Osteoporose (OP) - prevenção e tratamento, uma visão atual

A osteoporose e suas conseqüências têm despertado, por ser considerada um problema moderno de saúde pública, a atenção dos governos, especialmente dos países desenvolvidos e, mais recentemente, daqueles considerados em desenvolvimento ou semi-industrializados. Com o apoio da mídia nacional e internacional, a divulgação dos conhecimentos e informações nessa área da patologia médica tem propiciado a milhoes de seres humanos em todo o mundo, refletir sobre as nefastas conseqüências dessa síndrome que hoje sabemos, começa a ser desenvolvida na infância e na puberdade, quando o patrimônio ósseo está sendo estabelecido, por meio da indução genética

The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity

Objective To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. Methods Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy). Results Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard. Conclusion HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR''s

Moulded joining technology with modified bonded-in rods: developed and designed for modular roundwood trusses

Timber structures and buildings made from sustainable forestry might be the solution to today's ecological challenges when their renewable materials are locally processed with low energy consumption in production. The current market shows a dominance of rectangular cross-sections in engineered timber solutions. Roundwood - a traditional material in the past - is no longer common due to a lack of applications in modern structures, lost knowledge in handcraft skills and the high costs of digital manufacturing. However, solid timber with a circular cross-section outperforms other engineered wood products, such as glued laminated products, in terms of energy consumption and environmental aspects. To overcome restrictions in joint technologies and to increase the usability of roundwood in modern constructions, this doctoral thesis focuses on the development of a new joining technology for modular two dimensional trusses, adapted to the preferences of structural roundwood.Tesis Univ. Granada.German Federal Ministry for Economic Affairs and Energy (ZF4119606

OCCASIONAL SERIES - LUPUS AROUND THE WORLD SYSTEMIC LUPUS-ERYTHEMATOSUS IN SAO-PAULO, BRAZIL - A CLINICAL AND LABORATORY OVERVIEW

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Nonsteroid anti-inflammatory drugs

Non-steroidal anti-infl ammatory drugs are the most frequentlyprescribed medications worldwide. In the United States, around 17million people use daily these drugs, because many of them canbe bought as over the counter medication, and approximately 60million prescriptions are made yearly. The majority of users are oldpeople. These drugs have shown to be effective for symptomaticinfl ammatory pain relief whether acute or chronic, mainly in muscularskeletal pain syndromes