7,622 research outputs found
Assessment of economic factors affecting the satellite power system. Volume 2: The systems implications of rectenna siting issues
The feasibility was evaluated of finding potential sites for Solar Power Satellite (SPS) receiving antennas (rectennas) in the continental United States, in sufficient numbers to permit the SPS to make a major contribution to U.S. generating facilities, and to give statistical validity to an assessment of the characteristics of such sites and their implications for the design of the SPS system. It is found that the cost-optimum power output of the SPS does not depend on the particular value assigned to the cost per unit area of a rectenna and its site, as long as it is independent of rectenna area. Many characteristics of the sites chosen affect the optimum design of the rectenna itself
Host-driven diversification of gall-inducing Acacia thrips and the aridification of Australia
BACKGROUND: Insects that feed on plants contribute greatly to the generation of biodiversity. Hypotheses explaining rate increases in phytophagous insect diversification and mechanisms driving speciation in such specialists remain vexing despite considerable attention. The proliferation of plant-feeding insects and their hosts are expected to broadly parallel one another where climate change over geological timescales imposes consequences for the diversification of flora and fauna via habitat modification. This work uses a phylogenetic approach to investigate the premise that the aridification of Australia, and subsequent expansion and modification of arid-adapted host flora, has implications for the diversification of insects that specialise on them. RESULTS: Likelihood ratio tests indicated the possibility of hard molecular polytomies within two co-radiating gall-inducing species complexes specialising on the same set of host species. Significant tree asymmetry is indicated at a branch adjacent to an inferred transition to a Plurinerves ancestral host species. Lineage by time diversification plots indicate gall-thrips that specialise on Plurinerves hosts differentially experienced an explosive period of speciation contemporaneous with climatic cycling during the Quaternary period. Chronological analyses indicated that the approximate age of origin of gall-inducing thrips on Acacia might be as recent as 10 million years ago during the Miocene, as truly arid landscapes first developed in Australia. CONCLUSION: Host-plant diversification and spatial heterogeneity of hosts have increased the potential for specialisation, resource partitioning, and unoccupied ecological niche availability for gall-thrips on Australian Acacia
Probing the microbiome to predict response to biologic therapy in Inflammatory Bowel Disease: one step closer to precision medicine?
© 2022 by the AGA InstituteCurrent treatment algorithms in inflammatory bowel disease (IBD) rely on a âtrial and errorâ approach, and therefore, patients may receive ineffective and costly therapy for many months, with associated risks. Furthermore, after failure of the first biologic, response rates to second-line therapies drop considerably. Personalized medicine, which seeks to identify biomarkers that predict disease course and treatment efficacy,
thus remains a significant unmet need in IBD.info:eu-repo/semantics/publishedVersio
Generalized Rosenfeld scalings for tracer diffusivities in not-so-simple fluids: Mixtures and soft particles
Rosenfeld [Phys. Rev. A 15, 2545 (1977)] noticed that casting transport
coefficients of simple monatomic, equilibrium fluids in specific dimensionless
forms makes them approximately single-valued functions of excess entropy. This
has predictive value because, while the transport coefficients of dense fluids
are difficult to estimate from first principles, excess entropy can often be
accurately predicted from liquid-state theory. Here, we use molecular
simulations to investigate whether Rosenfeld's observation is a special case of
a more general scaling law relating mobility of particles in mixtures to excess
entropy. Specifically, we study tracer diffusivities, static structure, and
thermodynamic properties of a variety of one- and two-component model fluid
systems with either additive or non-additive interactions of the hard-sphere or
Gaussian-core form. The results of the simulations demonstrate that the effects
of mixture concentration and composition, particle-size asymmetry and
additivity, and strength of the interparticle interactions in these fluids are
consistent with an empirical scaling law relating the excess entropy to a new
dimensionless (generalized Rosenfeld) form of tracer diffusivity, which we
introduce here. The dimensionless form of the tracer diffusivity follows from
knowledge of the intermolecular potential and the transport / thermodynamic
behavior of fluids in the dilute limit. The generalized Rosenfeld scaling
requires less information, and provides more accurate predictions, than either
Enskog theory or scalings based on the pair-correlation contribution to the
excess entropy. As we show, however, it also suffers from some limitations,
especially for systems that exhibit significant decoupling of individual
component tracer diffusivities.Comment: 15 pages, 10 figure
Refining the planktic foraminiferal I/Ca proxy:Results from the Southeast Atlantic Ocean
Profound changes in upper ocean oxygenation have taken place in recent decades and are expected to continue in the future, but the complexity of the processes driving these changes has yet to be fully unraveled. Planktic foraminiferal I/Ca is a promising tool to reconstruct the extent of past upper ocean oxygenation, but a thorough assessment is necessary to evaluate both its potential and its limitations. We used foraminifers from Holocene core-tops (Southeast Atlantic Ocean) to document planktic I/Ca across a range of oceanographic conditions. Subsurface O2 concentrations may be the dominant control on planktic foraminiferal I/Ca and planktic I/Ca decreases rapidly at low O2 conditions (O2âŻ<âŻâŒ70â100âŻÂ”mol/kg). We thus document that low planktic I/Ca can be used empirically to indicate hypoxia in the upper water column, but questions remain as to the mechanistic understanding of the relation between seawater iodine speciation change, its O2 threshold and foraminiferal I/Ca. Planktic I/Ca records from core GeoB1720-2 (Benguela Upwelling System, SE Atlantic) suggest that hypoxic waters were present near the site persistently during the last 240âŻka, without clear glacial-interglacial variability
Impactor flux and cratering on Ceres and Vesta: Implications for the early Solar System
We study the impactor flux and cratering on Ceres and Vesta caused by the
collisional and dynamical evolution of the asteroid Main Belt. We develop a
statistical code based on a well-tested model for the simultaneous evolution of
the Main Belt and NEA size distributions. This code includes catastrophic
collisions and noncollisional removal processes such as the Yarkovsky effect
and the orbital resonances. The model assumes that the dynamical depletion of
the early Main Belt was very strong, and owing to that, most Main Belt
comminution occurred when its dynamical structure was similar to the present
one. Our results indicate that the number of D > 1 km Main Belt asteroids
striking Ceres and Vesta over the Solar System history are approximately 4 600
and 1 100 respectively. The largest Main Belt asteroids expected to have
impacted Ceres and Vesta had diameters of 71.7 km and 21.1 km. The number of D
> 0.1 km craters on Ceres is \sim 3.4 \times 10^8 and 6.2 \times 10^7 on Vesta.
The number of craters with D > 100 km are 47 on Ceres and 8 on Vesta. Our study
indicates that the D = 460 km crater observed on Vesta had to be formed by the
impact of a D \sim 66.2 km projectile, which has a probability of occurr \sim
30% over the Solar System history. If significant discrepancies between our
results about the cratering on Ceres and Vesta and data obtained from the Dawn
Mission were found, they should be linked to a higher degree of collisional
evolution during the early Main Belt and/or the existence of the late heavy
bombardment. An increase in the collisional activity in the early phase may be
provided for an initial configuration of the giant planets consistent with, for
example, the Nice model. From this, the Dawn Mission would be able to give us
clues about the initial configuration of the early Solar System and its
subsequent dynamical evolution.Comment: Accepted for publication in Astronomy and Astrophysic
Stochastic modelling of reaction-diffusion processes: algorithms for bimolecular reactions
Several stochastic simulation algorithms (SSAs) have been recently proposed
for modelling reaction-diffusion processes in cellular and molecular biology.
In this paper, two commonly used SSAs are studied. The first SSA is an
on-lattice model described by the reaction-diffusion master equation. The
second SSA is an off-lattice model based on the simulation of Brownian motion
of individual molecules and their reactive collisions. In both cases, it is
shown that the commonly used implementation of bimolecular reactions (i.e. the
reactions of the form A + B -> C, or A + A -> C) might lead to incorrect
results. Improvements of both SSAs are suggested which overcome the
difficulties highlighted. In particular, a formula is presented for the
smallest possible compartment size (lattice spacing) which can be correctly
implemented in the first model. This implementation uses a new formula for the
rate of bimolecular reactions per compartment (lattice site).Comment: 33 pages, submitted to Physical Biolog
Crystal structure of LIR-2 (ILT4) at 1.8 Ă : differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18
BACKGROUND: Leukocyte Immunoglobulin-like Receptor-1 (LIR-1) and LIR-2 (also known as ILT2 and ILT4 respectively) are highly related cell surface receptors that bind a broad range of class I MHC molecules with low (ÎŒM) affinities. Expressed on monocytic cells and macrophages, both molecules transmit inhibitory signals after binding ligands. In addition to binding host class I MHC, the LIR-1 molecule, which is also expressed on lymphoid tissues, binds with a high (nM) affinity to UL18, a class I MHC homolog encoded by Human Cytomegalovirus (HCMV). In comparison, LIR-2 binds UL18 only weakly (ÎŒM K(D)). To understand how HCMV preferentially targets the more broadly expressed LIR-1 molecule, we determined the crystal structure of a ligand-binding fragment of LIR-2, and compared this to the existing high-resolution crystal structure of LIR-1. RESULTS: Recombinant LIR-2 (domains 1 and 2) was produced in E. coli and crystallized using streak seeding to optimize the crystal morphology. A data set complete to 1.8 Ă
was collected at 100 K from a single crystal in the P4(1)2(1)2 spacegroup. The structure was solved by molecular replacement, using a search model based on the LIR-1 structure. CONCLUSIONS: The overall structure of LIR-2 D1D2 resembles both LIR-1, and Killer Inhibitory Receptors, in that the A strand in each domain forms hydrogen bonds to both ÎČ sheets, and there is a sharp angle between the two immunoglobulin-like domains. However, differences from LIR-1 are observed in each domain, with two key changes apparent in the ligand-binding domain, D1. The region corresponding to the residue 44â57 helix of LIR-1 adopts a topology distinct from that of both LIR-1 and the KIR structures, involving a shortened 3(10) helix. Secondly, the predicted UL18 binding region of LIR-1 is altered substantially in LIR-2: the 76â84 loop mainchain is displaced 11 Ă
with respect to LIR-1, and Tyrosine 38 adopts an alternative rotamer conformation. In summary, the structure of LIR-2 has revealed significant differences to LIR-1, including ones that may help to explain the >1000-fold lower affinity of LIR-2 for UL18
Introduction: looking beyond the walls
In its consideration of the remarkable extent and variety of non-university researchers, this book takes a broader view of âknowledgeâ and âresearchâ than in the many hot debates about todayâs knowledge society, âlearning ageâ, or organisation of research. It goes beyond the commonly held image of âknowledgeâ as something produced and owned by the full-time experts to take a look at those engaged in active knowledge building outside the university walls
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