El sud tranquil: el cas de Portugal

A Portugal només un de cada vint-i-cinc habitants és estranger. Polítiques força estrictes i centralitzades han marcat l’estabilitat del país. Destaca una marcada voluntat d’integrar als immigrants

The future of hiring : landing jobs as a paradigm of future trends

In today's evolving global landscape, effective talent management is critical for organizations to remain competitive and thrive. However, many businesses face challenges in their talent acquisition and management practices, including issues of cultural barriers, legal constraints, limited efficiency, and lack of innovation. Simultaneously, emerging technologies such as artificial intelligence (AI) and remote work are disrupting traditional processes across industries. These technologies hold the potential to revolutionize talent management practices, providing new opportunities for higher efficiency and effectiveness. This thesis discusses disruptions in the HR industry and their impact on global talent recruitment and management practices to address the gap between effective talent management and the challenges faced by organizations. The research combines comprehensive analysis of existing academic literature with qualitative insights from experts and executives in the field along with quantitative data gathered from a job posting platform. The results provide insights for firms seeking to enhance talent management practices. Practical recommendations are formulated based on the integration of expert insights and academic research. The thesis contributes to the growing body of knowledge on how to navigate in this rapid changing field of global talent management, providing evidence-based material that can inform strategic decision-making and drive organizational success in an increasingly competitive global market.No panorama de evolução global atual, uma gestão eficaz de talento é crucial para que as organizações prosperem e se mantenham competitivas. Não obstante, muitas empresas enfrentam desafios nas suas práticas de aquisição e gestão de talento, incluindo problemas de barreiras culturais, restrições jurídicas, pouca eficiência e falta de inovação. Simultaneamente, as tecnologias emergentes, tais como a inteligência artificial (AI) e o trabalho remoto, estão a perturbar os processos tradicionais em todas as indústrias. Estas tecnologias têm o potencial de revolucionar as práticas de gestão de talento, proporcionando novas oportunidades para uma maior eficiência e eficácia. Esta tese analisa as perturbações na indústria de recursos humanos e o seu impacto nas práticas globais de recrutamento e gestão de talento para colmatar a lacuna entre a gestão eficaz dos talentos e os desafios enfrentados pelas organizações. A investigação combina uma análise exaustiva da literatura académica existente com uma visão qualitativa de peritos e profissionais na indústria, bem como dados quantitativos recolhidos a partir de uma plataforma de emprego. Os resultados fornecem informações às empresas que procuram melhorar as práticas de gestão de talento. As recomendações práticas são formuladas com base na integração dos conhecimentos dos peritos e da investigação académica. A tese contribui para o crescente conhecimento de como navegar nesta indústria da gestão global de recursos humanos que se encontra em rápida mudança. Providenciando conhecimento consubstanciado em evidencias que permite informar a tomada de decisões estratégicas e impulsionar o sucesso organizacional num mercado global cada vez mais competitivo

Optimization of 3D porous structures for controlled drug delivery using quality by design method

The objective of this work was to apply Quality by Design approach to obtain the best conditions to produce 3D polymeric structures for two distinct applications: oral and vaginal route of administration. The first should release 50 mg drug/g scaffold, in 5 hours and the second one 800 mg drug/g scaffold, during 8 h. Initially, the data from previous studies was collected and inserted in MODDE software, and then the Design Space was built and according to those plots, the conditions to start the experimental validation were chosen. The model chosen to perform these studies was Partial Least Square Regression. Both green (probability of failure lower than 5 %) and yellow (probability of failure lower than 10%) zones from Design Space were taken into account and explored. For experimental validation, through the data obtained from QbD studies, scaffolds of chitosan (CHT), xanthan gum (XG) and mixture of CHT and XG were prepared, with N-N’-methylene-bis-acrylamide (MBA) as a crosslinker and tetramethylenediamine (TEMED) and ammonium persulfate (APS) as catalyst and initiator. For the characterization of the produced structures, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy – attenuated total reflectance (FTIR-ATR), mechanical analysis and swelling tests were performed and the ones that achieved the objective regarding morphological and swelling characteristics were chosen for drug impregnation and drug release studies. Additionally, mathematical models were adjusted to the experimental release profiles in order to describe the drug release mechanisms. The studies showed that the porous scaffold that showed better performance for oral route of administration, considering the defined goals, was CHT_6, with 3% chitosan, 2% crosslinker and freezing temperature of -20ºC, that presented drug release of 63,6 mg IBU/g scaffold, in 5 hours. CHT_7, with 3% chitosan, 2% crosslinker and freezing temperature of -80ºC achieved the objective in the second hour, releasing approximately 70 mg IBU/g scaffold. Regarding vaginal route of administration, the scaffold that showed better performance was CHTXG_1 which released 1200 mg IBU/g scaffold, in 8 hours, however, CHT_7 was also very close to the objective, releasing 720,1 mg IBU/g scaffold. Quality by Design approach was an essential and important tool during the development of these structures, once it allowed achieving the objectives set for this thesis, and also reducing the experimental shots (in more and less 60%) needed to achieve the desired goals, what reinforces the power of this tool in processes optimization

Salary and inequalities in Portugal

info:eu-repo/semantics/publishedVersio

Nuno Gama brand international expansion

CEM

Brand international expansion

CEM

Dismissal due to business reasons in Portugal

info:eu-repo/semantics/publishedVersio

Efflux pumps in acinetobacter baumannii: study of new 1-(1-NaphtylMethyl)-Piperazine analogs as potential inhibitors

Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2020, Universidade de Lisboa, Faculdade de Farmácia.Nos últimos anos, a Humanidade tem combatido um problema cada vez mais emergente: infeções bacterianas resistentes. O que foi outrora a solução faz agora parte do problema: antibióticos. Muitas espécies bacterianas tornaram-se resistentes a um largo expectro de moléculas e um desses exemplos é o bacilo Gram-negativo Acinetobacter baummannii – um patogénio responsável por infeções respiratórias e da pele em ambiente hospitalar. Os pacientes crónicos e/ou sujeitos a dispositvos médicos invasivos como catétes ou ventiladores e ainda aqueles cujos tratamentos incluem diálise ou terapêutica antimicrobana nos últimos 90 dias, são os que apresentam maior risco de infeção. A. baumannii apresenta um mecanismo de resistência baseado na extrusão de moléculas de antibiótico através das bombas localizadas na sua membrana. Estas bombas são chamadas bombas de efluxo e a sua presença diminui a susceptilibilidade de A. baumannii a algumas fluoroquinolonas como a ciprofloxacina, uma fluoroquinolona de segunda geração com um largo espectro de actividade antimicrobiana. Portugal foi um dos países com as maiores taxas (entre 25% e 50%) de isolados invasivos com resistência a fluoroquinolonas em 2018. O desenvolvimento de novas moléculas requer o uso de tempo e recursos, pelo que é mais vantajoso o desenvolvimento de moléculas que permitam restabelecer o poder antimicrobiano das moléculas já conhecidas e estudadas. No caso das bombas de efluxo, uma das vias possíveis consiste na utilização de moléculas que são denominadas de EPIs – Inibidores das Bombas de Efluxo que aorsentam actividade sinergística com as moléculas de antibiótico através da inativação das bombas de efluxo. As bombas da família resistência, nodulação e divisão celular são uma das famílias em que estão agrupadas os vários tipos de bombas de efluxo, tendo a 1-(1-naftilmetil)-piperazina (NMP) um efeito inibidor nas bombas desta família em A. baumannii. A principal bomba de efluxo nesta bactéria Gram-negativa é a AdeABC e os genes que codificam para esta estrutura tripartida são os genes adeA, adeB e adeC cuja expressão se encontra sob o controlo do sistema de regulação de dois componentes AdeRS. Neste estudo, testámos uma série de análogos de NMP e a sua capacidade para restaurar a atividade da ciprofloxacina em diferentes isolados de A. Baumannii, tendo ainda sido avaliada a expressão dos genes que codificam para estas bombas bem como os respectivos genes reguladores. Demonstrou-se que os EPIs que podiam reconstituir a atividade da ciprofloxacina contra A. baumannii foram aqueles cuja estrutura apresentava a amina deprotegida: . EPIs 2, 6,7 e 8.In the past few years, humanity has struggled with an emergent problem: multidrug bacterial infections. What was then the solution has now become part of the problem – antibiotics. Many bacterial species have become resistant to a wide range of molecules and such example is the Gram-negative bacillus Acinetobacter baumannii – a pathogen responsible for respiratory and skin infections in hospital environment. Patients who are chronically ill and those who have invasive medica devices such as catheters, sutures, ventilators and those treatments such as dialysis or antimicrobial therapy in the past 90 days are at the highest risk of infection. A. baumannii has a mechanism of resistance based in the extrusion of antibiotic molecules throughout pumps located in its membrane. These pumps are called efflux pumps and they decrease the susceptibility of A. baumannii to some fluoroquinolones such as ciprofloxacin, a second-generation fluoroquinolone with a wide range of action. Portugal was one of the countries with the higher (25% to 50%) percentages of invasive isolates with resistance to fluroquinolones in 2018. The development of new drugs is time and resource consuming and so it is more profitable to develop new molecules that will restore efficacy to old already studied and safety to use antibiotics. These new molecules are called EPIs - Efflux Pump Inhibitors and they synergize with the antibiotic molecules by inactivating the efflux pumps in A. baumannii. Resistance-Nodulation-Division (RND) is one of the families of pumps in which the efflux pumps are grouped and 1-(1-naphthylmethyl)-piperazine (NMP) is one of the EPIs that have effect in inhibiting this pump in A. baumannii. The major efflux pump in these Gram negative species is the AdeABC and the encoding genes of these tripartite structures are adeA, adeB and adeC and whose expression is regulated by a two-component regulation system: AdeRS. In this study we tested a series of analogs of NMP and their ability to restore the antibiotic efficacy of ciprofloxacin in several isolates of A. baumannii and the genes that regulate these pumps. It was shown that the EPIs that could restore the activity of the ciprofloxacin against A. baumannii were the ones in which the amine was unprotected – the EPIs 2,6,7 and 8.Com o patrocínio da Universidade Jules Vernes, Picardie

Still driven - Mobility patterns and gender roles in Portugal

This article explores the relationship between gender and mobility based on the results of a PhD research about the mobility patterns in Portuguese metropolis. Mobility of human groups is one of the strongest trends of the last century with continuity to the present (Sheller and Urry, 2006). Although the empowerment of women in western societies, geographical mobility continues to be gender specific. If this situation is not new at international scene, in Portugal it raises interesting questions as the country has suffered recent and important social changes precisely in what concerns women roles. Using both an hypothetical deductive analytical model and combining quantitative with qualitative techniques in this research we were able to identify different mobility profiles according mainly to social identity in which gender performs a central role

Assessing BPM’s role in a digital innovation project

Dissertation presented as the partial requirement for obtaining a Master's degree in Information Management, specialization in Information Systems and Technologies ManagementThe world is changing. In the digitalization era, digital devices are everywhere, enabled by the quick proliferation of smart and connected products. The transformation we are witnessing is not only about the new digital artefacts, but also includes the alignment of the operations, business processes, strategy and organizational, and IT structures, resulting in the so-called maturity. Although it might not be trivial, this increased efficiency is closely connected with the processes, of how to create opportunities for optimizing and redesigning them. However, the combination of digital innovation and business process management, and how one benefits the other, is not very explored in the literature, which constitutes a research gap. Given this, the importance of business process management practices and their relationship with the remaining organisation’s dimensions was studied and assessed through a comprehensive and systematic literature review. Hence, insights were gathered to create a framework that allows answering the research question “What is the BPM’s role in a digital innovation project?”. It was expected to understand the challenges associated with digital transformation, what core requirements are the most valuable, and what is the role of process management in all of it. A focus group has confirmed the usefulness of the artefact, by showing the correlation between the different elements in scope and allowing an understanding of the capabilities needed in the organisation. Nonetheless, the feedback suggested the adaptation of the framework to include a maturity assessment pre-stage and cost evaluation per digital transformation category, so it can be completely transversal to all types of organisations and all budgets