1,940 research outputs found
Performance of a thermally deformable mirror for correction of low-order aberrations in laser beams
The thermally deformable mirror is a device aiming at correcting beam-wavefront distortions for applications where classical mechanical methods are precluded by noise considerations, as in advanced gravitational wave interferometric detectors. This moderately low-cost technology can be easily implemented and controlled thanks to the good reproducibility of the actuation. By using a flexible printed circuit board technology, we demonstrate experimentally that a device of 61 actuators in thermal contact with the back surface of a high-reflective mirror is able to correct the low-order aberrations of a laser beam at 1064 nm and could be used to optimize the mode matching into Fabry-Perot cavities
Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria.
Mycobacteria share with other actinomycetes the ability to produce large quantities of triacylglycerol (TAG), which accumulate as intracytoplasmic lipid inclusions (ILI) also known as lipid droplets (LD). Mycobacterium tuberculosis (M. tb), the etiologic agent of tuberculosis, acquires fatty acids from the human host which are utilized to synthesize TAG, subsequently stored in the form of ILI to meet the carbon and nutrient requirements of the bacterium during long periods of persistence. However, environmental factors governing mycobacterial ILI formation and degradation remain poorly understood. Herein, we demonstrated that in the absence of host cells, carbon excess and nitrogen starvation promote TAG accumulation in the form of ILI in M. smegmatis and M. abscessus, used as surrogate species of M. tb. Based on these findings, we developed a simple and reversible in vitro model to regulate ILI biosynthesis and hydrolysis in mycobacteria. We also showed that TAG formation is tgs1 dependent and that lipolytic enzymes mediate TAG breakdown. Moreover, we confirmed that the nitrogen-deprived and ILI-rich phenotype was associated with an increased tolerance towards several drugs used for treating mycobacterial infections. Importantly, we showed that the presence of ILI substantially enhanced the bacterial burden and granuloma abundance in zebrafish embryos infected with lipid-rich M. abscessus as compared to embryos infected with lipid-poor M. abscessus, suggesting that ILI are actively contributing to mycobacterial virulence and pathogenesis
Minimax estimation of the Wigner function in quantum homodyne tomography with ideal detectors
We estimate the quantum state of a light beam from results of quantum
homodyne measurements performed on identically prepared pulses. The state is
represented through the Wigner function, a ``quasi-probability density'' on
which may take negative values and must respect intrinsic
positivity constraints imposed by quantum physics. The data consists of
i.i.d. observations from a probability density equal to the Radon transform of
the Wigner function. We construct an estimator for the Wigner function, and
prove that it is minimax efficient for the pointwise risk over a class of
infinitely differentiable functions. A similar result was previously derived by
Cavalier in the context of positron emission tomography. Our work extends this
result to the space of smooth Wigner functions, which is the relevant parameter
space for quantum homodyne tomography.Comment: 15 page
Observational Limits on Machos in the Galactic Halo
We present final results from the first phase of the EROS search for
gravitational microlensing of stars in the Magellanic Clouds by unseen
deflectors (machos: MAssive Compact Halo Objects). The search is sensitive to
events with time scales between 15 minutes and 200 days corresponding to
deflector masses in the range 1.e-7 to a few solar masses. Two events were
observed that are compatible with microlensing by objects of mass of about 0.1
Mo. By comparing the results with the expected number of events for various
models of the Galaxy, we conclude that machos in the mass range [1.e-7, 0.02]
Mo make up less than 20% (95% C.L.) of the Halo dark matter.Comment: 4 pages, 3 Postscript figures, to be published in Astronomy &
Astrophysic
The effect of metallicity on the Cepheid distance scale and its implications for the Hubble constant () determination
Recent HST determinations of the expansion's rate of the Universe (the Hubble
constant, H_0) assumed that the Cepheid Period-Luminosity relation at V and I
are independent of metallicity (Freedman, et al., 1996, Saha et al., 1996,
Tanvir et al., 1995). The three groups obtain different vales for H_0. We note
that most of this discrepancy stems from the asumption (by both groups) that
the Period-Luminosity relation is independent of metallicity. We come to this
conclusion as a result of our study of the Period-Luminosity relation of 481
Cepheids with 3 millions two colour measurements in the Large Magellanic Cloud
and the Small Magellanic Cloud obtained as a by-product of the EROS
microlensing survey. We find that the derived interstellar absorption
corrections are particularly sensitive to the metallicity and when our result
is applied to recent estimates based on HST Cepheids observations it makes the
low-H_0 values higher and the high-H_0 value lower, bringing those discrepant
estimates into agrement around .Comment: 4 pages, Latex, with 2 .ps accepted for publication astronomy and
astrophysics Letter
PHIL photoinjector test line
LAL is now equiped with its own platform for photoinjectors tests and
Research and Developement, named PHIL (PHotoInjectors at LAL). This facility
has two main purposes: push the limits of the photoinjectors performances
working on both the design and the associated technology and provide a low
energy (MeV) short pulses (ps) electron beam for the interested users. Another
very important goal of this machine will be to provide an opportunity to form
accelerator physics students, working in a high technology environment. To
achieve this goal a test line was realised equipped with an RF source, magnets
and beam diagnostics. In this article we will desrcibe the PHIL beamline and
its characteristics together with the description of the first two
photoinjector realised in LAL and tested: the ALPHAX and the PHIN RF Guns
EROS Variable Stars : Discovery of Beat Cepheids in the Small Magellanic Cloud and the effect of metallicity on pulsation
We report the discovery of eleven beat Cepheids in the Small Magellanic
Cloud, using data obtained by the EROS microlensing survey. Four stars are
beating in the fundamental and first overtone mode (F/1OT), seven are beating
in the first and second overtone (1OT/2OT). The SMC F/1OT ratio is
systematically higher than the LMC F/1OT, while the 1OT/2OT period ratio in the
SMC Cepheids is the same as the LMC one.Comment: 4 pages, Latex file with 4 .ps figures. accepted for publication in A
A Letter
A comparison of methods for gravitational wave burst searches from LIGO and Virgo
The search procedure for burst gravitational waves has been studied using 24
hours of simulated data in a network of three interferometers (Hanford 4-km,
Livingston 4-km and Virgo 3-km are the example interferometers). Several
methods to detect burst events developed in the LIGO Scientific Collaboration
(LSC) and Virgo collaboration have been studied and compared. We have performed
coincidence analysis of the triggers obtained in the different interferometers
with and without simulated signals added to the data. The benefits of having
multiple interferometers of similar sensitivity are demonstrated by comparing
the detection performance of the joint coincidence analysis with LSC and Virgo
only burst searches. Adding Virgo to the LIGO detector network can increase by
50% the detection efficiency for this search. Another advantage of a joint
LIGO-Virgo network is the ability to reconstruct the source sky position. The
reconstruction accuracy depends on the timing measurement accuracy of the
events in each interferometer, and is displayed in this paper with a fixed
source position example.Comment: LIGO-Virgo working group submitted to PR
PHIL Accelerator at LAL - Diagnostic status
http://accelconf.web.cern.ch/AccelConf/BIW2010/papers/tupsm100.pdfInternational audienceThe "Photo-Injector at LAL" (PHIL : http://phil.lal.in2p3.fr/) is a new electron beam accelerator at LAL. This accelerator is dedicated to test and characterise electron photo-guns and high-frequency structures for future accelerator projects (like the next generation lepton colliders, CLIC, ILC). This machine has been designed to produce low energy (E<10 MeV), small emittance (epsilon < 10 pi.mm.mrad), high current (charge 2 nC/bunch) electrons bunch at low repetition frequency (frep<10Hz) [1]. The first beam has been obtained on the 4th of November 2009. This paper will describe the current status and the futures developments of the diagnostics devices on this machine
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