Letter From Chandler P. Anderson to Francis Mairs Huntington-Wilson, January 16, 1911

This is a typed letter from the Counsellor of the Department of State to Huntington Wilson regarding fishing regulations on the Canadian borderhttps://digitalcommons.ursinus.edu/fmhw_other/1214/thumbnail.jp

Commercials, careers and culture: travelling salesmen in Britain 1890s-1930s

Within the lower middle-class, British commercial travellers established a strong fraternal culture before 1914. This article examines their interwar experiences in terms of income, careers, and associational culture. It demonstrates how internal labour markets operated, identifies the ways in which commercial travellers interpreted their role, and explores their social and political attitudes

ASTROD and ASTROD I -- Overview and Progress

In this paper, we present an overview of ASTROD (Astrodynamical Space Test of Relativity using Optical Devices) and ASTROD I mission concepts and studies. The missions employ deep-space laser ranging using drag-free spacecraft to map the gravitational field in the solar-system. The solar-system gravitational field is determined by three factors: the dynamic distribution of matter in the solar system; the dynamic distribution of matter outside the solar system (galactic, cosmological, etc.) and gravitational waves propagating through the solar system. Different relativistic theories of gravity make different predictions of the solar-system gravitational field. Hence, precise measurements of the solar-system gravitational field test all these. The tests and observations include: (i) a precise determination of the relativistic parameters beta and gamma with 3-5 orders of magnitude improvement over previous measurements; (ii) a 1-2 order of magnitude improvement in the measurement of G-dot; (iii) a precise determination of any anomalous, constant acceleration Aa directed towards the Sun; (iv) a measurement of solar angular momentum via the Lense-Thirring effect; (v) the detection of solar g-mode oscillations via their changing gravity field, thus, providing a new eye to see inside the Sun; (vi) precise determination of the planetary orbit elements and masses; (viii) better determination of the orbits and masses of major asteroids; (ix) detection and observation of gravitational waves from massive black holes and galactic binary stars in the frequency range 0.05 mHz to 5 mHz; and (x) exploring background gravitational-waves.Comment: 17 pages, 6 figures, presented to The Third International ASTROD Symposium on Laser Astrodynamics, Space Test of Relativity and Gravitational-Wave Astronomy, Beijing, July 14-16, 2006; International Journal of Modern Physics D, in press (2008

Action-derived molecular dynamics in the study of rare events

We present a practical method to generate classical trajectories with fixed initial and final boundary conditions. Our method is based on the minimization of a suitably defined discretized action. The method finds its most natural application in the study of rare events. Its capabilities are illustrated by non-trivial examples. The algorithm lends itself to straightforward parallelization, and when combined with molecular dynamics (MD) it promises to offer a powerful tool for the study of chemical reactions.Comment: 7 Pages, 4 Figures (3 in color), submitted to Phys. Rev. Let

Prospects of Transition Interface Sampling simulations for the theoretical study of zeolite synthesis

The transition interface sampling (TIS) technique allows to overcome large free energy barriers within reasonable simulation time, which is impossible for straightforward molecular dynamics. Still, the method does not impose an artificial driving force, but it surmounts the timescale problem by an importance sampling of true dynamical pathways. Recently, it was shown that the efficiency of TIS to calculate reaction rates is less sensitive to the choice of reaction coordinate than those of the standard free energy based techniques. This could be an important advantage in complex systems for which a good reaction coordinate is usually very difficult to find. We explain the principles of this method and discuss some of the promising applications related to zeolite formation.Comment: 9 pages, accepted for publication in Phys. Chem. Chem. Phys. for the special issue of the CECAM workshop: Computational aspects of building blocks, nucleation, and synthesis of porous materials Aug. 29 2006 to Aug. 31 200

Multispacecraft observations and modeling of the 22/23 June 2015 geomagnetic storm

The magnetic storm of 22–23 June 2015 was one of the largest in the current solar cycle. We present in situ observations from the Magnetospheric Multiscale Mission (MMS) and the Van Allen Probes (VAP) in the magnetotail, field‐aligned currents from AMPERE (Active Magnetosphere and Planetary Electrodynamics Response), and ionospheric flow data from Defense Meteorological Satellite Program (DMSP). Our real‐time space weather alert system sent out a “red alert,” correctly predicting Kp indices greater than 8. We show strong outflow of ionospheric oxygen, dipolarizations in the MMS magnetometer data, and dropouts in the particle fluxes seen by the MMS Fast Plasma Instrument suite. At ionospheric altitudes, the AMPERE data show highly variable currents exceeding 20 MA. We present numerical simulations with the Block Adaptive Tree‐Solarwind ‐ Roe ‐ Upwind Scheme (BATS‐R‐US) global magnetohydrodynamic model linked with the Rice Convection Model. The model predicted the magnitude of the dipolarizations, and varying polar cap convection patterns, which were confirmed by DMSP measurements.Key PointsMHD models can reproduce well the dipolarizations seen at MMS and VAP. Space weather forecasting can predict Kp variations within 0.5 stepBeams of O+ flowing downstream appear to cross the separatrix and become a second energized population of the tail plasma sheetMHD models successfully reproduced the polar cap convection patterns and cross‐polar cap potential drops for a range of IMF conditionsPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134114/1/grl54522_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134114/2/grl54522-sup-0002-FigureS1.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134114/3/grl54522.pd

A terminal assessment of stages theory : introducing a dynamic states approach to entrepreneurship

Stages of Growth models were the most frequent theoretical approach to understanding entrepreneurial business growth from 1962 to 2006; they built on the growth imperative and developmental models of that time. An analysis of the universe of such models (N=104) published in the management literature shows no consensus on basic constructs of the approach, nor is there any empirical confirmations of stages theory. However, by changing two propositions of the stages models, a new dynamic states approach is derived. The dynamic states approach has far greater explanatory power than its precursor, and is compatible with leading edge research in entrepreneurship

Limits on Gravitational-Wave Emission from Selected Pulsars Using LIGO Data

We place direct upper limits on the amplitude of gravitational waves from 28 isolated radio pulsars by a coherent multidetector analysis of the data collected during the second science run of the LIGO interferometric detectors. These are the first direct upper limits for 26 of the 28 pulsars. We use coordinated radio observations for the first time to build radio-guided phase templates for the expected gravitational-wave signals. The unprecedented sensitivity of the detectors allows us to set strain upper limits as low as a few times 10^(-24). These strain limits translate into limits on the equatorial ellipticities of the pulsars, which are smaller than 10^(-5) for the four closest pulsars

Immunosuppressive niche engineering at the onset of human colorectal cancer

The evolutionary dynamics of tumor initiation remain undetermined, and the interplay between neoplastic cells and the immune system is hypothesized to be critical in transformation. Colorectal cancer (CRC) presents a unique opportunity to study the transition to malignancy as pre-cancers (adenomas) and early-stage cancers are frequently resected. Here, we examine tumor-immune eco-evolutionary dynamics from pre-cancer to carcinoma using a computational model, ecological analysis of digital pathology data, and neoantigen prediction in 62 patient samples. Modeling predicted recruitment of immunosuppressive cells would be the most common driver of transformation. As predicted, ecological analysis reveals that progressed adenomas co-localized with immunosuppressive cells and cytokines, while benign adenomas co-localized with a mixed immune response. Carcinomas converge to a common immune “cold” ecology, relaxing selection against immunogenicity and high neoantigen burdens, with little evidence for PD-L1 overexpression driving tumor initiation. These findings suggest re-engineering the immunosuppressive niche may prove an effective immunotherapy in CRC