Medical Image Modality Classification using Feature Weighted Clustering Approach.

Sistem Dapat Semula Imej Perubatan merupakan satu bidang yang amat penting bagi pembekal penjagaan kesihatan. Medical Image Retrieval System is an area of great importance to the healthcare providers

Henize 2-10: the ongoing formation of a nuclear star cluster around a massive black hole

The central region of the galaxy Henize 2-10 has a central black hole (BH) with a mass of about $2\times 10^6$ M$_\odot$. While this black hole does not appear to coincide with any central stellar over density, it is surrounded by 11 young massive clusters with masses above $10^5$ M$_\odot$. The availability of high quality data on the structure of the galaxy and the age and mass of the clusters provides excellent initial conditions for studying the dynamical evolution of Henize 2-10's nucleus. Here we present a set of $N$-body simulations of the central clusters and black hole to understand whether and how they will merge to form a nuclear star cluster. Nuclear star clusters (NSCs) are present in a majority of galaxies with stellar mass similar to Henize 2-10. Despite the results depend on the choice of initial conditions, we find that a NSC with mass $M_{NSC}\simeq 4-6\times 10^6$ M$_\odot$ and effective radius $r_{NSC}\simeq 2.6-4.1$ pc will form within $0.2$ Gyr. This work is the first showing, in a realistic realization of the host galaxy and its star cluster system, that the formation of a bright nucleus is a process that can happen after the formation of a central massive BH leading to a composite NSC+BH central system. The merging process of the clusters does not affect significantly the kinematics of the BH, whose motion, after the globular cluster merger, is limited to a $\sim 1$ pc oscillation at less than $2$ kms$^{-1}$ speed.Comment: 14 pages, 17 figures, 5 tables. Accepted for publication in the Astrophysical Journa

A rare occurrence of bilateral C-shaped roots in mandibular first and second premolars diagnosed with the aid of spiral computed tomography

The C-shaped canal system is an anatomical variation mostly seen in mandibular second molars, although it can also occur in maxillary and other mandibular molars. Such variation in the root canal anatomy is uncommon in mandibular first premolars and very rare in mandibular second premolars. The C-shaped canal is so named for the cross-sectional morphology of the root and root canal. The main anatomic feature of C-shaped canals is the presence of a fin or web connecting the individual root canals. Failure of the Hertwig's epithelial root sheath to fuse on the lingual or buccal root surface is the main cause of C-shaped roots, which always contain a C-shaped canal. This case report describes an unusual occurrence of C-shaped roots in mandibular first and second premolars bilaterally, diagnosed with the aid of spiral computed tomography

Prediction of treatment response in patients with neovascular age-related macular degeneration

Neovascular age-related macular degeneration (nAMD) is a common cause of visual impairment, and is currently treated with intravitreal anti-vascular endothelial growth factor agents such as aflibercept. While these treatments may improve visual acuity (VA) in some patients, clinicians cannot currently predict who is likely to benefit before treatment starts. The aim of this study is to explore the effectiveness of using Deep Learning approaches to train models for predicting whether a patient’s VA will respond favourably to three months of aflibercept therapy, using pre-treatment OCT images and clinical/demographic variables. We train a number of models using standard machine learning, Deep Learning transfer learning, and fully trained Deep Learning approaches in two experiments using outcomes based on the VA at 4- 10 weeks after the final dose. In experiment one, we trained models to predict whether the VA will be at least 54 Early Treatment Diabetic Retinopathy Study (ETDRS) letters, while in experiment two we trained them to predict whether the VA will have increased by 10 or more letters. Model prediction quality was assessed using the Area Under the Curve (AUC) of the Receiver-Operating-Characteristic (ROC) curves. We found that all models performed significantly better than chance in both experiments, except for the fully trained Deep Learning model using just images in experiment two. The best performing model for experiment one was the Deep Learning transfer model using images and clinical/demographic variables (AUC=0.901), while in experiment two, none of the Deep Learning approaches performed better than a random forest using only clinical/demographic variables (AUC=0.751). Our experiments suggest that different Deep Learning approaches are required for predicting the second outcome if we want the models to perform better than those that use clinical/demographic variables alone

A Prospective Study of Prevalence of Carotid Artery Disease in Patients with Coronary Artery Disease and its Correlation with Traditional Atherosclerotic Risk Factors in Central India

Introduction: Early atherosclerosis mainly involves carotid artery, which leads to increased carotid artery intima media thickness (CIMT).The potential value of CIMT improving the predictive capacity of traditional risk factors of CAD is an understudied and underutilized issue. Because of increasing availability of highly sensitive ultrasonography probes and for a noninvasive procedures, we can predict coronary artery disease (CAD) more precisely in patients having multiple traditional risk factors so it may reduce morbidity and mortality due to CAD and elevated CIMT can be used as surrogate marker of underlying CAD.Methods: This study enrolled 250 admitted patients as a case of CAD. The patients were assessed by detailed history taking, thorough clinical examination, measurement of CIMT, blood sugar and lipid level.Results: Carotid artery disease was present in 88 (35%) of 250 CAD patients. All modifiable cardiovascular risk factors were statistically significantly high in patients of CAD with carotid artery disease. In obese, diabetic, hypertensive, dyslipidemia and smoker patients, carotid artery disease was present in 55% (P = 0.00), 41% (P = 0.00), 43% (P = 0.007), 47% (P = 0.002) and 43% (P = 0.003) respectively. CAD patients who had 1 risk factor, 29% were associated with carotid artery disease. Comparison of single risk factor with patients who had no risk factor, there was non-significant correlation for carotid artery disease. CAD patients who had 2, 3, 4 and 5 risk factors, carotid artery disease was present 24 (32%) (p = 0.02), 15 (55%) (P = 0.0003), 17 (61%) (P = 0.00006) and 6 (67%) (P = 0.0008).Conclusion: elevated CIMT can be used as one of the important risk factor for early diagnosis of CAD and to reduce morbidity and mortality due to CAD

Functional outcome of small and long bone lengthening by distraction osteogenesis

Background: Upper limb lengthening has limited indications because of the predominant non weight bearing nature. However, lengthening does have specific indications where the functional outcomes improve in selected patients. The aim of the study was to compare the clinical and radiological outcomes of upper limb long and short bone lengthening by distraction osteogenesis.Methods: A total of twenty four lengthenings were done in 21 patients, three cases being bilateral. The study group included cases of club hand, symbrachydactyly, multiple hereditary osteocondramatosis, traumatic amputations and congenital defects. Operative technique involved gradual mechanical distraction by orthofix external fixator after osteotomy. Clinical and radiological evaluation was done on follow up. The functional outcome for daily activities was assessed. The Healing index, Percentage healing index and Consolidation time were calculated.Results: The mean age of patients was 11.6 years. The percentage healing index of long bones was higher compared to short bones but the consolidation time was almost similar. Complications were seen in 35% patients. The satisfaction rates were higher in small bone lengthening and the complication rates were almost same as for long bones. Grasp, pinch strength and range of motion improved in cases of short bone lengthening.Conclusions: Distraction osteogenesis is reliable and predictable method of correction of osseous defects with vascular bone without sacrificing any adjacent digits or toes. It also gains soft tissue that is sensate with good blood supply

Clinico hematological profile of pancytopenia in pediatric patients: an institutional experience in North Himalayan region of India

Background: Pancytopenia is a common clinical pattern with an extensive differential diagnosis, but literature search shows only limited studies of pancytopenia in Pediatrics patients in Uttarakhand state of India. The present study was therefore conducted to study the spectrum of pancytopenia with bone marrow and haematological profile in Pediatrics patients in this north Himalayan state of India.Methods: Prospective observational study was conducted in the Department of Pediatrics in the teaching institute situated in Uttarakhand state of India over a period of 12 months. The study included all the patients of pancytopenia below 18 years of age who underwent bone marrow examination after written informed consent.Results: The study included total 50 pediatrics patients of pancytopenia with male to female ratio of 1.38:1. The mean age of patients was 10.58±4.94 with median age of 12 years. Mean hemoglobin was 5.31±2.09 g/dl, total leukocyte count was 2492.68±941.76/mm3, platelet count was 34724±26423/mm3, mean corpuscular volume was 90.95±16.65 fl, mean corpuscular hemoglobin was 30.11±6.07 pg, mean corpuscular hemoglobin concentration was 33.06±1.65% and reticulocyte count was 1.21±1.10%. Nutritional deficiency (28%) was the most common cause for pancytopenia followed by aplastic anemia (24%). Megaloblastic anemia was the commonest cause of nutritional deficiency anemia (71.42%) with pancytopenia.Conclusions: Pancytopenia is an important presentation in Pediatrics population with the most common cause being nutritional anemia and aplastic anemia. Megaloblastic anemia is the commonest cause of nutritional anemia with pancytopenia. The clinicians should be aware of spectrum of pancytopenia with clinical and haematological presentation in Pediatrics patients of this region so as to avoid unnecessary work ups and delay in treatment

Response of intercrops and nutrient management on the performance of tobacco based intercropping system and assessment of system sustainability

Intercropping of tobacco with garlic produced the highest total (2292 kg/ha) and first grade (1256 kg/ha) cured leaves of tobacco. In the recommended dose of respective intercrops 75% produced total and first grade cured tobacco leaves compared to 100 per cent of the recommended dose. Tobacco quality was also influenced with nutrient management. Puckering and maturity scores did not impaired up to 50 per cent application of nutrients to intercrops. Among the intercrops garlic gave the highest economic yield (1.18 t/ha) over three years on the basis of monetary gain. The highest net return (Rs 47,948 / ha) and cost benefit ratio (1:1.78) was achieved under tobacco + garlic intercropping system. Nutrient supplied at 75 percent of recommended dose provided net return (Rs 45551/ ha) and cost benefit ratio (1:1.81) equivalent to 100 per cent of recommended doses. Soil fertility was either maintained or improved due to intercropping intervention in comparison to cultivating tobacco sole. This record was migrated from the OpenDepot repository service in June, 2017 before shutting down

Biomolecular interaction simulation of supramolecular topologies of organometallic assemblies of Bi(V) with antibiotic Tetracycline Amoxicillin drugs and their experimental activities evaluation

This is an accepted manuscript of an article published by IS Publications in Journal of Biomedical & Therapeutic Sciences on 30/09/2020, available online: http://www.pubs.iscience.in/journal/index.php/jbts/article/view/926/594 The accepted version of the publication may differ from the final published version.Antibiotic drugs i.e. tetracycline and amoxicillin, were used mixed ligands (ML), for designing, architecturing, tailoring and synthesis for synthesis of supramolecular topologies of organometallic assemblies of Bi(V), represented as OMCs‐Bi(V), having O5 set for bonding. Molecular models were proposed as a standard to judge specific interactions in topologies of molecules of ML and derived organometallic assemblies. In OMCs‐Bi(V), on chelation, polarity of Bi(V) get reduced to great extent due to overlap of ML orbital. As a result, delocalization of π‐electrons density clouds get spread over the surface of chelating ring and enhances penetration power of OMCs‐Bi(V) into lipid membranes. This influenced binding with enzyme sites in microorganisms. Some electron set for bonding groups present in ligands moieties display extensive biological activity that may be responsible for increase in hydrophobic character and liposolubility of supramolecular topologies of organometallic of assemblies; ultimately enhanced biological activity of OMCs‐Bi(V)