate bay. Based on seasonal sampling over a complete year cycle, the diffusive oxygen uptake (DOU), community respiration (CR) and gross primary production (GPP) were measured in a Zostera noltei meadow within Arcachon Bay, taking into account its spatial heterogeneity. Oxygen fluxes were assessed in sediment cores, within which benthic macrofauna and seagrass abundances and biomasses were quantified. The presence of Z. noltei did not significantly affect the DOU. Seasonal changes in CR and GPP correlated strongly with temperature in the presence of Z. noltei. The characteristics of benthic macrofauna associated with Z. noltei only weakly affected seasonal changes in CR. High spatial changes in both GPP and CR were mainly driven by the aboveground biomass of Z. noltei. When extrapolated to the whole intertidal area of the bay, in spite of limitations, our results suggest (1) overall higher contributions to CR and GPP from the seagrass meadow than from bare sediments, even though alternative primary producers in bare sediments (likely microphytobenthos) contributed significantly during winter; (2) an annual decrease in CR and GPP of 35 and 41%, respectively, resulting from the decline in Z. noltei of 25% between 2005 and 2007; and (3) a strong seasonality in the magnitude of this decrease, which was high during autumn and low during winter.

Dark matter profiles and annihilation in dwarf spheroidal galaxies: prospectives for present and future γ-ray observatories - I. The classical dwarf spheroidal galaxies

Due to their large dynamical mass-to-light ratios, dwarf spheroidal galaxies (dSphs) are promising targets for the indirect detection of dark matter (DM) in γ-rays. We examine their detectability by present and future γ-ray observatories. The key innovative features of our analysis are as follows: (i) we take into account the angular size of the dSphs; while nearby objects have higher γ-ray flux, their larger angular extent can make them less attractive targets for background-dominated instruments; (ii) we derive DM profiles and the astrophysical J-factor (which parametrizes the expected γ-ray flux, independently of the choice of DM particle model) for the classical dSphs directly from photometric and kinematic data. We assume very little about the DM profile, modelling this as a smooth split-power-law distribution, with and without subclumps; (iii) we use a Markov chain Monte Carlo technique to marginalize over unknown parameters and determine the sensitivity of our derived J-factors to both model and measurement uncertainties; and (iv) we use simulated DM profiles to demonstrate that our J-factor determinations recover the correct solution within our quoted uncertainties. Our key findings are as follows: (i) subclumps in the dSphs do not usefully boost the signal; (ii) the sensitivity of atmospheric Cherenkov telescopes to dSphs within ∼20 kpc with cored haloes can be up to ∼50 times worse than when estimated assuming them to be point-like. Even for the satellite-borne Fermi-Large Area Telescope (Fermi-LAT), the sensitivity is significantly degraded on the relevant angular scales for long exposures; hence, it is vital to consider the angular extent of the dSphs when selecting targets; (iii) no DM profile has been ruled out by current data, but using a prior on the inner DM cusp slope 0 ≤γprior≤ 1 provides J-factor estimates accurate to a factor of a few if an appropriate angular scale is chosen; (iv) the J-factor is best constrained at a critical integration angle αc= 2rh/d (where rh is the half-light radius and d is the distance from the dwarf) and we estimate the corresponding sensitivity of γ-ray observatories; (v) the ‘classical' dSphs can be grouped into three categories: well constrained and promising (Ursa Minor, Sculptor and Draco), well constrained but less promising (Carina, Fornax and Leo I), and poorly constrained (Sextans and Leo II); and (vi) observations of classical dSphs with the Fermi-LAT integrated over the mission lifetime are more promising than observations with the planned Cherenkov Telescope Array for DM particle mass ≲ 700 GeV. However, even the Fermi-LAT will not have sufficient integrated signal from the classical dwarfs to detect DM in the ‘vanilla' Minimal Supersymmetric Standard Model. Both the Galactic Centre and the ‘ultrafaint' dwarfs are likely to be better targets and will be considered in future wor

Multidisciplinary Design and Optimization of Regional Jet Retrofitting Activity

A retrofit analysis on a 90 passengers regional jet aircraft is performed through a multidisciplinary collaborative aircraft design and optimization highlighting the impact on costs and performance. Two different activities are accounted for selecting the best aircraft retrofit solution: a re-engining operation that allows to substitute a conventional power-plant platform with advanced geared turbofan and an on-board-systems architecture modernization, considering different levels of electrification. Besides the variables that are directly dependent from these activities, also scenario variables are considered during the optimization such as the fuel price, the fleet size and the years of utilization of the upgraded systems. The optimization is led by impacts of the retrofitting process on emissions, capital costs and saving costs, computed at industrial level. Overall aircraft design competences (aerodynamics, masses, performance, noise, and emissions) have been computed increasing the level of fidelity and reliability. The whole process is implemented in the framework of the AGILE 4.0 research project in a collaborative remote multidisciplinary approach. Results show that the engine retrofitting can be a profitable solution for both manufacturers and airliners. Conversely, the on-board-system electrification seems to be not convenient in a retrofitting process due to the high capital costs. Depending on the operative scenario, involved stakeholders can properly orient their decision on a retrofitting strategy

A combined first and second order variational approach for image reconstruction

In this paper we study a variational problem in the space of functions of bounded Hessian. Our model constitutes a straightforward higher-order extension of the well known ROF functional (total variation minimisation) to which we add a non-smooth second order regulariser. It combines convex functions of the total variation and the total variation of the first derivatives. In what follows, we prove existence and uniqueness of minimisers of the combined model and present the numerical solution of the corresponding discretised problem by employing the split Bregman method. The paper is furnished with applications of our model to image denoising, deblurring as well as image inpainting. The obtained numerical results are compared with results obtained from total generalised variation (TGV), infimal convolution and Euler's elastica, three other state of the art higher-order models. The numerical discussion confirms that the proposed higher-order model competes with models of its kind in avoiding the creation of undesirable artifacts and blocky-like structures in the reconstructed images -- a known disadvantage of the ROF model -- while being simple and efficiently numerically solvable.Comment: 34 pages, 89 figure

Agammaglobulinaemia despite terminal B-cell differentiation in a patient with a novel LRBA mutation

Mutations in lipopolysaccharide-responsive vesicle trafficking, beach and anchor-containing protein (LRBA) cause immune deficiency and inflammation. Here, we are reporting a novel homozygous mutation in LRBA allele in 7-year-old Omani boy, born to consanguineous parents. He presented with type 1 diabetes, autoimmune haematological cytopenia, recurrent chest infections and lymphocytic interstitial lung disease. The patient was treated with CTLA4-Ig (abatacept) with good outcome every 2 weeks for a period of 3 months. He developed complete IgG deficiency, but remarkably, histological examination revealed germinal centres and plasma cells in lymphoid and inflamed lung tissue. Further charatecterisation showed these cells to express IgM but not IgG. This ex vivo analysis suggests that LRBA mutation confers a defect in class switching despite plasma cell formation