Dissecting the rules underlying de novo centrosome biogenesis

"The centrosome is the main microtubule organising centre (MTOC) in animal cells, regulating cell motility and polarity during interphase and organising the mitotic spindle in mitosis. Each centrosome has two centrioles, a mother and a daughter, which are surrounded by a multi-layered protein network called pericentriolar material (PCM) (Loncarek and Bettencourt-Dias, 2018; Nigg and Holland, 2018). The PCM contains critical components that anchor and nucleate microtubules (MTs). Centriole biogenesis is a highly regulated process that occurs only once per cell-cycle in proliferating cells (Breslow and Holland, 2019).(...)

Technological tattoo: in-between art and science

info:eu-repo/semantics/publishedVersio

The Museum Today. Towards a participatory and emancipated heterology

info:eu-repo/semantics/publishedVersio

Ronald Bogue: a monument

info:eu-repo/semantics/publishedVersio

The most profound is the skin – the power of tattoos

info:eu-repo/semantics/publishedVersio

O Pensamento como Criação: Filosofia, Arte e Ciência. O Desafio de Deleuze e Guattari

In their last four-handed book, Qu’est ce que la Philosophie?, Deleuze and Guattari support the thesis that philosophy, science and art constitute three different dimensions of thought. Different but complementary. Among them there is no hierarchy or dependency. Deleuze and Guattari state it clearly: “The three ways are specific, as straightforward as each other, and are distinguished by the nature of the plan and what occupies it. To think is to think by concepts, or by functions, or by sensations, and either of these thoughts is no better than the other, or more fully, more completely, more synthetically ‘thought’” . Further, Deleuze and Guattari affirm the creative dimension of thought. “The act of thinking (…) is the only true creation” . Science, art and philosophy thus have in common the fact that they are three creative forms of thought. Now, this article aims at clarifying the meaning of this thesis and at critically proposing an enlargement of its field of application, namely as a way of enlarging the scope and the metaphysical basis of the so-called area of Sci-Art. So, we will try to elucidate the relations between art, science and philosophy thought out by Deleuze and Guattari by gathering a series of concepts (such as “thought”, “chaos”, “virtual”, “becoming”, “infinite”). Moreover, we will critically point out the existence of a fundamental ambiguity concerning the status which Deleuze and Guattari end up by granting to philosophy in its relation to science and art. Finally, we will stress the need of enlarging to science and art the transversality attributed by Deleuze and Guattari to philosophy and we will call for another concept (“intercessors”) so that the relationship between science, art and philosophy can be more deeply though out.info:eu-repo/semantics/publishedVersio

O devir-Foucault de Deleuze

info:eu-repo/semantics/publishedVersio

Sobre O bailado da alma de Pio Abreu. À procura da alma perdida. Ensaio filosófico-científico-artístico sobre as danças e outras desventuras

info:eu-repo/semantics/publishedVersio

Le tatouage entre la science et l'art: secrets et couleurs

Depuis son début, le tatouage est une pratique entourée de secretisme. Par la présentation de quelques d’exemples classiques du tatouage, ainsi que de quelques-uns des plus récents, irrévérents et inattendus, cet article cherche à explorer de nouvelles formes de cette pratique d’inscription corporelle qui nous conduisent à des conceptions imprévues et radicales du secret par lequel que le tatouage est toujours entouré.info:eu-repo/semantics/publishedVersio

Noncanonical Biogenesis of Centrioles and Basal Bodies

The deposited article is a pre-print version.The deposited article version is the Epub Ahead of Print version of the article, posted online 23 April 2018, provided by Cold Spring Harbor Laboratory Press. It hasn't peer-review.This deposit is composed by the main article, and it hasn't any supplementary materials associated.Centrioles and basal bodies (CBBs) organize centrosomes and cilia within eukaryotic cells. These organelles are composed of microtubules and hundreds of proteins performing multiple functions such as signaling, cytoskeleton remodeling, and cell motility. The CBB is present in all branches of the eukaryotic tree of life and, despite its ultrastructural and protein conservation, there is diversity in its function, occurrence (i.e., presence/absence), and modes of biogenesis across species. In this review, we provide an overview of the multiple pathways through which CBBs are formed in nature, with a special focus on the less studied, noncanonical ways. Despite the differences among each mechanism herein presented, we highlighted some of their common principles. These principles, governing different steps of biogenesis, ensure that CBBs may perform a multitude of functions in a huge diversity of organisms but yet retained their robustness in structure throughout evolution.European Research Council Consolidator Grant: (CoG683528__Centriole-BirthDeath); Boehringer Ingelheim Fonds; Fundação para a Ciência e Tecnologia grant: (PD/BD/114350/2016).info:eu-repo/semantics/acceptedVersio