La tecnología en Tolombón : nuevas contribuciones al estudio de las sociedades tardías del NOA

En este trabajo se presentan los resultados de los análisis realizados sobre los materiales líticos recuperados en Tolombón, sitio ubicado en el extremo Norte del Valle de Yocavil, provincia de Salta. Esta investigación permite contribuir con nuevos aportes a varios temas y discusiones actuales de la arqueología del Noroeste argentino. Por un lado, la tecnología lítica de sociedades tardías e incas es un tema de creciente interés que se está instalando en la agenda permitiendo aportar líneas de investigación independientes acerca de la producción, el consumo y el intercambio. Paralelamente los estudios tecnológicos contribuyen a la caracterización de estas sociedades cuya estratificación social se está replanteando en la actualidad. Por último, este trabajo brinda nueva información acerca de uno de los sitios más significativos de la historia cultural del NOA.In this paper, the results of analysis made to the lithic material record from Tolombón site located at north of the Yocavil valley are presented. This research permits to contribute with new information to different themes and current discussions of the Norwest argentine’s archaeology. From one side, lithic technology from Inca and Late-Period societies is a topic of increase interest that is being installed in the agenda permitting to develop independent lines of inquiry about production, consume and exchange. In parallel, technological studies contribute to characterize these societies while at present its social stratification is being discussed and finally, this paper offers new information about one of the most important site of the cultural development from Argentine’s Norwest.Fil: Chaparro, María Gabriela. Universidad Nacional del Centro de la Provincia de Buenos Aire

Nuevas formas informativas: el periodismo de datos y su enseñanza en el contexto universitario

Data journalism is a journalistic specialization which is growing by the hand of Information and Communications Technology. In this descriptive research we will explain what this concept exactly is, what its historical roots are and we will see some examples made to their guidelines. In addition, we will pay attention at the main masters and postgraduate courses, in Spain and in other countries, which include it in their curricula. We will observe how Spanish educational offer in this area is insufficient.El periodismo de datos es una especialización periodística pujante, que está creciendo de la mano de las Tecnologías de la Información y la Comunicación. En este estudio descriptivo explicaremos en qué consiste exactamente este concepto, cuáles son sus raíces históricas y veremos algunos ejemplos elaborados según sus directrices. Además, nos detendremos en los principales másteres y posgrados, tanto españoles como extranjeros, que lo incluyen en sus planes de estudio. Observaremos cómo la oferta educativa española resulta insuficiente en este terreno

Revisión del mito geográfico de San Borondón y aproximación a su huella en la literatura y otras artes

Since in the sixth century Irish monk St. Brendan forged the myth of San Borondón, this imaginary territory has been part of hundreds of stories of travelers and different artistic expressions. In this paper we will make a tour of its origin and the speeches of travelers because, especially between the sixteenth and nineteenth centuries, they helped to social consolidation of this mysterious island of Canary Islands. In addition, we will study how the myth was reflected in Spanish literary works from different genres as well as other types of artistic representations, such as music.Desde que en siglo VI el monje irlandés San Brandán fraguó el mito de San Borondón, este territorio imaginario ha formado parte de cientos de historias de viajeros y de diferentes manifestaciones artísticas. En este trabajo realizaremos un recorrido por su origen y los discursos de los viajeros que, especialmente entre los siglos XVI y XIX, ayudaron en la consolidación social de esta isla misteriosa del archipiélago canario. Además, estudiaremos cómo se ha plasmado el mito en obras literarias españolas de diferentes géneros, así como en otros tipos de representaciones artísticas, como la música

Using MCD-DVS for dynamic thermal management performance improvement

With chip temperature being a major hurdle in microprocessor design, techniques to recover the performance loss due to thermal emergency mechanisms are crucial in order to sustain performance growth. Many techniques for power reduction in the past and some on thermal management more recently have contributed to alleviate this problem. Probably the most important thermal control technique is dynamic voltage and frequency scaling (DVS) which allows for almost cubic reduction in power with worst-case performance penalty only linear. So far, DVS techniques for temperature control have been studied at the chip level. Finer grain DVS is feasible if a globally-asynchronous locally-synchronous (GALS) design style is employed. GALS, also known as multiple-clock domain (MCD), allows for an independent voltage and frequency control for each one of the clock domains that are part of the chip. There are several studies on DVS for GALS that aim to improve energy and power efficiency but not temperature. This paper proposes and analyses the usage of DVS at the domain level to control temperature in a clustered MCD microarchitecture with the goal of improving the performance of applications that do not meet the thermal constraints imposed by the designers.Peer ReviewedPostprint (published version

Autoimmune pancreatitis in patients with inflammatory bowel disease: A real-world multicentre collaborative ECCO CONFER study

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si lo hubiere, y los autores pertenecientes a la UAMAutoimmune pancreatitis [AIP] is rarely associated with inflammatory bowel disease [IBD]. The long-term outcomes of AIP and IBD in patients with coexisting AIP–IBD and predictors of complicated AIP course have rarely been reported. Methods: An ECCO COllaborative Network For Exceptionally Rare case reports project [ECCO-CONFER] collected cases of AIP diagnosed in patients with IBD. Complicated AIP was defined as a composite of endocrine and/or exocrine pancreatic insufficiency, and/or pancreatic cancer. We explored factors associated with complicated AIP in IBD. Results: We included 96 patients [53% males, 79% ulcerative colitis, 72% type 2 AIP, age at AIP diagnosis 35 ± 16 years]. The majority of Crohn’s disease [CD] cases [78%] had colonic/ileocolonic involvement. In 59%, IBD preceded AIP diagnosis, whereas 18% were diagnosed simultaneously. Advanced therapy to control IBD was used in 61% and 17% underwent IBD-related surgery. In total, 82% of patients were treated with steroids for AIP, the majority of whom [91%] responded to a single course of treatment. During a mean follow-up of 7 years, AIP complications occurred in 25/96 [26%] individuals. In a multivariate model, older age at AIP diagnosis was associated with a complicated AIP course (odds ratio [OR] = 1.05, p = 0.008), whereas family history of IBD [OR = 0.1, p = 0.03], and CD diagnosis [OR = 0.2, p = 0.04] decreased the risk of AIP complications. No IBD- or AIP-related deaths occurred. Conclusions: In this large international cohort of patients with concomitant AIP–IBD, most patients have type 2 AIP and colonic IBD. AIP course is relatively benign and long-term outcomes are favourable, but one-quarter develop pancreatic complications. Age, familial history of IBD, and CD may predict uncomplicated AIP cours

Understanding the thermal implications of multicore architectures

Multicore architectures are becoming the main design paradigm for current and future processors. The main reason is that multicore designs provide an effective way of overcoming instruction-level parallelism (ILP) limitations by exploiting thread-level parallelism (TLP). In addition, it is a power and complexity-effective way of taking advantage of the huge number of transistors that can be integrated on a chip. On the other hand, today's higher than ever power densities have made temperature one of the main limitations of microprocessor evolution. Thermal management in multicore architectures is a fairly new area. Some works have addressed dynamic thermal management in bi/quad-core architectures. This work provides insight and explores different alternatives for thermal management in multicore architectures with 16 cores. Schemes employing both energy reduction and activity migration are explored and improvements for thread migration schemes are proposed.Peer ReviewedPostprint (published version

Magnetic parameters as proxies for anthropogenic pollution in water reservoir sediments from Mexico: an interdisciplinary approach

We assess the element pollution level of water reservoir sediments using environmental magnetism techniques as a novel approach. Although “La Purísima” Water Reservoir is an important source for multiple activities (e.g. recreational, fishing and agricultural) in Guanajuato state, it has been receiving for the last centuries a high load of pollutants by mining extraction, urbanization and land-use change from the Guanajuato Hydrological Basin. The analyses of environmental magnetism, geochemistry, X-ray energy dispersive spectroscopy, scanning electron microscopy and multivariate methods were applied to study sediments from the reservoir and basin. Accordingly, they indicate the presence of iron oxides (magnetite and hematite) and iron sulfides (pyrite and greigite), which evidences relevant differences in particle size and concentration within the water reservoir (median mass-specific magnetic susceptibility χ = 23.2 × 10−8 m3/kg), as well as with respect to the river basin sediments (median χ = 88.8 × 10−8 m3/kg). The highest enrichment factor EF values (median values of EF = 2–10 for As, Co, Ba, Cu, Cd, Ni and EF > 20 for S) are mainly associated with historical mining activities that have led to an enrichment of potentially toxic elements on these water reservoir sediments. We propose the use of concentration and grain size dependent magnetic parameters, i.e. χ, remanent magnetizations and anhysteretic ratios ARM/SIRM and χARM/χ, as proxies for Ba, Co, Cr, Ni, P and Pb pollution in these river and water reservoir sediments. Such parameters allow to evaluate this sedimentary environment, and similar ones, through useful and convenient proxies.Fil: Chaparro, Marcos Adrián Eduardo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; ArgentinaFil: Ramírez Ramírez, Margarita. Universidad de Guanajuato. División Ciencias de la Vida; MéxicoFil: Chaparro, Mauro Alejandro Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; ArgentinaFil: Miranda Avilés, Raúl. Universidad de Guanajuato; MéxicoFil: Puy Alquiza, María Jesús. Universidad de Guanajuato; MéxicoFil: Böhnel, Harald N.. Universidad Nacional Autónoma de México. Centro de Geociencias; MéxicoFil: Zanor, Gabriela Ana. Universidad de Guanajuato. División Ciencias de la Vida; Méxic

Anti‑TNF agents and new biological agents (Vedolizumab and Ustekinumab) in the prevention and treatment of postoperative recurrence after surgery in crohn’s disease

Surgery for Crohn’s disease (CD) is not curative, as postoperative recurrence (POR) after ileocolonic resection is the rule in the absence of prophylactic treatment. In the present article, we critically review available data on the role of anti-tumour necrosis factor (TNF) agents and new biologics (including vedolizumab and ustekinumab) in the prevention and treatment of POR after surgery in CD. Several studies (summarised in various meta-analyses) have confrmed the efcacy of anti-TNFs in the prevention of POR. We identifed 37 studies, including 1863 CD patients, with mean endoscopic POR at 6–12 months of 29%. Only few randomised controlled trials (RCTs) have directly compared thiopurines and anti-TNFs, with controversial results, although the superiority of the latter is supported by several meta-analyses. Infiximab and adalimumab seem equally efective. The combination of anti-TNFs and immunosuppressives should be considered in patients previously exposed to anti-TNFs. Several studies have shown that anti-TNFs remain an efective option to prevent POR also in patients with anti-TNF failure before surgery. In fact, the use of the same anti-TNF before and after surgery might be efective for the prevention of POR. Prophylactic anti-TNF treatment, once started, should be continued long term. Anti-TNFs are also efective for the treatment of established POR. Retreatment with anti-TNFs for POR is a valid strategy even after their preoperative failure. In six studies (including 156 patients) evaluating vedolizumab, mean endoscopic POR at 6–12 months was 41%. The non-randomised comparison of anti-TNFs and vedolizumab has provided controversial results. One placebo-controlled RCT confrmed that vedolizumab is quite efective in preventing POR in CD patients with increased risk of recurrence. Seven studies (including 162 patients) evaluated ustekinumab, with a mean endoscopic POR at 6–12 months of 41%. The comparative efcacy of ustekinumab and anti-TNFs is still unclear. Ustekinumab and vedolizumab seem to be equally efective, although the experience is very limited. In conclusion, to date, anti-TNFs are the most efective agents in preventing and treating POR in CD. Anti-TNFs remain an efective option to prevent POR also in patients with anti-TNF failure before surgery. Vedolizumab seems to be quite efective in the prevention of POR in patients with increased risk of recurrence. Ustekinumab is probably also efective in the postoperative setting, although the comparative efcacy with anti-TNFs or vedolizumab is still unclea