Dentin hassasiyet giderici ajanların tek aşamalı bir self-etch adezivin makaslama bağlanma dayanımına etkisi

Amaç: Bu çalışmanın amacı içerikleri farklı 12 adet dentin hassasiyet giderici ajanın (DHGA) bir self-etch adeziv rezinin makaslama bağlanma dayanımına etkisinin belirlenmesidir. Gereç ve Yöntem: Bu çalışmada kullanılmak üzere 195 adet çürüksüz daimi alt 3. molar dişin bukkal yüzeyindeki dentin dokusu açığa çıkacak şekilde mine dokusu uzaklaştırıldı. Dentin örnekleri rastgele 13 gruba ayrıldı (n=15). On iki farklı DHGA (Smart Protect, Systemp Desensitizer, Seal&Protect, Aqua-Prep F, Isodan, Gluma, BisBlock, D/Sense Crystal, UltraEZ, Colgate Sensitive Pro-  Relief, Topex ve Clinpro White Varnish) uygulama talimatlarına göre dentin yüzeylerine uygulandı. Kontrol grubuna DHGA uygulanmadı. Dentin örnekleri 14 gün boyunca 37°C’de yapay tükrük içinde bekletildi. Sonra yumuşak bir diş fırçası yardımıyla dentin yüzeyindeki kalıntılar 8-10 kez uygulanan dairesel hareketlerle uzaklaştırıldı. Clearfil Tri-S Bond (Kuraray Medical) dentin yüzeylerine uygulandıktan sonra silindirik kalıplar yardımıyla kompozit rezin (Filtek Z 250, 3M ESPE, USA) dentin yüzeyine uygulandı. Hazırlanan örnekler 24 saat boyunca distile suda, 37 ºC’de, etüvde bekletildi. Makaslama bağlanma dayanımının ölçüm testleri Universal Çekme-Basma Test Sistemi (Instron 3382, USA) kullanılarak yapıldı. Her bir grup için 3 adet dentin örneği hazırlanarak DHGA’nın dentin tübül tıkaç etkinliği SEM ile incelendi. Gruplar arasında bağlanma dayanımı yönünden farkın önemliliği Tek Yönlü Varyans Analizi (One-Way ANOVA) ve post hoc Tukey testi kullanılarak tespit edildi. p0.05). Sonuçlar: Bu in vitro çalışmada fluorür ve potasyum okzalat içeren DHGA uygulamaları tek aşamalı bir self-etch adezivin rezin-dentin makaslama bağlanma dayanım değerinde azalmaya neden olmuştur. Bunun muhtemel nedeni SEM incelemelerinde görüntülendiği gibi bu ajanların oluşturduğu dentin tübül tıkaçlarının, zayıf asiditesi olan self-etch adezivin dentin tübüllerine penetrasyonunu engellemesi olabilir

Add-on treatment of aripiprazole in an adult onychophagia patient

Tırnak yeme (onikofaji) sık görülen fakat hakkında az inceleme yapılmış bir bozukluktur. Sınıflandırılması ile ilgilifarklı görüşler bulunan onikofaji, DSM-IV-TR’e göre başka türlü adlandırılmayan dürtü kontrol bozukluğu olaraktanımlanmaktadır. Tedavisi ile ilgili bilgiler kısıtlıdır. Tedavisinde psikoterapi ile ilgili birkaç çalışma yanında farmakolojik tedavi ile ilgili sadece bir çalışma bulunmaktadır. Bazı çalışmalarda atipik bir antipsikotik olan aripiprazolündürtü kontrol bozukluklarında faydalı olabileceği bildirilmiştir. Biz bu yazıda essitalopram tedavisine daha önceliteratürde bildirilmemiş olan aripiprazol eklenmesiyle başarılı bir şekilde tedavi edilen onikofaji vakasını sunmayı amaçladık.Nail biting (onychophagia) is a common disorder which has not been investigated yet. There are different opinions about to classify onychophagia, but according to DSM-IV-TR it is classified as impulse control disorder not otherwise specified. The knowledge about treatment of onychophagia is limited. There are a few studies about treatment of onychophagia with psychotherapy and a study with pharmacotherapy. Some studies suggest that an atypical antipsychotic aripiprazole may have beneficial effects in the treatment of impulse control disorders. In this study we report a case of onychophagia which has successfully treated with aripiprazole add-on to escitalopram treatment that has never reported before

Examining the attitudes of University youth towards Syrians coming to Turkey (Case of Dicle University)

Göç olgusu, insanların umutlarını, beklentilerini kendileriyle birlikte başka ülkelere taşımanın, gelişen ve değişen durumlara göre geçici veya kalıcı olarak gidilen ülkelerde yaşamanın gerçekliğidir. 2010 yılında Arap halklarının demokrasi, özgürlük ve insan hakları taleplerinden ortaya çıkan, giderek büyüyüp Arap Baharı olarak adlandırılan bölgesel, toplumsal olaylar, Mısır, Tunus ve Libya’dan sonra 2011 yılında Suriye’ye sıçramıştır. Suriye’de 10 yıldan uzun süredir devam eden iç savaşın sonucu olarak İkinci Dünya Savaşından bu yana en büyük kitlesel göç hareketi gerçekleşmiştir. Sınır komşusu olmasının yanı sıra insani nedenlerden dolayı “açık kapı politikası” izleyen ve bu nedenle gelenlere kucak açan Türkiye bu göç olgusundan oldukça etkilenmiştir. Göç, doğasında barındırdığı sosyal ve kültürel uyumsuzluk potansiyeli nedeniyle yerel halkla sığınmacılar arasında birtakım sorunların yaşanmasına zemin oluşturmuştur. Araştırmanın alanı/evreni, Türkiye’ye gelen Suriyelilerin yoğun ilgi gösterdikleri illerden biri olan Diyarbakır’dır. Araştırma, yerel halkın dinamik bir unsuru olan üniversite gençliğinin, gelen Suriyelilerin geri dönüşlerine, sosyal ve ekonomik hayata etkilerinin ne olduğuna dair görüşlerinin alınarak, yaşanan sorunların tespitine ve giderilmesine yönelik önerilerin sunulmasını kapsamaktadır. Araştırmadan elde edilen verilerin analizinde, üniversite gençliğinin, gelen Suriyelilerin büyük çoğunluğunun ülkelerindeki olumsuz koşullar düzelse bile geri dönmeyeceklerine, Türkiye’nin ekonomik ve sosyal hayatına olumlu bir katkı sunmayacaklarına ilişkin kayda değer sonuçlara ulaşılmıştır.The phenomenon of migration is the reality of carrying people's hopes and expectations to other countries with them, and living in countries where they go temporarily or permanently according to developing and changing situations. The regional and social events that emerged from the demands of the Arab peoples for democracy, freedom and human rights in 2010 and grew gradually and became known as the Arab Spring, spread to Syria in 2011 after Egypt, Tunisia and Libya. As a result of the civil war that has been going on for more than 10 years in Syria, the largest mass migration has taken place since the Second World War. In addition to being a border neighbor, Turkey, which follows an "open door policy" for humanitarian reasons and therefore embraces those who come, has been greatly affected by this migration phenomenon. Migration has created a ground for some problems between the local people and asylum seekers due to the potential for social and cultural incompatibility it has in its nature. The area/universe of the research is Diyarbakır, which is one of the provinces where Syrians coming to Turkey show great interest. The research includes taking the opinions of university youth, who is a dynamic element of the local people, on the return of Syrians and their effects on social and economic life, and presenting suggestions for detecting and eliminating the problems experienced. In the analysis of the data obtained from the research, it was concluded that the university youth, the majority of the Syrians who came, would not return even if the unfavorable conditions in their countries improved, and they would not make a positive contribution to the economic and social life of Turkey

The prevalence and outcomes of inflammatory bowel disease among patients with cytomegalovirus disease

Aims: Cytomegalovirus (CMV) colitis in individuals with inflammatory bowel disease (IBD) is a serious condition. The present study evaluated the prevalence and outcome of IBD-CMV colitis among patients with CMV disease. Methods: We performed a retrospective study to evaluate the patients with IBD and CMV colitis between January 1, 2017, and December 31, 2022. We identified IBD-CMV colitis based on the presence of CMV in tissue or a polymerase chain reaction (PCR) result of ≥1000 copies/mL with no other clinical explanations. The frequency of IBD-CMV colitis, relapse rate, requirement of surgical interventions, and associated mortality were assessed. Results: Out of 163 patients with CMV disease screened, 28 (17.2%) were diagnosed with CMV colitis and IBD [median age: 54 (19-67) years, male: 77%]. The frequency of ulcerative colitis and Crohn’s disease was 93% and 7%, respectively. Most CMV PCR assays (97%) were performed using serum, whereas the remaining tests were performed using serum and tissue samples. CMV was not detected via immunohistochemistry or hematoxylin-eosin staining in any patient. Antiviral treatment was initiated in 74% of the patients and lasted a median of 20 days (6-32 days). No surgical interventions or disease-related deaths were identified. Conclusions: This electronic medical records study showed that IBD-CMV colitis was a rare disease among patients with CMV disease and generally followed a favorable course

Does Platelet Mass Index Play a Role in Predicting Biochemical Recurrence in Localized Prostate Cancer?

Objective:The aim of this study is to investigate the association of preoperative platelet mass index (PMI) with tumor pathologic features and postoperative biochemical recurrence in patients undergoing radical prostatectomy due to localized prostate cancer.Materials and Methods:Data of 141 patients, who underwent radical prostatectomy for localized prostate cancer between April 2004 and April 2017, were retrospectively screened. Patient age, preoperative prostate-specific antigen (PSA) level, platelet count, mean platelet volume and PMI value, neutrophil-lymphocyte ratio (NLR), tumor grade, Gleason score, tumor volume, lymph node involvement, surgical margin positivity and biochemical recurrence at 3 months were all noted. The relationship of preoperative PMI value with age, PSA, pathologic parameters, surgical margin positivity and biochemical recurrence was evaluated.Results:The mean age of the patients was 61.79±5.98 years, the mean PSA value was 9.50±6.69 ng/mL, mean PMI was 2003.91±486.69, and the mean NLR was 2.79±2.06. There was no correlation of PMI value with PSA, pathological stage, Gleason score, lymph node involvement, tumor volume, surgical margin positivity, and biochemical recurrence. There was statistically significant negative correlation between PMI and Gleason score.Conclusion:In our study, we could not demonstrate preoperative PMI as a prognostic factor for early biochemical recurrence in patients undergoing radical prostatectomy for prostate cancer. To achieve a better conclusion that we can generalize, there is a need for prospective studies with larger patient series

The investigation of factors related to suicide attempts in Southeastern Turkey

BACKGROUND: Suicide is an important health problem in Turkey as it is in all regions of the world. Suicidal behavior has multiple causes, which are broadly divided into those related to proximal stressors and those due to predisposition. Suicide statistics may be associated with mental health disorders, which are among the foremost predictors of suicide attempts. More than 90% of patients who commit suicide have a diagnosable psychiatric disorder, usually a major depressive disorder. Other major risk factors for suicide attempts are history of suicide attempts in the family, stressful life events, sleep disturbances, poor income, unemployment, severity of symptoms of depression, and anxiety. Sleep is a complex phenomenon. Sleep disturbances can therefore be contributed to the emergence of suicidal behavior allowing for the possibility of predicting future suicides. METHODS: We evaluated 106 patients who were admitted after suicide attempts to the Department of Psychiatry at Dicle University Faculty of Medicine. The recruited subjects were assessed by Structured Clinical Interview for DSM-IV Axis I disorders, and the intensity of symptoms was evaluated using the Beck Anxiety Inventory, Hamilton Depression Rating Scale, and Pittsburgh Sleep Quality Index. The mean values of the subjects attempting multiple and single suicides were compared using appropriate inferential statistical tests. RESULTS: Most suicide attempts are believed to be preventable. Our results revealed that a great variety of risk factors are associated with an increased risk for multiple suicide attempts. Most of these attempts appeared to be spontaneous and impulsive rather than planned. In particular, this study highlights the importance of previous suicide attempts, history of suicide in the family, history of stressful life events in the previous 6 months, poor income, unemployment, sleep disturbances, severe hopelessness with depression, and coexisting symptoms of anxiety as risk factors. CONCLUSION: The first step in prevention of suicides is doubtlessly strong and reliable communication, due to the fact that the majority of subjects who commit suicide have had contact with a health professional during the month before the suicide

Investigation of genetic causes in non-obstructive azoospermic patients

Background: Male factor infertility is a health problem that affects millions of couples around the world. Male factor infertility is responsible for approximately more than half of all cases of infertility. About 15% of men and 10% of women with infertility may have genetic abnormalities, including chromosomal abnormalities and single gene mutations. In this study, results of genetic analys is of the infertile male patients who underwent testicular sperm extraction (TESE) with the diagnosis of non-obstructive azoospermia were evaluated in order to reveal genetic defects that impair or prevent spermatogenesis in male infertility. Methods: We compared the results of peripheral blood chromosome analysis, molecular karyotyping, male infertility genetic panel, and also testosterone, prolactin, follicular stimulating hormone and luteinizing hormone levels in non-obstructive azoospermic infertile patients aged 26–44 years, and investigated the relationship between these parameters and genetic mutations. Results: As a result of this research, among 26 patients, INSL3 (insulin-like peptide 3) gene mutation, which is considered pathogenic according to the criteria published by the American College of Medical Genetics and Genomics (ACMG) was detected in 1, FSHR (follicle stimulating hormone receptor) gene polymorphism in 17, CFTR (cystic fibrosis transmembrane conductance regulator) mutations in 5, CATSPER1 (cation channel sperm associated 1) and TEX101 (testis expressed 101) in 1, LHCGR (luteinizing hormone/choriogonadotropin receptor) in 1, ZMYND15 (zinc finger mynd-type containing 15) in 1, DNAH5 (dynein axonemal heavy chain 5) in 2, and DNAH11 (dynein axonemal heavy chain 11) changes in 1 patient. In the chromosome analysis, 47XXY Klinefelter syndrome was observed in 6 patients. Conclusions: The results have shown that non-obstructivea zoospermic patients with complaints of infertility may have other genetic abnormalities leading to infertility, despite the results of chromosomal analysis of the peripheral blood samples were within normal reference limits. Investigating these underlying genetic disorders helped us find the cause of infertility in ourpatient population

A case of psychosis who amputated his finger

Kendine zarar verme davranışı intihar amacı olmadan kişinin vücuduna ya da vücudun bir kısmına kasıtlı olarak zarar vermesidir. Kendine zarar verme davranışı hafif şekillerde görülürken bazen ağır şekillerde de kendini gösterebilmektedir. Ağır kendine zarar verme davranışı genellikle ciddi bir psikiyatrik rahatsızlığın göstergesidir ve organ ve/veya organ fonksiyon kaybı ile sonuçlanabilir. Biz burada tekrarlayan şekilde kendini yaralama davranışı gösteren bir şizofreni vakasını sunmayı amaçladık. Özellikle riskli şizofreni hasta gruplarında kendine zarar verme davranışı olasılığının göz önünde bulundurulmasını önermekteyiz.Self-harm behavior is defined as the person’s intentional, direct injuring of some body tissue or the whole body most often done without suicidal intentions. Mild types of selfmutilation is seen frequently however more severe ones are rarely seen. Severe self-mutilation is generally a sign of a serious psychiatric disorder and it can result in organ and/or organ functionality loss. In this study we aimed to present a schizophrenic patient with repetitive self-mutilation. As a conclusion, practicing clinicians should take into consideration the possibility of self-harm behavior in schizophrenia patients especially if they have high risk properties

Using Positron Emission Tomography/Computed Tomography to Diagnose Atypically Located Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type, Mimicking Necrotising Soft Tissue Infection

Extranodal natural killer/T-cell lymphoma (ENKTL) is an Epstein-Barr virus-associated, rapidly spreading lymphoproliferative disorder with a poor prognosis. Although it usually manifests with nasal involvement, different clinical and histopathological features can be detected. In nasal form, it may be confused with mucormycosis. Identifying the appropriate biopsy site is crucial for an accurate ENKTL-nasal type diagnosis, and positron emission tomography/computed tomography (PET/CT) can facilitate this. In this paper, we share the case of a 73-year-old male who presented with nasal and skin involvement, and was diagnosed with an unfavourable prognosis using PET/CT-guided biopsy. Unfortunately, the initial biopsies were inconclusive and led to an unnecessary antimicrobial treatment. Combining fluorodeoxyglucose PET/CT images allowed us to pinpoint the biopsy location and assess the depth of tissue infiltration, resulting in a successful biopsy even in this rare case

Risk factors for linezolid-associated thrombocytopenia and negative effect of carbapenem combination

Introduction: Linezolid is a synthetic antimicrobial agent with a broad spectrum of activity against virtually all Gram-positive bacteria. Although linezolid is generally well tolerated, the prolonged use of linezolid can lead to myelosuppression, including neutropenia, thrombocytopenia, and anemia. The aim of this study was investigating the risk factors for thrombocytopenia in patients who received linezolid therapy. Methodology: This retrospective study was performed on patients who received linezolid therapy between July 2007 and December 2017. Thrombocytopenia was defined as either a platelets count of < 100×109/L or a 25% reduction from the baseline platelet count. Results: A total of 371 patients, (198 (53%) male and 173(47%) female were included into the study. Mean duration of therapy was 12.81 ± 5.19 days. Linezolid-induced thrombocytopenia was detected in a total of 111 patients. Using the univariate analysis advanced sex, serum urea concentration, baseline platelet level and low eGFR value were found to be risk factors for linezolid associated thrombocytopenia (p < 0.05). According to a multivariate analysis, patients undergoing carbapenem treatment combination therapy (p = 0.003) and with a baseline platelet level of < 200×109/L (p = 0.00) were found to have a high risk of developing thrombocytopenia. Conclusions: Several factors may influence of linezolid associated thrombocytopenia. Platelet count should be monitored during therapy and thrombocytopenia should be kept in mind in patients with baseline platelet level of < 200×109/L, low eGFR, linezolid-carbapenem combination therapy