Investigating the Impact of a Dual Musical Brain-Computer Interface on Interpersonal Synchrony: A Pilot Study

This study looked into how effective a Musical Brain-Computer Interface (MBCI) can be in providing feedback about synchrony between two people. Using a double EEG setup, we compared two types of musical feedback; one that adapted in real-time based on the inter-brain synchrony between participants (Neuroadaptive condition), and another music that was randomly generated (Random condition). We evaluated how these two conditions were perceived by 8 dyads (n = 16) and whether the generated music could influence the perceived connection and EEG synchrony between them. The findings indicated that Neuroadaptive musical feedback could potentially boost synchrony levels between people compared to Random feedback, as seen by a significant increase in EEG phase-locking values. Additionally, the real-time measurement of synchrony was successfully validated and musical neurofeedback was generally well-received by the participants. However, more research is needed for conclusive results due to the small sample size. This study is a stepping stone towards creating music that can audibly reflect the level of synchrony between individuals.Comment: 6 pages, 4 figure

A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data are currently available concerning its role in thyroid cancer. In this study we quantitatively explored a series of 51 paired-normal and papillary thyroid carcinoma (PTC) tissues for AHR-related genes. We identified an increased AHR expression/activity in PTC, independently from its nuclear dimerization partner and repressor but strictly related to a constitutive active MAPK/ERK pathway. The AHR up-regulation followed by an increased expression of AHR target genes was confirmed by a meta-analysis of published microarray data, suggesting a ligand-independent active AHR pathway in PTC. In-vitro studies using a PTC-derived cell line (BCPAP) and HEK293 cells showed that BRAF(V600E) may directly modulate AHR localization, induce AHR expression and activity in an exogenous ligand-independent manner. The AHR pathway might represent a potential novel therapeutic target for PTC in the clinical practice

A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in 'real-world' services

Imaging or Adrenal Vein Sampling Approach in Primary Aldosteronism? A Patient-Based Approach

Primary aldosteronism (PA) is the most frequent cause of secondary hypertension, associated with an increased risk of cardiovascular and cerebral disease, compared to essential hypertension. Therefore, it is mandatory to promptly recognize the disease and offer to the patient the correct diagnostic–therapeutic process in order to reduce new-onset cardiovascular events. It is fundamental to define subtype classification (unilateral or bilateral disease), in order to provide the best treatment (surgery for unilateral and medical treatment for bilateral disease). Here, we report five clinical cases of different subtypes of PA (patients with monolateral or bilateral PA, nondiagnostic AVS, allergy to iodinated contrast, and patients not suitable for surgery), with particular attention to the diagnostic–therapeutic process and the different approaches tailored to a single case. Since PA is a spectrum of various diseases, it needs a personalized diagnostic–therapeutic process, customized for the individual patient, depending on previous medical history, suitability for the surgery and patient’s preferences

Hyperthyroidism incidence in a large population-based study in northeastern Italy

Objective: an improvement in iodine status in Veneto region has been documented in the last decade. We aimed at estimating the incidence of hyperthyroidism in the Veneto region (Italy) over the period 2013-2022. Methods: retrospective population-based study conducted in Veneto (4.9 million people) using the population registry, an administrative health database. Between 2012 and 2022, hyperthyroidism incidence was defined thank to a healthcare co-payment exemption for hyperthyroidism or any hospital diagnosis of hyperthyroidism. Incident hyperthyroidism was defined from 2013 to 2022 to exclude prevalent cases. Standardized incidence rates (IR) were reported by age, sex and etiology of thyroid hyperfunction too. Results: we identified 26,602 incident cases (IR of 54.38 per 100,000 person-years, 2.47-fold higher in females than in males). IR decreased from 69.87 (95%CI, 67.49, 72.25) in 2013 to 42.83 (95%CI, 40.99, 44.66) in 2022. In 2020, an out-of-trend decrease in hyperthyroidism incidence was documented, corresponding to the SARS-CoV-2 pandemic outbreak, with a realignment to the trend in the subsequent years. The annual percentage change according to the cause of hyperthyroidism was as follows: -6.62% (95%CI, 8.47, 4.73) (P<0.0001) in toxic multinodular goiter, -7.56% in toxic uninodular goiter (95%CI, 10.54, 4.48) (P<0.001) and -4.70% (95%CI, 6.33, 3.04) in toxic diffuse goiter (Graves' disease) (P<0.001). Conclusions: we documented a decline in the incidence of hyperthyroidism in the Veneto region, paralleling the improvement of the iodine status, thanks to a long and sustained iodine prophylaxis campaign. SARS-CoV-2 pandemic and vaccination campaign did not change the declining trend of hyperthyroidism incidence in our region

Therapeutic Plasma Exchange for the Treatment of Hyperthyroidism: Approach to the Patient with Thyrotoxicosis or Antithyroid-Drugs Induced Agranulocytosis

: Primary hyperthyroidism is an endocrine disorder characterized by excessive thyroid hormone synthesis and secretion by the thyroid gland. Clinical manifestations of hyperthyroidism can vary from subclinical to overt forms. In rare cases, hyperthyroidism may represent a clinical emergency, requiring admission to an intensive care unit due to an acute and severe exacerbation of thyrotoxicosis, known as a thyroid storm. First-line treatment of hyperthyroidism is almost always based on medical therapy (with thioamides, beta-adrenergic blocking agents, glucocorticoids), radioactive iodine or total thyroidectomy, tailored to the patient's diagnosis. In cases of failure/intolerance/adverse events or contraindication to these therapies, as well as in life-threatening situations, including a thyroid storm, it is necessary to consider an alternative treatment with extracorporeal systems, such as therapeutic plasma exchange (TPE). This approach can promptly resolve severe conditions by removing circulating thyroid hormones. Here we described two different applications of TPE in clinical practice: the first case is an example of thyrotoxicosis due to amiodarone treatment, while the second one is an example of a severe adverse event to antithyroid drugs (agranulocytosis induced by methimazole)

Salt in Late Iron Age Italy. A multidisciplinary approach to the exploration of Italy's coastal exploitation sites:Piscina Torta (Ostia, Rome) case study

During the Copper Age and onwards, unique archaeological sites emerged throughout Europe. These sites exhibit distinct features such as the absence of typical household pottery, the presence of kilns, and extensive layers composed solely of fragments of reddish-brown jars. Scholars generally interpret these sites as specialized locations for salt production through the technique of boiling saltwater, known as briquetage. In Italy, many of these sites are found along the Tyrrhenian coast and span from the Middle Bronze Age to the Roman era, with a particular concentration during the early Iron Age. However, the archaeological evidence in Italy differs from that of other European sites, suggesting that these Italian sites were not solely dedicated to salt production but also involved other economic activities. To delve deeper into the understanding of these sites and their socio-economic context, the University of Groningen initiated the Salt &amp; Power: Early States, Rome and Resource Control project in 2021. The project aims to comprehensively analyze these sites and shed light on the production of salt within their broader societal and economic framework. In this contribution, we present preliminary findings derived from intensive surveys, coring campaigns, and geophysical investigations conducted at one such site, Piscina Torta. This site is believed to be connected to the city of Rome and dates back to the 7th and 6th centuries BCE. Furthermore, we propose a multidisciplinary workflow for studying specialized sites, incorporating various research methodologies and disciplines.</p