TIC y usos en la producción de sentidos para la comunicación institucional del Concejo Deliberante de la Ciudad de Pinamar

Este Trabajo realizado en el marco de la “Especialización en Comunicación Digital” de la Facultad de Periodismo y Comunicación social de la UNLP, parte de la necesidad de la especificidad relacional de lo situado para analizar los procesos comunicacionales de las organizaciones, si se piensa en su gestión o intervención social en general o comunicacional en particular. Tal como lo enuncia en su título: “TIC y usos en la producción de sentidos para la comunicación institucional del Concejo Deliberante de la Ciudad de Pinamar”, el trabajo aborda como tema central las relaciones entre Tecnologías de la Información y la Comunicación y la construcción de procesos en varios sentidos, que expresan la comunicación institucional y organizacional de un espacio político legislativo concreto. Poner el foco en un Concejo Deliberante determinado, evitando la generalización, parte de la idea de que la relación entre comunicación y política en espacios legislativos requiere de saberes específicos y situados ya que -por más que parezca una obviedad- no es lo mismo referirse a la comunicación en un espacio de poder político ejecutivo que a la comunicación en un espacio de poder político legislativo, como tampoco es lo mismo pensarlo en su nivel nacional como provincial o municipal. Finalmente, nuestro abordaje para conocer, partió desde la premisa de actuar como indagadores sociales tal lo planteado por Florencia Saintout: “desplazarse de los sujetos y sus prácticas, sus discursos, a las dimensiones estructurales, y de allí nuevamente a las prácticas: sentido y fuerza. Incorporar el conflicto en el territorio de las significaciones: la politicidad de la comunicación”. Desde allí, este trabajo intentó observar, describir y analizar los usos y apropiaciones que, empleadas y empleados del lugar, hacen de las tecnologías digitales para gestionar procesos de información y comunicación y sus relaciones con la cultura organizacional que los contextualiza, con la intención de reconocer los sentidos situados que adquiere la gestión en comunicación digital en un Concejo Deliberante bonaerense. Buscando con ello, ser un aporte al campo de estudios de la gestión de la comunicación digital organizacional en su articulación con el campo político legislativo comunal.Facultad de Periodismo y Comunicación Socia

MONTE CARLO SIMULATION OF ORANGE JUICE PECTINMETHYLESTERASE (PME) INACTIVATION BY COMBINED PROCESSES OF HIGH HYDROSTATIC PRESSURE (HHP) AND TEMPERATURE

The variability effect of kinetic data was investigated by simulating orange juice pectinmethylesterase (PME) inactivation with combined processes of high hydrostatic pressure-temperature (100-500 MPa; 20-40°C), applying the Monte Carlo method. Parameters from an Eyring-Arrheniius model that predicts the kinetic inactivation constant (k) as a function of both pressure and temperature were found reported in literature and considered for the analysis. The kinetic analysis was carried out with both Monte Carlo simulations and the traditional deterministic approach, which only considers mean values and does not take into account data variability. Simulations with the Monte Carlo method demonstrated that residual PME activity predicted with deterministic calculations greatly differed from those obtained through confidence intervals of simulated probabilistic distributions. Mean values overrated residual enzyme activity from 4% to ≈2,800% when compared to the 95% confidence intervals generated with the Monte Carlo method. This divergence augmented as both applied pressure and temperature levels increased. Similar risk analysis projects can be further developed to establish the foundations for future food processing regulations of enzymatic control.This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Universidad Autónoma Metropolitana Unidad Iztapalapa and can be found at: http://www.redalyc.org/revista.oa?id=620.Keywords: Process simulation, High hydrostatic pressure (HHP), Orange juice, Pectinmethylesterase (PME), Monte CarloKeywords: Process simulation, High hydrostatic pressure (HHP), Orange juice, Pectinmethylesterase (PME), Monte Carl

Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress

Tumor growth is influenced by a complex network of interactions between multiple cell types in the tumor microenvironment (TME). These constrained conditions trigger the endoplasmic reticulum (ER) stress response, which extensively reprograms mRNA translation. When uncontrolled over time, chronic ER stress impairs the antitumor effector function of CD8 T lymphocytes. How cells promote adaptation to chronic stress in the TME without the detrimental effects of the terminal unfolded protein response (UPR) is unknown. Here, we find that, in effector CD8 T lymphocytes, RNA-binding protein CPEB4 constitutes a new branch of the UPR that allows cells to adapt to sustained ER stress, yet remains decoupled from the terminal UPR. ER stress, induced during CD8 T-cell activation and effector function, triggers CPEB4 expression. CPEB4 then mediates chronic stress adaptation to maintain cellular fitness, allowing effector molecule production and cytotoxic activity. Accordingly, this branch of the UPR is required for the antitumor effector function of T lymphocytes, and its disruption in these cells exacerbates tumor growth.© 2023 The Authors. Published under the terms of the CC BY NC ND 4.0 license

Benefits and limitations of food processing by high-pressure technologies: effects on functional compounds and abiotic contaminants

The continuing and worldwide growth of pressure processing technologies to pasteurize and sterilize foods justifies the need to study the effects on functional compounds and nonbiotic contaminants as affected by high pressure processing (HPP) and pressureassisted thermal processing (PATP). Substantially more research will be required to determine the complex effects of the food matrix on chemical reactions leading to losses of nutrients and functional components, production of toxic compounds, and to modifications of toxic residues of chemicals used in food production or coming from food contact materials. In PATP treatments, pressure can also increase, decrease or have no effect on the thermal degradation rate of these substances. HPP has no major negative and often beneficial effects on the retention of nutrients and functional components. However, information on PATP effects is very limited and additional research will be required before implementing this promising new technology.Keywords: polyphenols, pressure-assisted thermal processing (PATP), abiotic contaminants, antioxidants, food packaging plastic materials, heterocyclic aromatic amines (HCAs), acrylamide, polycyclic aromatic hydrocarbons (PAHs), chloropropanols, vitamins, nonbiotic contaminants, pesticides, high-pressure processing (HPP

Monte Carlo analysis of the product handling and high-pressure treatment effects on the Vibrio vulnificus risk to raw oysters consumers

A Monte Carlo procedure considering the variability in oyster handling from harvest to raw consumption estimated reductions in the number of Vibrio vulnificus induced septicemia cases achieved by high-pressure processing (HPP). The calculations yielded pathogen load distributions in raw oysters from harvest to consumption. In the warm season, 2-6 min treatments at 250 MPa and 1°C would lower the predicted number of septicemia cases associated with raw oyster consumption from 4,932 to less than four per 100 million consumption events (95% confidence). This study highlighted that HPP conditions should be selected according to the seasonal pathogen load and environment temperature. Finally, the procedure emphasized that the variability in the V. vulnificus population at harvest, before and after HPP treatments, reflecting in part the microbiological quantification methods used, significantly affected the estimated number of septicemia cases. Therefore, improving microbiological quantification should provide better predictions of the number of septicemia cases.Keywords: Beta-Poisson dose response models, Monte Carlo analysis, Vibrio vulnificus, Oyster, High pressure processing, Seafood poisoning ris

Manipulation of Pre-Target Activity on the Right Frontal Eye Field Enhances Conscious Visual Perception in Humans

The right Frontal Eye Field (FEF) is a region of the human brain, which has been consistently involved in visuo-spatial attention and access to consciousness. Nonetheless, the extent of this cortical site’s ability to influence specific aspects of visual performance remains debated. We hereby manipulated pre-target activity on the right FEF and explored its influence on the detection and categorization of low-contrast near-threshold visual stimuli. Our data show that pre-target frontal neurostimulation has the potential when used alone to induce enhancements of conscious visual detection. More interestingly, when FEF stimulation was combined with visuo-spatial cues, improvements remained present only for trials in which the cue correctly predicted the location of the subsequent target. Our data provide evidence for the causal role of the right FEF pre-target activity in the modulation of human conscious vision and reveal the dependence of such neurostimulatory effects on the state of activity set up by cue validity in the dorsal attentional orienting network