Modulation of Drosophila Retinal Epithelial Integrity by the Adhesion Proteins Capricious and Tartan

Background The development of the Drosophila eye imaginal disc requires complex epithelial rearrangements. Cells of the morphogenetic furrow are apically constricted and this leads to a physical indentation in the epithelium. Posterior to the furrow, cells start to rearrange into distinct clusters and eventually form a precisely patterned array of ommatidia. These morphogenetic processes include regulated changes of adhesion between cells. Methodology/Principal Findings Here, we show that two transmembrane adhesion proteins, Capricious and Tartan, have dynamic and complementary expression patterns in the eye imaginal disc. We also describe novel null mutations in capricious and double null mutations in capricious and tartan. We report that they have redundant functions in regulating the architecture of the morphogenetic furrow and ommatidial spacing. Conclusions/Significance We conclude that Capricious and Tartan contribute to the adhesive properties of the cells in the morphogenetic furrow and that this regulated adhesion participates in the control of spacing ommatidial clusters

Estadísticas de juego en balonmano masculino en los Juegos Olímpicos (2004-2016): Diferencias y poder discriminatorio

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesHandball can be considered a complex game. Sports performance analysis is a relevant topic for scientists and coaches. The objectives of the present study were: (i) to compare handball game-related statistics by match outcome (winning and losing teams) and (ii) to identify characteristics that discriminate the performance in elite men's handball. The game-related statistics of the 324 games played in the last four Olympic Games (Athens, Greece, 2004; Beijing, China, 2008; London, United Kingdom, 2012; and Rio de Janeiro, Brazil, 2016) were analyzed. Differences between match outcomes (winning or losing teams) were determined by using the chi-squared statistic, and by calculating the effect sizes of the differences. A discriminant analysis was then performed applying the sample-splitting method according to match outcomes. The results showed that the differences between winning and losing teams were shots, 9 m shots, assists, goalkeeper-blocked shots fast break. Also, discriminant analysis selected four variables (shots, goalkeeper-blocked shots, technical foul, and attacks) that classified correctly 82% of matches (Wilks's lambda=0.575; canonical correlation index 0.652). The selected variables included offensive and defensive predictors: Shots, goalkeeper-blocked shots, technical foul, attacks. Coaches and players can use these results as a reference against which to assess their performance and plan their team's training.Resumen. El balonmano puede considerarse un juego complejo. El análisis del rendimiento deportivo es un tópico relevante para los científicos y entrenadores. Los objetivos del presente estudio fueron: (i) comparar las estadísticas de juego en balonmano en función del contexto (equipos ganadores y perdedores) e (ii) identificar las estadísticas que discriminan el rendimiento en el balonmano masculino de élite. Se analizaron las estadísticas de juego de los 324 partidos disputados en los últimos cuatro Juegos Olímpicos (Atenas, Grecia, 2004, Beijing, China, 2008, Londres, Reino Unido, 2012 y Río de Janeiro, Brasil, 2016). Las diferencias entre los equipos ganadores y perdedores) se determinaron usando el estadístico chi-cuadrado y calculando los tamaños del efecto de las diferencias. A continuación, se realizó un análisis discriminante aplicando el método de por pasos. Los resultados mostraron que las diferencias entre los equipos vencedores y perdedores se presentaron en las variables lanzamientos de 9 m, asistencias, lanzamientos bloqueados por el portero en situación de contrataque. Además, el análisis discriminante seleccionó cuatro variables (lanzamientos, lanzamientos bloqueados por el portero, falta técnica y número de ataques) que clasificaron correctamente el 82% de los partidos (Lambda de Wilks=0,575; índice de correlación canónica=0,652). Las variables seleccionadas incluyeron predictores ofensivos y defensivos: lanzamientos, paradas del portero, faltas técnicas y ataques. Los entrenadores y los jugadores pueden utilizar estos resultados como referencia para evaluar su rendimiento y planificar el entrenamiento del equipo. Palabras clave: análisis notacional, rendimiento, partido, lanzamiento, portero

Autonomous GN and C for Spacecraft Exploration of Comets and Asteroids

A spacecraft guidance, navigation, and control (GN&C) system is needed to enable a spacecraft to descend to a surface, take a sample using a touch-and-go (TAG) sampling approach, and then safely ascend. At the time of this reporting, a flyable GN&C system that can accomplish these goals is beyond state of the art. This article describes AutoGNC, which is a GN&C system capable of addressing these goals, which has recently been developed and demonstrated to a maturity TRL-5-plus. The AutoGNC solution matures and integrates two previously existing JPL capabilities into a single unified GN&C system. The two capabilities are AutoNAV and GREX. AutoNAV is JPL s current flight navigation system, and is fairly mature with respect to flybys and rendezvous with small bodies, but is lacking capability for close surface proximity operations, sampling, and contact. G-REX is a suite of low-TRL algorithms and capabilities that enables spacecraft operations in close surface proximity and for performing sampling/contact. The development and integration of AutoNAV and G-REX components into AutoGNC provides a single, unified GN&C capability for addressing the autonomy, close-proximity, and sampling/contact aspects of small-body sample return missions. AutoGNC is an integrated capability comprising elements that were developed separately. The main algorithms and component capabilities that have been matured and integrated are autonomy for near-surface operations, terrain-relative navigation (TRN), real-time image-based feedback guidance and control, and six degrees of freedom (6DOF) control of the TAG sampling event. Autonomy is achieved based on an AutoGNC Executive written in Virtual Machine Language (VML) incorporating high-level control, data management, and fault protection. In descending to the surface, the AutoGNC system uses camera images to determine its position and velocity relative to the terrain. This capability for TRN leverages native capabilities of the original AutoNAV system, but required advancements that integrate the separate capabilities for shape modeling, state estimation, image rendering, defining a database of onboard maps, and performing real-time landmark recognition against the stored maps. The ability to use images to guide the spacecraft requires the capability for image-based feedback control. In Auto- GNC, navigation estimates are fed into an onboard guidance and control system that keeps the spacecraft guided along a desired path, as it descends towards its targeted landing or sampling site. Once near the site, AutoGNC achieves a prescribed guidance condition for TAG sampling (position/orientation, velocity), and a prescribed force profile on the sampling end-effector. A dedicated 6DOF TAG control then implements the ascent burn while recovering from sampling disturbances and induced attitude rates. The control also minimizes structural interactions with flexible solar panels and disallows any part of the spacecraft from making contact with the ground (other than the intended end-effector)

Mid-Rapidity Direct-Photon Production in p+p Collisions at sqrt(s) = 200 GeV

A measurement of direct photons in p+p collisions at sqrt(s)=200 GeV is presented. A photon excess above background from pi^0 --> gamma+gamma, eta --> gamma+gamma, and other decays is observed in the transverse momentum range 5.5 < p_T < 7 GeV/c. The result is compared to a next-to-leading-order perturbative QCD calculation. Within errors, good agreement is found between the QCD calculation and the measured result.Comment: 330 authors, 7 pages text, RevTeX, 2 figures, 2 tables. Submitted to Physical Review D. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Deuteron and antideuteron production in Au+Au collisions at sqrt(s_NN)=200 GeV

The production of deuterons and antideuterons in the transverse momentum range 1.1 < p_T < 4.3 GeV/c at mid-rapidity in Au + Au collisions at sqrt(s_NN)=200 GeV has been studied by the PHENIX experiment at RHIC. A coalescence analysis comparing the deuteron and antideuteron spectra with those of protons and antiprotons, has been performed. The coalescence probability is equal for both deuterons and antideuterons and increases as a function of p_T, which is consistent with an expanding collision zone. Comparing (anti)proton yields p_bar/p = 0.73 +/- 0.01, with (anti)deuteron yields: d_bar/d = 0.47 +/- 0.03, we estimate that n_bar/n = 0.64 +/- 0.04.Comment: 326 authors, 6 pages text, 5 figures, 1 Table. Submitted to PRL. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Suppressed pi^0 Production at Large Transverse Momentum in Central Au+Au Collisions at sqrt(s_NN) = 200 GeV

Transverse momentum spectra of neutral pions in the range 1 < p_T < 10 GeV/c have been measured at mid-rapidity by the PHENIX experiment at RHIC in Au+Au collisions at sqrt(s_NN) = 200 GeV. The pi^0 multiplicity in central reactions is significantly below the yields measured at the same sqrt(s_NN) in peripheral Au+Au and p+p reactions scaled by the number of nucleon-nucleon collisions. For the most central bin, the suppression factor is ~2.5 at p_T = 2 GeV/c and increases to ~4-5 at p_T ~= 4 GeV/c. At larger p_T, the suppression remains constant within errors. The deficit is already apparent in semi-peripheral reactions and increases smoothly with centrality.Comment: 326 authors, 6 pages text, RevTeX, 3 figures, 2 tables. Submitted to PRL. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

High transverse momentum eta meson production in p+p, d+Au and Au+Au collisions at sqrt(s_NN) = 200 GeV

Inclusive transverse momentum spectra of eta mesons in the range p_T~2-12 GeV/c have been measured at mid-rapidity (|\eta| < 0,35) by the PHENIX experiment at RHIC in p+p, d+Au and Au+Au collisions at sqrt(s_NN) = 200 GeV. The eta mesons are reconstructed through their eta--> \gamma\gamma channel for the three colliding systems as well as through the eta-->pi^0 pi+ pi- decay mode in p+p and d+Au collisions. The nuclear modification factor in d+Au collisions, R_dAu(p_T~1.0-1.1, suggests at most only modest p_T broadening ("Cronin enhancement"). In central Au+Au reactions, the eta yields are significantly suppressed, with R_AuAu(pT)~0.2. The ratio of eta to pi^0 yields is approximately constant as a function of p_T for the three colliding systems in agreement with the high-p_T world average of R_eta/pi^0 \approx 0.5 in hadron-hadron, hadron-nucleus, and nucleus-nucleus collisions for a wide range of center-of-mass energies [sqrt(s_NN)~3-1800 GeV] as well as, for high scaled momentum x_p, in e+e- annihilations at sqrt(s)=91.2 GeV. These results are consistent with a scenario where high-p_T eta production in nuclear collisions at RHIC is largely unaffected by initial-state effects, but where light-quark mesons (pi^0;eta) are equally suppressed due to final-state interactions of the parent partons in the dense medium produced in Au+Au reactions.Comment: 391 authors, NN pages text, RevTeX4, figures, tables. Submitted to Physical Review C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Scaling properties of proton and anti-proton production in sqrt(s_NN) = 200 GeV Au + Au collisions

We report on the yield of protons and anti-protons, as a function of centrality and transverse momentum, in Au+Au collisions at sqrt(s_NN) = 200 GeV measured at mid-rapidity by the PHENIX experiment at RHIC. In central collisions at intermediate transverse momenta (1.5 < p_T < 4.5 GeV/c) a significant fraction of all produced particles are protons and anti-protons. They show a centrality-scaling behavior different from that of pions. The p-bar/pion and p/pion ratios are enhanced compared to peripheral Au+Au, p+p, and electron+positron collisions. This enhancement is limited to p_T < 5 GeV/c as deduced from the ratio of charged hadrons to pi^0 measured in the range 1.5 < p_T < 9 GeV/c.Comment: 325 authors, 6 pages text, 4 figures, RevTeX 4. Minor changes to text and figures to meet PRL length restrictions; no changes to figures; resubmitted to PRL. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

A Detailed Study of High-pT Neutral Pion Suppression and Azimuthal Anisotropy in Au+Au Collisions at \sqrt{s_{NN}} = 200 GeV

Measurements of neutral pion production at midrapidity in sqrt(s_NN) = 200 GeV Au+Au collisions as a function of transverse momentum, p_T, collision centrality, and angle with respect to reaction plane are presented. The data represent the final pi^0 results from the PHENIX experiment for the first RHIC Au+Au run at design center-of-mass-energy. They include additional data obtained using the PHENIX Level-2 trigger with more than a factor of three increase in statistics over previously published results for p_T > 6 GeV/c. We evaluate the suppression in the yield of high-p_T pi^0's relative to point-like scaling expectations using the nuclear modification factor R_AA. We present the p_T dependence of R_AA for nine bins in collision centrality. We separately integrate R_AA over larger p_T bins to show more precisely the centrality dependence of the high-p_T suppression. We then evaluate the dependence of the high-p_T suppression on the emission angle \Delta\phi of the pions with respect to event reaction plane for 7 bins in collision centrality. We show that the yields of high-p_T pi^0's vary strongly with \Delta\phi, consistent with prior measurements. We show that this variation persists in the most peripheral bin accessible in this analysis. For the peripheral bins we observe no suppression for neutral pions produced aligned with the reaction plane while the yield of pi^0's produced perpendicular to the reaction plane is suppressed by more than a factor of 2. We analyze the combined centrality and \Delta\phi dependence of the pi^0 suppression in different p_T bins using different possible descriptions of parton energy loss dependence on jet path-length averages to determine whether a single geometric picture can explain the observed suppression pattern.Comment: 330 authors, pages text, RevTeX4, figures, tables. Submitted to Physical Review C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm