35 research outputs found
Π‘ΠΈΠ½ΡΠ΅Π· ΡΠ° Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½Π° Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ Π±ΡΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΡΠ΄ΠΎΠΊΠ°Π»ΡΠΊΡΠ°ΡΠ΅Π½Ρ
Aim. To develop the method for the synthesis of the conjugate of diaminocalix[4]arene with 2-(2,3-dimethylphenyl)aminobenzoic acid (mefenamic acid) β bis-mefenamidocalixarene, determine its structure and physicochemical properties and assess its anti-exudative activity (AeA).Results and discussion. The conjugate of diaminocalixarene with mefenamic acid β bis-mefenamidocalixarene was synthesized at one step by the reaction of reactants in equimolar amounts in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. The structure of the compound obtained was determined by spectral methods. AeA of bis-mefenamidocalixarene was studied in rats using the model of formalin edema. The results of the experimental studies showed that bis-mefenamidocalixarene exhibited the anti-exudative activity, which was equal to the reference drug β sodium diclofenac.Experimental part. The reaction of diaminocalixaren with 2- (2,3-dimethylphenyl)aminobenzoic acid (mefenamic acid) led to bis-mefenamidocalixarene with 40 % yield. The screening of AeA was carried out using modern digital plethysmometer (IITC Life Science (USA)).Conclusions. The effective one-stage method for the synthesis of the conjugate of diaminocalix[4]arene with 2-(2,3-dimethylphenyl)aminobenzoic acid β bis-mefenamidocalixarene has been developed. Its structure has been proven, and AeA has been studied. AeA is equal to the reference drug. It has been found that bis-mefenamidokalixaren synthesized is a promising compound for further profound studies.Π¦Π΅Π»Ρ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΠΌΠ΅ΡΠΎΠ΄ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ° Π΄ΠΈΠ°ΠΌΠΈΠ½ΠΎΠΊΠ°Π»ΠΈΠΊΡ[4]Π°ΡΠ΅Π½Π° Ρ 2-(2,3-Π΄ΠΈΠΌΠ΅ΡΠΈΠ»ΡΠ΅Π½ΠΈΠ»)Π°ΠΌΠΈΠ½ΠΎΠ±Π΅Π½Π·ΠΎΠΉΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠΉ (ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠΉ) β Π±ΠΈΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΠΈΠ΄ΠΎΠΊΠ°Π»ΠΈΠΊΡΠ°ΡΠ΅Π½, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π΅Π³ΠΎ ΡΡΡΠΎΠ΅Π½ΠΈΠ΅ ΠΈ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π°, ΠΎΡΠ΅Π½ΠΈΡΡ Π΅Π³ΠΎ Π°Π½ΡΠΈΡΠΊΡΡΡΠ΄Π°ΡΠΈΠ²Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΠΎΠ½ΡΡΠ³Π°Ρ Π΄ΠΈΠ°ΠΌΠΈΠ½ΠΎΠΊΠ°Π»ΠΈΠΊΡΠ°ΡΠ΅Π½Π° Ρ ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠΉ β Π±ΠΈΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΠΈΠ΄ΠΎΠΊΠ°Π»ΠΈΠΊΡΠ°ΡΠ΅Π½ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ Π² ΠΎΠ΄Π½Ρ ΡΡΠ°Π΄ΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΠΈΡΡ
ΠΎΠ΄Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π² ΡΠΊΠ²ΠΈΠΌΠΎΠ»ΡΡΠ½ΡΡ
ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π°Ρ
Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ 1-ΡΡΠΈΠ»-3-(3-Π΄ΠΈΠΌΠ΅ΡΠΈΠ»Π°ΠΌΠΈΠ½ΠΎΠΏΡΠΎΠΏΠΈΠ»)ΠΊΠ°ΡΠ±ΠΎΠ΄ΠΈΠΈΠΌΠΈΠ΄Π°. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΎ ΡΡΡΠΎΠ΅Π½ΠΈΠ΅ ΠΈ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ°. ΠΠ° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΠΎΡΠΌΠ°Π»ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΠΎΡΠ΅ΠΊΠ° Ρ ΠΊΡΡΡ ΠΈΠ·ΡΡΠ΅Π½Π° Π°Π½ΡΠΈΡΠΊΡΡΡΠ΄Π°ΡΠΈΠ²Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠ° Π΄ΠΈΠ°ΠΌΠΈΠ½ΠΎΠΊΠ°Π»ΠΈΠΊΡ[4]Π°ΡΠ΅Π½Π° Ρ 2-(2,3-Π΄ΠΈΠΌΠ΅ΡΠΈΠ»ΡΠ΅Π½ΠΈΠ»)Π°ΠΌΠΈΠ½ΠΎΠ±Π΅Π½Π·ΠΎΠΉΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠΉ β Π±ΠΈΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΠΈΠ΄ΠΎΠΊΠ°Π»ΠΈΠΊΡΠ°ΡΠ΅Π½Π°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ Π±ΠΈΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΠΈΠ΄ΠΎΠΊΠ°Π»ΠΈΠΊΡΠ°ΡΠ΅Π½ ΠΏΡΠΎΡΠ²Π»ΡΠ΅Ρ Π°Π½ΡΠΈΡΠΊΡΡΡΠ΄Π°ΡΠΈΠ²Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π½Π° ΡΡΠΎΠ²Π½Π΅ ΡΠ΅ΡΠ΅ΡΠ΅Π½Ρ-ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° β Π΄ΠΈΠΊΠ»ΠΎΡΠ΅Π½Π°ΠΊΠ° Π½Π°ΡΡΠΈΡ.ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π°Ρ ΡΠ°ΡΡΡ. Π±ΠΈΡ-ΠΠ΅ΡΠ΅Π½Π°ΠΌΠΈΠ΄ΠΎΠΊΠ°Π»ΠΈΠΊΡΠ°ΡΠ΅Π½ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ Π΄ΠΈΠ°ΠΌΠΈΠ½ΠΎΠΊΠ°Π»ΠΈΠΊΡΠ°ΡΠ΅Π½Π° c 2-(2,3-Π΄ΠΈΠΌΠ΅ΡΠΈΠ»ΡΠ΅Π½ΠΈΠ»)Π°ΠΌΠΈΠ½ΠΎΠ±Π΅Π½Π·ΠΎΠΉΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠΉ (ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠΉ) Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ 1-ΡΡΠΈΠ»-3-(3-Π΄ΠΈΠΌΠ΅ΡΠΈΠ»Π°ΠΌΠΈΠ½ΠΎΠΏΡΠΎΠΏΠΈΠ»)ΠΊΠ°ΡΠ±ΠΎΠ΄ΠΈΠΈΠΌΠΈΠ΄Π° Π³ΠΈΠ΄ΡΠΎΡ
Π»ΠΎΡΠΈΠ΄Π° Ρ Π²ΡΡ
ΠΎΠ΄ΠΎΠΌ 40 %. Π‘ΠΊΡΠΈΠ½ΠΈΠ½Π³ Π°Π½ΡΠΈΡΠΊΡΡΡΠ΄Π°ΡΠΈΠ²Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΈΡΡΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠ»Π΅ΡΠΈΠ·ΠΌΠΎΠΌΠ΅ΡΡΠ° IITC Life Science (Π‘Π¨Π).ΠΡΠ²ΠΎΠ΄Ρ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΎΠ΄Π½ΠΎΡΡΠ°Π΄ΠΈΠΉΠ½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΡΠΈΠ½ΡΠ΅Π·Π° Π±ΠΈΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΠΈΠ΄ΠΎΠΊΠ°Π»ΠΈΠΊΡΠ°ΡΠ΅Π½Π°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ Π΅Π³ΠΎ ΡΡΡΠΎΠ΅Π½ΠΈΠ΅ ΠΈ ΠΈΠ·ΡΡΠ΅Π½Π° Π°Π½ΡΠΈΡΠΊΡΡΡΠ΄Π°ΡΠΈΠ²Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΎΠΊΠ°Π·Π°Π»Π°ΡΡ Π½Π° ΡΡΠΎΠ²Π½Π΅ ΡΠ΅ΡΠ΅ΡΠ΅Π½Ρ-ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ Π±ΠΈΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΠΈΠ΄ΠΎΠΊΠ°Π»ΠΈΠΊΡΠ°ΡΠ΅Π½ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ Π΄Π»Ρ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠΈΡ
ΡΠ³Π»ΡΠ±Π»Π΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ.ΠΠ΅ΡΠ°. Π ΠΎΠ·ΡΠΎΠ±ΠΈΡΠΈ ΠΌΠ΅ΡΠΎΠ΄ ΠΎΡΡΠΈΠΌΠ°Π½Π½Ρ ΠΊΠΎΠ½βΡΠ³Π°ΡΡ Π΄ΡΠ°ΠΌΡΠ½ΠΎΠΊΠ°Π»ΡΠΊΡ[4]Π°ΡΠ΅Π½Ρ Π· 2-(2,3-Π΄ΠΈΠΌΠ΅ΡΠΈΠ»ΡΠ΅Π½ΡΠ»)Π°ΠΌΡΠ½ΠΎΠ±Π΅Π½Π·ΠΎΠΉΠ½ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΡ (ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΡΠ½ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΡ) β Π±ΡΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΡΠ΄ΠΎΠΊΠ°Π»ΡΠΊΡΠ°ΡΠ΅Π½Ρ, Π²ΠΈΠ·Π½Π°ΡΠΈΡΠΈ ΠΉΠΎΠ³ΠΎ Π±ΡΠ΄ΠΎΠ²Ρ ΡΠ° ΡΡΠ·ΠΈΠΊΠΎ-Ρ
ΡΠΌΡΡΠ½Ρ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΡ, ΠΎΡΡΠ½ΠΈΡΠΈ ΠΉΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ΅ΠΊΡΡΠ΄Π°ΡΠΈΠ²Π½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ° ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. ΠΠΎΠ½βΡΠ³Π°Ρ Π΄ΡΠ°ΠΌΡΠ½ΠΎΠΊΠ°Π»ΡΠΊΡΠ°ΡΠ΅Π½Ρ Π· ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΡΠ½ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΡ β Π±ΡΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΡΠ΄ΠΎΠΊΠ°Π»ΡΠΊΡΠ°ΡΠ΅Π½ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΎ Π² ΠΎΠ΄Π½Ρ ΡΡΠ°Π΄ΡΡ Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡΡ Π²ΠΈΡ
ΡΠ΄Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ Π² Π΅ΠΊΠ²ΡΠΌΠΎΠ»ΡΡΠ½ΠΈΡ
ΠΊΡΠ»ΡΠΊΠΎΡΡΡΡ
Ρ ΠΏΡΠΈΡΡΡΠ½ΠΎΡΡΡ 1-Π΅ΡΠΈΠ»-3-(3-Π΄ΠΈΠΌΠ΅ΡΠΈΠ»Π°ΠΌΡΠ½ΠΎΠΏΡΠΎΠΏΡΠ»)ΠΊΠ°ΡΠ±ΠΎΠ΄ΡΡΠΌΡΠ΄Ρ. ΠΠΈΠ·Π½Π°ΡΠ΅Π½ΠΎ Π±ΡΠ΄ΠΎΠ²Ρ ΠΎΡΡΠΈΠΌΠ°Π½ΠΎΠ³ΠΎ ΠΊΠΎΠ½βΡΠ³Π°ΡΡ Π·Π° Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΎΡ ΡΠΏΠ΅ΠΊΡΡΠ°Π»ΡΠ½ΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΡΠ² Π°Π½Π°Π»ΡΠ·Ρ. ΠΠ° ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠ²ΠΎΠ³ΠΎ Π½Π°Π±ΡΡΠΊΡ Ρ ΡΡΡΡΠ² Π²ΠΈΠ²ΡΠ΅Π½ΠΎ Π°Π½ΡΠΈΠ΅ΠΊΡΡΠ΄Π°ΡΠΈΠ²Π½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ Π±ΡΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΡΠ΄ΠΎΠΊΠ°Π»ΡΠΊΡΠ°ΡΠ΅Π½Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΈΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΠΎ Π±ΡΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΡΠ΄ΠΎΠΊΠ°Π»ΡΠΊΡΠ°ΡΠ΅Π½ Π²ΠΈΡΠ²ΠΈΠ² Π°Π½ΡΠΈΠ΅ΠΊΡΡΠ΄Π°ΡΠΈΠ²Π½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ, ΡΠΊΠ° Π±ΡΠ»Π° Π½Π° ΡΡΠ²Π½Ρ ΡΠ΅ΡΠ΅ΡΠ΅Π½Ρ-ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ β Π΄ΠΈΠΊΠ»ΠΎΡΠ΅Π½Π°ΠΊΡ Π½Π°ΡΡΡΡ.ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π° ΡΠ°ΡΡΠΈΠ½Π°.Β Π±ΡΡ-ΠΠ΅ΡΠ΅Π½Π°ΠΌΡΠ΄ΠΎΠΊΠ°Π»ΡΠΊΡΠ°ΡΠ΅Π½ ΠΎΡΡΠΈΠΌΡΠ²Π°Π»ΠΈ Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡΡ Π΄ΡΠ°ΠΌΡΠ½ΠΎΠΊΠ°Π»ΡΠΊΡΠ°ΡΠ΅Π½Ρ Π· 2-(2,3-Π΄ΠΈΠΌΠ΅ΡΠΈΠ»ΡΠ΅Π½ΡΠ»)Π°ΠΌΡΠ½ΠΎΠ±Π΅Π½Π·ΠΎΠΉΠ½ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΡ (ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΡΠ½ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΡ) Ρ ΠΏΡΠΈΡΡΡΠ½ΠΎΡΡΡ 1-Π΅ΡΠΈΠ»-3-(3-Π΄ΠΈΠΌΠ΅ΡΠΈΠ»Π°ΠΌΡΠ½ΠΎΠΏΡΠΎΠΏΡΠ»)ΠΊΠ°ΡΠ±ΠΎΠ΄ΡΡΠΌΡΠ΄Ρ Π³ΡΠ΄ΡΠΎΡ
Π»ΠΎΡΠΈΠ΄Ρ Π· Π²ΠΈΡ
ΠΎΠ΄ΠΎΠΌ 40 %. Π‘ΠΊΡΠΈΠ½ΡΠ½Π³ Π°Π½ΡΠΈΠ΅ΠΊΡΡΠ΄Π°ΡΠΈΠ²Π½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈ Π·Π° Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΎΡ ΡΠΈΡΡΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠ»Π΅ΡΠΈΠ·ΠΌΠΎΠΌΠ΅ΡΡΠ° IITC Life Science (Π‘Π¨Π).ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. Π ΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΎ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΈΠΉ ΠΎΠ΄Π½ΠΎΡΡΠ°Π΄ΡΠΉΠ½ΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΡΠΈΠ½ΡΠ΅Π·Ρ Π±ΡΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΡΠ΄ΠΎΠΊΠ°Π»ΡΠΊΡΠ°ΡΠ΅Π½Ρ. ΠΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΉΠΎΠ³ΠΎ Π±ΡΠ΄ΠΎΠ²Ρ ΡΠ° Π²ΠΈΠ²ΡΠ΅Π½ΠΎ Π°Π½ΡΠΈΠ΅ΠΊΡΡΠ΄Π°ΡΠΈΠ²Π½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ, ΡΠΊΠ° Π²ΠΈΡΠ²ΠΈΠ»Π°ΡΡ Π½Π° ΡΡΠ²Π½Ρ ΡΠ΅ΡΠ΅ΡΠ΅Π½Ρ-ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΠΎ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΡΡ-ΠΌΠ΅ΡΠ΅Π½Π°ΠΌΡΠ΄ΠΎΠΊΠ°Π»ΡΠΊΡΠ°ΡΠ΅Π½ Ρ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΈΠΌ Π΄Π»Ρ ΠΏΠΎΠ΄Π°Π»ΡΡΠΈΡ
ΠΏΠΎΠ³Π»ΠΈΠ±Π»Π΅Π½ΠΈΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ
Prediction of the Antiinflammatory Activity of New S-alkyl Derivatives of 1,2,4-triazol-3-thiones Using the PASS Computer Program and Molecular Docking
The strategy of rational approaches to the search for selective COX-2 inhibitors as potential antiinflammatory agents has been proposed and elaborated. It is based on the use of PASS-prediction and molecular docking. The choice of the basic structure of 4-amino-3-thio-1,2,4-triazole as a promising object of chemical modification has been substantiated. Using a modification of the primary molecule, a virtual library of S-derivatives of 5-substituted 4-amino(pyrrol)3-thio-4H-1,2,4-triazoles in the amount of 100 compounds (ten groups) has been obtained by introducing various pharmacophore fragments. Based on the analysis of the results of the PASS-prediction and molecular docking, six of the ten planned groups of compounds have been selected for the synthesis as promising selective COX-2 inhibitors. The reliability of the prediction results has already been confirmed for one of the promising group 4-amino-5-(pyridine-4-yl)-1,2,4-triazole (4Π)-3-yl-thioacetamides
Analysis of production levels of InlA and InlB invasion factors in Listeria monocytogenes isolates collected in the Russian Federation
Background. Listeria monocytogenes is characterized by the presence of epidemic hypervirulent clones. A key feature of L. monocytogenes is its capacity to invade non-professional phagocytic cells. Hypervirulent clones are strongly associated with the increased production and/or the presence of certain isoforms of invasion factors InlA and InlB.
The purpose of the study is to create a test system for InlA and InlB detection and to measure the InlA and InlB production levels in L. monocytogenes isolates belonging to clonal groups with different virulence potential.
Materials and methods. The study was performed using 32 L. monocytogenes strains belonging to epidemic clones ECII, ECIV, ECVII (clonal complexes CC1, CC2, CC7) and hypovirulent clonal complex CC9. Sequencing of inlA and inlB genes was performed. The indirect enzyme-linked immunosorbent assay was used to analyze the production levels of InlA and InlB proteins.
Results. The variability of InlA was revealed among strains belonging to the same clonal complex: 3 InlA isoforms were identified among strains belonging to CC7; out of 8 strains belonging to CC9, one strain had a stop codon in the inlA gene, leading to the loss of function of the InlA protein. The differences between inlB alleles correlated with the specificity of strains belonging to a certain clonal complex. Differences in production levels of invasion factors were measured. In strains belonging to CC9, the InlA production level was 2.5 times as low compared to strains belonging to CC1, CC2, and CC7. In strains belonging to phylogenetically related CC1 and CC2, the InlB production level was on average 4 times as high compared to strains belonging to CC7 and CC9.
Conclusion. The obtained results confirm the variability of major invasion factors both among clonal complexes and strains of the same complex. The increased production of invasion factors InlA and InlB correlates with the potential virulence of strains
Variability of Hot Supergiant IRAS 19336-0400 in the Early Phase of its Planetary Nebula Ionization
We present photoelectric and spectral observations of a hot candidate
proto-planetary nebula - early B-type supergiant with emission lines in
spectrum - IRAS 19336-0400. The light and color curves display fast irregular
brightness variations with maximum amplitudes Delta V=0.30 mag, Delta B=0.35
mag, Delta U=0.40 mag and color-brightness correlations. By the variability
characteristics IRAS 19336-0400 appears similar to other hot proto-planetary
nebulae. Based on low-resolution spectra in the range lambda 4000-7500 A we
have derived absolute intensities of the emission lines H_alpha, H_beta,
H_gamma, [SII], [NII], physical conditions in gaseous nebula: n_e=10^4 cm^{-3},
T_e=7000 \pm 1000 K. The emission line H_alpha, H_beta equivalent widths are
found to be considerably variable and related to light changes. By
UBV-photometry and spectroscopy the color excess has been estimated:
E_{B-V}=0.50-0.54. Joint photometric and spectral data analysis allows us to
assume that the star variability is caused by stellar wind variations.Comment: 11 pages, 6 figures, 2 tables, accepted for publication in Pis'ma
Astron. Zh. (Astronomy Letters
One Hundred Years of Observations of the Be Star HDE 245770 (the X-ray Binary A0535+26/V725 Tau): The End of an Active Phase
UBV observations of the X-ray binary system A0535+26/V725 Tau at the Crimean
Station of the Sternberg Astronomical Institute in 1980-1998 are presented.
Based on our and published data, we analyze the photometric history of the star
from 1898.Comment: Translated from Pis'ma Astronomicheskii Zhurnal, Vol. 26, No. 1,
2000, pp. 13-2
Social Risks as a Factor of Regulation of the System of Social Protection of the Population in Ukraine
The article classifies social risks into traditional and non-traditional and their impact on the regulation of the social protection system in Ukraine. The modern problems of financing the sphere of social protection of the population in Ukraine are revealed and the ways of their overcoming are outlined. The dynamics of arrears of wages in Ukraine and the dynamics of real disposable income of the population of Ukraine for 2005-2018 are presented. It is proved that one of the significant obstacles to the effective implementation of social policy in our country is the insufficient level of its financial support in combination with irrational planning, distribution and inefficient use of available financial resources. Respondentsβ assessment of the degree of impact of traditional and non-traditional social risks on the social protection of citizens is presented. It is determined that the progressive and dynamic development of Ukraine today can focus on the socialization of the economic system with full consideration of the needs, interests of the population, its incentives for productive work to realize their own professional potential, comprehensive development, receiving a decent reward for work.Π£ ΡΡΠ°ΡΡΡ Π·Π΄ΡΠΉΡΠ½Π΅Π½ΠΎ ΠΊΠ»Π°ΡΠΈΡΡΠΊΠ°ΡΡΡ ΡΠΎΡΡΠ°Π»ΡΠ½ΠΈΡ
ΡΠΈΠ·ΠΈΠΊΡΠ² Π½Π° ΡΡΠ°Π΄ΠΈΡΡΠΉΠ½Ρ Ρ Π½Π΅ΡΡΠ°Π΄ΠΈΡΡΠΉΠ½Ρ ΡΠ° ΡΡ
Π²ΠΏΠ»ΠΈΠ² Π½Π° ΡΠ΅Π³ΡΠ»ΡΠ²Π°Π½Π½Ρ ΡΠΈΡΡΠ΅ΠΌΠΈ ΡΠΎΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π·Π°Ρ
ΠΈΡΡΡ Π½Π°ΡΠ΅Π»Π΅Π½Π½Ρ Π² Π£ΠΊΡΠ°ΡΠ½Ρ. ΠΠΈΡΠ²Π»Π΅Π½ΠΎ ΡΡΡΠ°ΡΠ½Ρ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΈ ΡΡΠ½Π°Π½ΡΡΠ²Π°Π½Π½Ρ ΡΡΠ΅ΡΠΈ ΡΠΎΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π·Π°Ρ
ΠΈΡΡΡ Π½Π°ΡΠ΅Π»Π΅Π½Π½Ρ Π² Π£ΠΊΡΠ°ΡΠ½Ρ ΡΠ° ΠΎΠΊΡΠ΅ΡΠ»Π΅Π½ΠΎ ΡΠ»ΡΡ
ΠΈ ΡΡ
ΠΏΠΎΠ΄ΠΎΠ»Π°Π½Π½Ρ. ΠΠ°Π²Π΅Π΄Π΅Π½ΠΎ Π΄ΠΈΠ½Π°ΠΌΡΠΊΡ Π·Π°Π±ΠΎΡΠ³ΠΎΠ²Π°Π½ΠΎΡΡΡ Π· Π²ΠΈΠΏΠ»Π°ΡΠΈ Π·Π°ΡΠΎΠ±ΡΡΠ½ΠΎΡ ΠΏΠ»Π°ΡΠΈ Π² Π£ΠΊΡΠ°ΡΠ½Ρ ΡΠ° Π΄ΠΈΠ½Π°ΠΌΡΠΊΡ ΡΠ΅Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π½Π°ΡΠ²Π½ΠΎΠ³ΠΎ Π΄ΠΎΡ
ΠΎΠ΄Ρ Π½Π°ΡΠ΅Π»Π΅Π½Π½Ρ Π£ΠΊΡΠ°ΡΠ½ΠΈ Π·Π° 2005-2018 ΡΠΎΠΊΠΈ. ΠΠΎΠ²Π΅Π΄Π΅Π½ΠΎ, ΡΠΎ ΠΎΠ΄Π½ΡΡΡ ΡΠ· Π²Π°Π³ΠΎΠΌΠΈΡ
ΠΏΠ΅ΡΠ΅ΡΠΊΠΎΠ΄ Π½Π° ΡΠ»ΡΡ
Ρ Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡ ΡΠ΅Π°Π»ΡΠ·Π°ΡΡΡ Π² Π½Π°ΡΡΠΉ ΠΊΡΠ°ΡΠ½Ρ ΡΠΎΡΡΠ°Π»ΡΠ½ΠΎΡ ΠΏΠΎΠ»ΡΡΠΈΠΊΠΈ Ρ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠ½ΡΠΉ ΡΡΠ²Π΅Π½Ρ ΡΡ ΡΡΠ½Π°Π½ΡΠΎΠ²ΠΎΠ³ΠΎ Π·Π°Π±Π΅Π·ΠΏΠ΅ΡΠ΅Π½Π½Ρ Ρ ΠΏΠΎΡΠ΄Π½Π°Π½Π½Ρ Π· Π½Π΅ΡΠ°ΡΡΠΎΠ½Π°Π»ΡΠ½ΠΈΠΌ ΠΏΠ»Π°Π½ΡΠ²Π°Π½Π½ΡΠΌ, ΡΠΎΠ·ΠΏΠΎΠ΄ΡΠ»ΠΎΠΌ Ρ Π½Π΅Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΈΠΌ Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½Π½ΡΠΌ Π½Π°ΡΠ²Π½ΠΈΡ
ΡΡΠ½Π°Π½ΡΠΎΠ²ΠΈΡ
ΡΠ΅ΡΡΡΡΡΠ². ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΎ ΠΎΡΡΠ½ΠΊΡ ΡΠ΅ΡΠΏΠΎΠ½Π΄Π΅Π½ΡΠ°ΠΌΠΈ ΡΡΡΠΏΠ΅Π½Ρ Π²ΠΏΠ»ΠΈΠ²Ρ ΡΡΠ°Π΄ΠΈΡΡΠΉΠ½ΠΈΡ
Ρ Π½Π΅ΡΡΠ°Π΄ΠΈΡΡΠΉΠ½ΠΈΡ
ΡΠΎΡΡΠ°Π»ΡΠ½ΠΈΡ
ΡΠΈΠ·ΠΈΠΊΡΠ² Π½Π° ΡΠΎΡΡΠ°Π»ΡΠ½Ρ Π·Π°Ρ
ΠΈΡΠ΅Π½ΡΡΡΡ Π³ΡΠΎΠΌΠ°Π΄ΡΠ½. ΠΠΈΠ·Π½Π°ΡΠ΅Π½ΠΎ, ΡΠΎ ΠΏΠΎΡΡΡΠΏΠ°Π»ΡΠ½ΠΈΠΉ ΡΠ° Π΄ΠΈΠ½Π°ΠΌΡΡΠ½ΠΈΠΉ ΡΠΎΠ·Π²ΠΈΡΠΎΠΊ Π£ΠΊΡΠ°ΡΠ½ΠΈ ΡΡΠΎΠ³ΠΎΠ΄Π½Ρ ΠΏΠΎΠ²ΠΈΠ½Π΅Π½ ΠΎΡΡΡΠ½ΡΡΠ²Π°ΡΠΈΡΡ Π½Π° ΡΠΎΡΡΠ°Π»ΡΠ·Π°ΡΡΡ Π΅ΠΊΠΎΠ½ΠΎΠΌΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ Π· Π½Π°ΠΉΠΏΠΎΠ²Π½ΡΡΠΈΠΌ ΡΡΠ°Ρ
ΡΠ²Π°Π½Π½ΡΠΌ ΠΏΠΎΡΡΠ΅Π±, ΡΠ½ΡΠ΅ΡΠ΅ΡΡΠ² Π½Π°ΡΠ΅Π»Π΅Π½Π½Ρ, ΠΉΠΎΠ³ΠΎ ΡΡΠΈΠΌΡΠ»ΡΠ² Π΄ΠΎ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΡ ΡΡΡΠ΄ΠΎΠ²ΠΎΡ Π΄ΡΡΠ»ΡΠ½ΠΎΡΡΡ Π΄Π»Ρ ΡΠ΅Π°Π»ΡΠ·Π°ΡΡΡ Π²Π»Π°ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠΉΠ½ΠΎ-ΠΊΠ²Π°Π»ΡΡΡΠΊΠ°ΡΡΠΉΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ΅Π½ΡΡΠ°Π»Ρ, Π²ΡΠ΅Π±ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ·Π²ΠΈΡΠΊΡ, ΠΎΠ΄Π΅ΡΠΆΠ°Π½Π½Ρ Π³ΡΠ΄Π½ΠΎΡ Π²ΠΈΠ½Π°Π³ΠΎΡΠΎΠ΄ΠΈ Π·Π° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΠΏΡΠ°ΡΡ.Π ΡΡΠ°ΡΡΠ΅ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½Π° ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΡ
ΡΠΈΡΠΊΠΎΠ² Π½Π° ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΈ Π½Π΅ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΈ ΠΈΡ
Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π·Π°ΡΠΈΡΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ Π² Π£ΠΊΡΠ°ΠΈΠ½Π΅. ΠΡΡΠ²Π»Π΅Π½Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΡΠΈΠ½Π°Π½ΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ΅ΡΡ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π·Π°ΡΠΈΡΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ Π² Π£ΠΊΡΠ°ΠΈΠ½Π΅ ΠΈ ΠΎΡΠ΅ΡΡΠ΅Π½Ρ ΠΏΡΡΠΈ ΠΈΡ
ΠΏΡΠ΅ΠΎΠ΄ΠΎΠ»Π΅Π½ΠΈΡ. ΠΡΠΈΠ²Π΅Π΄Π΅Π½Π° Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° Π·Π°Π΄ΠΎΠ»ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΏΠΎ Π²ΡΠΏΠ»Π°ΡΠ΅ Π·Π°ΡΠ°Π±ΠΎΡΠ½ΠΎΠΉ ΠΏΠ»Π°ΡΡ Π² Π£ΠΊΡΠ°ΠΈΠ½Π΅ ΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° ΡΠ΅Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠ΅ΡΡΠ΅Π³ΠΎΡΡ Π΄ΠΎΡ
ΠΎΠ΄Π° Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ Π£ΠΊΡΠ°ΠΈΠ½Ρ Π·Π° 2005-2018 Π³ΠΎΠ΄Ρ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· Π²Π΅ΡΠΎΠΌΡΡ
ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΠΈΠΉ Π½Π° ΠΏΡΡΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π² Π½Π°ΡΠ΅ΠΉ ΡΡΡΠ°Π½Π΅ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΠ»ΠΈΡΠΈΠΊΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Π΅Π΅ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΠΎΠ³ΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Π½Π΅ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌ ΠΏΠ»Π°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ, ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΈ Π½Π΅ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈΠΌΠ΅ΡΡΠΈΡ
ΡΡ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΡΡ
ΡΠ΅ΡΡΡΡΠΎΠ². ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° ΡΠ΅ΡΠΏΠΎΠ½Π΄Π΅Π½ΡΠ°ΠΌΠΈ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΡ
ΠΈ Π½Π΅ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΡ
ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΡ
ΡΠΈΡΠΊΠΎΠ² Π½Π° ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΡ Π·Π°ΡΠΈΡΠ΅Π½Π½ΠΎΡΡΡ Π³ΡΠ°ΠΆΠ΄Π°Π½. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΏΠΎΡΡΡΠΏΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ Π£ΠΊΡΠ°ΠΈΠ½Ρ ΡΠ΅Π³ΠΎΠ΄Π½Ρ Π΄ΠΎΠ»ΠΆΠ½ΠΎ ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²Π°ΡΡΡΡ Π½Π° ΡΠΎΡΠΈΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Ρ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΏΠΎΠ»Π½ΡΠΌ ΡΡΠ΅ΡΠΎΠΌ Π½ΡΠΆΠ΄, ΠΈΠ½ΡΠ΅ΡΠ΅ΡΠΎΠ² Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ, Π΅Π³ΠΎ ΡΡΠΈΠΌΡΠ»ΠΎΠ² ΠΊ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΡΡΠ΄ΠΎΠ²ΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π΄Π»Ρ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ-ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π°, Π²ΡΠ΅ΡΡΠΎΡΠΎΠ½Π½Π΅Π³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ, ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π΄ΠΎΡΡΠΎΠΉΠ½ΠΎΠ³ΠΎ Π²ΠΎΠ·Π½Π°Π³ΡΠ°ΠΆΠ΄Π΅Π½ΠΈΡ Π·Π° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΡΡΠ΄Π°
Strangulation and Necrosis of an Epiploic Appendage of the Sigmoid Colon in a Right Inguinal Hernia
An epiploic appendage of the sigmoid colon is considered to be an unusual type of inguinal hernia content. The strangulation of a sigmoid colon appendage into a right inguinal hernia is exclusively rare. We present a case of an 81-year-old female patient with severe cardiovascular comorbidities who was urgently admitted after an episode of strangulation and subsequent spontaneous reduction of a right inguinal hernia. The condition of the patient was stable, and an urgent operation was not indicated for three days after admission. However, we had to operate because the hernia strangulation recurred. In the hernia sac, a free fatty body (a separated and saponified epiploic appendage of the colon) and a strangulated epiploic appendage of dolichosigmoid, with signs of necrosis, were found. Removal of the free fatty body and necrotic epiploic appendage and subsequent anterior-wall inguinal hernioplasty were successfully performed. In the world literature, this case may be the first report of a sigmoid epiploic appendage strangulation in a right inguinal hernia that is well documented by photography