Governance and the centrality of failure: a comedy of errors

Governance, and particularly what is widely referred to as ‘new’ governance, is currently a hot topic in social research. New governance is widely understood to be a response to the failures of both top down ‘command and control’ and unregulated markets, and the growing complexity, fragmentation and dynamic nature of society. Yet alternative forms of governance are themselves subject to failure. Despite this, failure has aroused little sustained interest among social scientists. This paper attempts to remedy this situation and proposes an alternative approach located within a comic frame which views failure arising in misrecognition

Blocking of word-boundary consonant lengthening in Sienese Italian

This paper examines an aspect of Raddoppiamento sintattico (RS), the lengthening of word-initial consonants following certain words e.g. tre [mm]ele ‘three apples’ in Italian. Most phonological accounts claim the phenomenon is predictable and obligatory (e.g. Nespor & Vogel 1986). However, descriptive sources on Italian (e.g. Camilli 1941) have long claimed that RS interacts with and can be blocked by other phenomena operative in natural speech e.g. pausing. In this paper we outline the phonetic details of the RS blocking phenomena and present the results of an auditory and preliminary acoustic analysis of the interaction between RS and these other phenomena based on a corpus of spontaneous speech data

The Authenticity of Mass Tourism Attractions: Evidence from American Millennials Visiting the Tower of London

The concept of authenticity has been profoundly researched within Tourism Studies with multiple theoretical approaches in existence. Authenticity is considered a key motivational driver for prospective tourists within tourism destinations and has an immediate effect on return visitor intentions. Changing tourism trends observe new ways of uncovering authenticity and with the new demographic millennial travelers (the future of travel), searching for low budget, genuine backstage experiences, is on the rise. Cultural tourism is where people explore or experience a different way of life, reflecting on traditions, ethnicity and objects that may be unfamiliar. The presence of this concept in early theories of tourism has launched a vast discussion which continues in today’s academia considering Tourism Experience, Authenticity and Perceptions. It is the experience that will be the focus of this thesis, which aims to explore individual tourists’ perceptions of one of London’s most prodigious, commodified assets, the Tower of London and extend the interest of the concept authenticity. Guided by Wang’s (1999) constructivist typology, the research involves exploration of tourist recall and evaluates their observations through subjective recollection in relation to authenticity. The empirical study was conducted with five millennial participants, investigating experiential data using qualitative methodology (in-depth interviews), and analyzed using content analysis. Tourists were asked to evaluate the authenticity based on their understanding and experience of the concept, and any authentic/inauthentic aspects they encounter. The findings and discussion focus on the role of perceived authenticity as a measure of product quality and as a determinant of tourist satisfaction. This study analyzes the tourists’ experience at the cultural heritage attraction, addressing research gaps in tourist experience and discussing London as a heritage brand. The results revealed that a high perception of authenticity is desired and can be achieved even though commodification is present. Reconstruction is therefore a sustainable form of tourism development. Cultural authenticity is not impacted by the troubles of mass tourism, therefore, restoring, preserving and managing cultural buildings could fulfil the quest for authenticity. It was established that memorable experiences of London and the role of the American millennial tourist market has helped develop a tailored brand of heritage attractions in London for future tourists. Focusing on authenticity could help heritage managers and marketers better tailor their product

The effect of boundary constraints on finite element modelling of the human pelvis

The use of finite element analysis (FEA) to investigate the biomechanics of anatomical systems critically relies on the specification of physiologically representative boundary conditions. The biomechanics of the pelvis has been the specific focus of a number of FEA studies previously, but it is also a key aspect in other investigations of, for example, the hip joint or new design of hip prostheses. In those studies, the pelvis has been modelled in a number of ways with a variety of boundary conditions, ranging from a model of the whole pelvic girdle including soft tissue attachments to a model of an isolated hemi-pelvis. The current study constructed a series of FEA models of the same human pelvis to investigate the sensitivity of the predicted stress distributions to the type of boundary conditions applied, in particular to represent the sacro-iliac joint and pubic symphysis. Varying the method of modelling the sacro-iliac joint did not produce significant variations in the stress distribution, however changes to the modelling of the pubic symphysis were observed to have a greater effect on the results. Over-constraint of the symphysis prevented the bending of the pelvis about the greater sciatic notch, and underestimated high stresses within the ilium. However, permitting medio-lateral translation to mimic widening of the pelvis addressed this problem. These findings underline the importance of applying the appropriate boundary conditions to FEA models, and provide guidance on suitable methods of constraining the pelvis when, for example, scan data has not captured the full pelvic girdle. The results also suggest a valid method for performing hemi-pelvic modelling of cadaveric or archaeological remains which are either damaged or incomplete

Changes in the pronunciation of Māori and implications for teachers and learners of Māori

This paper discusses changes in the pronunciation of Māori and implications for teachers and learners of Māori. Data on changes in the pronunciation of Māori derives from the MAONZE project (Māori and New Zealand English with support from the Marsden fund). The project uses recordings from three sets of speakers to track changes in the pronunciation of Māori and evaluate influence from English. Results from the project show changes in both vowel quality and vowel duration and some evidence of diphthong mergers in pairs such as ai/ae and ou/au, especially amongst the younger speakers. In terms of duration the younger speakers are producing smaller length distinctions between long/short vowel pairs other than /ā, a/. We discuss the implications of such changes for those teaching Māori and for students learning Māori as a subject. These changes raise interesting questions concerning the pronunciation of Māori by future generations

/u/ fronting and /t/ aspiration in Māori and New Zealand English

This article examines the relationship between the frontness of /u/ and the aspiration of /t/ in both Māori and New Zealand English (NZE). In both languages, these processes can be observed since the earliest recordings dating from the latter part of the nineteenth century. We report analyses of these developments for three groups of male speakers of Māori spanning the twentieth century. We compare the Māori analyses with analyses of related features of the speakers' English and of the English of monolingual contemporaries. The occurrence of these processes in Māori cannot be seen simply as interference from NZE as the Māori-speaking population became increasingly bilingual. We conclude that it was the arrival of English with its contrast between aspirated and unaspirated plosives, rather than direct borrowing, that was the trigger for the fronting of the hitherto stable back Māori /u/ vowel together with increased aspiration of /t/ before both /i/ and /u/

Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation

<p>Abstract</p> <p>Background</p> <p>Manipulating apoptotic resistance represents an important strategy for the treatment of hormone refractory prostate cancer. We hypothesised that the Inhibitor of Apoptosis (IAP) Proteins may be mediating this resistance and knockdown of cIAP-1, cIAP-2 and XIAP would increase sensitivity to apoptosis.</p> <p>Methods</p> <p>cIAP-1, cIAP-2 and XIAP where knocked down either individually or in combination using siRNA in androgen independent prostate cancer PC-3 cells as confirmed by real-time PCR and western blotting. Cells were then treated with TRAIL, Etoposide, or Tunicamycin, and apoptosis assessed by PI DNA staining. Apoptosis was confirmed with Annexin V labelling and measurement of PARP cleavage, and was inhibited using the pan-caspase inhibitor, zVAD.fmk. Clonogenic assays and assessment of ID-1 expression by western blotting were used to measure recovery and proliferation.</p> <p>Results</p> <p>PC-3 are resistant to TRAIL induced apoptosis and have elevated expression of cIAP-1, cIAP-2 and XIAP. Combined knockdown sensitised PC-3 to TRAIL induced apoptosis, but not to Etoposide or Tunicmycin, with corresponding increases in caspase activity and PARP cleavage which was inhibited by ZVAD.fmk. Triple knock down decreased proliferation which was confirmed by decreased ID-1 expression.</p> <p>Conclusion</p> <p>Simultaneous knock down of the IAPs not only sensitised the PC-3 to TRAIL but also inhibited their proliferation rates and clonogenic survival. The inability to alter sensitivity to other triggers of apoptosis suggests that this effect is specific for death receptor pathways and knock down might facilitate immune-surveillance mechanisms to counter cancer progression and, in combination with therapeutic approaches using TRAIL, could represent an important treatment strategy.</p