Efeitos da fisioterapia em grupo através do teleatendimento na qualidade de vida e sintomas urinários de pacientes com esclerose múltipla

Introdução: A Esclerose Múltipla (EM) acarreta diversas alterações motoras. Os portadores de EM podem apresentar fraqueza muscular, diminuição da flexibilidade, espasticidade, fadiga, sintomas urinários. Objetivo: Avaliar os efeitos da fisioterapia em grupo por meio do teleatendimento na qualidade de vida e sintomas urinários dos pacientes com Esclerose Múltipla. Métodos: Foram incluídos no estudo 7 participantes que possuíam Esclerose Múltipla e apresentavam alguma queixa urinária. Foram aplicados os questionários Impacto da Incontinência Urinária (IIQ-7) e o Inventário da Angústia Urogenital (UDI-6), para mensuração dos sintomas urinários. Para qualidade de vida e bexiga hiperativa os questionários Determinação Funcional da Qualidade de Vida na Esclerose Múltipla (DEFU) e ICIQ-OAB. Os pacientes foram divididos em dois grupos para os teleatendimentos semanais para a realização de exercícios. Resultados: Todos os participantes apresentavam o tipo EM surto-remissão, a pontuação média na EDSS foi de 3,3(±0,41). Os sintomas urinários mais prevalentes foram: perda de urina, sensação de urgência, bexiga hiperativa e retenção urinária. Quando comparados os questionários pré e pós-intervenção, os resultados não mostraram diferenças significativas (p<0,05). Conclusão: A intervenção fisioterapêutica realizada de forma remota com duração de 12 semanas não melhorou a qualidade de vida e os sintomas urinários nos pacientes com EM.Introduction: Multiple sclerosis (MS) causes several motor changes. MS patients may have muscle weakness, decreased flexibility, spasticity, fatigue, and urinary symptoms. Objective: Objective: Evaluate the effects of group physical therapy through Tele monitoring on the quality of life and urinary symptoms of patients with multiple sclerosis.. Methods: Seven participants who had Multiple Sclerosis and had some urinary complaint were included in the study. The Urinary Incontinence Impact questionnaires (IIQ-7) and the Urogenital Distress Inventory (UDI-6) were applied to measure urinary symptoms. For quality of life and overactive bladder, the Functional Determination of Quality of Life in Multiple Sclerosis (DEFU) and ICIQ-OAB questionnaires. Patients were divided into two groups for weekly remote meetings to perform exercises. Results: All participants had relapsing-remitting MS, the mean EDSS FOOI score of 3.3(±0.41). The most prevalent urinary symptoms were: loss of urine, sense of urgency, overactive bladder and urinary retention. When comparing pre- and post-intervention questionnaires, the results did not show significant differences (p<0.05). Conclusion: The physical therapy intervention performed remotely lasting 12 weeks did not improve the quality of life and urinary symptoms in patients with MS

Comparative overview of the effects of aerobic and resistance exercise on anxiety-like behavior, cognitive flexibility, and hippocampal synaptic plasticity parameters in healthy rats

Clinical studies show that physical exercise has anxiolytic and pro-cognitive properties for both healthy individuals and psychiatric patients. Most of these data refer to the effects of aerobic exercise. However, other modalities such as resistance exercise deserve more attention because they may also modulate brain function. This study aimed to compare the effects of an aerobic exercise protocol on a treadmill and a resistance exercise protocol on a ladder apparatus on anxiety-like behavior, cognitive flexibility, and neuroplasticity parameters in healthy animals. Adult male Wistar rats were divided into three groups: sedentary control, aerobic training, and resistance training. Subsequently, they were evaluated in the elevated plus-maze (EPM), light-dark box, and modified hole board (mHB) tests. The expressions of synaptophysin and postsynaptic plasticity protein 95 in the dorsal and ventral hippocampus were analyzed by immunofluorescence. The results demonstrated an anxiolytic effect promoted by exercise in the EPM, particularly in the animals submitted to aerobic training, and a mild pro-learning effect of both exercise modalities was observed in the mHB test. All groups showed similar outcomes in the other evaluations. Therefore, the exercise modalities investigated in the present study did not provide considerable modifications to such aspects of the emotional/cognitive functions and neuroplasticity under physiological contexts. Perhaps the two types of exercise acted in neurobiological pathways not analyzed in this study, or the effects may emerge under pathological contexts. These hypotheses should be tested in future studies

Imunidade humoral não é alterada em éguas Crioulas gestantes com sobrepeso

Tanto a gestação quanto a obesidade podem influenciar o desenvolvimento de alterações significativas no sistema imune, portanto, o presente estudo teve como objetivo avaliar a resposta imune humoral de éguas gestantes com sobrepeso em resposta a uma vacina comercial. Trinta éguas Crioulas gestantes foram separadas de acordo com o escore de condição corporal (ECC) em éguas com sobrepeso (ECC≥7/9) e éguas controles (ECC=5-6/9) e, ainda, em cada grupo, os animais também foram separados em vacinados e controles. As éguas foram vacinadas contra o EHV-1 em duas doses com intervalo de 21 dias, sendo realizadas coletas de sangue mensalmente durante cinco meses para avaliação de anticorpos neutralizantes. Ambos os grupos vacinados tiveram aumento de anticorpos neutralizantes específicos após a vacina, porém, após a segunda dose, não foi observado aumento de anticorpos em nenhum dos grupos. Nenhuma diferença foi observada entre éguas vacinadas com sobrepeso e as éguas controles em nenhum momento. Assim, este estudo demonstrou que a obesidade não é um fator que influencia a resposta imune humoral de éguas Crioulas gestantes.Both pregnancy and obesity can influence significant changes in the immune system. On this basis, the present study proposes to evaluate the humoral immune response of overweight pregnant mares in response to a commercial vaccine. Thirty pregnant Crioulo mares were separated according to body condition score (BCS) into overweight (BCS≥7/9) or lean-control (BCS= 5-6/9). In each group, the animals were subdivided into vaccinated and controls. The mares were vaccinated against EHV-1 in two doses spaced 21 days apart and had their blood collected monthly, for five months, for antibody evaluation. Both vaccinated groups had an increase in specific neutralizing antibodies after the vaccine. However, after the second dose, there was no increase in antibodies in any of the groups. Vaccinated overweight and lean-control mares did not differ at any time point. Therefore, this study demonstrated that obesity does not influence the humoral immune response in pregnant Crioulo mares

Comparative overview of the effects of aerobic and resistance exercise on anxiety-like behavior, cognitive flexibility, and hippocampal synaptic plasticity parameters in healthy rats

Clinical studies show that physical exercise has anxiolytic and pro-cognitive properties for both healthy individuals and psychiatric patients. Most of these data refer to the effects of aerobic exercise. However, other modalities such as resistance exercise deserve more attention because they may also modulate brain function. This study aimed to compare the effects of an aerobic exercise protocol on a treadmill and a resistance exercise protocol on a ladder apparatus on anxiety-like behavior, cognitive flexibility, and neuroplasticity parameters in healthy animals. Adult male Wistar rats were divided into three groups: sedentary control, aerobic training, and resistance training. Subsequently, they were evaluated in the elevated plus-maze (EPM), light-dark box, and modified hole board (mHB) tests. The expressions of synaptophysin and postsynaptic plasticity protein 95 in the dorsal and ventral hippocampus were analyzed by immunofluorescence. The results demonstrated an anxiolytic effect promoted by exercise in the EPM, particularly in the animals submitted to aerobic training, and a mild pro-learning effect of both exercise modalities was observed in the mHB test. All groups showed similar outcomes in the other evaluations. Therefore, the exercise modalities investigated in the present study did not provide considerable modifications to such aspects of the emotional/cognitive functions and neuroplasticity under physiological contexts. Perhaps the two types of exercise acted in neurobiological pathways not analyzed in this study, or the effects may emerge under pathological contexts. These hypotheses should be tested in future studies