Do N3 Fatty Acid Supplements Effect Depressive Symptoms Post Cardiovascular Event in Men and Women Ages 40 and Older?

OBJECTIVE: The objective of this selective EBM review is to determine whether or not n-3 fatty acids have an effect on depressive symptoms post cardiovascular event in men and women ages 40 and older. STUDY DESIGN: Systematic review of three English language random controlled trials published between 2011-2012. DATA SOURCES: Two randomized controlled trials published after 2011 comparing the effects of n-3 fatty acid supplementation on depressive symptoms post cardiovascular event and one randomized controlled trial comparing n-3 fatty acid supplementation effects on depressive symptoms in elderly patients with diagnosed depression. The studies were obtained using the PubMed database. OUTCOMES MEASURED: Depressive symptoms, assessed using the Geriatric Depression Scale, was the primary outcome measured in all three studies. In all studies patients depressive symptoms were measured with the GDS-15 before the trial of supplementation vs. placebo began, and then after the trial was over. Results were then compared before and after supplementation. RESULTS: The results of these studies show an insignificant decrease in depressive symptoms of patients supplemented with n-3 fatty acids post cardiovascular event vs. a placebo. However, one study showed the potential for n-3 fatty acid supplementation in depressed elderly patients unrelated to cardiovascular events with a decrease in depressive symptoms after supplementation.6 One subgroup in the study by Andreeva and colleagues reported an increase in depressive symptoms in men who were supplemented n-3 fatty acids for the trial.4 CONCLUSIONS: Based on these studies, the use of n-3 fatty acids for decreasing depressive symptoms in post-cardiovascular events can not be justified. Andreeva and colleagues, as well as Giltay and colleagues, both showed no significant difference in depressive symptoms in patients post-cardiovascular event supplemented with n-3 fatty acids assessed by the GDS-15.4,5 However, Tajalizadekhoob et al. showed n-3 fatty acid supplementation in elderly patients with diagnosed depression does in fact improve their depressive symptoms with a NNT of 8. 6 Although the total patient number of this study was small, further investigation should continue as this proves there is lead way for the use of n-3 fatty acids for their effect in depression

Primate Model for Testing Periodontal Treatment Procedures: II. Production of Contralaterally Similar Lesions

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141689/1/jper0506.pd

High fidelity imaging and high performance computing in nonlinear EIT

We show that nonlinear EIT provides images with well defined characteristics when smoothness of the image is used as a constraint in the reconstruction process. We use the gradient of the logarithm of resistivity as an effective measure of image smoothness, which has the advantage that resistivity and conductivity are treated with equal weight. We suggest that a measure of the fidelity of the image to the object requires the explicit definition and application of such a constraint. The algorithm is applied to the simulation of intra-ventricular haemorrhaging (IVH) in a simple head model. The results indicate that a 5% increase in the blood content of the ventricles would be easily detectable with the noise performance of contemporary instrumentation. The possible implementation of the algorithm in real time via high performance computing is discussed

An Environmental and Energy Information System

The Environmental Information System Office (EISO) at Oak Ridge National Laboratory (ORNL) provides information support for researchers and administrators involved with energy and environmental policy and progress. Multiple EISO activities for various governmental agencies have resulted in establishment of compatible data bases concerned with energy and environmental information, methods for effectively developing these, development and computer display of numerical data summaries, and reports evaluating published information. Direction is provided by continuing dialogue between users and information system staff

Phase Dependent Spectroscopy of Mira Variable Stars

Spectroscopic measurements of Mira variable stars, as a function of phase, probe the stellar atmospheres and underlying pulsation mechanisms. For example, measuring variations in TiO, VO, and ZrO with phase can be used to help determine whether these molecular species are produced in an extended region above the layers where Balmer line emission occurs or below this shocked region. Using the same methods, the Balmer-line increment, where the strongest Balmer line at phase zero is H-delta and not H-alpha can be measured and explanations tested, along with another peculiarity, the absence of the H-epsilon line in the spectra of Miras when other Balmer lines are strong. We present new spectra covering the spectral range from 6200 Angstroms to 9000 Angstroms of 20 Mira variables. A relationship between variations in the CaII IR triplet and H-alpha as a function of phase support the hypothesis that H-epsilon's observational characteristics result from an interaction of H-epsilon photons with the CaII H line. New periods and epochs of variability are also presented for each star

Exploring the Pathogenic and Drug Resistance Mechanisms of Staphylococcus aureus

We have previously identified σS, an ECF sigma factor that is important in the virulence and stress response of S. aureus. Transcriptional profiling of sigS revealed that it is differentially regulated in a variety of laboratory and clinical strains of S. aureus, suggesting that there exists a regulatory network that modulates its expression. In order to identify direct regulators of sigS expression, we performed a biotin pull down assay in tandem with mass spectrometry. We identified CymR as a direct regulator and observed that sigS expression is increased in cells lacking cymR. In addition, transposon mutagenesis was performed to identify regulators of sigS expression. We identified insertions in genes that are transcriptional regulators, and elements involved in amino acid biosynthesis and DNA replication, recombination and repair as influencing sigS expression. Finally, methyl nitro-nitrosoguanidine mutagenesis in conjunction with whole genome sequencing was employed and revealed mutations in the lactose repressor, lacR, and the membrane sensor histidine kinase, kdpD, as negatively effecting sigS expression. EMSAs revealed that LacR is an indirect regulator of sigS expression, while the response regulator KdpE is a direct repressor. These results indicate that a complex regulatory network is in place for sigS that modulates its expression. In a continuation of studies on σS regulation, we next explored interplay with the products of genes conserved within the sigS locus. We determined that this region is conserved amongst all the sequenced staphylococci, and includes four genes: SAUSA300_1721 (a conserved hypothetical protein), as well as sigS, ecfX, and ecfY. In order to investigate the relationship between EcfX and σS we performed protein pull down assays and observed that these two protein interact. Further to this, transcriptional analysis of sigS in an ecfX mutant reveal that expression of sigS is decreased, indicating that it is an activator. Architectural analysis of the sigS locus via RNAseq revealed that the majority of transcription in this region comes from ecfY, a gene that is downstream and divergent to sigS. We demonstrate that inactivation of ecfY leads to a significant increase in sigS expression, and that ecfY null strains are more resistant to DNA damaging agents such as UV, H2O2, MMS, and ethidium bromide, which we have previously demonstrated that a sigS mutant is highly sensitive to. Our studies also revealed that an ecfY null strain is better able to survive intracellularly following phagocytosis by RAW 264.7 cell and demonstrates increased survival in whole-human blood, which is again opposed to that previously observed for sigS deficient strains. Because the ecfY null strain overexpresses sigS, we investigated the regulon of this sigma factor using this mutant in conjunction with RNAseq analysis. We identified that genes putatively under the control of σS are involved in DNA damage and repair, virulence, amino acid starvation and nucleic acid biosynthesis. Collectively, our results indicate that σS is regulated via a unique mechanism: positively through an apparent need for an activator protein (EcfX) and negatively via RNA-RNA interaction (the 3’ UTR of ecfY). We suggest that the evidence presented here greatly adds not only to our understanding of the regulatory circuits extant within S. aureus, but also to alternative sigma factor biology in general. Finally, we evaluated the efficacy of a novel library of quinazoline-based compounds against a highly drug resistant strain of S. aureus. We performed structure activity and structure property relationship assays in order to identify lead compounds. These methods lead to the identification of N2,N4-disubstituted quinazoline-2,4-diamines that had low minimum inhibitory concentrations, along with favorable physiochemical properties. Evaluation of their biological activity demonstrated limited potential for resistance of to our quinazoline based compounds, low toxicity to human epithelial cells, and strong efficacy in vivo. Taken together, our findings support the use of quinazoline derivatives as potential new antimicrobials against multidrug resistant S. aureus

Development of superconducting YBa2Cu3O(x) wires with low resistance electrical contacts

Materials exhibiting superconductivity above liquid nitrogen temperatures (77 K) will enable new applications of this phenomena. One of the first commercial applications of this technology will be superconducting magnets for medical imaging. However, a large number of aerospace applications of the high temperature superconducting materials have also been identified. These include magnetic suspension and balance of models in wind tunnels and resistanceless leads to anemometers. The development of superconducting wires fabricated from the ceramic materials is critical for these applications. The progress in application of a patented fiber process developed by Clemson University for the fabrication of superconducting wires is reviewed. The effect of particle size and heat treatment on the quality of materials is discussed. Recent advances made at Christopher Newport College in the development of micro-ohm resistance electrical contacts which are capable of carrying the highest reported direct current to this material is presented

Signatures of the disk-jet coupling in the Broad-line Radio Quasar 4C+74.26

Here we explore the disk-jet connection in the broad-line radio quasar 4C+74.26, utilizing the results of the multiwavelength monitoring of the source. The target is unique in that its radiative output at radio wavelengths is dominated by a moderately-beamed nuclear jet, at optical frequencies by the accretion disk, and in the hard X-ray range by the disk corona. Our analysis reveals a correlation (local and global significance of 96\% and 98\%, respectively) between the optical and radio bands, with the disk lagging behind the jet by $250 \pm 42$ days. We discuss the possible explanation for this, speculating that the observed disk and the jet flux changes are generated by magnetic fluctuations originating within the innermost parts of a truncated disk, and that the lag is related to a delayed radiative response of the disk when compared with the propagation timescale of magnetic perturbations along relativistic outflow. This scenario is supported by the re-analysis of the NuSTAR data, modelled in terms of a relativistic reflection from the disk illuminated by the coronal emission, which returns the inner disk radius $R_{\rm in}/R_{\rm ISCO} =35^{+40}_{-16}$. We discuss the global energetics in the system, arguing that while the accretion proceeds at the Eddington rate, with the accretion-related bolometric luminosity $L_{\rm bol} \sim 9 \times 10^{46}$ erg s$^{-1}$ $\sim 0.2 L_{\rm Edd}$, the jet total kinetic energy $L_\textrm{j} \sim 4 \times 10^{44}$ erg s$^{-1}$, inferred from the dynamical modelling of the giant radio lobes in the source, constitutes only a small fraction of the available accretion power.Comment: 9 pages and 6 figures, ApJ accepte

Stability of density-stratified viscous Taylor-Couette flows

The stability of density-stratified viscous Taylor-Couette flows is considered using the Boussinesq approximation but without any use of the short-wave approximation. The flows which are unstable after the Rayleigh criterion (\hat \mu<\hat \eta^2, with \hat \mu=\Omega_{out}/\Omega_{in} and \hat \eta= R_{in}/R_{out}) now develop overstable axisymmetric Taylor vortices. For the considered wide-gap container we find the nonaxisymmetric modes as the most unstable ones. The nonaxisymmetric modes are unstable also beyond the Rayleigh line. For such modes the instability condition seems simply to be \hat\mu<1 as stressed by Yavneh, McWilliams & Molemaker (2001). However, we never found unstable modes for too flat rotation laws fulfilling the condition \hat \mu >\hat \eta. The Reynolds numbers rapidly grow to very high values if this limit is approached (see Figs. 3 and 4). Also striking is that the marginal stability lines for the higher $m$ do less and less enter the region beyond the Rayleigh line so that we might have to consider the stratorotational instability as a 'low-$m$ instability'. The applicability of these results to the stability problem of accretion disks with their strong stratification and fast rotation is shortly discussed.Comment: 7 pages, 7 figures, Astron. Astrophys. (subm.