7 research outputs found
We Donât Need No Water: The Cadre Burns the Union Jack
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Recommended from our members
Slow acceptance of universal antiretroviral therapy (ART) among mothers enrolled in IMPAACT PROMISE studies across the globe
- Author
- Aizire J.
- Anekthananon T.
- Angelidou K.
- Aurpibul L.
- Basar M.
- Browning R.
- Brummel S.
- Chakhtoura N.
- Chamanga R.
- Chanaiwa V.
- Colett A.
- Currier J.
- Flynn P.
- Fowler M. G.
- Hanley S.
- Joao E.
- Kamateeka M.
- Maluwa M.
- Masheto G.
- McCarthy K.
- Mhembere T.
- Mlay P.
- MubianaâMbewe M.
- Mutambanengwe M.
- Nevrekar N.
- Nyati M.
- Oliveira R.
- Pilotto J.
- Santos B.
- StranixâChibanda L.
- Theron G.
- Tierney C.
- Ziemba L.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
CITATION: StranixâChibanda, L., et al. 2019. Slow acceptance of universal antiretroviral therapy (ART) among mothers enrolled in IMPAACT PROMISE studies across the globe. AIDS and Behavior, 23:2522-2531, doi:10.1007/s10461-019-02624-3.The original publication is available at https://link.springer.comThe PROMISE trial enrolled asymptomatic HIV-infected pregnant and postpartum women not eligible for antiretroviral treatment (ART) per local guidelines and randomly assigned proven antiretroviral strategies to assess relative efficacy for perinatal prevention plus maternal/infant safety and maternal health. The START study subsequently demonstrated clear benefit in initiating ART regardless of CD4 count. Active PROMISE participants were informed of results and women not receiving ART were strongly recommended to immediately initiate treatment to optimize their own health. We recorded their decision and the primary reason given for accepting or rejecting the universal ART offer after receiving the START information. One-third of participants did not initiate ART after the initial session, wanting more time to consider. Six sessions were required to attain 95% uptake. The slow uptake of universal ART highlights the need to prepare individuals and sensitize communities regarding the personal and population benefits of the âTreat Allâ strategy.https://link.springer.com/article/10.1007/s10461-019-02624-3Publisher's versio
MFUNDISI WE-AFRICA: UM ITINERĂRIO EDUCACIONAL DE ENFRENTAMENTO DO RACISMO E DA DESIGUALDADE
- Author
- ALLO A.
- Antonio Evaldo Almeida Barros
- BARBOSA V. O.
- BHEBE N.
- BOAHEN A. B.
- CHANAIWA D.
- COMAROFF J.
- COMAROFF J.
- CRITTENDEN W. B.
- DAVIS JR R. H.
- DINNERSTEIN M.
- DUBE J. L
- DUBE J. L.
- DUBE J. L.
- DUBE J. L.
- DUBE J. L.
- DUBE J. L.
- EVANS M. S.
- FOSTER F. H.
- GASA E. D.
- GEBARA I.
- GUNNER L.
- HABTE A.
- HAMPATĂ BĂ A.
- HARRIS V.
- HERNANDEZ L. L.
- HUGHES H.
- HUGHES H.
- JONGE K.
- KUMALO S.
- MARABLE M.
- MARKS S.
- MBEMBE A.
- NGCONGCO L. D.
- NGOENHA S. E.
- NGOENHA S. E.
- RALSTON R. D.
- SANTOS B. S.
- SIVETYE G. M.
- TABATA I. B.
- TABATA I. B.
- VALDĂS E. D.
- VILAKAZI B.
- WILCOX W. C.
- YOUNG R. J. C.
- ZAMPARONI V. D.
- ZAMPARONI V. D.
- ZUMA J.
- ZUMA J.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2020
- Field of study
The White Man's Burden: On the Effect of African Resistance to European Domination
- Author
- A A Boahen
- A Aduboahen
- A Aduboahen
- A B Davidson
- A E Afigbo
- A Emmanuel
- A Fosu
- A Isaacman
- A Isaacman
- A Isaacman
- A J Hanna
- A Lewis
- A Maddison
- A Mafeje
- A Olatunjioloruntimehin
- A Philippe
- Ahmed Ibrahim
- B A Ogot
- C Coquery-Vidrovitch
- C Meillassoux
- C Monga
- D Bezemer
- D Chanaiwa
- D Moyo
- E Frankema
- E Frankema
- E Frankema
- E Huillery
- E Huillery
- E Huillery
- E T Lwoga
- F Obeng-Odoom
- F Obeng-Odoom
- G Austin
- G Bertocchi
- G N Uzoigwe
- H A Ibrahim
- H A Mwanzi
- H A Mwanzi
- H Fofack
- I Drine
- J
- J A Langley
- J Bolt
- J D Sachs
- J Dorfman
- J Duffy
- J W Musila
- K Raseroka
- L H Gann
- L Wantchïżœkon
- M A Adewole
- M Crowder
- M Crowder
- M Crowder
- M Esoavelomandroso
- M Gueye
- M Jerven
- M P K Sorrenson
- M Salibian-Barrera
- Matthias M. Cinyabuguma
- N Nunn
- N Nunn
- N Nunn
- N Nunn
- N Nunn
- O Ikime
- O Kodila-Tedika
- O Kodila-Tedika
- O Kodila-Tedika
- Oasis Kodila-Tedika
- P Englebert
- P Englebert
- P J Rousseeuw
- P M Parker
- P Richens
- R America
- R E Looney
- R E Lucas
- R M Grier
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S Amin
- S Amin
- S B Brush
- S J Ndlovu-Gatsheni
- S Kayizzi-Mugerwa
- S Kayizzi-Mugerwa
- S Koffi
- S V Tchamyou
- Simplice A. Asongu
- T C Weiskel
- T J Besley
- T O Ranger
- T Packenham
- U Efobi
- V H Amavilah
- V H Amavilah
- V H Amavilah
- V H Amavilah
- V Thompson
- V Thompson
- W Rodney
- W Whatley
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
Slow Acceptance of Universal Antiretroviral Therapy (ART) Among Mothers Enrolled in IMPAACT PROMISE Studies Across the Globe
- Author
- A Chadambuka
- A Coutsoudis
- A. Coletti
- B. Santos
- C. Tierney
- E Buregyeya
- E Geng
- E McLean
- E. Joao
- G. Masheto
- G. Theron
- IM Hodgson
- J Chinkonde
- J Njunga
- J. Aizire
- J. Currier
- J. Pilotto
- JM Turan
- JS Currier
- K Clouse
- K. Angelidou
- K. McCarthy
- KL Dunkle
- L Katirayi
- L Katirayi
- L. Aurpibul
- L. Stranix-Chibanda
- L. Ziemba
- LA Parker
- M Fowler
- M Ngarina
- M. Basar
- M. G. Fowler
- M. Kamateeka
- M. Maluwa
- M. Mubiana-Mbewe
- M. Mutambanengwe
- M. Nyati
- MC Hosseinipour
- MP Fox
- MP Kieffer
- N Phanuphak
- N. Chakhtoura
- N. Nevrekar
- ND Labhardt
- P. Flynn
- P. Mlay
- PA Vanable
- R. Browning
- R. Chamanga
- R. Oliveira
- S Ashaba
- S Rosen
- S. Brummel
- S. Hanley
- SP Koenig
- SW Rigby
- T Kalua
- T. Anekthananon
- T. Mhembere
- V. Chanaiwa
- VL Flax
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A perspectiva africana na HistĂłria Geral da Ăfrica (Unesco)
- Author
- ABDEL-MALEK A
- ADEDEJI A
- AFIGBO A. E
- ANDAH B. W
- ANDAH B. W
- ASANTE S. K. B.
- BARRY B
- BOAHEN A
- BOAHEN A. A
- BOAHEN A. A
- CALDWELL J
- CHANAIWA D.
- CHINWEIZU D
- CLARK J. D
- COQUERY-VIDROVITCH C
- COQUERY-VIDROVITCH C
- DEVISSE J
- DIAGNE P
- DIOP C. A
- EHRET C
- EHRET C
- ELAIGWU J. I.
- FASI M. E.
- HARRIS J. E
- HARRIS J. E
- HRBEK I
- HUFFMAN T. N
- HUGOT H. J
- INIKORI J. E
- IZARD M.
- KANIKI M. H
- KI-ZERBO J
- KI-ZERBO J.
- KIPRE P
- KNIGHT F. W.
- KOBISHANOV Y. M
- LAROUI A
- LOPES C
- LWANGO-LUNYIIGO S.
- MAJHOUBI A
- MALOWIST M
- MATVEIEV V
- MAZRUI A
- MUDIMBE V.-Y
- MUTIBWA P. M.
- NGCONGCO L. D
- NGCONGCO L. D
- NGCONGCO L. D
- NGCONGCO L. D
- OGOT B. A
- OGOT B. A
- OSUWU M
- PANKHURST R
- PARKINGTON J. E
- PERSON Y
- PHILLIPSON D. W
- PHILLIPSON D. W
- RODNEY W
- SALAMA P
- SALAMA P
- SHERIFF A
- SUTTON J
- SUTTON J
- UZOIGWE G. N
- VANSINA J
- VANSINA J
- VANSINA J
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
- Author
- Abach J
- Abdallah J
- Abdallah S
- Abdallah S
- Aberle-Grasse J
- Abimiku A
- Abishev A
- Abongomera G
- Aboud M
- Aboud M
- Abramovitz D
- Abrams E
- Abrams E
- Abrams E
- Abrams E
- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
- Adeyemi O
- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
- Agolory S
- Agot K
- Agot K
- Agovi A-A
- Aguiar P
- Aguilar-Martinez J
- Agutu C
- Ahmed M
- Ahmed R
- Ahmed S
- Ahmed S
- Ahmed S
- Aizire J
- Ajibola G
- Ajok S
- Albert-Hope C
- Alejos B
- Alexander G
- Alicea C
- Allen H
- Allen M
- Allen S
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- Alloui C
- Altice F
- Altice F
- Amara R
- Ambani A
- Ambrose K
- Amico R
- Amin J
- Amin T
- Amole C
- Amoros I
- Anahtar M
- Ananworanich J
- Ananworanich J
- Ancuta P
- Andama A
- Anderegg N
- Anderson A
- Anderson A
- Anderson E
- Anderson J
- Anderson J
- Anderson S
- Andersson M
- Andrade A
- Andrew E
- Andrew P
- Andrew P
- Andrews L
- Angel J
- Angelidou K
- Anglaret X
- Anoma C
- Ansari A
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apollon A
- Apondi E
- Aptekar S
- Ardiet D
- Arellano G
- Arenas-Pinto A
- Arhel N
- Armstrong D
- Arthos J
- Artz L
- Arunmanakul A
- Asari V
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- Asiimwe S
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- Asiimwe S
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- Atuhumuza E
- Atujuna M
- Audet C
- Auerbach J
- Auld A
- Aung P
- Aurpibul L
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- Avalos A
- Avihingsanon A
- Avihingsanon A
- Avihingsanon A
- Awori Q
- Awotwi E
- Ayala V
- Ayalew M
- Ayaya S
- Ayieko J
- Ayieko J
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- Aylott A
- Azar M
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- Babiker A
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- Back D
- Badjé A
- Baeten J
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- Baijnath P
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- Bajracharya A
- Bajunirwe F
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- Doerholt K
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated