12 research outputs found
Can consumption of raw vegetables decrease the count of sister chromatid exchange? : results from a cross-sectional study in Krakow, Poland
BACKGROUND: Sister chromatid exchange (SCE) is a widely used sensitive cytogenetic biomarker of exposure to genotoxic and cancerogenic agents. Results of human monitoring studies and cytogenetic damage have revealed that biological effects of genotoxic exposures are influenced by confounding factors related to life-style. Vegetable and fruit consumption may play a role, but available results are not consistent. The purpose of the study was to investigate the effect of consumption of raw and cooked vegetables and fruits on SCE frequency. METHODS: A total of 62 participants included colorectal cancer (CRC) patients, hospital-based controls and healthy laboratory workers. SCE frequency was assessed in blood lymphocytes. Frequency of vegetable and fruit consumption was gathered by structured semi-quantitative food frequency questionnaire. RESULTS: SCE frequency was lowest among hospital-based controls (4.4 ± 1.1), a bit higher in CRC patients (4.5 ± 1.0) and highest among laboratory workers (7.4 ± 1.2) (p < 0.05). Multivariable linear regression showed a significant inverse effect (b = −0.20) of raw vegetable consumption, but not so for intake of cooked vegetables and fruits. CONCLUSIONS: The results of the study have shown the beneficial effect of consumption of raw vegetables on disrupted replication of DNA measured by SCE frequency, implying protection against genotoxic agents. Further effort is required to verify the role of cooked vegetables and fruits
Study on students' awareness concerning environmental and occupational hazardous agents of cancer risk and prevention methods
Background. The aim of our study was to assess the level
of awareness and knowledge on environmental and
occupational risk of cancer and its prevention among Polish
students. We were interested also in their sources of
knowledge.
Methods. Survey, using the questionnaire, was conducted
among 1080 respondents, who are or probably will be
in their future work, exposed to harmful agents, due to
study profile.
Results. Students rated their knowledge on environmental
and occupational cancer agents and cancer prevention
mostly as limited (over 77%). Participation in
“Safety Work and Environment” courses did not differentiate
their level of cancer risk awareness. 901 students
(84%) responded to question about specific substances,
which may cause cancer. Almost 2% of students indicated
none from 10 given agents as carcinogenic. About 34% of
respondents pointed all given agents, 39% pointed on 8–9
of them, 5–7 agents 13.2% of surveyed and 9% of them
indicated on 1–4 agents. Students were aware of carcinogenic
features of radiation, asbestos, cigarettes smoking
(93.2–93.8%), benzene, benzo[?]pirene and pesticides
(79,2 –83,6%). Less of them declared carcinogenic features
of PAHs (75.4%), heavy metals (73.9%), electromagnetic
field (64.8%) and infections (60.8%). Only 48% of
respondents specified possible lowering of the cancer by
risk intervention practices. Medical and engineering profile,
as well as attendance in courses covering the issues of
health safety at work or environment (SWE) significantly
decreased percentage of respondents who didn’t specified
any procedure (but it was still high: 48–62%).
Conclusion. Our results demonstrate that most students,
only to some extent, are aware of the most well
known cancer-causing substances occurrence. Their
knowledge is mostly limited and they do not know prevention
procedures and ways to lower or eliminate the
risk. Therefore the modernization of educational programs
and development of more efficient communication
strategies in that issues are emerging
An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
none24noneS. BONASSI; A. ZNAOR; M. CEPPI; C. LANDO; W.P. CHANG; N. HOLLAND; M. KIRSCH-VOLDERS; E. ZEIGER; S. BAN; R. BARALE; M.P. BIGATTI; C. BOLOGNESI; A. CEBULSKA-WASILEWSKA; E. FABIANOVA; A. FUCIC; L. HAGMAR; G. JOKSIC; A. MARTELLI; L. MIGLIORE; E. MIRKOVA; M.R. SCARFI; A. ZIJNO; H. NORPPA; M. FENECHS., Bonassi; A., Znaor; M., Ceppi; C., Lando; W. P., Chang; N., Holland; M., KIRSCH VOLDERS; E., Zeiger; S., Ban; R., Barale; M. P., Bigatti; C., Bolognesi; A., CEBULSKA WASILEWSKA; E., Fabianova; A., Fucic; L., Hagmar; G., Joksic; Martelli, ANTONIETTA MARIA; L., Migliore; E., Mirkova; M. R., Scarfi; A., Zijno; H., Norppa; M., Fenec
Influence of mercury vapors on lymphocytes in vivo and on their susceptibility to UV-C and X-rays, and repair efficiency in vitro
Retrospective biological dosimetry at low and high doses of radiation and radioiodine impact on individual susceptibility to ionizing radiation
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