Bibliografia

Abstract

Note on strongly Lie nilpotent rings

This note contains a few introductory results on strongly Lie nilpotent rings and, in particular, an analogue of a well known theorem of P. Hall on nilpotent groups

Set-theoretic solutions to the Yang-Baxter equation and generalized semi-braces

none3This paper aims to introduce a construction technique of set-theoretic solutions of the Yang-Baxter equation, called strong semilattice of solutions. This technique, inspired by the strong semilattice of semigroups, allows one to obtain new solutions. In particular, this method turns out to be useful to provide non-bijective solutions of finite order. It is well-known that braces, skew braces and semi-braces are closely linked with solutions. Hence, we introduce a generalization of the algebraic structure of semi-braces based on this new construction technique of solutions.openCatino F.; Colazzo I.; Stefanelli P.Catino, F.; Colazzo, I.; Stefanelli, P

Struttura degli ortogruppi

Abstract

Screening for developmental disorders in 3- and 4-year-old italian children: a preliminary study

BACKGROUND: The "Osserviamo" project, coordinated by the Municipality of Rome and the Department of Pediatrics and Child Neuropsychiatry of Sapienza University, aimed to validate an Italian version of the Ages and Stages Questionnaire-3 and to collect, for the first time in Italy, data on developmental disorders in a sample of 4,000 children aged 3 and 4 years. The present paper presents the preliminary results of the "Osserviamo" project. METHODS: 600 parents of children between 39 and 50 months of age (divided in two age stages: 42 and 48 months) were contacted from 15 kindergarden schools. RESULTS: 23.35% of the whole sample scored in the risk range of at least one developmental area of the Ages and Stages Questionnaire-3rd Edition (ASQ-3) and 7.78% scored in the clinical range. Specifically, 23.97% of the children in the 42-month age stage scored in the risk range and 5.79% scored in the clinical range. Males scored lower than females in the fine motor skills and personal-social development domains. Moreover, 22.79% of the children in the 48-month age stage scored in the risk range, while 9.55% scored in the clinical range. Males scored lower than females in fine motor skills. CONCLUSION: Italian validation of the ASQ-3 and recruitment of all 4,000 participants will allow these data on the distribution of developmental disorders to be extended to the general Italian pediatric population. One main limitation of the study is the lack of clinical confirmation of the data yielded by the screening programme, which the authors aim to obtain in later stages of the study

Ortogruppi

Abstract

Set-theoretic solutions of the Yang–Baxter equation associated to weak braces

We investigate a new algebraic structure which always gives rise to a set-theoretic solution of the Yang–Baxter equation. Specifically, a weak (left) brace is a non-empty set S endowed with two binary operations + and ∘ such that both (S, +) and (S, ∘) are inverse semigroups and a∘(b+c)=(a∘b)-a+(a∘c)anda∘a-=-a+ahold, for all a, b, c∈ S, where - a and a- are the inverses of a with respect to + and ∘ , respectively. In particular, such structures include that of skew braces and form a subclass of inverse semi-braces. Any solution r associated to an arbitrary weak brace S has a behavior close to bijectivity, namely r is a completely regular element in the full transformation semigroup on S× S. In addition, we provide some methods to construct weak braces

Interleukin-10 inhibits tumor metastasis through an NK-cell dependent mechanism

Interleukin-10 (IL-10) is a recently described pleiotropic cytokine secreted mainly by type 2 helper T cells. Previous studies have shown that IL-10 suppresses cytokine expression by natural killer (NK) and type 1 T cells, thus down-regulating cell-mediated immunity and stimulating humoral responses. We here report that injected IL-10 protein is an efficient inhibitor of tumor metastasis in experimental (B16-F10) and spontaneous (M27 and Lox human melanoma) metastasis models in vivo at doses that do not have toxic effects on normal or cancer cells. Histological characterization after IL-10 treatment confirmed the absence of CD8+ and CD4+ T cells and macrophages at the sites of tumor growth, but abundant NK cells were localized at these sites. This unexpected finding was confirmed by showing that IL-10 inhibits most B16-F10 and Lox metastases in mice deficient in T or B cells (SCID and nu/nu mice), but not in those deficient in NK cells (beige mice or NK cell-depleted mice). However, IL-10 downregulation of pro-inflammatory cytokine production and/or recruitment of additional effector cells may also be involved in the anti-tumor effect at higher local concentrations of IL-10, since transfected B16 tumor cells expressing high amounts of IL-10 were rejected by normal, nu/nu, or SCID mice at the primary tumor stage, and there was still a 33% inhibition of tumor metastasis in beige mice

Predictive score using clinical and blood biomarkers in advanced non-small cell lung cancer (aNSCLC) patients treated with immunotherapy

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