Microbial Air Contamination in an Intensive Care Unit

Unit layout affects every aspect of intensive care services, including patient safety. A previous study has shown that patients admitted to beds adjacent to the sink and to the door of a large bayroom had the highest number of positive blood cultures and the highest blood culture incidence density, respectively. The present study measures microbial air contamination in a medical intensive care unit of a medical center in central Taiwan. Of the 17 rooms, 8 rooms with distinct physical environmental characteristics were selected. Sampling tests were conducted between December 2013 and February 2014 with a microbial air sampler (MAS-100NT). TSA was used for bacteria collection and DG18 for fungi collection. The overall average bacterial and fungal concentrations were 83CFU/m3 and 69CFU/m3, respectively. The ranges were between 8-354 CFU/m3 and 0-1468 CFU/m3, respectively. A significant difference was found in the bacterial concentration (p=.005) between different room locations. The highest concentration was found in the rooms located at the front end of the circulation (99 CFU/m3), while the lowest was found in the rooms located at the rear end of the circulation (55CFU/m3). Differences in fungal concentrations for different room locations did not reach statistical significance. In addition, differences in bacterial and fungal concentrations for rooms with different sink locations did not reach statistical significance. Even though the microbial concentrations generally complied with standards, the results may help designers and hospital administrators develop a healthier environment for patients

Very Old Isolated Compact Objects as Dark Matter Probes

Very old isolated neutron stars and white dwarfs have been suggested to be probes of dark matter. To play such a role, two requests should be fulfilled, i.e., the annihilation luminosity of the captured dark matter particles is above the thermal emission of the cooling compact objects (request-I) and also dominate over the energy output due to the accretion of normal matter onto the compact objects (request-II). Request-I calls for very dense dark matter medium and the critical density sensitively depends on the residual surface temperature of the very old compact objects. The accretion of interstellar/intracluster medium onto the compact objects is governed by the physical properties of the medium and by the magnetization and rotation of the stars and may outshine the signal of dark matter annihilation. Only in a few specific scenarios both requests are satisfied and the compact objects are dark matter burners. The observational challenges are discussed and a possible way to identify the dark matter burners is outlined.Comment: 9 pages including 1 Figure, to appear in Phys. Rev.

Morphological variation of the foraminifer Ammonia beccarii (Linné) from the Atlantic coast of the United States

24 p., 4 fig.http://paleo.ku.edu/contributions.htm

Carrier multiplication yields in PbS and PbSe nanocrystals measured by transient photoluminescence

We report here an assessment of carrier multiplication (CM) yields in PbSe and PbS nanocrystals (NCs) by a quantitative analysis of biexciton and exciton dynamics in transient photoluminescence decays. Interest in CM, the generation of more than one electron and hole in a semiconductor after absorption of one photon, has renewed in recent years because of reports suggesting greatly increased efficiencies in nanocrystalline materials compared to the bulk form, in which CM was otherwise too weak to be of consequence in photovoltaic energy conversion devices. In our PbSe and PbS NC samples, however, we estimate using transient photoluminescence that at most 0.25 additional e-h pairs are generated per photon even at energies hv > 5Eg, instead of the much higher values reported in the literature. We argue by comparing NC CM estimates and reported bulk values on an absolute energy basis, which we justify as appropriate on physical grounds, that the data reported thus far are inconclusive with respect to the importance of nanoscale-specific phenomena in the CM process.Comment: 10 pages, 7 figure

Locality of not-so-weak coloring

Many graph problems are locally checkable: a solution is globally feasible if it looks valid in all constant-radius neighborhoods. This idea is formalized in the concept of locally checkable labelings (LCLs), introduced by Naor and Stockmeyer (1995). Recently, Chang et al. (2016) showed that in bounded-degree graphs, every LCL problem belongs to one of the following classes: - "Easy": solvable in $O(\log^* n)$ rounds with both deterministic and randomized distributed algorithms. - "Hard": requires at least $\Omega(\log n)$ rounds with deterministic and $\Omega(\log \log n)$ rounds with randomized distributed algorithms. Hence for any parameterized LCL problem, when we move from local problems towards global problems, there is some point at which complexity suddenly jumps from easy to hard. For example, for vertex coloring in $d$-regular graphs it is now known that this jump is at precisely $d$ colors: coloring with $d+1$ colors is easy, while coloring with $d$ colors is hard. However, it is currently poorly understood where this jump takes place when one looks at defective colorings. To study this question, we define $k$-partial $c$-coloring as follows: nodes are labeled with numbers between $1$ and $c$, and every node is incident to at least $k$ properly colored edges. It is known that $1$-partial $2$-coloring (a.k.a. weak $2$-coloring) is easy for any $d \ge 1$. As our main result, we show that $k$-partial $2$-coloring becomes hard as soon as $k \ge 2$, no matter how large a $d$ we have. We also show that this is fundamentally different from $k$-partial $3$-coloring: no matter which $k \ge 3$ we choose, the problem is always hard for $d = k$ but it becomes easy when $d \gg k$. The same was known previously for partial $c$-coloring with $c \ge 4$, but the case of $c < 4$ was open

GPER-induced signaling is essential for the survival of breast cancer stem cells.

G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs than non-BCSCs of three patient-derived xenografts of ER- /PR+ breast cancers. GPER silencing reduced stemness features of BCSCs as reflected by reduced mammosphere forming capacity in vitro, and tumor growth in vivo with decreased BCSC populations. Comparative phosphoproteomics revealed greater GPER-mediated PKA/BAD signaling in BCSCs. Activation of GPER by its ligands, including tamoxifen (TMX), induced phosphorylation of PKA and BAD-Ser118 to sustain BCSC characteristics. Transfection with a dominant-negative mutant BAD (Ser118Ala) led to reduced cell survival. Taken together, GPER and its downstream signaling play a key role in maintaining the stemness of BCSCs, suggesting that GPER is a potential therapeutic target for eradicating BCSCs