Radiation-induced edge effects in deep submicron CMOS transistors

The study of the TID response of transistors and isolation test structures in a 130 nm commercial CMOS technology has demonstrated its increased radiation tolerance with respect to older technology nodes. While the thin gate oxide of the transistors is extremely tolerant to dose, charge trapping at the edge of the transistor still leads to leakage currents and, for the narrow channel transistors, to significant threshold voltage shift-an effect that we call Radiation Induced Narrow Channel Effect (RINCE)

Molecular detection of parasites (Trematoda, Digenea: Bucephalidae and Monorchiidae) in the European flat oyster Ostrea edulis (Mollusca: Bivalvia)

Members of the globally distributed bivalve family Ostreidae (oysters) have a significant role in marine ecosystems and include species of high economic importance. In this work, we report the occurrence of digenean parasites of the families Bucephalidae (Prosorhynchoides sp.) and Monorchiidae (Postmonorchis sp.) in Mediterranean native populations of Ostrea edulis (but not in the introduced Magallana gigas). Molecular detection was based on DNA sequencing of the ribosomal intergenic spacer 2 (ITS2) marker. The importance of detecting the presence of overlooked digenean parasites in Mediterranean oysters is discussed. © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

Comparison of the ERA5 Wave Forecasting Dataset against Buoy Record

Appropriate design of marine structures, such as offshore facilities and harbours, requires a detailed estimation of synthetic wave parameters. Inaccuracies and unreliability of wave data have implications in many aspects of marine engineering, such as structural strength, cost, and design. In this paper, a critical analysis of the most common data acquisition methods is made, focusing on in-situ instrumentation and numerical models. Considering the Pantelleria island as case study, records of a proprietary wave buoy and the ERA5 dataset of ECMWF (European Centre for Medium-Range Weather Forecasts) have been compared. This paper first highlights the methods and challenges of offshore experimental campaigns for wave monitoring and eventually presents a critical and quantitative comparison of the two approaches (experimental versus numerical), highlighting their respective advantages and disadvantages

Time stability of asymmetric Fabry-Perot modulator based analog lightwave links

Lightwave links for analog signal transfer are being developed and evaluated for application in high-density interconnects. The reflective links are based on compact electro-optic intensity modulators connected by ribbons of single-mode fibres to remotely located transceivers (lasers and photoreceivers) and read-out electronics. For long-term characterization, four Asymmetric Fabry-Perot Modulator (AFPM) prototypes were continuously operated and monitored over a period of eight monthes. The collected data allow evaluation of the system time stability and simulation of the possible recalibration procedures. The recalibration requirements to achieve the desirable accuracy and reliability are inferred statistically

Radiation damage and annealing in 1310 nm InGaAsP/InP lasers for the CMS tracker

Radiation damage in 1310 nm InGaAsP/InP multi-quantum-well lasers caused by 0.8 MeV neutrons is compared with the damage from other radiation sources, in terms of the increase in laser threshold current. The annealing behavior is then presented both in terms of both temperature and forward-bias current dependence. The annealing can be described by a model where radiation induced defects have a uniform distribution of activation energies for annealing. This model can then be used to predict the long-term damage expected for lasers operating inside the CMS tracker. (19 refs)

Adipose-derived stem/stromal cells in kidney transplantation: Status quo and future perspectives

Kidney transplantation (KT) is the gold standard treatment of end-stage renal disease. Despite progressive advances in organ preservation, surgical technique, intensive care, and immunosuppression, long-term allograft survival has not significantly improved. Among the many peri-operative complications that can jeopardize transplant outcomes, ischemia-reperfusion injury (IRI) deserves special consideration as it is associated with delayed graft function, acute rejection, and premature transplant loss. Over the years, several strategies have been proposed to mitigate the impact of IRI and favor tolerance, with rather disappointing results. There is mounting evidence that adipose stem/stromal cells (ASCs) possess specific characteristics that could help prevent, reduce, or reverse IRI. Immunomodulating and tolerogenic properties have also been suggested, thus leading to the development of ASC-based prophylactic and therapeutic strategies in pre-clinical and clinical models of renal IRI and allograft rejection. ASCs are copious, easy to harvest, and readily expandable in culture. Furthermore, ASCs can secrete extracellular vesicles (EV) which may act as powerful mediators of tissue repair and tolerance. In the present review, we discuss the current knowledge on the mechanisms of action and therapeutic opportunities offered by ASCs and ASC-derived EVs in the KT setting. Most relevant pre-clinical and clinical studies as well as actual limitations and future perspective are highlighted