Optimizing survival outcomes with post-remission therapy in acute myeloid leukemia.

Optimization of post-remission therapies to maintain complete remission and prevent relapse is a major challenge in treating patients with acute myeloid leukemia (AML). Monitoring patients for measurable residual disease (MRD) is helpful to identify those at risk for relapse. Hypomethylating agents are being investigated as post-remission therapy. Identification of recurrent genetic alterations that drive disease progression has enabled the design of new, personalized approaches to therapy for patients with AML. Emerging data suggest that targeted post-remission therapy, alone or in combination with chemotherapy, may improve outcomes. Results of ongoing clinical trials will further define potential clinical benefits

Assuring E-Commerce Business Activities

Trust is imperative for conducting online transactions. To reduce online risks and foster trust, assurance service providers, such as TRUSTe, BBBonline, and WebTrust, audit online businesses to assure their compliance with principles and criteria for e-commerce business activities. Of these assurance service providers, WebTrust offers the most comprehensive services, including programs for business to consumer and business to business transactions, certification authorities (CA) and service providers. WebTrust jointly developed by the American Institute of Certified Public Accountants (AICPA) and the Canadian Institute of Chartered Accountants (CICA) offers best practices and a framework of measurable controls for electronic businesses, and thus, fosters online trust and confidence that are critical to the success of electronic commerce. As e-commerce matures, WebTrust will play an increasingly important role in CA-based e-commerce as well as in the applications service provider industry

Kinetic Resolution in Asymmetric Epoxidation using Iminium Salt Catalysis

The first reported examples of kinetic resolution in epoxidation reactions using iminium salt catalysis are described, providing up to 99% ee in the epoxidation of racemic cis-chromenes

Overview of an Advanced Warehouse Management System

Today’s warehouses are no longer merely places to accumulate and store inventory to meet future demand. Through the use of real-time technology, warehouses are being transformed into distribution centers that speed inventory through the supply chain and configure the goods just prior to shipment to meet customer requirements. Therefore, today’s Warehouse Management System is expected to be a key link in enabling efficiency in the overall supply chain process [3,7]. The modern WMSs are expected to provide extensive warehousing functions as well as a wide range of value-added services. WMS vendors are beginning to bundle other applications that are traditionally associated with Supply Chain packages. This paper introduces an advanced eWarehouse Management System (eWMS), its high level functionality, its architecture, and a high level benefit analysis over existing WMS implementations. In addition, a brief survey of WMS market in Hong Kong is also described

Noncommutative Field Theory from twisted Fock space

We construct a quantum field theory in noncommutative spacetime by twisting the algebra of quantum operators (especially, creation and annihilation operators) of the corresponding quantum field theory in commutative spacetime. The twisted Fock space and S-matrix consistent with this algebra have been constructed. The resultant S-matrix is consistent with that of Filk\cite{Filk}. We find from this formulation that the spin-statistics relation is not violated in the canonical noncommutative field theories.Comment: 13 pages, 1 figure, minor changes, add reference

Stripe order in the underdoped region of the two-dimensional Hubbard model

Competing inhomogeneous orders are a central feature of correlated electron materials including the high-temperature superconductors. The two- dimensional Hubbard model serves as the canonical microscopic physical model for such systems. Multiple orders have been proposed in the underdoped part of the phase diagram, which corresponds to a regime of maximum numerical difficulty. By combining the latest numerical methods in exhaustive simulations, we uncover the ordering in the underdoped ground state. We find a stripe order that has a highly compressible wavelength on an energy scale of a few Kelvin, with wavelength fluctuations coupled to pairing order. The favored filled stripe order is different from that seen in real materials. Our results demonstrate the power of modern numerical methods to solve microscopic models even in challenging settings

Chimera Grid Tools

Chimera Grid Tools (CGT) is a software package for performing computational fluid dynamics (CFD) analysis utilizing the Chimera-overset-grid method. For modeling flows with viscosity about geometrically complex bodies in relative motion, the Chimera-overset-grid method is among the most computationally cost-effective methods for obtaining accurate aerodynamic results. CGT contains a large collection of tools for generating overset grids, preparing inputs for computer programs that solve equations of flow on the grids, and post-processing of flow-solution data. The tools in CGT include grid editing tools, surface-grid-generation tools, volume-grid-generation tools, utility scripts, configuration scripts, and tools for post-processing (including generation of animated images of flows and calculating forces and moments exerted on affected bodies). One of the tools, denoted OVERGRID, is a graphical user interface (GUI) that serves to visualize the grids and flow solutions and provides central access to many other tools. The GUI facilitates the generation of grids for a new flow-field configuration. Scripts that follow the grid generation process can then be constructed to mostly automate grid generation for similar configurations. CGT is designed for use in conjunction with a computer-aided-design program that provides the geometry description of the bodies, and a flow-solver program