Effects of blood transfusion on exercise capacity in thalassemia major patients

Anemia has an important role in exercise performance. However, the direct link between rapid changes of hemoglobin and exercise performance is still unknown.To find out more on this topic, we studied 18 beta-thalassemia major patients free of relevant cardiac dysfunction (age 33.5±7.2 years,males = 10). Patients performed a maximal cardiopulmolmonary exercise test (cycloergometer, personalized ramp protocol, breath-by-breath measurements of expired gases) before and the day after blood transfusion (500 cc of red cell concentrates). After blood transfusion, hemoglobin increased from 10.5±0.8 g/dL to 12.1±1.2 (p<0.001), peak VO2 from 1408 to 1546mL/min (p<0.05), and VO2 at anaerobic threshold from 965 to 1024mL/min (p<0.05). No major changes were observed as regards heart and respiratory rates either at peak exercise or at anaerobic threshold. Similarly, no relevant changes were observed in ventilation efficiency, as evaluated by the ventilation vs. carbon dioxide production relationship, or in O2 delivery to the periphery as analyzed by the VO2 vs. workload relationship. The relationship between hemoglobin and VO2 changes showed, for each g/dL of hemoglobin increase, a VO2 increase = 82.5 mL/min and 35 mL/min, at peak exercise and at anaerobic threshold, respectively. In beta-thalassemia major patients, an acute albeit partial anemia correction by blood transfusion determinates a relevant increase of exercise performance, observed both at peak exercise and at anaerobic threshold

Lung function with carvedilol and bisoprolol in chronic heart failure: is beta selectivity relevant?

BACKGROUND: Carvedilol is a beta-blocker with similar affinity for beta1- and beta2 receptors, while bisoprolol has higher beta1 affinity. The respiratory system is characterized by beta2-receptor prevalence. Airway beta receptors regulate bronchial tone and alveolar beta receptors regulate alveolar fluid re-absorption which influences gas diffusion. AIMS: To compare the effects of carvedilol and bisoprolol on lung function in patients with chronic heart failure (CHF). METHODS AND RESULTS: We performed a double-blind, cross-over study in 53 CHF patients. After 2 months of full dose treatment with either carvedilol or bisoprolol, we assessed lung function by salbutamol challenge, carbon monoxide lung diffusion (DLCO), including membrane conductance (DM), and gas exchange during exercise. FEV1 and FVC were similar; after salbutamol FEV1 was higher with bisoprolol (p<0.04). DLco was 82+/-21% of predicted with carvedilol and 90+/-20% with bisoprolol (p<0.01) due to DM changes. Peak VO2 was 17.8+/-4.5 mL/min/kg on bisoprolol and 17.0+/-4.6 on carvedilol, (p<0.05) with no differences in bronchial tone (same expiratory time) throughout exercise. Differences were greater in the 22 subjects with DLCO<80%. CONCLUSION: Carvedilol and bisoprolol have different effects on DLCO and response to salbutamol. DLCO differences, being DM related, are due to changes in active membrane transport which is under alveolar beta2-receptor control. Peak VO2 was slightly higher with bisoprolol particularly in CHF patients with reduced DLCO

Beta decay of 115-In to the first excited level of 115-Sn: Potential outcome for neutrino mass

Recent observation of beta decay of 115-In to the first excited level of 115-Sn with an extremely low Q_beta value (Q_beta ~ 1 keV) could be used to set a limit on neutrino mass. To give restriction potentially competitive with those extracted from experiments with 3-H (~2 eV) and 187-Re (~15 eV), atomic mass difference between 115-In and 115-Sn and energy of the first 115-Sn level should be remeasured with higher accuracy (possibly of the order of ~1 eV).Comment: 9 pages, 3 figures; talk at the NANP'05 Conferenc

Highly sensitive gamma-spectrometers of GERDA for material screening: Part I

The GERDA experiment aims to search for the neutrinoless double beta-decay of 76Ge and possibly for other rare processes. The sensitivity of the first phase is envisioned to be more than one order of magnitude better than in previous neutrinoless double beta-decay experiments. This implies that materials with ultra-low radioactive contamination need to be used for the construction of the detector and its shielding. Therefore the requirements on material screening include high-sensitivity low-background detection techniques and long measurement times. In this article, an overview of material-screening laboratories available to the GERDA collaboration is given, with emphasis on the gamma-spectrometry. Additionally, results of an intercomparison of the evaluation accuracy in these laboratories are presented.Comment: Featured in: Proceedings of the XIV International Baksan School "Particles and Cosmology" Baksan Valley, Kabardino-Balkaria, Russia, April 16-21,2007. INR RAS, Moscow 2008. ISBN 978-5-94274-055-9, pp. 228-232; (5 pages, 0 figures

Observables sensitive to absolute neutrino masses: Constraints and correlations from world neutrino data

In the context of three-flavor neutrino mixing, we present a thorough study of the phenomenological constraints applicable to three observables sensitive to absolute neutrino masses: The effective neutrino mass in Tritium beta decay (m_beta); the effective Majorana neutrino mass in neutrinoless double beta decay (m_2beta); and the sum of neutrino masses in cosmology (Sigma). We discuss the correlations among these variables which arise from the combination of all the available neutrino oscillation data, in both normal and inverse neutrino mass hierarchy. We set upper limits on m_beta by combining updated results from the Mainz and Troitsk experiments. We also consider the latest results on m_2beta from the Heidelberg-Moscow experiment, both with and without the lower bound claimed by such experiment. We derive upper limits on Sigma from an updated combination of data from the Wilkinson Microwave Anisotropy Probe (WMAP) satellite and the 2 degrees Fields (2dF) Galaxy Redshifts Survey, with and without Lyman-alpha forest data from the Sloan Digital Sky Survey (SDSS), in models with a non-zero running of the spectral index of primordial inflationary perturbations. The results are discussed in terms of two-dimensional projections of the globally allowed region in the (m_beta,m_2beta,Sigma) parameter space, which neatly show the relative impact of each data set. In particular, the (in)compatibility between Sigma and m_2beta constraints is highlighted for various combinations of data. We also briefly discuss how future neutrino data (both oscillatory and non-oscillatory) can further probe the currently allowed regions.Comment: 17 pages (RevTeX) + 7 figures (PostScript). Minor changes in text; references added; results unchanged. To appear in PR

A new approach to the front-end readout of cryogenic ionization detectors

We present a novel approach to the readout of ionization detectors. The solution allows to minimize the number of components and the space occupation close to the detector. This way a minimal impact is added on the radioactive background in those experiments where very low signal rates are expected, such as GERDA and MAJORANA. The circuit consists in a JFET transistor and a remote second stage. The DC feedback path is closed using a diode. Two signal cables are only necessary for biasing and readout.Comment: 14 pages, 15 figures and 15 equation

Variation in host susceptibility and infectiousness generated by co-infection: the myxoma–Trichostrongylus retortaeformis case in wild rabbits

One of the conditions that can affect host susceptibility and parasite transmission is the occurrence of concomitant infections. Parasites interact directly or indirectly within an individual host and often these interactions are modulated by the host immune response. We used a free-living rabbit population co-infected with the nematode Trichostrongylus retortaeformis, which appears to stimulate an acquired immune response, and the immunosuppressive poxvirus myxoma. Modelling was used to examine how myxoma infection alters the immune-mediated establishment and death/expulsion of T. retortaeformis, and consequently affects parasite intensity and duration of the infection. Simulations were based on the general TH1–TH2 immunological paradigm that proposes the polarization of the host immune response towards one of the two subsets of T helper cells. Our findings suggest that myxoma infections contribute to alter host susceptibility to the nematode, as co-infected rabbits showed higher worm intensity compared with virus negative hosts. Results also suggest that myxoma disrupts the ability of the host to clear T. retortaeformis as worm intensities were consistently high and remained high in old rabbits. However, the co-infection model has to include some immune-mediated nematode regulation to be consistent with field data, indicating that the TH1–TH2 dichotomy is not complete. We conclude that seasonal myxoma outbreaks enhance host susceptibility to the nematode and generate highly infected hosts that remain infectious for a longer time. Finally, the virus–nematode co-infection increases heterogeneities among individuals and potentially has a large effect on parasite transmission

Global fits to neutrino oscillation data

I summarize the determination of neutrino oscillation parameters within the three-flavor framework from world neutrino oscillation data with date of May 2006, including the first results from the MINOS long-baseline experiment. It is illustrated how the determination of the leading "solar" and "atmospheric" parameters, as well as the bound on $\theta_{13}$ emerge from an interplay of various complementary data sets. Furthermore, I discuss possible implications of sub-leading three-flavor effects in present atmospheric neutrino data induced by $\Delta m^2_{21}$ and $\theta_{13}$ for the bound on $\theta_{13}$ and non-maximal values of $\theta_{23}$, emphasizing, however, that these effects are not statistically significant at present. Finally, in view of the upcoming MiniBooNE results I briefly comment on the problem to reconcile the LSND signal.Comment: 5 pages, 5 figures, talk presented at the SNOW2006 workshop, Stockholm, 2-6 May 200

Geotomography with solar and supernova neutrinos

We show how by studying the Earth matter effect on oscillations of solar and supernova neutrinos inside the Earth one can in principle reconstruct the electron number density profile of the Earth. A direct inversion of the oscillation problem is possible due to the existence of a very simple analytic formula for the Earth matter effect on oscillations of solar and supernova neutrinos. From the point of view of the Earth tomography, these oscillations have a number of advantages over the oscillations of the accelerator or atmospheric neutrinos, which stem from the fact that solar and supernova neutrinos are coming to the Earth as mass eigenstates rather than flavour eigenstates. In particular, this allows reconstruction of density profiles even over relatively short neutrino path lengths in the Earth, and also of asymmetric profiles. We study the requirements that future experiments must meet to achieve a given accuracy of the tomography of the Earth.Comment: 35 pages, 7 figures; minor textual changes in section