Fabrication of hierarchical macroporous biocompatible scaffolds by combining Pickering high internal phase emulsion templates with three-dimensional printing

Biocompatible and biodegradable porous scaffolds with adjustable pore structure have aroused increasing interest in bone tissue engineering. Here, we report a facile method to fabricate hierarchical macroporous biocompatible (HmPB) scaffolds by combining Pickering high internal phase emulsion (HIPE) templates with three-dimensional (3D) printing. HmPB scaffolds composed of a polymer matrix of poly(L-lactic acid), PLLA, and poly(ε-caprolactone), PCL, are readily fabricated by solvent evaporation of 3D printed Pickering HIPEs which are stabilized by hydrophobically modified silica nanoparticles (h-SiO2). The pore structure of HmPB scaffolds is easily tailored to be similar to natural extracellular matrix (ECM) by varying the fabrication conditions of the Pickering emulsion or adjusting the printing parameters. In addition, in vivo drug release studies which employ enrofloxacin (ENR) as a model drug indicate the potential of HmPB scaffolds as a drug carrier. Furthermore, in vivo cell culture assays prove that HmPB scaffolds possesses good biocompatibility as mouse bone mesenchymal stem cells (mBMSCs) can adhere and proliferate well on them. All the results suggest that HmPB scaffolds hold great potential in bone tissue engineering applications

The Impact of Casing Damage Critical Condition on Marker Bed With Differential Internal and External Pressure in Daqing Oilfield

During long-term development of Daqing oilfield of marker bed has been affected sliding between layers, causing a large area of casing damage. The marker bed casing damage mechanism has been basically clear at present, but the influencing factors of casing damage are not yet consummate. There is fluid impact of pressure on the casing on the marker bed, and fluid pressure on the critical conditions of casing damage has not yet been carried out in research. To research the critical conditions, taking into account the mechanics characteristics of the formation and elastic-plastic the finite element model has been established, and different sets of pressure differential as critical condition impact on casing damage were studied in this paper. The results showed that the internal and external casing liquid pressure difference has little effect on the formation of critical slippage. High internal casing pressure wells, with small casing damage critical slippage, are more likely to damage

LightSpeed: Light and Fast Neural Light Fields on Mobile Devices

Real-time novel-view image synthesis on mobile devices is prohibitive due to the limited computational power and storage. Using volumetric rendering methods, such as NeRF and its derivatives, on mobile devices is not suitable due to the high computational cost of volumetric rendering. On the other hand, recent advances in neural light field representations have shown promising real-time view synthesis results on mobile devices. Neural light field methods learn a direct mapping from a ray representation to the pixel color. The current choice of ray representation is either stratified ray sampling or Plucker coordinates, overlooking the classic light slab (two-plane) representation, the preferred representation to interpolate between light field views. In this work, we find that using the light slab representation is an efficient representation for learning a neural light field. More importantly, it is a lower-dimensional ray representation enabling us to learn the 4D ray space using feature grids which are significantly faster to train and render. Although mostly designed for frontal views, we show that the light-slab representation can be further extended to non-frontal scenes using a divide-and-conquer strategy. Our method offers superior rendering quality compared to previous light field methods and achieves a significantly improved trade-off between rendering quality and speed.Comment: Project Page: http://lightspeed-r2l.github.io/ . Add camera ready versio

Metabolic dynamics and physiological adaptation of Panax ginseng during development

Being an essential Oriental medicinal plant, ginseng (Panax ginseng Meyer) is a slow-growing perennial herb-accumulating pharmaceutically active metabolites such as ginsenosides in roots during growth. However, little is known about how ginseng plants survive in the harsh environments such as winter cold and summer heat for a longer period and accumulates those active metabolites as the plant grows. To understand the metabolic kinetics in both source and sink organs such as leaves and roots of ginseng plant, respectively, and to assess the changes in ginsenosides biosynthesis during ginseng growth, we investigated the metabolic profiles from leaves and roots of 1-, 4-, and 6-year-old field-grown ginseng plants. Using an integrated non-targeted metabolomic approach, we identified in total 348 primary and secondary metabolites, which provided us for the first time a global metabolomic assessment of ginseng during growth, and morphogenesis. Strikingly, the osmoprotectants and oxidized chemicals were highly accumulated in 4- and 6-year-old ginseng leaves suggested that ginseng develop a wide range of metabolic strategies to adapt unfavorable conditions as they mature. In 6-year-old plants, ginsenosides were decreased in leaves but increased in roots up to 1.2- to sixfold, supporting the view that there is a long-distance transport of ginsenosides from leaves to roots as ginseng plants mature. Our findings provide insights into the metabolic kinetics during the development of ginseng plant and this could complement the pharmacological importance of ginseng and its compounds according to their age

Research of Seepage Flow Law of Tight Oil Reservoir in North Songliao Basin

Tight oil resources in north Songliao basin is rich and abundant, which is the most important energy sources foundation of Stable and raising oil production in Daqing oilfield. However, it is difficult to develop such oil resources by the regular ways and has no economic benefit for the poor reservoir property and thin reservoir thickness. Using the way of horizontal well by volume fracturing can reach the high oil production, which has showed good results up till now. But now tight oil in Daqing oilfield exploration and development is still in its infancy, the pore structure and seepage flow law of tight oil reservoir in north Songliao basin is not clear, which is potential barrier for exploring tight oil reservoirs effective development mode. Tight oil reservoir single phase and two phase fluid seepage rule are researched by means of theoretical and experimental, the results of which can provides a reliable theoretical basis for tight oil reservoir developed effectively

Routing and Spectrum Allocation in Spectrum-Sliced Elastic Optical Path Networks: A Primal-Dual Framework

The recent decade has witnessed a tremendous growth of Internet traffic, which is expected to continue climbing for the foreseeable future. As a new paradigm, Spectrum-sliced Elastic Optical Path (SLICE) networks promise abundant (elastic) bandwidth to address the traffic explosion, while bearing other inherent advantages including enhanced signal quality and extended reachability. The fundamental problem in SLICE networks is to route each traffic demand along a lightpath with continuously and consecutively available sub-carriers, which is known as the Routing and Spectrum Allocation (RSA) problem. Given its NP-Hardness, the solutions to the RSA problem can be classified into two categories: optimal solutions using link-based, path-based, and channel-based Integer Linear Programming (ILP) models, which require extensive computational time; and sub-optimal heuristic and meta-heuristic algorithms, which have no guarantee on the solution quality. In this work, inspired by a channel-based ILP model, we propose a novel primal-dual framework to address the RSA problem, which can obtain a near-optimal solution with guaranteed per-instance closeness to the optimal solution

Productivity Evaluation Method of Horizontal Well Volume Fracturing in Tight Oil Reservoir

Tight oil resources in north Songliao basin is rich and abundant, which is the most important energy sources foundation of stable and raising oil production in Daqing oil field. However, it is difficult to develop such oil resources by the regular ways for the poor reservoir property and thin reservoir thickness. Using the way of horizontal well by volume fracturing can increase contract area of well and the reservoir, improve reservoir flow performance and reach the high oil production, which has showed good results up till now. The accurate productivity evaluation of volume fracturing horizontal well is an important content of reservoir and production engineering field, which is also to develop solutions and decision-making basis. The current formula of horizontal well in low permeability reservoirs production did not consider the effect of seepage volume form fracturing, so it is poorly adapt to calculate the productivity of volume fracturing horizontal well. Based on the tight oil reservoir geological characteristics and seepage characteristics, equation are solved coupling with flow through fractures in the substrate, productivity prediction model is established and the innovation is based on considering horizontal well reservoir heterogeneity, fracturing scale and any artificial fracture distribution form, the results of which can provides a reliable theoretical basis for tight oil reservoir developed effectively

Tripping Friction Model for Multi-Stage Fracturing and Completion String in Horizontal Well

The structure of multi-stage fracturing completion string in horizontal well is complicated. The downhole tools such as packers and sliding sleeves whose dimensions are very close to the size of the borehole, and the completion string has strong stiffness as well. Thus, it leads to larger frictional restriction when running string. Based on the above reasons, it is essential to calculate the tripping capacity before the strings running into the well in case of sticking off. However, calculation errors of conventional string tripping models are relatively larger. This paper took the structure of multi-stage fracturing completion string into consideration, divided completion string by contact points between string and borehole to establish the stress and bending model of the string between two contact points, and established the tripping friction and hookload model for multi-stage fracturing completion string. An applied example of multi-stage fracturing horizontal well in Hong 90-1 block of Jilin Oil Field shows that the created model in the paper is more accurate. The accuracy of hookload while the string running in form curved section to bottom is 95.80%. The established model is more accurate and reliable. It can be used to estimate the tripping ability of the multi-stage fracturing completion string.Key words: Multistage fracturing; Tripping; Tripping friction; Mechanical mode