Interaction of dietary polyphenols and gut microbiota: Microbial metabolism of polyphenols, influence on the gut microbiota, and implications on host health

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Role of Dietary Antioxidants in Neurodegenerative Diseases: Where are We Standing?

Capanoglu, Esra/0000-0003-0335-9433; Khan, Haroon/0000-0002-1736-4404; Kamal, Mohammad Amjad/0000-0003-0088-0565; Ceylan, Fatma Duygu/0000-0002-2858-2482WOS: 000521826200002PubMed: 31914905This review presents the potential effects of dietary antioxidants on neurodegenerative diseases. the relationship between autoimmunity and antioxidants. and their preventive effect on neurodegenerative diseases are evaluated. the driven factors of neurodegeneration and the potential effects of natural antioxidants are summarized for Alzheimer's disease, Parkinson's disease, multiple sclerosis, spongiform encephalopathy, Huntington's disease, and amyotrophic lateral sclerosis. the effect of oxidative stress on neurodegenerative diseases and regulative effect of antioxidants on oxidative balance is discussed. This review provides beneficial information for the possible cure of neurodegenerative diseases with dietary intake of antioxidants

<i>Cucurbits</i> Plants: A Key Emphasis to Its Pharmacological Potential

Cucurbita genus has received a renowned interest in the last years. This plant species, native to the Americas, has served worldwide folk medicine for treating gastrointestinal diseases and intestinal parasites, among other clinical conditions. These pharmacological effects have been increasingly correlated with their nutritional and phytochemical composition. Among those chemical constituents, carotenoids, tocopherols, phenols, terpenoids, saponins, sterols, fatty acids, and functional carbohydrates and polysaccharides are those occurring in higher abundance. However, more recently, a huge interest in a class of triterpenoids, cucurbitacins, has been stated, given its renowned biological attributes. In this sense, the present review aims to provide a detailed overview to the folk medicinal uses of Cucurbita plants, and even an in-depth insight on the latest advances with regards to its antimicrobial, antioxidant and anticancer effects. A special emphasis was also given to its clinical effectiveness in humans, specifically in blood glucose levels control in diabetic patients and pharmacotherapeutic effects in low urinary tract diseases