Aromatic nitration at high sulphuric acid strengths

The nitration of aromatic compounds has been performed on an industrial scale since the turn of the century. The rapid development of nitroaromatics as explosives and their use today in the dye industry and as intermediates in organic syntheses makes nitration an important, large scale process. The importance of nitration as a model electrophilic aromatic substitution reaction for the investigation of electronic effects in organic molecules led to it being studied in great depth in the homogeneous phase. Until recently, however, there was a sparse amount of information on the industrially significant two-phase reaction with mixed sulphuric and nitric acids and little attempt had been made to apply the results of kinetic experiments in a single phase to the phenomena observed in two phase batch and continuous nitration plants. In the last few years, however, much progress has been made arid a better understanding of the processes involved in these systems is now possible. The rates of nitration in a miniature stirred batch reactor and stirred cell containing pure toluene and chlorobenzene have been successfully interpreted on the basis of Danckwerts' Surface Renewal Theory of mass transfer. Many of the factors which affect the rate in these systems have been investigated and suitable rate equations tested experimentally. Despite the progress, however, the results obtained are not totally conclusive and several anomalous features have become apparent. The object of this work is to account for these features and hence try to substantiate the Theory of Danckwerts as applied by Cox and Strachan to the nitration of aromatics in two-phase systems

The Dream of Mary

https://digitalcommons.library.umaine.edu/mmb-me/1385/thumbnail.jp

No evidence that the introduced parasite Orthione griffenis markham, 2004 causes sex change or differential mortality in the native mud shrimp, Upogebia pugettensis (Dana, 1852)

Dramatic, rapid, population declines of the native North American burrowing shrimp Upogebia pugettensis (Dana, 1852) are associated with intense infestations by the introduced Asian bopyrid isopod parasite, Orthione griffenis Markham, 2004. However, expected host weight losses with increasing parasite weights do not occur, even among apparently castrated females. The prevailing assumption that energetic losses cause host castration have thus remained open to question, and the mechanism(s) resulting in castration and consequent population declines of U. pugettensis have remained unclear. Proposed alternative explanations for these declines, which have been based on a dramatically greater prevalence of O. griffenis among U. pugettensis females, include parasite induced sex change, increased male mortality, and differential tidal exposure of sexes to settling O. griffenis larvae. We examined 508 O. griffenis infestations from 2,014 shrimp collected from 26 stations in 5 Oregon estuaries to test these alternative hypotheses. We expected greater infestation frequencies among females than among males and a close association of O. griffenis infestations with intersex shrimp in the overall population if feminization occurs. We also expected covariation in sex ratio with tide exposure if O. griffenis settlement is sex linked. Instead, we found an overall 1:1.07 sex ratio, a lack of association of intersex U. pugettensis with O. griffenis infestations, and an unchanging sex ratio with tidal exposure, precluding parasite induced sex change, male mortality, or tidal immersion effects on infestations. The most likely mechanism driving U. pugettensis declines thus remains castration due to host energetic losses. This energetic interaction is likely to be resolved quantitatively through controlled experiments and increasingly detailed field surveys over time

Development of a time-to-digital converter ASIC for the upgrade of the ATLAS Monitored Drift Tube detector

The upgrade of the ATLAS muon spectrometer for high-luminosity LHC requires new trigger and readout electronics for the various elements of the detector. We present the design of a time-to-digital converter (TDC) ASIC prototype for the ATLAS Monitored Drift Tube (MDT) detector. The chip was fabricated in a GlobalFoundries 130 nm CMOS technology. Studies indicate that its timing and power consumption characteristics meet the design specifications, with a timing bin variation of 40 ps for all 48 channels with a power consumption of about 6.5 mW per channel.Comment: 9 pages, 12 figure

Models of OH Maser Variations in U Her

Arecibo spectra of the mainline OH maser emission from U Her over more than a decade show variations of the OH emission over these time scales. These observations are combined with high spatial resolution VLBA maps to investigate the causes of the variations in the velocities of the maser components. Global properties of the dust shell, such as accelerations, variations in the pump and shell-wide magnetic field changes are examined as possibilities, and eliminated. A possible solution to the problem involving plasma turbulence and the local magnetic field is introduced, and the relevant time scales of the turbulence are calculated. The turbulent velocity field yields time scales of the turbulence are calculated. The turbulent velocity field yields time scales that are too long (of order centuries), while the turbulent magnetic field produces variations on appropriate time scales of a few years. A line-of-sight model of the turbulence is developed and investigated. The complete exploration of this solution requires extensive theoretical and observational work. Possible avenues of investigation of the plasma turbulence model are presented.Comment: 23 pages, 17 figures, ApJ: accepted Sept, 199

Countermovement jump and squat jump force-time curve analysis in control and fatigue conditions

This study aimed to reanalyze previously published discrete force data from countermovement jumps (CMJs) and squat jumps (SJs) using statistical parametric mapping (SPM), a statistical method that enables analysis of data in its native, complete state. Statistical parametric mapping analysis of 1-dimensional (1D) force-time curves was compared with previous zero-dimensional (0D) analysis of peak force to assess sensitivity of 1D analysis. Thirty-two subjects completed CMJs and SJs at baseline, 15 minutes, 1, 24, and 48 hours following fatigue and control conditions in a pseudo random cross-over design. Absolute (CMJABS/SJABS) and time-normalized (CMJNORM/SJNORM) force-time data were analyzed using SPM 2-way repeated measures analysis of variance with significance accepted at α = 0.05. The SPM indicated a magnitude of difference between force-time data with main effects for time (p \u3c 0.001) and interaction (p \u3c 0.001) observed in CMJABS, SJABS, and SJNORM, whereas previously published 0D analysis reported no 2-way interaction in CMJ and SJ peak force. This exploratory research demonstrates the strength of SPM to identify changes between entire movement force-time curves. Continued development and use of SPM analysis techniques could present the opportunity for refined assessment of athlete fatigue and readiness with the analysis of complete force-time curves

Using inertial measurement units to quantify shoulder elevation after reverse total shoulder arthroplasty: a pilot study comparing goniometric measures captured clinically to inertial measures captured ‘in-the-wild’

Background: Reverse total shoulder arthroplasty (rTSA) is utilized for a variety of indications, but most commonly for patients with rotator cuff arthropathy. This procedure reduces pain, improves satisfaction, and increases clinically measured range of motion (ROM). However, traditional clinical ROM measurements captured via goniometer may not accurately represent ‘real-world’ utilization of ROM. In contrast, inertial measurement units (IMUs) are useful for establishing ROM outside the clinical setting. We sought to measure ‘real-world’ ROM after rTSA using IMUs. Methods: A previously validated IMU-based method for continuously capturing shoulder elevation was used to assess 10 individuals receiving rTSA (1M, 82 ± 5 years) and compared to a previously captured 10 healthy individuals (4M, 69 ± 20 years) without shoulder dysfunction. Control subject data were previously collected over 1 week of continuous use. Patients undergoing rTSA donned sensors for 1 week pre-rTSA, 6 weeks at 3 months post-rTSA following clearance to perform active-independent ROM, and 1 week at 1 year and 2 years post-rTSA. Shoulder elevation was computed continuously each day. Daily continuous elevation was broken into 5° angle ‘bins’ (eg, 0-5°, 5-10°, etc.) and converted to percentage of the total day. IMU-based outcome measures were ROM binned percent (as described previously) and maximum/average elevation each week. Clinical goniometric ROM and patient-reported outcome measures were also captured. Results: No differences existed between patient and healthy control demographics. While patients showed improvement in American Shoulder and Elbow Surgeon (ASES) score, pain score, and goniometric ROM, IMU-based average and maximum elevation were equal between control subjects and patients both pre- and post-rTSA. The percent of time spent above 90° was equal between cohorts pre-rTSA, rose significantly at 3 months post-rTSA, and returned to preoperative levels thereafter. Discussion: Although pain, satisfaction, and ROM measured clinically may improve following rTSA, real-world utilization of improved ROM was not seen herein. Improvements during the acute rehabilitation phase may be transient, indicating longer or more specific rehabilitation protocols are necessary to see chronic improvements in post-rTSA movement patterns

Repository Metadata: Approaches and Challenges

Many institutional repositories have pursued a mixed metadata environment, relying on description by multiple workflows. Strategies may include metadata converted from other systems, metadata elicited from the document creator or manager, and metadata created by library or repository staff. Additional editing or proofing may or may not occur. The mixed environment brings challenges of creation, management, and access. In this article, repository efforts at three major universities are discussed. All three repositories run on the DSpace software package, and the opportunities and limitations of that system will be examined. The authors discuss local strategies in light of current thinking on metadata creation, user behavior, and the aggregation of heterogeneous metadata. The contrasts between the mission of each repository effort will show the importance of local customization, while the experience of all three institutions forms the basis for recommendations on strategies of benefit to a wide range of librarians and repository planners