A partial consequence account of truthlikeness

Popper\u2019s original definition of truthlikeness relied on a central insight: that truthlikeness combines truth and information, in the sense that a proposition is closer to the truth the more true consequences and the less false consequences it entails. As intuitively compelling as this definition may be, it is untenable, as proved long ago; still, one can arguably rely on Popper\u2019s intuition to provide an adequate account of truthlikeness. To this aim, we mobilize some classical work on partial entailment in defining a new measure of truthlikeness which satisfies a number of desiderata. The resulting account has some interesting and surprising connections with other accounts on the market, thus shedding new light on current attempts of systematizing different approaches to verisimilitude

Electrochemotherapy Is Effective in the Treatment of Bone Metastases

Bone metastases induce pain, risk of fracture, and neural compression, and reduced mobility and quality of life. Electrochemotherapy (ECT) is a minimally invasive local treatment based on a high-voltage electric pulse combined with an anticancer drug. Preclinical and clinical studies have supported the use of ECT in patients with metastatic bone disease, demonstrating that it does not damage the mineral structure of the bone and its regenerative capacity, and that is feasible and efficient for the treatment of bone metastases. Since 2009, 88 patients with bone metastasis have received ECT at the Rizzoli Institute. 2014 saw the start of a registry of patients with bone metastases treated with ECT, whose data are recorded in a shared database. We share the Rizzoli Institute experience of 38 patients treated with ECT for a bone metastasis, excluding patients not included in the registry (before 2014) and those treated with bone fixation. Mean follow-up was 2 months (1–52). Response to treatment using RECIST criteria was 29% objective responses, 59% stable disease, and 16% progressive disease. Using PERCIST, the response was 36% OR, 14% SD, and 50% PD with no significant differences between the two criteria. A significant decrease in pain and better quality of life was observed at FU

Acido laurico saponificato con il calcio nella dieta di suinetti in post svezzamento: effetti sulle performance di crescita e sulla salute intestinale

\uc8 noto che gli acidi grassi a media catena (MCFA) hanno un\u2019azione antibatterica, in particolare nei confronti dei batteri Gram+. Lo scopo del lavoro \ue8 stato valutare gli effetti dell\u2019acido laurico (C12) saponificato con il calcio sulle performance produttive e la salute intestinale dei suinetti in svezzamento. Per la prova sono stati impiegati 192 suinetti, ripartiti in 3 gruppi, alimentati rispettivamente con una dieta basale (Db= Ctr), Db+Amoxicillina, 400mg/kg (T1) e Db+C12-Ca, 1kg/ton (T2). L\u2019integrazione della dieta con C12-Ca ha comportato una riduzione della mortalit\ue0 e dei trattamenti medicamentosi rispetto ai soggetti Ctr. L\u2019efficienza alimentare \ue8 risultata analoga nei soggetti alimentati con la dieta integrata con laurato di calcio e in quelli trattati con antibiotico, con una differenza significativa rispetto ai controlli (P<0,05). La somministrazione del laurato ha infine determinato un miglioramento dello stato antiossidante della mucosa intestinale rispetto ai soggetti degli altri due gruppi con un aumento della capacit\ue0 antiossidante totale TAOC (P <0,01) e una riduzione dei livelli di Malondialdeide (P<0,01). I risultati suggeriscono che l\u2019inclusione nella dieta dei suinetti di C12-Ca pu\uf2 migliorare la salute intestinale e pu\uf2 rappresentare una possibile alternativa all\u2019antibiotico, impiegato per scopi di profilassi

The daytime Taurid complex meteor streams: Activity and mass distribution

The activity and mass distribution of the summer daytime Taurid meteor complex streams Zeta Perseids and Beta Taurids in 1997-2004 is analysed and discussed. The results are based on radio observations obtained by the BLM forward-scatter system (Italy-Slovakia) and by the Ondrejov backscatter meteor radar (Czech Republic). The observed positions of maxima of the streams are in a general agreement with previous analysis. The observations indicate a filamentary structure of the streams, the existence of which is supported also by the mass exponent values

Clinical and functional outcomes of the saddle prosthesis

BACKGROUND:The implantation of a saddle prosthesis after resection of a pelvic tumor has been proposed as a simple method of reconstruction that provides good stability and reduces the surgical time, thus limits the onset of intraoperative complications. There are no studies in the literature of patients evaluated using gait analysis after being implanted with a saddle prosthesis. The present study is a retrospective case review aimed at illustrating long-term clinical and functional findings in tumor patients reconstructed with a saddle prosthesis. MATERIALS AND METHODS:A series of 15 patients who received pelvic reconstruction with a saddle prosthesis were retrospectively reviewed in terms of clinical, radiographic, and functional evaluations. Two patients were additionally assessed by gait analysis. RESULTS:Long-term functional follow-up was achieved in only 6 patients, and ranged from 97 to 167 months. Function was found to be rather impaired, as a mean of only 57 % of normal activity was restored. Gait analysis demonstrated that the implant had poor biomechanics, as characterized by very limited hip motion. CONCLUSIONS: Though the saddle prosthesis was proposed as advance in tumor-related pelvic surgery, the present study indicates that it yields unsatisfactory clinical and functional results due to both clinical complications and the poor biomechanics of the device. The use of a saddle prosthesis in tumor surgery did not provide satisfactory results in long-term follow-up. It is no longer implanted at our institute, and is currently considered a "salvage technique.

What is theoretical progress of science?

The epistemic conception of scientific progress equates progress with accumulation of scientific knowledge. I argue that the epistemic conception fails to fully capture scientific progress: theoretical progress, in particular, can transcend scientific knowledge in important ways. Sometimes theoretical progress can be a matter of new theories ‘latching better onto unobservable reality’ in a way that need not be a matter of new knowledge. Recognising this further dimension of theoretical progress is particularly significant for understanding scientific realism, since realism is naturally construed as the claim that science makes theoretical progress. Some prominent realist positions (regarding fundamental physics, in particular) are best understood in terms of commitment to theoretical progress that cannot be equated with accumulation of scientific knowledge

The wind regime of the mesosphere and lower thermosphere during the DYANA campaign-II. Semi-diurnal tide

Co-ordinated ground-based radar measurements carried out during the 15 January-15 March 1990 DYANA campaign at 14 different geographical sites have provided a good opportunity to investigate the characteristics of semi-diurnal tidal variations in the mesosphere/lower thermosphere over a wide spectrum of space/time scales. It is pointed out that significant differences of monthly mean tidal parameters observed at the various sites may be explained by latitudinal and longitudinal effects. Well-defined 2-3-week oscillations of the tidal parameters are found to be typical of all observational sites. Their estimated space scales do not contradict the hypothesis about a possible coupling between these oscillations and the low wave-number processes in the stratosphere. Tidal parameter oscillations with 2-5-day periods may be explained to be effects of the nonstationary processes with longitudinal wave numbers S > 3. © 1994

The wind regime of the mesosphere and lower thermosphere during the DYANA campaign-I. Prevailing winds

During the DYANA campaign, winds and tides at mesospheric and lower thermospheric altitudes were measured by 14 ground based experiments (MF radars, meteor radars and LF-drift systems). The experiments were located between 107°W and 102°E, mostly in northern mid-latitudes with well covered areas in Central and Eastern Europe. Emphasis is placed here upon the vertical profiles and height-time contours of the prevailing zonal and meridional winds with different resolution (15 d, 4d). Generally, westerly winds are observed at heights below 95 km with a strong mesospheric variability and with longitudinal differences between the data of Central Europe, Eastern Europe, Asia and Canada. Planetary waves and a minor stratospheric warming in the first 10 days of February 1990 are the cause of this behaviour. In connection with the stratospheric warming, a wind reversal to summer east winds reaching from the upper stratosphere up to 95 km is observed. The close connection of the behaviour of the stratosphere with the observed longitudinal differences in the mesospheric response on the stratospheric warming and with the occurrence of wind oscillations (10-15 d) is discussed. © 1994