74 research outputs found
A study to assess clinical profile of Indian type 2 diabetes mellitus patients treated with Teneligliptin-ASPIRE study
Background: Teneligliptin is a DPP-4 inhibitor with unique chemical structure. Efficacy and safety of Teneligliptin is well established in the patients with type 2 diabetes mellitus (T2DM) in different randomized controlled trials. However, limited real-world data is available for Teneligliptin pertaining to Indian T2DM patient profile such as demographics, duration of disease, currently prescribed anti-hyperglycemic drugs, initiation of Teneligliptin as monotherapy or as an add on therapy.Methods: A cross-sectional, multicenter, non-interventional study was conducted to understand the demographics and clinical profile of Indian T2DM patients (n=5091) who were prescribed Teneligliptin.Results: Majority of patients were male (65.2%) with family history of T2DM present in 43.45% of cases. Age at onset of T2DM was 51.1±11.6 years. Among the T2DM patients, 36.2% of patients were newly diagnosed and more than half of them (54.7%) were uncontrolled with current anti-hyperglycemic drugs. Mean HbA1c level among these patients was 8.09±1.3%. Mean fasting and postprandial blood glucose levels were 170.2±46.9 mg/dl and 255.3±69.3 mg/dl respectively. Teneligliptin was prescribed as monotherapy in 2165 (41.66 %) of patients while as dual, triple and quadruple therapy in 2346 (46.08%) and 551 (10.82%) and 29 (0.56%) respectively. Among the patients on current anti-hyperglycemic treatment, most commonly prescribed drugs along with Teneligliptin were metformin (43.39%) followed by glimepiride (11%) and voglibose (3.42%).Conclusions: Teneligliptin is preferred as monotherapy and combination with metformin and sulfonylureas (mostly glimepiride) in newly diagnosed and uncontrolled T2DM patients in Indian scenario
Factify 2: A Multimodal Fake News and Satire News Dataset
The internet gives the world an open platform to express their views and
share their stories. While this is very valuable, it makes fake news one of our
society's most pressing problems. Manual fact checking process is time
consuming, which makes it challenging to disprove misleading assertions before
they cause significant harm. This is he driving interest in automatic fact or
claim verification. Some of the existing datasets aim to support development of
automating fact-checking techniques, however, most of them are text based.
Multi-modal fact verification has received relatively scant attention. In this
paper, we provide a multi-modal fact-checking dataset called FACTIFY 2,
improving Factify 1 by using new data sources and adding satire articles.
Factify 2 has 50,000 new data instances. Similar to FACTIFY 1.0, we have three
broad categories - support, no-evidence, and refute, with sub-categories based
on the entailment of visual and textual data. We also provide a BERT and Vison
Transformer based baseline, which acheives 65% F1 score in the test set. The
baseline codes and the dataset will be made available at
https://github.com/surya1701/Factify-2.0.Comment: Defactify@AAAI202
Findings of Factify 2: Multimodal Fake News Detection
With social media usage growing exponentially in the past few years, fake
news has also become extremely prevalent. The detrimental impact of fake news
emphasizes the need for research focused on automating the detection of false
information and verifying its accuracy. In this work, we present the outcome of
the Factify 2 shared task, which provides a multi-modal fact verification and
satire news dataset, as part of the DeFactify 2 workshop at AAAI'23. The data
calls for a comparison based approach to the task by pairing social media
claims with supporting documents, with both text and image, divided into 5
classes based on multi-modal relations. In the second iteration of this task we
had over 60 participants and 9 final test-set submissions. The best
performances came from the use of DeBERTa for text and Swinv2 and CLIP for
image. The highest F1 score averaged for all five classes was 81.82%.Comment: Defactify2 @AAAI 202
Overview of Memotion 3: Sentiment and Emotion Analysis of Codemixed Hinglish Memes
Analyzing memes on the internet has emerged as a crucial endeavor due to the
impact this multi-modal form of content wields in shaping online discourse.
Memes have become a powerful tool for expressing emotions and sentiments,
possibly even spreading hate and misinformation, through humor and sarcasm. In
this paper, we present the overview of the Memotion 3 shared task, as part of
the DeFactify 2 workshop at AAAI-23. The task released an annotated dataset of
Hindi-English code-mixed memes based on their Sentiment (Task A), Emotion (Task
B), and Emotion intensity (Task C). Each of these is defined as an individual
task and the participants are ranked separately for each task. Over 50 teams
registered for the shared task and 5 made final submissions to the test set of
the Memotion 3 dataset. CLIP, BERT modifications, ViT etc. were the most
popular models among the participants along with approaches such as
Student-Teacher model, Fusion, and Ensembling. The best final F1 score for Task
A is 34.41, Task B is 79.77 and Task C is 59.82.Comment: Defactify2 @AAAI 202
Prevalence of malocclusion and orthodontic treatment needs among 12â15-year-old schoolchildren of fishermen of Kutch coast, Gujarat, India
Background: Malocclusion is one of the most common dental problems in mankind. Planning orthodontic treatment as well as an interceptive approach within a public health system requires information on the prevalence of malocclusions.Aim: The aim of the study was to assess the prevalence of malocclusion and orthodontic treatment needs among 12â15-year-old school children of fishermen of Kutch coast, Gujarat, India.Materials and methods: A cross-sectional descriptive survey was conducted among 947 school children offishermen of Kutch coast, Gujarat, India aged 12â15 years. The prevalence of malocclusion and orthodontic treatment needs was assessed using Dental Aesthetic Index. General information on demographic data was also recorded. A c2 test, analysis of variance (ANOVA) and Sheffeâs test were employed for statistical analysis.Results: Malocclusion and orthodontic treatment need was reported among 33.4% of the participants. Younger age group and female gender had significantly greater treatment need. Males and older age groups had significantly lesser prevalence of anterior crowding and largest anterior maxillary irregularity.Conclusions: Orthodontic treatment need among 33.4% calls for developing school based oral health promotion programmes for children with an inculcation of orthodontic treatment and educational programmes for parents (fishermen) addressing prevention and early interceptive treatment of malocclusion
Tumor-induced osteomalacia: experience from three tertiary care centers in India
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by recalcitrant hypophosphatemia. Reports from the Indian subcontinent are scarce, with most being single center experiences involving few patients. Herein, we conducted a retrospective analysis of 30 patients of TIO diagnosed at three tertiary care hospitals in India. Patients with persistent hypophosphatemia (despite correction of hypovitaminosis D), normocalcemia, elevated alkaline phosphatase, low TmP/GFR and elevated or âinappropriately normalâ FGF23 levels were labeled as having TIO. They were sequentially subjected to functional followed by anatomical imaging. Patients with a well-localized tumor underwent excision; others were put on phosphorous and calcitriol supplementation. The mean age at presentation was 39.6Â years with female:male ratio of 3:2. Bone pain (83.3%) and proximal myopathy (70%) were the chief complaints; 40% of cases had fractures. The mean delay in diagnosis was 3.8Â years. Tumors were clinically detectable in four patients (13.3%). The mean serum phosphate was 0.50 mmol/L with a median serum FGF23 level of 518 RU/mL. Somatostatin receptor-based scintigraphy was found to be superior to FDG-PET in tumor localization. Lower extremities were the most common site of the tumor (72%). Tumor size was positively correlated with serum FGF23 levels. Twenty-two patients underwent tumor resection and 16 of them had phosphaturic mesenchymal tumors. Surgical excision led to cure in 72.7% of patients whereas disease persistence and disease recurrence were seen in 18.2% and 9.1% of cases, respectively. At the last follow-up, serum phosphate in the surgically treated group was significantly higher than in the medically managed group
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
Predictors of mortality among hospitalized COVID-19 patients and risk score formulation for prioritizing tertiary careâAn experience from South India
BACKGROUND: We retrospectively data-mined the case records of Reverse Transcription Polymerase Chain Reaction (RT-PCR) confirmed COVID-19 patients hospitalized to a tertiary care centre to derive mortality predictors and formulate a risk score, for prioritizing admission. METHODS AND FINDINGS: Data on clinical manifestations, comorbidities, vital signs, and basic lab investigations collected as part of routine medical management at admission to a COVID-19 tertiary care centre in Chengalpattu, South India between May and November 2020 were retrospectively analysed to ascertain predictors of mortality in the univariate analysis using their relative difference in distribution among âsurvivorsâ and ânon-survivorsâ. The regression coefficients of those factors remaining significant in the multivariable logistic regression were utilised for risk score formulation and validated in 1000 bootstrap datasets. Among 746 COVID-19 patients hospitalised [487 âsurvivorsâ and 259 ânon-survivorsâ (deaths)], there was a slight male predilection [62.5%, (466/746)], with a higher mortality rate observed among 40â70 years age group [59.1%, (441/746)] and highest among diabetic patients with elevated urea levels [65.4% (68/104)]. The adjusted odds ratios of factors [OR (95% CI)] significant in the multivariable logistic regression were SaO(2)3; 3.01 (1.61â5.83), Age â„50 years;2.52 (1.45â4.43), Pulse Rate â„100/min: 2.02 (1.19â3.47) and coexisting Diabetes Mellitus; 1.73 (1.02â2.95) with hypertension and gender not retaining their significance. The individual risk scores for SaO(2)3â11, Age â„50 years-9, Pulse Rate â„100/min-7 and coexisting diabetes mellitus-6, acronymed collectively as âOUR-ARDs scoreâ showed that the sum of scores â„ 25 predicted mortality with a sensitivity-90%, specificity-64% and AUC of 0.85. CONCLUSIONS: The âOUR ARDsâ risk score, derived from easily assessable factors predicting mortality, offered a tangible solution for prioritizing admission to COVID-19 tertiary care centre, that enhanced patient care but without unduly straining the health system
Baseline factors associated with early and late death in intracerebral haemorrhage survivors
Background and purpose:
The aim of this study was to determine whether early and late death are associated with different baseline factors in intracerebral haemorrhage (ICH) survivors.
Methods:
This was a secondary analysis of the multicentre prospective observational CROMISâ2 ICH study. Death was defined as âearlyâ if occurring within 6 months of study entry and âlateâ if occurring after this time point.
Results:
In our cohort (n = 1094), there were 306 deaths (per 100 patientâyears: absolute event rate, 11.7; 95% confidence intervals, 10.5â13.1); 156 were âearlyâ and 150 âlateâ. In multivariable analyses, early death was independently associated with age [per year increase; hazard ratio (HR), 1.05, P = 0.003], history of hypertension (HR, 1.89, P = 0.038), preâevent modified Rankin scale score (per point increase; HR, 1.41, P < 0.0001), admission National Institutes of Health Stroke Scale score (per point increase; HR, 1.11, P < 0.0001) and haemorrhage volume >60 mL (HR, 4.08, P < 0.0001). Late death showed independent associations with age (per year increase; HR, 1.04, P = 0.003), preâevent modified Rankin scale score (per point increase; HR, 1.42, P = 0.001), prior anticoagulant use (HR, 2.13, P = 0.028) and the presence of intraventricular extension (HR, 1.73, P = 0.033) in multivariable analyses. In further analyses where time was treated as continuous (rather than dichotomized), the HR of previous cerebral ischaemic events increased with time, whereas HRs for Glasgow Coma Scale score, National Institutes of Health Stroke Scale score and ICH volume decreased over time.
Conclusions:
We provide new evidence that not all baseline factors associated with early mortality after ICH are associated with mortality after 6 months and that the effects of baseline variables change over time. Our findings could help design better prognostic scores for later death after ICH
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