The First Sinomastodon (Gomphotheriidae, Proboscidea) Skull From the Quaternary in China

The first Sinomastodon (Gomphotheriidae, Proboscidea) skull of the Early Pleistocene, collected from the Renzidong Cave deposits in Anhui Province, Eastern China, is described here as S. jiangnanensis sp. nov. As the only brevirostrine trilophodont gomphotheriid known from the Old World, Sinomastodon was mainly indigenous to China from the Early Pliocene to the Pleistocene. Compared with a few single Pleistocene teeth previously found in China, S. jiangnanensis sp. nov. is represented by a relatively complete skull, mandible and dentition, which is the first discovery of a Quaternary Sinomastodon skull from China. With a brevirostrine, elephant-like skull, no lower tusks, and simple bunodont and trilophodont intermediate molars, the new species is morphologically distinct from other gomphotheres and should belong to the genus Sinomastodon. The new species is more progressive than S. hanjiangensis and the Pliocene type species S. intermedius in its skull and mandible morphology, but is evidently more primitive than the Pleistocene S. yangziensis in its molar morphology. The faunal analysis suggests that the emergence of S. jiangnanensis sp. nov. in Jiangnan area and its southward migration may have been related to a cooling event at the beginning of the Quaternary in Eastern China

The First Sinomastodon (Gomphotheriidae, Proboscidea) Skull From the Quaternary in China

The first Sinomastodon (Gomphotheriidae, Proboscidea) skull of the Early Pleistocene, collected from the Renzidong Cave deposits in Anhui Province, Eastern China, is described here as S. jiangnanensis sp. nov. As the only brevirostrine trilophodont gomphotheriid known from the Old World, Sinomastodon was mainly indigenous to China from the Early Pliocene to the Pleistocene. Compared with a few single Pleistocene teeth previously found in China, S. jiangnanensis sp. nov. is represented by a relatively complete skull, mandible and dentition, which is the first discovery of a Quaternary Sinomastodon skull from China. With a brevirostrine, elephant-like skull, no lower tusks, and simple bunodont and trilophodont intermediate molars, the new species is morphologically distinct from other gomphotheres and should belong to the genus Sinomastodon. The new species is more progressive than S. hanjiangensis and the Pliocene type species S. intermedius in its skull and mandible morphology, but is evidently more primitive than the Pleistocene S. yangziensis in its molar morphology. The faunal analysis suggests that the emergence of S. jiangnanensis sp. nov. in Jiangnan area and its southward migration may have been related to a cooling event at the beginning of the Quaternary in Eastern China

Strongly-coupled nanotube electromechanical resonators

Coupling an electromechanical resonator with carbon-nanotube quantum dots is a significant method to control both the electronic charge and the spin quantum states. By exploiting a novel micro-transfer technique, we fabricate two strongly-coupled and electrically-tunable mechanical resonators on a single carbon nanotube for the first time. The frequency of the two resonators can be individually tuned by the bottom gates, and strong coupling is observed between the electron charge and phonon modes of each resonator. Furthermore, the conductance of either resonator can be nonlocally modulated by the phonon modes in the other resonator. Strong coupling is observed between the phonon modes of the two resonators, which provides an effective long distance electron-electron interaction. The generation of phonon-mediated-spin entanglement is also theoretically analyzed for the two resonators. This strongly-coupled nanotube electromechanical resonator array provides an experimental platform for future studies of the coherent electron-phonon interaction, the phonon mediated long-distance electron interaction, and entanglement state generation

Energy-time Entanglement Coexisting with Fiber Optical Communication at Telecom C-band

The coexistence of quantum and classical light in the same fiber link is extremely desired in developing quantum communication. It has been implemented for different quantum information tasks, such as classical light coexisting with polarization-entangled photons at telecom O-band, and with quantum signal based quantum key distribution (QKD). In this work, we demonstrate the coexistence of energy-time entanglement based QKD and fiber optical communication at the telecom C-band. The property of noise from the classical channel is characterized with classical light at different wavelengths. With the largest noise, i.e., the worst case, the properties of energy-time entanglement are measured at different fiber optical communication rates. By measuring the two-photon interference of energy-time entanglement, our results show that a visibility of 82.01$\pm$1.10\% is achieved with a bidirectional 20 Gbps fiber optical communication over 40 km. Furthermore, by performing the BBM92 protocol for QKD, a secret key rate of 245 bits per second could be generated with a quantum bit error rate of 8.88\% with the coexisted energy-time entanglement.~Our demonstration paves the way for developing the infrastructure for quantum networks compatible with fiber optical communication.Comment: 6 pages, 3 figures

Demethylating agents in combination with CD7-targeted CAR-T for the successful treatment of a case with mixed-phenotype acute leukemia relapsed after allogeneic hematopoietic stem cell transplantation: A Case Report

BackgroundAllogeneic hematopoietic stem cell transplantation (allo-HSCT) has cured many patients with malignant hematologic diseases such as mixed phenotype acute leukemia (MPAL), while those relapsing after allo-HSCT still exhibit high mortality, poor prognosis, and no standard treatment modalities. It is necessary to explore more therapeutic modalities for patients with post-transplant relapse to obtain a better prognosis.Case presentationIn this case report, a young male with MPAL received allo-HSCT after reaching complete remission (CR) by induction chemotherapy. Unfortunately, relapse of both myeloid and T lineages occurred nine months later. After receiving demethylating chemotherapy, myeloid lineage measurable residual disease (MRD) turned negative. T-lineage MRD turned negative after CD7-targeted chimeric antigen receptor (CAR)-T cell therapy. The bone marrow remained MRD-negative for 4 months. This case preliminarily demonstrated a long-lasting CR with CD7-targeted CAR-T cell therapy, allowing a better prognosis.ConclusionDemethylating drugs combined with CD7-targeted CAR-T cell therapy is feasible in treating MPAL patients with relapse after transplantation, with good efficacy and safety, which will be a promising treatment option for MPAL

A simulation study on the measurement of D0-D0bar mixing parameter y at BES-III

We established a method on measuring the \dzdzb mixing parameter $y$ for BESIII experiment at the BEPCII $e^+e^-$ collider. In this method, the doubly tagged $\psi(3770) \to D^0 \overline{D^0}$ events, with one $D$ decays to CP-eigenstates and the other $D$ decays semileptonically, are used to reconstruct the signals. Since this analysis requires good $e/\pi$ separation, a likelihood approach, which combines the $dE/dx$, time of flight and the electromagnetic shower detectors information, is used for particle identification. We estimate the sensitivity of the measurement of $y$ to be 0.007 based on a $20fb^{-1}$ fully simulated MC sample.Comment: 6 pages, 7 figure

Antiviral Therapy and Outcomes of Patients with Pneumonia Caused by Influenza A Pandemic (H1N1) Virus

There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when the treatment was administered more than 48 hours after symptom onset.During the pandemic in 2009, a cohort of pH1N1 influenza pneumonia was built in China, and their clinical information was collected systematically, and analyzed with Cox models.<200, oseltamivir administration reduced the mortality risk by 92.1%, 88% and 83.5%, respectively. Higher doses of oseltamivir (>3.8 mg/kg/d) did not improve clinical outcome (mortality, higher dose 2.5% vs standard dose 2.8%, p>0.05).<200

Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits

Understanding the genetic changes underlying phenotypic variation in sheep (Ovis aries) may facilitate our efforts towards further improvement. Here, we report the deep resequencing of 248 sheep including the wild ancestor (O. orientalis), landraces, and improved breeds. We explored the sheep variome and selection signatures. We detected genomic regions harboring genes associated with distinct morphological and agronomic traits, which may be past and potential future targets of domestication, breeding, and selection. Furthermore, we found non-synonymous mutations in a set of plausible candidate genes and significant differences in their allele frequency distributions across breeds. We identified PDGFD as a likely causal gene for fat deposition in the tails of sheep through transcriptome, RT-PCR, qPCR, and Western blot analyses. Our results provide insights into the demographic history of sheep and a valuable genomic resource for future genetic studies and improved genome-assisted breeding of sheep and other domestic animals