Comparison of serum and bronchoalveolar lavage fluid sialic acid levels between malignant and benign lung diseases

BACKGROUND: It is known that tissue and serum sialic acid levels may be altered by malignant transformation. In this study, sialic acid levels were determined in bronchoalveolar lavage fluid (BAL) and serum in two groups of patients with lung cancer and non-malignant diseases of the lung. METHODS: Colorimetric methods were used for determination sialic acid in serum and in BAL samples. Flexible bronchoscopy was used to obtain the latter. RESULTS: Sialic acid levels in bronchoalveolar lavage fluid and serum did not show any statistically significant difference between subjects with malignant and the non-malignant lung diseases (p > 0.05). Sialic acid levels were also unrelated to the stage and localization of the tumor (p > 0.05). CONCLUSIONS: Sialic acid levels do not appear to be a good marker for discriminating malignant from non-malignant diseases of the lung

Near-ground Effect of Height on Pollen Exposure

The effect of height on pollen concentration is not well documented and little is known about the near-ground vertical profile of airborne pollen. This is important as most measuring stations are on roofs, but patient exposure is at ground level. Our study used a big data approach to estimate the near-ground vertical profile of pollen concentrations based on a global study of paired stations located at different heights. We analyzed paired sampling stations located at different heights between 1.5 and 50m above ground level (AGL). This provided pollen data from 59 Hirst-type volumetric traps from 25 different areas, mainly in Europe, but also covering North America and Australia, resulting in about 2,000,000 daily pollen concentrations analyzed. The daily ratio of the amounts of pollen from different heights per location was used, and the values of the lower station were divided by the higher station. The lower station of paired traps recorded more pollen than the higher trap. However, while the effect of height on pollen concentration was clear, it was also limited (average ratio 1.3, range 0.7–2.2). The standard deviation of the pollen ratio was highly variable when the lower station was located close to the ground level (below 10m AGL). We show that pollen concentrations measured at >10m are representative for background near-ground levels

Research needs in allergy: an EAACI position paper, in collaboration with EFA

Abstract In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21 st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein

Clustering Internet Usage Behaviours with SOM Neural Networks

According to different needs of users, there are different consumption habits. Consumption habits of people, which have the same age group or the same professions, are similar. A type of internet usage habits of people in this way is one of these habits. In recent years, developments in technology, GSM, and especially with 4G mobile internet usage have found applications in many areas of daily life. Enter to internet, wherever users need to, creates freedom. Messaging, media, finance and many different needs can be met through this connection. Users' occupation, age, gender, location, usage patterns according to different characteristics such as income level and the relevant properties are similar to each other according to the amount of internet usage (in Mb Download) connected to internet and internet usage frequency and duration of exposure can be clustered. SOM type of study, personal internet usage by artificial neural networks (data of the CDR) process and their profession, age, gender, location is to cluster usage patterns according to the values

Immigrant panel > Relationship Diary

Each day for 28 days, panel members filled out diaries about the experiences with their partner that day. The month prior to the survey, a filter question was presented to determine who met the criteria and were willing to participate. A few days prior to the survey, a letter with more detailed information was sent to the selected panel members. The diary took about 5 minutes to complete and panel members could earn up to 7 euros bonus

What makes couples happy? Marital and life satisfaction among ethnic groups in the Netherlands

This study examines predictors of life satisfaction that are more distal (spousal normative beliefs and attitudes) and more proximal (marital satisfaction) in 404 mainstreamers, 375 Western, and 195 non-Western immigrants living in the Netherlands. In the immigrant groups, we used ethnic and mainstream identity and perceived discrimination as distal predictors. Results revealed that path models in which proximal variables mediated the relation between distal variables and outcomes were valid in all groups. Significant, yet small group differences were found between the non-Western immigrants and Western immigrants on all scales (to a lesser extent between non-Western immigrants and mainstreamers). Traditional marital types and perceived discrimination were more prevailing in the non-Western group, whereas a harmonious marital type, mainstream identity, and marital satisfaction were more salient in the Western group. The mainstream Dutch group was similar to the Western group in all marriage-related aspects. Validity of marriage models were discussed in light of a bottom-up approach to life satisfaction. Group differences and similarities were discussed in terms of differences in family formation and structure as well as adjustment to the Dutch society. Keywords: acculturation, immigrants, life satisfaction, marital satisfaction, spousal attitudes, spousal normative beliefs, the Netherland