Understanding Diabetes Through Pathway Analysis Evaluation

Metabolic disorders affect many people and identifying significantly perturbed biological processes in a metabolic disease can provide valuable insight into the disease’s mechanisms. Evaluating the proposed Metabolic Pathway Analysis Method (RAMP) will enable us to reliably use it to identify significantly perturbed metabolic pathways that could help identify disease mechanisms and potential therapy targets or disease bio-markers of a metabolic disorder

La monarchie imaginée: sur le royalisme dans l'idéologie de l'Action Française

International audienceThis paper focus on the links between nationalism and royalism within the Action Française. By analyzing different angles of Maurras' ideological construct of Monarchy, disowned by both the old royalists and the pretenders to the throne, we try to explain why this way of picturing the royalty was not a simple anachronistic nostalgia of times gone by. Following Brian Jenkins and Zeev Sternhell's vision of a "populist-modern" rather than "elitist-reactionary" Action Française, this paper explains to what extent and through which channels monarchy became to this movement an increasingly symbolic choice to create an alternative national imagination against the Third Republic's one. A conceptual tool, necessarily dynamic and creative, subordinate to the integral nationalism's requirements.Cet article porte sur les liens entre nationalisme et royalisme au sein de l'Action Française. De quelle façon ce mouvement, qui ne comptait qu'un seul royaliste dans ses rangs lors de sa naissance, parvint à devenir peu de temps après le mouvement royaliste par excellence? En analysant plusieurs aspects de la construction idéologique a posteriori de la monarchie élaborée par Maurras, désavouée à la fois par les anciens royalistes et par les prétendants au trône eux-mêmes, nous tentons ici d'expliquer pourquoi cette image du Roi était bien loin d'être une simple nostalgie anachronique du passé monarchique. En accord avec les thèses de Brian Jenkins et Zeev Sternhell - d'après lesquels l'Action Française était "populiste-moderne" plutôt que "élitiste-réactionnaire" - l'article explique dans quelle mesure et par quelles voies la monarchie est devenue pour le mouvement une option de plus en plus symbolique pour la création d'un imaginaire de la nation alternatif à celui créé par la IIIème République: un outil conceptuel "nécessairement dynamique et créatif", subordonné aux exigences du nationalisme intégral

Computer-Assisted Vocabulary Learning For Deaf Learners Of Foreign Sign Languages

Deaf people have as great or greater need and desire to learn foreign languages as their hearing peers. Currently it is difficult for these learners to find courses and materials that are appropriate for their learning needs. Especially difficult is finding courses or learning materials for learning sign languages, which are more motivating and more accessible for Deaf learners than spoken languages. Additionally, evidence is presented that learning a foreign sign language can act as a bridge to learning a spoken language from the same region. The study presented in this thesis tested the efficacy of a computer-assisted vocabulary learning program designed for learners of signed languages. Participants using the experimental program were able to learn vocabulary from Chilean Sign Language more efficiently than studying vocabulary from a dictionary, the method most commonly available for learning foreign sign language vocabulary at this time. These statistically significant results show that even relatively simple programs can improve upon current vocabulary learning resources

X-ray frequency combs from optically controlled resonance fluorescence

An x-ray pulse-shaping scheme is put forward for imprinting an optical frequency comb onto the radiation emitted on a driven x-ray transition, thus producing an x-ray frequency comb. A four-level system is used to describe the level structure of N ions driven by narrow-bandwidth x rays, an optical auxiliary laser, and an optical frequency comb. By including many-particle enhancement of the emitted resonance fluorescence, a spectrum is predicted consisting of equally spaced narrow lines which are centered on an x-ray transition energy and separated by the same tooth spacing as the driving optical frequency comb. Given a known x-ray reference frequency, our comb could be employed to determine an unknown x-ray frequency. While relying on the quality of the light fields used to drive the ensemble of ions, the model has validity at energies from the 100 eV to the keV range.Comment: 11 pages, 2 figure

Astrophysical line diagnosis requires non-linear dynamical atomic modeling

Line intensities and oscillator strengths for the controversial 3C and 3D astrophysically relevant lines in neonlike Fe${}^{16+}$ ions are calculated. We show that, for strong x-ray sources, the modeling of the spectral lines by a peak with an area proportional to the oscillator strength is not sufficient and non-linear dynamical effects have to be taken into account. Furthermore, a large-scale configuration-interaction calculation of oscillator strengths is performed with the inclusion of higher-order electron-correlation effects. The dynamical effects give a possible resolution of discrepancies of theory and experiment found by recent measurements, which motivates the use of light-matter interaction models also valid for strong light fields in the analysis and interpretation of astrophysical and laboratory spectra.Comment: 5 pages, 3 figure