Fluctuations in partitioning systems with few degrees of freedom

We study the behavior of a moving wall in contact with a particle gas and subjected to an external force. We compare the fluctuations of the system observed in the microcanonical and canonical ensembles, at varying the number of particles. Static and dynamic correlations signal significant differences between the two ensembles. Furthermore, velocity-velocity correlations of the moving wall present a complex two-time relaxation which cannot be reproduced by a standard Langevin-like description. Quite remarkably, increasing the number of gas particles in an elongated geometry, we find a typical timescale, related to the interaction between the partitioning wall and the particles, which grows macroscopically.Comment: 10 pages, 12 figure

Evaluación continua y su importancia en el proceso de enseñanza-aprendizaje de Climatología en la carrera de Agronomía

La evaluación tradicionalmente se ha centrado en la etapa final del proceso de enseñanza-aprendizaje llevando en muchos casos a que los alumnos se enfoquen más en aprobar la asignatura que en lograr un aprendizaje significativo. Sin embargo, el docente no debe sólo evaluar al final del curso, sino que debe hacerlo en cada uno de los bloques de conocimiento para facilitar el aprovechamiento y el aprendizaje progresivo de los contenidos de la asignatura. Al aplicar la evaluación continua, el profesor puede detectar los problemas de aprendizaje del estudiante y realizar una valoración integral del proceso de enseñanza-aprendizaje. El objetivo del trabajo fue evaluar la identificar los temas que presentan más dificultades en el proceso de enseñanza – aprendizaje mediante la evaluación continua. Se implementó un proceso de evaluación continua con la finalidad de facilitar la asimilación y el desarrollo progresivos de los contenidos de la asignatura Climatología correspondiente al primer cuatrimestre del segundo año de la carrera de Ingeniería Agronómica. Se utilizó como fuente de datos un cuestionario estructurado, al inicio de la clase práctica, se evalúan los fundamentos teóricos a emplearse en el práctico. Éstas evaluaciones constituyen el 30% de la nota del parcial correspondiente.En el presente trabajo se presentan los resultados observados a lo largo de 7 ciclos lectivos (2012 a 2018). Las unidades que presentaron menor porcentaje de acierto fueron Bio y Agrometeorología, Radiación y Balance Hidrológico (con 42, 47 y 47%, respectivamente) y aquellas de mejor desempeño fueron Introducción, Vientos y Heladas (con 59; 60 y 64%, respectivamente). Los temas con menores porcentajes de aciertos pueden ser debidos a dificultad y el tiempo de aprendizaje. La evaluación continua le permite al estudiante recibir información sobre su ritmo de aprendizaje, y puede de esta manera reorientar su aprendizaje. A los docentes, les permite identificar las fortalezas y las dificultades, del tema desarrollado

Biology and ecology of the invasive lionfishes, Pterois miles and Pterois volitans

The Indo-Pacific lionfishes, Pterois miles and P. volitans, are now established along the U.S. southeast coast, Bermuda, Bahamas, and are becoming established in the Caribbean. While these lionfish are popular in the aquarium trade, their biology and ecology are poorly understood in their native range. Given the rapid establishment and potential adverse impacts of these invaders, comprehensive studies of their biology and ecology are warranted. Here we provide a synopsis of lionfish biology and ecology including invasion chronology, taxonomy, local abundance, reproduction, early life history and dispersal, venomology, feeding ecology, parasitology, potential impacts, and control and management. This information was collected through review of the primary literature and published reports and by summarizing current observations. Suggestions for future research on invasive lionfish in their invaded regions are provided

Multidisciplinary Design and Optimization of Regional Jet Retrofitting Activity

A retrofit analysis on a 90 passengers regional jet aircraft is performed through a multidisciplinary collaborative aircraft design and optimization highlighting the impact on costs and performance. Two different activities are accounted for selecting the best aircraft retrofit solution: a re-engining operation that allows to substitute a conventional power-plant platform with advanced geared turbofan and an on-board-systems architecture modernization, considering different levels of electrification. Besides the variables that are directly dependent from these activities, also scenario variables are considered during the optimization such as the fuel price, the fleet size and the years of utilization of the upgraded systems. The optimization is led by impacts of the retrofitting process on emissions, capital costs and saving costs, computed at industrial level. Overall aircraft design competences (aerodynamics, masses, performance, noise, and emissions) have been computed increasing the level of fidelity and reliability. The whole process is implemented in the framework of the AGILE 4.0 research project in a collaborative remote multidisciplinary approach. Results show that the engine retrofitting can be a profitable solution for both manufacturers and airliners. Conversely, the on-board-system electrification seems to be not convenient in a retrofitting process due to the high capital costs. Depending on the operative scenario, involved stakeholders can properly orient their decision on a retrofitting strategy

Human, donkey and cow milk differently affects energy efficiency and inflammatory state by modulating mitochondrial function and gut microbiota

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Unexpected silicon localization in calcium carbonate exoskeleton of cultured and fossil coccolithophores

Coccolithophores, marine calcifying phytoplankton, are important primary producers impacting the global carbon cycle at different timescales. Their biomineral structures, the calcite containing coccoliths, are among the most elaborate hard parts of any organism. Understanding the morphogenesis of coccoliths is not only relevant in the context of coccolithophore eco-physiology but will also inform biomineralization and crystal design research more generally. The recent discovery of a silicon (Si) requirement for crystal shaping in some coccolithophores has opened up a new avenue of biomineralization research. In order to develop a mechanistic understanding of the role of Si, the presence and localization of this chemical element in coccoliths needs to be known. Here, we document for the first time the uneven Si distribution in Helicosphaera carteri coccoliths through three synchrotron-based techniques employing X-ray Fluorescence and Infrared Spectromicroscopy. The enrichment of Si in specific areas of the coccoliths point to a targeted role of this element in the coccolith formation. Our findings mark a key step in biomineralization research because it opens the door for a detailed mechanistic understanding of the role Si plays in shaping coccolith crystals

Regulatory noncoding and predicted pathogenic coding variants of ccr5 predispose to severe covid-19

Genome-wide association studies (GWAS) found locus 3p21.31 associated with severe COVID-19. CCR5 resides at the same locus and, given its known biological role in other infection diseases, we investigated if common noncoding and rare coding variants, affecting CCR5, can predispose to severe COVID-19. We combined single nucleotide polymorphisms (SNPs) that met the suggestive significance level (P ≤ 1 × 10−5 ) at the 3p21.31 locus in public GWAS datasets (6406 COVID-19 hospitalized patients and 902,088 controls) with gene expression data from 208 lung tissues, Hi-C, and Chip-seq data. Through whole exome sequencing (WES), we explored rare coding variants in 147 severe COVID-19 patients. We identified three SNPs (rs9845542, rs12639314, and rs35951367) associated with severe COVID-19 whose risk alleles correlated with low CCR5 expression in lung tissues. The rs35951367 resided in a CTFC binding site that interacts with CCR5 gene in lung tissues and was confirmed to be associated with severe COVID-19 in two independent datasets. We also identified a rare coding variant (rs34418657) associated with the risk of developing severe COVID-19. Our results suggest a biological role of CCR5 in the progression of COVID-19 as common and rare genetic variants can increase the risk of developing severe COVID-19 by affecting the functions of CCR5

HIV-1 Tat mimetic of VEGF correlates with increased microvessels density in AIDS-related diffuse large B-cell and Burkitt lymphomas

Angiogenic switch marks the beginning of tumor’s strategy to acquire independent blood supply. In some subtypes of non-Hodgkin’s lymphomas, higher local vascular endothelial growth factor (VEGF) expression correlates with increased microvessel density. However, this local VEGF expression is higher only in tumors with elevated expression of the receptors of the growth factor, suggesting an autocrine growth-promoting feedback loop. Several studies have indicated that VEGF receptors are also targeted by Tat protein from the HIV-1-infected cells. Given the similarity of the basic region of Tat to the angiogenic factors (basic fibroblast growth factor, VEGF), Tat mimics these proteins and binds to their receptors. We evaluated the role of HIV-1 Tat in regulating the level of VEGF expression and microvessel density in the AIDS-related diffuse large B-cell (DLBCL) and Burkitt lymphomas (BL). By luciferase assay, we showed that VEGF promoter activity was downregulated in vitro in cells transfected with Tat. Reduced VEGF protein expression in primary HIV-1 positive BL and DLBCL, compared to the negative cases, supported the findings of promoter downregulation from the cell lines. Microvascular density assessed by CD34 expression was, however, higher in HIV-1 positive than in HIV-1 negative tumors. These results suggest that Tat has a wider angiogenic role, besides the regulation of VEGF expression. Thus, targeting Tat protein itself and stabilizing transient silencing of VEGF expression or use of monoclonal antibodies against their receptors in the AIDS-associated tumors will open a window for future explorable pathways in the management of angiogenic phenotypes in the AIDS-associated non-Hodgkin’s lymphomas