Chiral recognition between 1-(4-fluorophenyl)ethanol and 2-butanol: higher binding energy of homochiral complexes in the gas phase

Diastereomeric adducts between (S)-1-(4-fluorophenyl)-ethanol and R and S 2-butanol, formed by supersonic expansion, were studied by a combination of mass selected resonant two-photon ionization-spectroscopy and IR depletion spectroscopy. Chiral recognition is evidenced by the specific spectroscopic signatures of the S1 S0 electronic transition as well as different frequencies and intensities of the OH stretch vibrational mode in the ground state. D-DFT calcns. were performed to assist in the anal. of the spectra and the detn. of the structures. The homochiral and heterochiral complexes show slight structural differences, in particular in the interaction of the alkyl groups of 2-butanol with the arom. ring. The homochiral [FESBS] complex is more stable than the heterochiral [FESBR] diastereomer in both the ground and excited states. The binding energy difference was evaluated to be >0.60 kcal mol-1

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening

Gemini North and South Laser Guide Star Systems Requirements and Preliminary Designs

In the near future, the Gemini Observatory will offer Laser Guide Star Adaptive Optics (LGS AO) observations on both Gemini North and South telescopes. The Gemini North AO system will use a 10W-class sodium laser to produce one laser guide star at Mauna Kea, Hawaii, whereas the Gemini South AO System will use up to five such lasers or a single 50W-class laser to produce one to five sodium beacons at Cerro Pachón, Chile. In this paper we discuss the similarities and differences between the Gemini North and South Laser Guide Star Systems. We give a brief overview of the Gemini facility Adaptive Optics systems and the on-going laser research and development program to procure efficient, affordable and reliable lasers. The main part of the paper presents the top-level requirements and preliminary designs for four of the Gemini North and South Laser Guide Star subsystems: the Laser Systems (LS), Beam Transfer Optics (BTO), Laser Launch Telescopes (LLT), and their associated Periscopes

GNRH and testis of alpaca (Lama pacos): occurence of receptor and in vitro effects

The objectives of these experiments were to found in alpaca (Lama pacos) testis the presence of GnRH receptor, as well as to study the effects of this decapeptide on the testicular endocrine activity. Testes of sexually mature alpacas were used for immunohistochemistry and in vitro studies. Testis pieces were incubated with analogue (buserelin) or antagonist (antide ) of GnRH. The levels of testosterone, PGF2alpha and PGE2 were determined by RIA. GnRH receptor was immunolocalized in the cytoplasm of Leydig cells. Buserelin increased testosterone, PGF2alpha and PGE2 in vitro secretion, while antide reduced the above hormone secretion. The present study indicates, for the first time, that GnRH is one of the main factors that directly modulate, by paracrine and/or autocrine mechanisms, the testicular activity of alpac

Feasibility of transrectal ultrasound method for determination of early pregnancy in Sarda breed lambs

Feasibility of transrectal ultrasound method for determination of early pregnancy in Sarda breed lamb