Strategic silence: why are some companies not publicising their environmental certifications?

It’s for fears of accusations of greenwashing, argue Chad Carlos and Ben Lewis

AtomSim: web-deployed atomistic dynamics simulator

AtomSim, a collection of interfaces for computational crystallography simulations, has been developed. It uses forcefield-based dynamics through physics engines such as the General Utility Lattice Program, and can be integrated into larger computational frameworks such as the Virtual Neutron Facility for processing its dynamics into scattering functions, dynamical functions etc. It is also available as a Google App Engine-hosted web-deployed interface. Examples of a quartz molecular dynamics run and a hafnium dioxide phonon calculation are presented

Imprints, [Vol. 5]

This 1989 edition includes winners of the T. E. Ferguson writing Contest, two honorable mentions, and a number of other entries that we felt deserved to be published. I would like to give special thanks to all the judges of the Ferguson Writing Contest who helped make this publication possible, and especially to Dr. Patricia Russell, who one again proved to be an invaluable asset. Her dedication and love for the organization and all it stands for has made this one of the most successful years ever.https://scholarworks.sfasu.edu/imprints/1000/thumbnail.jp

Imprints, Vol. 5

This 1989 edition includes winners of the T. E. Ferguson writing Contest, two honorable mentions, and a number of other entries that we felt deserved to be published. I would like to give special thanks to all the judges of the Ferguson Writing Contest who helped make this publication possible, and especially to Dr. Patricia Russell, who one again proved to be an invaluable asset. Her dedication and love for the organization and all it stands for has made this one of the most successful years ever

A high-resolution map of human evolutionary constraint using 29 mammals.

The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome has undergone purifying selection, and locate constrained elements covering ∼4.2% of the genome. We use evolutionary signatures and comparisons with experimental data sets to suggest candidate functions for ∼60% of constrained bases. These elements reveal a small number of new coding exons, candidate stop codon readthrough events and over 10,000 regions of overlapping synonymous constraint within protein-coding exons. We find 220 candidate RNA structural families, and nearly a million elements overlapping potential promoter, enhancer and insulator regions. We report specific amino acid residues that have undergone positive selection, 280,000 non-coding elements exapted from mobile elements and more than 1,000 primate- and human-accelerated elements. Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease

A warm Jupiter transiting an M dwarf: A TESS single transit event confirmed with the Habitable-zone Planet Finder

We confirm the planetary nature of a warm Jupiter transiting the early M dwarf TOI-1899, using a combination of available TESS photometry; high-precision, near-infrared spectroscopy with the Habitable-zone Planet Finder; and speckle and adaptive optics imaging. The data reveal a transiting companion on an $\sim29$-day orbit with a mass and radius of $0.66\pm0.07\ \mathrm{M_{J}}$and$1.15_{-0.05}^{+0.04}\ \mathrm{R_{J}}$, respectively. The star TOI-1899 is the lowest-mass star known to host a transiting warm Jupiter, and we discuss the follow-up opportunities afforded by a warm ($\mathrm{T_{eq}}\sim362$ K) gas giant orbiting an M0 star. Our observations reveal that TOI-1899.01 is a puffy warm Jupiter, and we suggest additional transit observations to both refine the orbit and constrain the true dilution observed in TESS.Comment: 24 pages, 5 figures, 3 tables, published in A

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts