Hyperbaric oxygen treatment of superficial soft tissue lesions in children with oncologic disease

This study aimed to assess the feasibility and results of hyperbaric oxygen therapy (HOT) as supportive treatment of lesions of superficial soft tissues in children with oncological diseases. This was a retrospective analysis and review of all records of children observed at the Pediatric Hematology-Oncology Department of the University of Padova and treated adjuvantly with HOT. Between 1996 and 2010, 12 patients (5 males and 7 females, median age 7 years, range 0.5–16) underwent HOT. The effectiveness of HOT varied according to the lesion treated. Ten out of 12 patients were cured. Efficacy was most questionable in 2 patients with skin graft and flaps at risk. Compliance to therapy was close to 100%. In just one case, HOT was interrupted for the appearance of local skin metastases close to the site of primary tumor. HOT showed itself to be safe and effective in most patients even those immunocompromised or critically ill

Teaching evidence-based practice to physiotherapy students in Italy:a cross sectional study

Background: Evidence-based practice (EBP) is being rapidly adopted by the Italian physiotherapy community, although a knowledge gap persists at clinical level with consequent lack of integration of EBP into ground roots practice. Teaching of EBP during the Bachelor of Science (BSc) undergraduate course in physiotherapy likely has a vital role to play in the spread of knowledge, providing a grounding in the fundamental concepts of EBP. The aim of the present study was to investigate the prevalence of EBP educational content in Italian BSc courses in physiotherapy. Methods: This is a cross-sectional study during which characteristics of EBP teaching in BSc degree courses of physiotherapy in Italy were collected from institutional websites during the period May to September 2021 with an update in August 2022. We used the STrengthening the Reporting of Observational studies in Epidemiology (STROBE) guidelines for our manuscript.Results: Forty-two physiotherapy BSc degree programs were retrieved, accounting for all the BSc delivered in the 2021–2022 academic year. Fourteen of these (33.3%) did not report EBP content. Northern universities provided EBP content in 16 out of 18 (88%) degree courses. Central Italian universities provided EBP content in 6 out of 9 (66.6%) degree courses. Southern universities delivered EBP content in 3 out of 9 (33.3%) degree courses. The universities of Sicily and Sardinia provided EBP content in 2 out of 5 (40%) degree courses. The degree courses taught in public universities were more likely to contain EBP material (25 out of 37, 67.4%), compared to those taught within the private system (3 out of 5, 60%). Conclusions: The prevalence of EBP content within physiotherapy BSc degree programs in Italy can be considered suboptimal, with both regional differences and according to the system (public vs private). The results of this study could be used as a stimulus for increasing investment in the teaching of EBP in Italian physiotherapy degree courses, thereby improving educational standards.</p

Respiratory physiotherapy in patients with COVID-19 infection in acute setting: a Position Paper of the Italian Association of Respiratory Physiotherapists (ARIR)

Respiratory physiotherapy in patients with COVID-19 infection in acute setting: a Position Paper of the Italian Association of Respiratory Physiotherapists (ARIR) On February 2020, Italy, especially the northern regions, was hit by an epidemic of the new SARS-Cov-2 coronavirus that spread from China between December 2019 and January 2020. The entire healthcare system had to respond promptly in a very short time to an exponential growth of the number of subjects affected by COVID-19 (Coronavirus disease 2019) with the need of semi-intensive and intensive care units

[3H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions

[3H]Adenine has previously been used to label the newly discovered G protein-coupled murine adenine receptors. Recent reports have questioned the suitability of [3H]adenine for adenine receptor binding studies because of curious results, e.g. high specific binding even in the absence of mammalian protein. In this study, we showed that specific [3H]adenine binding to various mammalian membrane preparations increased linearly with protein concentration. Furthermore, we found that Tris-buffer solutions typically used for radioligand binding studies (50 mM, pH 7.4) that have not been freshly prepared but stored at 4°C for some time may contain bacterial contaminations that exhibit high affinity binding for [3H]adenine. Specific binding is abolished by heating the contaminated buffer or filtering it through 0.2-μm filters. Three different, aerobic, gram-negative bacteria were isolated from a contaminated buffer solution and identified as Achromobacter xylosoxidans, A. denitrificans, and Acinetobacter lwoffii. A. xylosoxidans, a common bacterium that can cause nosocomial infections, showed a particularly high affinity for [3H]adenine in the low nanomolar range. Structure–activity relationships revealed that hypoxanthine also bound with high affinity to A. xylosoxidans, whereas other nucleobases (uracil, xanthine) and nucleosides (adenosine, uridine) did not. The nature of the labeled site in bacteria is not known, but preliminary results indicate that it may be a high-affinity purine transporter. We conclude that [3H]adenine is a well-suitable radioligand for adenine receptor binding studies but that bacterial contamination of the employed buffer solutions must be avoided

L’odontotiranno, “drago” dell’India: un’ipotesi interpretativa

The Odontotyrannos (Gk. ὀδοντοτύραννος, Skt. dvijarāja: “the king of the serpents”) appears for the first time in Book 3 of the&nbsp;Alexander Romance, within the letter of Alexander to Aristotle on the wonders of India, near the description of Mount Aorno (Skt. āvaraṇa: “fortified place”) and a “sea monster-island” (κῆτος). The Odontotyrannos is presented also in the&nbsp;De gentibus Indiae et bragmanibus, attributed to Ps.-Palladius, which has been interpolated in the Alexander Romance, near the “letter of Alexander to Aristotle”. The first part of the De gentibus tells of the journey of a “cultured man” (σχολαστικός) toward India, who describes the island of Taprobane as a heavenly place inhabited by long-living people (Μακρόβιοι) and surrounded by “magnetic islands”. He also describes the ascetic way of living of the Gymnosophists (γυμνοσοφισταί: “naked wise men”): what they eat, how they spend their time and how they reproduce. In the wake of Goossens 1927 the data will be collected and analyzed in order to highlight the iconography and the textual evidence of the Odontotyrannos. The guiding idea of this article is to explore the context in which the creature appears and show its metamorphosis up to the specific image of a “dragon”

Cor, gênero e classe: dinâmicas da discriminação entre jovens de grupos populares cariocas Color, gender and social class: dynamics of discrimination of lower income youth from Rio de Janeiro

Este trabalho discute as dinâmicas de discriminação entre moças e rapazes das camadas populares do Rio de Janeiro, considerando o papel que as hierarquias de cor/raça, gênero e classe social desempenham na configuração das práticas sociais. A análise tem por base entrevistas em profundidade com 42 jovens, de 18 a 24 anos. As situações de discriminação são referidas com maior frequência pelos rapazes. Entre os homens tais experiências estão associadas principalmente aos espaços públicos e ao mercado de trabalho, enquanto entre as mulheres a discriminação está mais vinculada aos espaços privados e ao local de moradia. Os dados estimulam uma discussão sobre a heterogeneidade das experiências de discriminação, na qual a cor/raça está associada às condições sociais e às relações de gênero.This work discuss the dynamics of discrimination of lower income male and female youths from Rio de Janeiro, considering the impact of the color/race, gender and social class hierarchies in the configurations of social practices. The analysis is based on in-depth interviews of 42 young people from 18 to 24 years of age. Situations of discrimination are much more referred to by men. The public spaces and the labor market are cited mainly by the boys. In the girls' view the discrimination is more associated to the place of residence and the private sphere. These data stimulate an analysis about the heterogeneity of the experiences of discrimination, where color/race is associated to social condition and gender relations

Juvenile trajectories and social interventions: repercussions for social practices and health (Rio de Janeiro, Brazil)

Submitted by Sandra Infurna ([email protected]) on 2019-08-29T15:51:45Z No. of bitstreams: 1 SimoneMonteiro_FatimaCecchetto_IOC_2006.pdf: 70298 bytes, checksum: 23b334ceba78b0eb578a0c01b10c38a5 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2019-08-29T15:56:38Z (GMT) No. of bitstreams: 1 SimoneMonteiro_FatimaCecchetto_IOC_2006.pdf: 70298 bytes, checksum: 23b334ceba78b0eb578a0c01b10c38a5 (MD5)Made available in DSpace on 2019-08-29T15:56:38Z (GMT). No. of bitstreams: 1 SimoneMonteiro_FatimaCecchetto_IOC_2006.pdf: 70298 bytes, checksum: 23b334ceba78b0eb578a0c01b10c38a5 (MD5) Previous issue date: 2006Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.This article analyzes the perceptions of a group of youth from the lower economic levels of Rio de Janeiro, Brazil, about the repercussions of social programs on their affective/sexual and educational/professional trajectories. From a comparative perspective, we examined the perspectives, practices, and conditions of life of 42 boys and girls, between 18 and 24 years of age, who did and did not participate in social projects directed at professionalizing and promoting the population. In particular, we discuss the impacts of interventions on concepts of health and AIDS, on indicators of social mobility and professionalization, and on the formation of social networks, including the dimension of gender.We sought to address the effects of civic organizations on the low-income youth population, in the context of socioeconomic crisis and of few social policy advances. We emphasize that in spite of the limitations of such interventions in the greater social context, the experience of social support promoted by the projects contributes to the expansion of life perspectives and the symbolic capital of this social group, with positive impacts for the health field