Dimorphandra mollis: An alternative as a source of flavonoids with antioxidant action

Os frutos da espécie Dimorphandra mollis são ricos nos flavonóides rutina e quercetina, que são compostos com alta atividade antioxidante, podendo assim ser utilizados na prevenção de enfermidades causados por radicais livres. O objetivo deste estudo foi obter um extrato rico em flavonóides a partir dos frutos de D. mollis. O extrato foi analisado utilizando os métodos de doseamento por espectrofotometria e cromatografia líquida de alta eficiência. Foi identificada a presença de rutina e quercetina no extrato, que apresentou um teor de flavonóides totais de 33,71 %. O extrato, ainda, apresentou ação antioxidante favorável frete aos radicais DPPH e ABTS. Assim, foi possível concluir que os frutos de D. mollis são uma rica fonte de flavonóides de ação antioxidante.Dimorphandra mollis fruits are rich in flavonoids rutin and quercetin, which are compounds with high antioxidant activity and can be used to prevent diseases caused by free radicals. The aim of this study was to obtain an extract rich in flavonoids from fruits of D. mollis. The extract was analyzed using the methods of determination by spectrophotometry and high performance liquid chromatography. The presence of rutin and quercetin was identified in the extract, which showed a total flavonoids content of 33.71 %. The extract also showed antioxidant activity as scanvanger of DPPH and ABTS radicals. It was possible to conclude that D. mollis fruits are a rich source of flavonoids with antioxidant action.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Development and evaluation of an emulsion containing lycopene for combating acceleration of skin aging

Licopeno é um carotenóide com potente atividade antioxidante encontrado em grande quantidade no tomate e usado no combate a diversas doenças como doenças cardiovasculares e diferentes tipos de cânceres, incluindo o câncer de próstata. O objetivo desse trabalho foi desenvolver uma emulsão contendo extrato de licopeno obtido do tomate salada e avaliar a citotoxicidade do extrato, a estabilidade, o comportamento reológico, atividade antioxidante e permeação do fitocosmético. O cosmético foi desenvolvido utilizando fase oleosa contendo derivados de Karité e submetido à avaliação da estabilidade físico-química, espalhabilidade, análise térmica, comportamento reológico, qualidade microbiológica, citotoxicidade, atividade antioxidante e testes de permeação e retenção cutânea. Os resultados demonstraram que o fitocosmético é estável, apresenta comportamento reológico desejável para uma formulação tópica e é um produto promissor para ser utilizado no combate à aceleração do envelhecimento cutâneo.Lycopene, a carotenoid and potent antioxidant is found in large quantities in tomatoes. Lycopene combats diseases, such as cardiovascular disease and different types of cancer, including prostate cancer. However, its topical use in emulsion form for the combat of skin aging is under-explored. The aim of the present study was to develop an emulsion containing lycopene extracted from salad tomatoes and evaluate its cytotoxicity, stability, rheological behavior, antioxidant activity and phytocosmetic permeation. The developed cosmetic comprised an oil phase made up of shea derivatives and was evaluated in terms of its physiochemical stability, spreadability, thermal analysis, rheological behavior, microbiological quality, cytotoxicity, antioxidant activity, cutaneous permeation and retention. The results demonstrate that this phytocosmetic is stable, exhibits satisfactory rheological behavior for a topical formula and is a promising product for combating skin aging

Tomato salad: an alternative as antioxidant source for topic use

O tomate é a principal fonte de licopeno que é um carotenóide com alta atividade antioxidante, podendo assim ser utilizado topicamente na forma de um fitocosmético no combate ao envelhecimento cutâneo. O objetivo deste estudo foi obter um extrato rico em licopeno através da polpa do tomate tipo salada. O extrato foi analisado utilizando os métodos de espectroscopia no ultravioleta/visível, cromatografia de camada delgada e cromatografia líquida de alta eficiência. A atividade antioxidante do extrato foi avaliada utilizando o método do radical livre DPPH. Foi identificada a presença de licopeno na polpa do tomate salada e o extrato apresentou uma fração apolar rica em carotenóides referente a 96,70% de licopeno. Na avaliação da atividade antioxidante usando o radical DPPH, o extrato apresentou atividade (IC50 de 0,311 mg/mL). Nós concluímos que o tomate salada é uma fonte rica em licopeno e pode ser utilizado futuramente como antioxidante para uso tópicoTomato is the principal source of lycopene, a carotenoid with high antioxidant activity which can be used topically as a phytocosmetic to combat skin aging. The aim of this study was to get a lycopene-rich extract from salad tomato pulp. The extract was analyzed using UV/vis spectroscopy, thin layer chromatography and high performance liquid chromatography. Oxidant activity was analyzed using the free radical DPPH method. The presence of lycopene in the salad tomato was confirmed. It was present in the apolar fraction rich in carotenoids, which was 96.70% lycopene. In the evaluation of the antioxidant activity, using the radical DPPH, the extract showed activity (IC50 = 0,311 mg/mL). We conclude that the salad tomato can be used as a source of antioxidants for topic use.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Determination of the Real Influence of the Addition of Four Thickening Agents in Creams Using Rheological Measurements

This study aimed to characterize different emulsions obtained by the addition of four thickening agents, using rheological measurements, beyond analyzing the emulsions by polarized light microscopy looking for liquid crystals on them. The addition of these four thickening agents did not modify the base emulsion rheology, only an improvement in the sensory of the formulation was verified. The polarized light microscopy showed the formation of liquid crystalline structures in all the formulations, thus, the thickening agents did not influence in this parameter too. However, the emulsions could be considered appropriated for cosmetic purposes, probably being highly physically stable. © 2013 Copyright Taylor and Francis Group, LLC

Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems

Rosacea is a multifactorial chronic inflammatory dermatosis characterized by flushing, nontransient erythema, papules and pustules, telangiectasia, and phymatous alterations accompanied by itching, burning, or stinging, the pathophysiology of which is not yet fully understood. Conventional topical treatments usually show limited efficacy due to the physical barrier property of the skin that hinders skin penetration of the active ingredients, thereby hampering proper drug skin delivery and the respective therapeutic or cosmetic effects. New advances regarding the physiopathological understanding of the disease and the underlying mechanisms suggest the potential of new active ingredients as promising therapeutic and cosmetic approaches to this dermatosis. Additionally, the development of new drug delivery systems for skin delivery, particularly the potential of nanoparticles for the topical treatment and care of rosacea, has been described. Emphasis has been placed on their reduced nanometric size, which contributes to a significant improvement in the attainment of targeted skin drug delivery. In addition to the exposition of the known pathophysiology, epidemiology, diagnosis, and preventive measures, this Review covers the topical approaches used in the control of rosacea, including skin care, cosmetics, and topical therapies, as well as the future perspectives on these strategies