1,161 research outputs found
The Littlewood-Gowers problem
We show that if A is a subset of Z/pZ (p a prime) of density bounded away
from 0 and 1 then the A(Z/pZ)-norm (that is the l^1-norm of the Fourier
transform) of the characterstic function of A is bounded below by an absolute
constant times (log p)^{1/2 - \epsilon} as p tends to infinity. This improves
on the exponent 1/3 in recent work of Green and Konyagin.Comment: 31 pp. Corrected typos. Updated references
Perturbative neutrino pair creation by an external source
We consider the rate of fermion-antifermion pair creation by an external
field. We derive a rate formula that is valid for a coupling with arbitrary
vector and axial vector components to first order in perturbation theory. This
is then applied to study the creation of neutrinos by nuclear matter, a problem
with astrophysical relevance. We present an estimate for the creation rate per
unit volume, compare this to previous results and comment on the role of the
neutrino mass.Comment: 7 pages, 1 figure, REVTeX
Esculin hydrolysis negative and TcdA âonly producing strains of clostridium (Clostridiodes) difficile from the environment in Western Australia
Background and Aims
Clostridium (Clostridiodes) difficile clade 3 ribotype (RT) 023 strains that fail to produce black colonies on bioMĂ©rieux ChromID agar have been reported, as well as variant strains of C. difficile that produce only toxin A. We have recently isolated strains of C. difficile from the environment in Western Australia (WA) with similar characteristics. The objective of this study was to characterize these strains. It was hypothesized that a putative ÎČ-glucosidase gene was lacking in these strains of C. difficile, including RT 023, leading to white colonies.
Methods and Results
A total of 17 environmental isolates of C. difficile from garden soil and compost, and gardening shoe soles in Perth, WA, failed to produce black colonies on ChromID agar. MALDI-TOF MS analysis confirmed these strains as C. difficile. Four strains contained only a tcdA gene (A+BâCDTâ) by PCR and were a novel RT (QX 597). All isolates were susceptible to all antimicrobials tested except one with low-level resistance to clindamycin (MIC = 8 mg/L). The four tcdA-positive strains were motile. All isolates contained neither bgl locus but only bgl K or a putative ÎČ-glucosidase gene by PCR. Whole-genome sequencing showed the 17 strains belonged to novel multi-locus sequence types 632, 848, 849, 850, 851, 852 and 853, part of the evolutionarily divergent clade C-III. Four isolates carried a full-length tcdA but not tcdB nor binary toxin genes.
Conclusions
ChromID C. difficile agar is used for the specific detection of C. difficile in the samples. To date, all strains except RT 023 strains from clinical samples hydrolyse esculin. This is the first report to provide insights into the identification of esculin hydrolysis negative and TcdA-only producing (A+BâCDTâ) strains of C. difficile from environmental samples.
Significance and Impact of the Study
White colonies of C. difficile from environmental samples could be overlooked when using ChromID C. difficile agar, leading to false-negative results, however, whether these strains are truly pathogenic remains to be proven
The Molecular Basis of Selective Permeability of Connexins is Complex and Includes Both Size And Charge
Although gap junction channels are still widely viewed as large, non-specific pores connecting cells, the diversity in the connexin family has led more attention to be focused on their permeability characteristics. We summarize here the current status of these investigations, both published and on-going, that reveal both charge and size selectivity between gap junction channels composed of different connexins. In particular, this review will focus on quantitative approaches that monitor the expression level of the connexins, so that it is clear that differences that are seen can be attributed to channel properties. The degree of selectivity that is observed is modest compared to other channels, but is likely to be significant for biological molecules that are labile within the cell. Of particular relevance to the in vivo function of gap junctions, recent studies are summarized that demonstrate that the connexin phenotype can control the nature of the endogenous traffic between cells, with consequent effects on biological effects of gap junctions such as tumor suppression
Human Clostridium difficile infection caused by a livestock-associated PCR ribotype 237 strain in Western Australia
Introduction:
Clostridium difficile infection (CDI) is a significant gastrointestinal disease in the developed world and increasingly recognised as a zoonotic infection. In North America and Europe, the PCR ribotype (RT) 078 strain of C. difficile is commonly found in production animals and as a cause of disease in humans although proof of transmission from animals is lacking. This strain is absent in Australian livestock. We report a case of human CDI caused by a strain of C. difficile belonging to known Australian livestock-associated RT 237.
Case presentation:
A young male was admitted for multiple trauma following a motor vehicle accident and placed on piperacillin/tazobactam for pneumonia. After 4 days of treatment, he developed symptoms of CDI, which was confirmed in the laboratory. His symptoms resolved after 6 days of intravenous metronidazole. The strain of C. difficile isolated was identified as RT 237, an unusual RT previously found in with several Western Australia piggeries.
Conclusion:
This case of CDI caused by an unusual livestock-associated C. difficile RT 237 supports the hypothesis of zoonotic transmission. The case highlights the potential of livestock to act as reservoir for C. difficile and the need for continued surveillance of CDI in both human and animal populations
The Abundance of New Kind of Dark Matter Structures
A new kind of dark matter structures, ultracompact minihalos (UCMHs) was
proposed recently. They would be formed during the radiation dominated epoch if
the large density perturbations are existent. Moreover, if the dark matter is
made up of weakly interacting massive particles, the UCMHs can have effect on
cosmological evolution because of the high density and dark matter annihilation
within them. In this paper, one new parameter is introduced to consider the
contributions of UCMHs due to the dark matter annihilation to the evolution of
cosmology, and we use the current and future CMB observations to obtain the
constraint on the new parameter and then the abundance of UCMHs. The final
results are applicable for a wider range of dark matter parametersComment: 4 pages, 1 tabl
Suppression and enhancement of the critical current in multiterminal S/N/S mesoscopic structures
We analyse the measured critical current in a mesoscopic
4-terminal S/N/S structure. The current through the S/N interface is shown to
consist not only of the Josephson component but also a
phase-coherent part of the subgap current. The current
is determined by the both components and and depends
in a nonmonotonic way on the voltage between superconductors and normal
reservoirs reaching a maximum at . The obtained theoretical
resultas are in qualitative agreement with recent experimental data.Comment: 4 page, 3 figures. To be puplished in PRB Rapid co
The X10 Flare on 2003 October 29: Triggered by Magnetic Reconnection between Counter-Helical Fluxes?
Vector magnetograms taken at Huairou Solar Observing Station (HSOS) and Mees
Solar Observatory (MSO) reveal that the super active region (AR) NOAA 10486 was
a complex region containing current helicity flux of opposite signs. The main
positive sunspots were dominated by negative helicity fields, while positive
helicity patches persisted both inside and around the main positive sunspots.
Based on a comparison of two days of deduced current helicity density,
pronounced changes were noticed which were associated with the occurrence of an
X10 flare that peaked at 20:49 UT, 2003 October 29. The average current
helicity density (negative) of the main sunspots decreased significantly by
about 50. Accordingly, the helicity densities of counter-helical patches
(positive) were also found to decay by the same proportion or more. In
addition, two hard X-ray (HXR) `footpoints' were observed by the Reuven Ramaty
High Energy Solar Spectroscopic Imager (RHESSI} during the flare in the 50-100
keV energy range. The cores of these two HXR footpoints were adjacent to the
positions of two patches with positive current helicity which disappeared after
the flare. This strongly suggested that the X10 flare on 2003 Oct. 29 resulted
from reconnection between magnetic flux tubes having opposite current helicity.
Finally, the global decrease of current helicity in AR 10486 by ~50% can be
understood as the helicity launched away by the halo coronal mass ejection
(CME) associated with the X10 flare.Comment: Solar Physics, 2007, in pres
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