548 research outputs found

    Relations entre profils identitaires et profils motivationnels au lycée

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    International audienceLes années lycées correspondent aux années importantes en termes d'explorations et de choix dans des domaines qui comptent pour la construction identitaire (qui suis-je, qu'est-ce que je vaux, où vais-je ? etc). La motivation intrinsèque ou l'autodétermination (intégration d'une régulation externe de la motivation) des élèves sont des facteurs de réussite scolaire (Vallerand, Fortier & Guay (1997). De nombreux travaux menés auprès de lycéens ou de collégiens ont étudiés la présence de profils d'élèves autodéterminés ou non autodéterminés (Ratelle, Guay, Vallerand, Larose et Senecal, 2007). Dans le cadre d'une étude exploratoire, notre objectif est de définir chez les lycéens des profils motivationnels et d'étudier la façon dont ceux-ci se caractérisent du point de vue des statuts identitaires et du niveau d'autodétermination. L'échantillon de population est constitué de 427 lycéens scolarisés en Terminale dans des établissements des villes de Toulouse, Bordeaux et Grenoble (moyenne d'âge =16.84, ET= .87 ; 62.3% filles). Les dimensions identitaires sont évaluées à partir de la version française de la DIDS (Dimension of Identity Development Scale - Luyckx et al., 2008) validée par notre équipe (Zimmermann et al., EARA 2012) et les profils motivationnels à partir de l'échelle de motivation dans les études (EME-U28) de Vallerand et al. (1989). A partir d'une analyse en clusters nous identifions 4 profils allant de la motivation complète à l'a-motivation. Le croisement entre les profils motivationnels et le genre et les profils identitaires (statuts et processus) montrent des associations significatives. Par exemple, les garçons et les identités diffuses (en particulier les diffus insouciants) se retrouvent plutôt dans la classe des amotivés. Le croisement des clusters motivationnels et identitaires, en nous permettant de disposer à la fois des caractéristiques de la motivation, de l'identité et du genre, nous amène à identifier des profils d'élèves à risque de décrochage

    Rapid climate change results in long-lasting spatial homogenization of phylogenetic diversity

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    Scientific understanding of biodiversity dynamics, resulting from past climate oscillations and projections of future changes in biodiversity, has advanced over the past decade. Little is known about how these responses, past or future, are spatially connected. Analyzing the spatial variability in biodiversity provides insight into how climate change affects the accumulation of diversity across space. Here, we evaluate the spatial variation of phylogenetic diversity of European seed plants among neighboring sites and assess the effects of past rapid climate changes during the Quaternary on these patterns. Our work shows a marked homogenization in phylogenetic diversity across Central and Northern Europe linked to high climate change velocity and large distances to refugia. Our results suggest that the future projected loss in evolutionary heritage may be even more dramatic, as homogenization in response to rapid climate change has occurred among sites across large landscapes, leaving a legacy that has lasted for millennia

    MurGame: Protect your village from debris flows!

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    Past debris flow events, like in Bondo (2017) and Brienz (2005) in Switzerland have been heavily covered in the (Swiss) media, illustrating how destructive such events can get. Protection measures play an important role in dealing with natural hazards. Debris flows are considered to be very rare, complex and multidimensional processes. Imagining and foreseeing the course and progression of a debris flow as well as estimating the potential damage and the influence of protection measures is a difficult task. Serious games offer a possibility to simulate these kinds of situations. With the MurGame, we have developed an application for natural hazard prevention. In the three-dimensional, interactive game, a village is created by selecting different objects, such as residential buildings or schools. Debris flow simulations show, which buildings would be destroyed and what damage would occur in the event of a debris flow. Different protection measures can be implemented to protect the village and their effectiveness can be monitored during the simulations. After the event, it is necessary to evaluate which measures offer the desired protection, what they may cost and how the needs of the population are met. The MurGame can be played online at www.murgame.ch

    Future Challenges in Psychotherapy Research for Personality Disorders

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    Purpose of Review Individuals with personality disorders are frequently seen in mental health settings. Their symptoms typically reflect a high level of suffering and burden of disease, with potentially harmful societal consequences, including costs related to absenteeism at work, high use of health services, ineffective or harmful parenting, substance use, suicidal and non-suicidal self-harming behavior, and aggressiveness with legal consequences. Psychotherapy is currently the first-line treatment for patients with personality disorders, but the study of psychotherapy in the domain of personality disorders faces specific challenges. Recent Findings Challenges include knowing what works for whom, identifying which putative mechanisms of change explain therapeutic effects, and including the social interaction context of patients with a personality disorder. By following a dimensional approach, psychotherapy research on personality disorders may serve as a model for the development and study of innovative psychotherapeutic interventions. Summary We recommend developing the following: (a) an evidence base to make treatment decisions based on individual features; (b) a data-driven approach to predictors, moderators, and mechanisms of change in psychotherapy; (c) methods for studying the interaction between social context and psychotherapy

    The role of lysine palmitoylation/myristoylation in the function of the TEAD transcription factors

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    The TEAD transcription factors are the most downstream elements of the Hippo pathway. Their transcriptional activity is modulated by different regulator proteins and by the palmitoylation/myristoylation of a specific cysteine residue. In this report, we show that a conserved lysine present in these transcription factors can also be acylated, probably following the intramolecular transfer of the acyl moiety from the cysteine. Using Scalloped (Sd), the Drosophila homolog of human TEAD, as a model, we designed a mutant protein (Glu352Gln Sd ) that is predominantly acylated on the lysine (Lys350 Sd ). This protein binds in vitro to the three Sd regulators-Yki, Vg and Tgi-with a similar affinity as the wild type Sd, but it has a significantly higher thermal stability than Sd acylated on the cysteine. This mutant was also introduced in the endogenous locus of the sd gene in Drosophila using CRISPR/Cas9. Homozygous mutants reach adulthood, do not present obvious morphological defects and the mutant protein has both the same level of expression and localization as wild type Sd. This reveals that this mutant protein is both functional and able to control cell growth in a similar fashion as wild type Sd. Therefore, enhancing the lysine acylation of Sd has no detrimental effect on the Hippo pathway. However, we did observe a slight but significant increase of wing size in flies homozygous for the mutant protein suggesting that a higher acylation of the lysine affects the activity of the Hippo pathway. Altogether, our findings indicate that TEAD/Sd can be acylated either on a cysteine or on a lysine, and suggest that these two different forms may have similar properties in cells

    Einfluss der Fellbach-Wasserfälle auf das Fliessverhalten von Murgängen und auf mögliche Schutzmassnahmen

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    Aufsatz veröffentlicht in: "Wasserbau-Symposium 2021: Wasserbau in Zeiten von Energiewende, Gewässerschutz und Klimawandel, Zurich, Switzerland, September 15-17, 2021, Band 1" veröffentlicht unter: https://doi.org/10.3929/ethz-b-00049975

    Developing a model of short-term integrated palliative and supportive care for frail older people in community settings: perspectives of older people, carers and other key stakeholders

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    Background: Understanding how best to provide palliative care for frail older people with non-malignant conditions is an international priority. We aimed to develop a community-based episodic model of short-term integrated palliative and supportive care (SIPS) based on the views of service users and other key stakeholders in the United Kingdom. Method: Transparent expert consultations with health professionals, voluntary sector and carer representatives including a consensus survey; and focus groups with older people and carers were used to generate recommendations for the SIPS model. Discussions focused on three key components of the model: potential benefit of SIPS; timing of delivery; and processes of integrated working between specialist palliative care and generalist practitioners. Content and descriptive analysis was employed and findings integrated across the data sources. Findings: We conducted two expert consultations (n=63), a consensus survey (n=42) and three focus groups (n=17). Potential benefits of SIPS included holistic assessment, opportunity for end of life discussion, symptom management, and carer reassurance. Older people and carers advocated early access to SIPS, while other stakeholders proposed delivery based on complex symptom burden. A priority for integrated working was the assignment of a key worker to coordinate care, but the assignment criteria remain uncertain. Interpretation: Key stakeholders agree that a model of SIPS for frail older people with non-malignant conditions has potential benefits within community settings, but differ in opinion on the optimal timing and indications for this service. Our findings highlight the importance of consulting all key stakeholders in model development prior to feasibility evaluation

    Blue and green food webs respond differently to elevation and land use

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    While aquatic (blue) and terrestrial (green) food webs are parts of the same landscape, it remains unclear whether they respond similarly to shared environmental gradients. We use empirical community data from hundreds of sites across Switzerland and a synthesis of interaction information in the form of a metaweb to show that inferred blue and green food webs have different structural and ecological properties along elevation and among various land-use types. Specifically, in green food webs, their modular structure increases with elevation and the overlap of consumers’ diet niche decreases, while the opposite pattern is observed in blue food webs. Such differences between blue and green food webs are particularly pronounced in farmland-dominated habitats, indicating that anthropogenic habitat modification modulates the climatic effects on food webs but differently in blue versus green systems. These findings indicate general structural differences between blue and green food webs and suggest their potential divergent future alterations through land-use or climatic changes
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