Einstein and Jordan frames reconciled: a frame-invariant approach to scalar-tensor cosmology

Scalar-Tensor theories of gravity can be formulated in different frames, most notably, the Einstein and the Jordan one. While some debate still persists in the literature on the physical status of the different frames, a frame transformation in Scalar-Tensor theories amounts to a local redefinition of the metric, and then should not affect physical results. We analyze the issue in a cosmological context. In particular, we define all the relevant observables (redshift, distances, cross-sections, ...) in terms of frame-independent quantities. Then, we give a frame-independent formulation of the Boltzmann equation, and outline its use in relevant examples such as particle freeze-out and the evolution of the CMB photon distribution function. Finally, we derive the gravitational equations for the frame-independent quantities at first order in perturbation theory. From a practical point of view, the present approach allows the simultaneous implementation of the good aspects of the two frames in a clear and straightforward way.Comment: 15 pages, matches version to be published on Phys. Rev.

Analyzing Direct Dark Matter Detection Data by the AMIDAS Website

In this talk I have presented the data analysis results of extracting properties of halo WIMPs: the mass and the (ratios between the) spin-independent and spin-dependent couplings/cross sections on nucleons by the AMIDAS website. Although non-standard astronomical setup has been used to generate pseudodata sets for our analyses, it has been found that, without prior information/assumption about the local density and velocity distribution of halo Dark Matter, these WIMP properties have been reconstructed with ~5% to < ~40% deviations from the input values.Comment: 12 pages, 8 eps figures, 1 table, to appear in the proceedings of the 3rd Workshop on Directional Detection of Dark Matter (CYGNUS 2011), June 7-10, 2011, Aussois, Franc

The Brain Network of Expectancy and Uncertainty Processing

[Background] The Stimulus Preceding Negativity (SPN) is a non-motor slow cortical potential elicited by temporally predictable stimuli, customarily interpreted as a physiological index of expectancy. Its origin would be the brain activity responsible for generating the anticipatory mental representation of an expected upcoming event. The SPN manifests itself as a slow cortical potential with negative slope, growing in amplitude as the stimulus approximates. The uncertainty hypothesis we present here postulates that the SPN is linked to control-related areas in the prefrontal cortex that become more active before the occurrence of an upcoming outcome perceived as uncertain. [Methods/Findings] We tested the uncertainty hypothesis by using a repeated measures design in a Human Contingency Learning task with two levels of uncertainty. In the high uncertainty condition, the outcome is unpredictable. In the mid uncertainty condition, the outcome can be learnt to be predicted in 75% of the trials. Our experiment shows that the Stimulus Preceding Negativity is larger for probabilistically unpredictable (uncertain) outcomes than for probabilistically predictable ones. sLoreta estimations of the brain activity preceding the outcome suggest that prefrontal and parietal areas can be involved in its generation. Prefrontal sites activation (Anterior Cingulate and Dorsolateral Prefrontal Cortex) seems to be related to the degree of uncertainty. Activation in posterior parietal areas, however, does not correlates with uncertainty. [Conclusions/Significance] We suggest that the Stimulus Preceding Negativity reflects the attempt to predict the outcome, when posterior brain areas fail to generate a stable expectancy. Uncertainty is thus conceptualized, not just as the absence of learned expectancy, but as a state with psychological and physiological entity.Research by A. Catena is funded by CONSOLIDER-INGENIO CSD2007-00012 (http://www.bcbl.eu/consolider/index.php). Research by J.C. Perales is founded by a Spanish Ministry of Science and Innovation (MICINN) grant (Dirección General de Programas y Transferencia de Conocimiento, Ref. PSI2009-13133, http://www.micinn.es/). Research by A. Catena, A. Candido, and A. Maldonado is founded by a Spanish Ministry of Science and Innovation (MICINN) grant (Dirección General de Programas y Transferencia de Conocimiento, Ref. PSI2009-12217, http://www.micinn.es/). Research was also founded by a Junta de Andalucía grant (Reference P09/SEJ-4752, http://www.juntadeandalucia.es/servicios​/ayudas/detalle/69962.html)

Monocular electro-optical stereo scanner

MEOSS is a single optics and single spectral band camera. Three CCD's working in pushbroom mode are mounted perpendicular to the flight direction on a common focal plate. Their oblique views of + and - 23 degrees forward and backward, as well as nadir oriented, lead to threefold stereoscopic images. This principle allows a nearly simultaneous generation of all three images of a stereo triplet. The time gap between the forward and aft looking images guarantees constant illumination conditions. The ground resolution of MEOSS will be 52 by 80 m ground pixel size, height resolution of 55 m and swath width of 255 km. The drifting ground coverage pattern of MEOSS is unique compared to polar orbiting satellites and will allow images of an area to be taken at different times of the day. A scene will consist of 3144 scan lines, with each having 3236 pixels. The data will be received by the Deep Space Network of JPL Goldstone and mailed to Goddard

Polyphenols rich diets and risk of type 2 diabetes

Type 2 diabetes is an increasing health concern worldwide. Both genetic and environmental risk factors as improper dietary habits or physical inactivity are known to be crucial in the pathogen-esis of type 2 diabetes. Polyphenols are a group of plant-derived compounds with anti-inflammatory and antioxidant properties that are associated with a low prevalence of metabolic conditions charac-terized by insulin resistance, including obesity, diabetes, and hypertension. Moreover, there is now full awareness that foods that are rich in phytochemicals and polyphenols could play an important role in preserving human cardiovascular health and substantial clinical evidence indicates that regu-lar dietary consumption of such foods affects favorably carbohydrate metabolism. This review briefly summarizes the evidence relating dietary patterns rich in polyphenols with glucose metabolism and highlights the potential benefits of these compounds in the prevention of type 2 diabetes

Association of arterial stiffness with a prothrombotic state in uncomplicated nondiabetic hypertensive patients

Background and aims: Past studies reported a significant contribution of a prothrombotic state to the development and progression of target organ damage in hypertensive patients. Stiffening of arterial vessels is associated with aging and hypertension, and additional factors could contribute to this process. This study was designed to examine the relationships between arterial stiffening and the hemostatic and fibrinolytic system. Methods: In 128 middle-aged, nondiabetic, essential hypertensive patients without major cardiovascular and renal complications, we measured coagulation markers that express the spontaneous activation of the hemostatic and fibrinolytic system and assessed stiffness of the arterial tree by measurement of the carotid/femoral pulse wave velocity (cfPWV) and pulse wave analysis with calculation of the brachial augmentation index (AIx). Results: Levels of fibrinogen (FBG), D-dimer (D-d), and plasminogen activator-inhibitor 1 (PAI-1) were significantly higher in patients with PWV and AIx above the median of the distribution. FBG, D-d, and PAI-1 were significantly and directly related with both cfPWV and AIx, and multivariate regression analysis indicated that the relationships of D-d and PAI-1 with both cfPWV and AIx and of FBG with AIx, were independent of age, body mass index, severity and duration of hypertension, use of antihypertensive drugs, blood glucose, and plasma lipids. Conclusion: In middle-aged, uncomplicated, nondiabetic patients with essential hypertension, spontaneous activation of plasma hemostatic cascade and impaired fibrinolysis is significantly and independently associated with stiffening of the arterial tree

Probing the stability of superheavy dark matter particles with high-energy neutrinos

Two of the most fundamental properties of the dark matter particle, the mass and the lifetime, are only weakly constrained by the astronomical and cosmological evidence of dark matter. We derive in this paper lower limits on the lifetime of dark matter particles with masses in the range 10 TeV-10^15 TeV from the non-observation of ultrahigh energy neutrinos in the AMANDA, IceCube, Auger and ANITA experiments. For dark matter particles which produce neutrinos in a two body or a three body decay, we find that the dark matter lifetime must be longer than O(10^26-10^28) s for masses between 10 TeV and the Grand Unification scale. Finally, we also calculate, for concrete particle physics scenarios, the limits on the strength of the interactions that induce the dark matter decay.Comment: 17 pages, 6 figures; v2: references added, discussion improved, matches the version published at JCA

The need for new "patient-related" guidelines for the treatment of acute cholecystitis

Heterogeneity of patients affected by acute cholecystitis, and their co-morbidities make very difficult to standardize the therapy for this very common condition. The staging system suggested in the recent "Tokyo guidelines", did not show a relevant impact on the management of patients and on the outcome of the disease. The relation among local pathological picture, patient clinical status and treatment algorithm, has to be better studied

Sepsis Team Organizational Model to Decrease Mortality for Intra-Abdominal Infections: Is Antibiotic Stewardship Enough?

Introduction. Sepsis is an overwhelming reaction to infection with significant morbidity, requiring urgent interventions in order to improve outcomes. The 2016 Sepsis-3 guidelines modified the previous definitions of sepsis and septic shock, and proposed some specific diagnostic and therapeutic measures to define the use of fluid resuscitation and antibiotics. However, some open issues still exist. Methods. A literature research was performed on PubMed and Cochrane using the terms “sepsis” AND “intra-abdominal infections” AND (“antibiotic therapy” OR “antibiotic treatment”). The inclusion criteria were management of intra-abdominal infection (IAI) and effects of antibiotic stewardships programs (ASP) on the outcome of the patients. Discussion. Sepsis-3 definitions represent an added value in the understanding of sepsis mechanisms and in the management of the disease. However, some questions are still open, such as the need for an early identification of sepsis. Sepsis management in the context of IAI is particularly challenging and a prompt diagnosis is essential in order to perform a quick treatment (source control and antibiotic treatment). Antibiotic empirical therapy should be based on the kind of infection (community or hospital acquired), local resistances, and patient’s characteristic and comorbidities, and should be adjusted or de-escalated as soon as microbiological information is available. Antibiotic Stewardship Programs (ASP) have demonstrated to improve antimicrobial utilization with reduction of infections, emergence of multi-drug resistant bacteria, and costs. Surgeons should not be alone in the management of IAI but ideally inserted in a sepsis team together with anaesthesiologists, medical physicians, pharmacists, and infectious diseases specialists, meeting periodically to reassess the response to the treatment. Conclusion. The cornerstones of sepsis management are accurate diagnosis, early resuscitation, effective source control, and timely initiation of appropriate antimicrobial therapy. Current evidence shows that optimizing antibiotic use across surgical specialities is imperative to improve outcomes. Ideally every hospital and every emergency surgery department should aim to provide a sepsis team in order to manage IAI